Binimetinib (BioDeep_00000229533)

   

human metabolite


代谢物信息卡片


5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-1,3-benzodiazole-6-carboximidate

化学式: C17H15BrF2N4O3 (440.0296)
中文名称: 贝美替尼
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN1C=NC2=C(F)C(NC3=CC=C(Br)C=C3F)=C(C=C12)C(=O)NOCCO
InChI: InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

描述信息

L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01E - Protein kinase inhibitors > L01EE - Mitogen-activated protein kinase (mek) inhibitors
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C69145 - Mitogen-Activated Protein Kinase Kinase Inhibitor
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
C471 - Enzyme Inhibitor > C1404 - Protein Kinase Inhibitor

同义名列表

17 个代谢物同义名

5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-1,3-benzodiazole-6-carboximidate; 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-1,3-benzodiazole-6-carboxamide; 5-[(4-Bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide; 6-[(4-bromo-2-fluorophenyl)amino]-7-fluoro-N-(2-hydroxyethoxy)-3-methyl-1,3-benzodiazole-5-carboxamide; N-(2-Hydroxyethoxy)-4-fluoro-5-(2-fluoro-4-bromophenylamino)-1-methyl-1H-benzoimidazole-6-carboxamide; MEK-162arry-438162binimetinib; MEK162(ARRY-162,ARRY-438162); Binimetinibum; ARRY 438162; Binimetinib; ARRY-438162; NVP-MEK162; ARRY 162; ARRY-162; MEK-162; Mektovi; MEK162



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

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Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Anuradha Reddy, Tarang Jadav, Amit Kumar Sahu, Pinaki Sengupta. LC-MS/MS bioanalytical method for quantification of binimetinib and venetoclax, and their pharmacokinetic interaction. Bioanalysis. 2022 Jan; 14(2):75-86. doi: 10.4155/bio-2021-0207. [PMID: 34841894]
  • Paola Mian, Elvera Meussen, Djura Piersma, Nienke A G Lankheet. Relatively mild symptoms after chronic overdose with a double-dose encorafenib: a case report. Anti-cancer drugs. 2021 06; 32(5):589-591. doi: 10.1097/cad.0000000000001052. [PMID: 33587356]
  • Francesco Spagnolo. [Long-term efficacy of encorafenib plus binimetinib combined treatment: case report.]. Recenti progressi in medicina. 2021 04; 112(4):49e-52e. doi: 10.1701/3584.35698. [PMID: 33877100]
  • Romain Stammler, Claire Gallois, Julien Taieb, Jean-Paul Duong, Alexandre Karras, Eric Thervet, Hélène Lazareth. Acute renal failure under encorafenib, binimetinib and cetuximab for BRAF V600E-mutated colorectal cancer. European journal of cancer (Oxford, England : 1990). 2021 04; 147(?):60-62. doi: 10.1016/j.ejca.2021.01.024. [PMID: 33618199]
  • Marine Rousset, Karine Titier, Stephane Bouchet, Caroline Dutriaux, Anne Pham-Ledard, Sorilla Prey, Mireille Canal-Raffin, Mathieu Molimard. An UPLC-MS/MS method for the quantification of BRAF inhibitors (vemurafenib, dabrafenib) and MEK inhibitors (cobimetinib, trametinib, binimetinib) in human plasma. Application to treated melanoma patients. Clinica chimica acta; international journal of clinical chemistry. 2017 Jul; 470(?):8-13. doi: 10.1016/j.cca.2017.04.009. [PMID: 28412197]
  • Mehdi Maanaoui, Camille Saint-Jacques, Viviane Gnemmi, Marie Frimat, Arnaud Lionet, Marc Hazzan, Christian Noël, François Provot. Glomerulonephritis and granulomatous vasculitis in kidney as a complication of the use of BRAF and MEK inhibitors in the treatment of metastatic melanoma: A case report. Medicine. 2017 Jun; 96(25):e7196. doi: 10.1097/md.0000000000007196. [PMID: 28640105]
  • Johanna C Bendell, Milind Javle, Tanios S Bekaii-Saab, Richard S Finn, Zev A Wainberg, Daniel A Laheru, Colin D Weekes, Benjamin R Tan, Gazala N Khan, Mark M Zalupski, Jeffrey R Infante, Suzanne Jones, Kyriakos P Papadopoulos, Anthony W Tolcher, Renae E Chavira, Janna L Christy-Bittel, Emma Barrett, Amita Patnaik. A phase 1 dose-escalation and expansion study of binimetinib (MEK162), a potent and selective oral MEK1/2 inhibitor. British journal of cancer. 2017 Feb; 116(5):575-583. doi: 10.1038/bjc.2017.10. [PMID: 28152546]
  • Dongyun Zhang, Marvin Bergsneider, Marilene B Wang, Anthony P Heaney. Targeting the ERK pathway for the treatment of Cushing's disease. Oncotarget. 2016 Oct; 7(43):69149-69158. doi: 10.18632/oncotarget.12381. [PMID: 27708250]