Remdesivir (BioDeep_00000229514)
human metabolite
代谢物信息卡片
(2S)-2-{(2R,3S,4R,5R)-[5-(4-aminopyrrolo[2,1-F][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionic acid 2-ethyl-butyl ester
化学式: C27H35N6O8P (602.2254)
中文名称: 瑞德西韦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(CC)COC(=O)C(C)NP(=O)(OCC1C(C(C(O1)(C#N)C2=CC=C3N2N=CN=C3N)O)O)OC4=CC=CC=C4
InChI: InChI=1S/C27H35N6O8P/c1-4-18(5-2)13-38-26(36)17(3)32-42(37,41-19-9-7-6-8-10-19)39-14-21-23(34)24(35)27(15-28,40-21)22-12-11-20-25(29)30-16-31-33(20)22/h6-12,16-18,21,23-24,34-35H,4-5,13-14H2,1-3H3,(H,32,37)(H2,29,30,31)/t17-,21+,23+,24+,27-,42-/m0/s1
描述信息
J - Antiinfectives for systemic use > J05 - Antivirals for systemic use > J05A - Direct acting antivirals > J05AB - Nucleosides and nucleotides excl. reverse transcriptase inhibitors
COVID info from DrugBank, Guide to PHARMACOLOGY, clinicaltrial, clinicaltrials, clinical trial, clinical trials
C254 - Anti-Infective Agent > C281 - Antiviral Agent > C190794 - SARS-CoV-2 Antiviral Agent
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D009676 - Noxae > D000963 - Antimetabolites
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
14 个代谢物同义名
(2S)-2-{(2R,3S,4R,5R)-[5-(4-aminopyrrolo[2,1-F][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionic acid 2-ethyl-butyl ester; (2S)-2-{(2R,3S,4R,5R)-[5-(4-aminopyrrolo[2,1-F][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxy]phenoxy-(S)-phosphorylamino}propionate 2-ethyl-butyl ester; 2-Ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-F][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoic acid; 2-Ethylbutyl (2S)-2-(((2R, 3S, 4R, 5R)-5-(4-aminopyrrolo(2,1-F) (1,2,4)triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl) methoxy)(phenoxy) phosphoryl) amino) propanoate; 2-Ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-F][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate; 2-ethylbutyl (2S)-2-{[(S)-{[(2R,3S,4R,5R)-5-{4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl}-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy}(phenoxy)phosphoryl]amino}propanoate; 2-ethylbutyl (2S)-2-{[(S)-[(2R,3S,4R,5R)-5-{4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl}-5-cyano-3,4-dihydroxyoxolan-2-yl]methoxy(phenoxy)phosphoryl]amino}propanoate; L-Alanine, N-((S)-hydroxyphenoxyphosphinyl)-, 2-ethylbutyl ester, 6-ester with 2-C-(4-aminopyrrolo(2,1-F)(1,2,4)triazin-7-yl)-2,5-anhydro-D-altrononitrile; Remdesivirum; Remdesivir; Veklury; GS-5734; GS 5734; GS5734
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:145994
- PubChem: 121304016
- HMDB: HMDB0304869
- DrugBank: DB14761
- ChEMBL: CHEMBL4065616
- Wikipedia: Remdesivir
- chemspider: 58827832
- CAS: 1809249-37-3
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Al Zahraa G Al Ashmawy, Gehan F Balata. Formulation and in vitro characterization of nanoemulsions containing remdesivir or licorice extract: A potential subcutaneous injection for coronavirus treatment.
Colloids and surfaces. B, Biointerfaces.
2024 Feb; 234(?):113703. doi:
10.1016/j.colsurfb.2023.113703. [PMID: 38096607] - Rachel E McMillan, Michael K Lo, Xing-Quan Zhang, James R Beadle, Nadejda Valiaeva, Aaron F Garretson, Alex E Clark, Jon E Freshman, Joyce Murphy, Joel M Montgomery, Christina F Spiropoulou, Robert T Schooley, Karl Y Hostetler, Aaron F Carlin. Enhanced broad spectrum in vitro antiviral efficacy of 3-F-4-MeO-Bn, 3-CN, and 4-CN derivatives of lipid remdesivir nucleoside monophosphate prodrugs.
Antiviral research.
2023 11; 219(?):105718. doi:
10.1016/j.antiviral.2023.105718. [PMID: 37758067] - Tamas Kovacs, Kitti Kurtan, Zoltan Varga, Peter Nagy, Gyorgy Panyi, Florina Zakany. Veklury® (remdesivir) formulations inhibit initial membrane-coupled events of SARS-CoV-2 infection due to their sulfobutylether-β-cyclodextrin content.
British journal of pharmacology.
2023 08; 180(16):2064-2084. doi:
10.1111/bph.16063. [PMID: 36848880] - Aswad Khadilkar, Zoie L Bunch, Jessica Wagoner, Vandana Ravindran, Jessica M Oda, Warren S Vidar, Trevor N Clark, Preston K Manwill, Daniel A Todd, Sarah A Barr, Lauren K Olinger, Susan L Fink, Wendy K Strangman, Roger G Linington, John B MacMillan, Nadja B Cech, Stephen J Polyak. Modulation of in Vitro SARS-CoV-2 Infection by Stephania tetrandra and Its Alkaloid Constituents.
Journal of natural products.
2023 Apr; 86(4):1061-1073. doi:
10.1021/acs.jnatprod.3c00159. [PMID: 37043739] - Mohsin Kazi, Yousef Alanazi, Ashok Kumar, Ahmad Abdul-Wahhab Shahba, Syed Rizwan Ahamad, Khalid M Alghamdi. Oral Bioactive Self-Nanoemulsifying Drug Delivery Systems of Remdesivir and Baricitinib: A Paradigmatic Case of Drug Repositioning for Cancer Management.
Molecules (Basel, Switzerland).
2023 Feb; 28(5):. doi:
10.3390/molecules28052237. [PMID: 36903483] - Woo-Jin Jeon, Hong-Ki Lee, Young-Guk Na, Minwoo Jung, Su-Cheol Han, Jeong Ho Hwang, Eunhye Jung, Dasom Hwang, Jin Soo Shin, Cheong-Weon Cho. Antiviral Lipid Nanocarrier Loaded with Remdesivir Effective Against SARS-CoV-2 in vitro Model.
International journal of nanomedicine.
2023; 18(?):1561-1575. doi:
10.2147/ijn.s391462. [PMID: 37007987] - David H Drewry, Frances M Potjewyd, Armin Bayati, Jeffery L Smith, Rebekah J Dickmander, Stefanie Howell, Sharon Taft-Benz, Sophia M Min, Mohammad Anwar Hossain, Mark Heise, Peter S McPherson, Nathaniel J Moorman, Alison D Axtman. Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses.
Journal of medicinal chemistry.
2022 10; 65(19):12860-12882. doi:
10.1021/acs.jmedchem.2c00697. [PMID: 36111834] - Ahmed H Abdelazim, Sherif Ramzy. Spectrophotometric quantitative analysis of remdesivir using acid dye reagent selected by computational calculations.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 Aug; 276(?):121188. doi:
10.1016/j.saa.2022.121188. [PMID: 35395463] - Marko Lucijanic, Tomislav Cikara, Petra Bistrovic, Ivan Papic, Maja Ortner Hadziabdic, Nikolina Busic, Marina Lackovic, Natalia Cesar, Valentina Koscak, Josko Mitrovic, Bruno Barsic, Tomo Lucijanic. Remdesivir use in COVID-19 patients might predispose bacteremia, matched case-control analysis.
The Journal of infection.
2022 Aug; 85(2):174-211. doi:
10.1016/j.jinf.2022.04.045. [PMID: 35513188] - Issa Haddad, Priyal Agarwal, Mohamed Hassanein. Remdesivir use in COVID-19 patients with end-stage kidney disease on intermittent hemodialysis: An absolute contraindication?.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2022 Aug; 26(4):850-851. doi:
10.1111/1744-9987.13833. [PMID: 35261170] - Manjit Kaur, Deepika Tiwari, Vishal Sidana, Kanya Mukhopadhyay. Remdesivir-Induced Liver Injury in a COVID-Positive Newborn.
Indian journal of pediatrics.
2022 Aug; 89(8):826. doi:
10.1007/s12098-022-04237-6. [PMID: 35583631] - Lucio Boglione, Valentina Dodaro, Giulia Meli, Roberto Rostagno, Federica Poletti, Roberta Moglia, Bianca Bianchi, Maria Esposito, Silvio Borrè. Remdesivir treatment in hospitalized patients affected by COVID-19 pneumonia: A case-control study.
Journal of medical virology.
2022 Aug; 94(8):3653-3660. doi:
10.1002/jmv.27768. [PMID: 35411627] - Yusuke Marikawa, Vernadeth B Alarcon. Remdesivir impairs mouse preimplantation embryo development at therapeutic concentrations.
Reproductive toxicology (Elmsford, N.Y.).
2022 08; 111(?):135-147. doi:
10.1016/j.reprotox.2022.05.012. [PMID: 35605700] - Marta Colaneri, Nicolò Amarasinghe, Leonardo Rezzonico, Teresa Chiara Pieri, Emilio Segalini, Margherita Sambo, Silvia Roda, Federica Meloni, Marilena Gregorini, Teresa Rampino, Stefano Pelenghi, Alessandra Ricciardi, Raffaele Bruno. Early remdesivir to prevent severe COVID-19 in recipients of solid organ transplant: a real-life study from Northern Italy.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2022 Aug; 121(?):157-160. doi:
10.1016/j.ijid.2022.05.001. [PMID: 35533831] - Mohsen Sedighi, Alireza Amanollahi, Omid Moradi Moghaddam, Hamed Basir Ghafouri, Seyede Elham Hoseini, Nader Tavakoli. Linear mixed model analysis to evaluate correlations between remdesivir adverse effects with age and gender of patients with mild Covid-19 pneumonia.
Journal of medical virology.
2022 Aug; 94(8):3783-3790. doi:
10.1002/jmv.27800. [PMID: 35491957] - Katja Merches, Leonie Breunig, Julia Fender, Theresa Brand, Vanessa Bätz, Svenja Idel, Laxmikanth Kollipara, Yvonne Reinders, Albert Sickmann, Angela Mally, Kristina Lorenz. The potential of remdesivir to affect function, metabolism and proliferation of cardiac and kidney cells in vitro.
Archives of toxicology.
2022 08; 96(8):2341-2360. doi:
10.1007/s00204-022-03306-1. [PMID: 35579693] - Natalia Krisanova, Natalia Pozdnyakova, Artem Pastukhov, Marina Dudarenko, Oleg Shatursky, Olena Gnatyuk, Uliana Afonina, Kyrylo Pyrshev, Galina Dovbeshko, Semen Yesylevskyy, Tatiana Borisova. Amphiphilic anti-SARS-CoV-2 drug remdesivir incorporates into the lipid bilayer and nerve terminal membranes influencing excitatory and inhibitory neurotransmission.
Biochimica et biophysica acta. Biomembranes.
2022 08; 1864(8):183945. doi:
10.1016/j.bbamem.2022.183945. [PMID: 35461828] - Liva Checkmahomed, Julie Carbonneau, Venice Du Pont, Nicholas C Riola, Jason K Perry, Jiani Li, Bastien Paré, Shawn M Simpson, Martin A Smith, Danielle P Porter, Guy Boivin. In Vitro Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance.
Antimicrobial agents and chemotherapy.
2022 Jul; 66(7):e0019822. doi:
10.1128/aac.00198-22. [PMID: 35708323] - Jonathan Fintzi, Tyler Bonnett, Daniel A Sweeney, Nikhil A Huprikar, Anuradha Ganesan, Maria G Frank, Susan L F McLellan, Lori E Dodd, Pablo Tebas, Aneesh K Mehta. Deconstructing the Treatment Effect of Remdesivir in the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1: Implications for Critical Care Resource Utilization.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2022 Jul; 74(12):2209-2217. doi:
10.1093/cid/ciab712. [PMID: 34409989] - Markus Fischer, Peter Müller, Holger A Scheidt, Meike Luck. Drug-Membrane Interactions: Effects of Virus-Specific RNA-Dependent RNA Polymerase Inhibitors Remdesivir and Favipiravir on the Structure of Lipid Bilayers.
Biochemistry.
2022 Jul; 61(13):1392-1403. doi:
10.1021/acs.biochem.2c00042. [PMID: 35731976] - Meng Yuan, Wenjuan Hu, Yingying Feng, Yue Tong, Xin Wang, Bo Tan, Hui Xu, Jia Liu. Development and validation of an LC-MS/MS method for simultaneous determination of remdesivir and its hydrolyzed metabolite and nucleoside, and its application in a pharmacokinetic study of normal and diabetic nephropathy mice.
Biomedical chromatography : BMC.
2022 Jul; 36(7):e5380. doi:
10.1002/bmc.5380. [PMID: 35373846] - Carlos K H Wong, Ivan C H Au, Wing Yiu Cheng, Kenneth K C Man, Kristy T K Lau, Lung Yi Mak, Sing Leung Lui, Matthew S H Chung, Xi Xiong, Eric H Y Lau, Benjamin J Cowling. Remdesivir use and risks of acute kidney injury and acute liver injury among patients hospitalised with COVID-19: a self-controlled case series study.
Alimentary pharmacology & therapeutics.
2022 07; 56(1):121-130. doi:
10.1111/apt.16894. [PMID: 35318694] - Justin G Julander, Elaine Bunyan, Robert Jordan, Danielle P Porter. Remdesivir efficacy against yellow fever in a hamster model.
Antiviral research.
2022 07; 203(?):105331. doi:
10.1016/j.antiviral.2022.105331. [PMID: 35533777] - Petra Bistrovic, Sime Manola, Marko Lucijanic. Bradycardia during remdesivir treatment might be associated with improved survival in patients with COVID-19: a retrospective cohort study on 473 patients from a tertiary centre.
Postgraduate medical journal.
2022 07; 98(1161):501-502. doi:
10.1136/postgradmedj-2021-141079. [PMID: 34876485] - Andrea Giacomelli, Alessandro Cozzi-Lepri, Giacomo Casalini, Letizia Oreni, Anna Lisa Ridolfo, Spinello Antinori. Estimating the effectiveness of remdesivir on risk of COVID-19 mortality: The role of observational data.
Pharmacological research.
2022 07; 181(?):106268. doi:
10.1016/j.phrs.2022.106268. [PMID: 35605811] - Tamer Z Attia, John M Boushra, Ahmed F Abdel Hakiem, Adel S Lashien, Deena A M Noureldeen. Spectrofluorimetric determination of the anti-Covid 19 agent, remdesivir, in vials and spiked human plasma.
Luminescence : the journal of biological and chemical luminescence.
2022 Jul; 37(7):1192-1199. doi:
10.1002/bio.4274. [PMID: 35548893] - Takashi Ichiyama, Masamichi Komatsu, Yosuke Wada, Masayuki Hanaoka. Report of a combination of remdesivir, intravenous methylprednisolone pulse, and tocilizumab for severe coronavirus disease: 20-case series at a single institution.
Respiratory investigation.
2022 Jul; 60(4):604-606. doi:
10.1016/j.resinv.2022.04.001. [PMID: 35501265] - Sushmita Khadka, Karen Williams, Shantanu Solanki. Remdesivir-Associated Pancreatitis.
American journal of therapeutics.
2022 Jul; 29(4):e444-e446. doi:
10.1097/mjt.0000000000001266. [PMID: 33590992] - Andrea Tumminia, Raffaella Romano, Giuseppe Brugaletta, Roberto Scicali, Giuseppina Biondi, Rosario Oliveri, Marcello Romano, Paola Magnano San Lio. The impact of obesity and dyslipidemia on Remdesivir effectiveness in hospitalized patients with SARS-CoV-2-related pneumonia: An observational study.
Nutrition, metabolism, and cardiovascular diseases : NMCD.
2022 07; 32(7):1635-1641. doi:
10.1016/j.numecd.2022.04.005. [PMID: 35508458] - Ling Yang, I-Hsin Lin, Lie-Chwen Lin, Jeffrey W Dalley, Tung-Hu Tsai. Biotransformation and transplacental transfer of the anti-viral remdesivir and predominant metabolite, GS-441524 in pregnant rats.
EBioMedicine.
2022 Jul; 81(?):104095. doi:
10.1016/j.ebiom.2022.104095. [PMID: 35671622] - Johannes Jungwirth, Clio Häring, Sarah König, Liane Giebeler, Heena Doshi, Christian Brandt, Stefanie Deinhardt-Emmer, Bettina Löffler, Christina Ehrhardt. D,L-Lysine-Acetylsalicylate + Glycine (LASAG) Reduces SARS-CoV-2 Replication and Shows an Additive Effect with Remdesivir.
International journal of molecular sciences.
2022 Jun; 23(13):. doi:
10.3390/ijms23136880. [PMID: 35805887] - E Leegwater, D J A R Moes, L B E Bosma, T H Ottens, I M van der Meer, C van Nieuwkoop, E B Wilms. Population Pharmacokinetics of Remdesivir and GS-441524 in Hospitalized COVID-19 Patients.
Antimicrobial agents and chemotherapy.
2022 06; 66(6):e0025422. doi:
10.1128/aac.00254-22. [PMID: 35647646] - Jared Pitts, Jiani Li, Jason K Perry, Venice Du Pont, Nicholas Riola, Lauren Rodriguez, Xianghan Lu, Chaitanya Kurhade, Xuping Xie, Gregory Camus, Savrina Manhas, Ross Martin, Pei-Yong Shi, Tomas Cihlar, Danielle P Porter, Hongmei Mo, Evguenia Maiorova, John P Bilello. Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants.
Antimicrobial agents and chemotherapy.
2022 06; 66(6):e0022222. doi:
10.1128/aac.00222-22. [PMID: 35532238] - NULL. COVID-19 update: remdesivir (Veklury) FDA-approved for children <12 years old.
The Medical letter on drugs and therapeutics.
2022 06; 64(1652):e1. doi:
NULL. [PMID: 35657368] - Rachel Beckerman, Andrea Gori, Sushanth Jeyakumar, Jakob J Malin, Roger Paredes, Pedro Póvoa, Nathaniel J Smith, Armando Teixeira-Pinto. Remdesivir for the treatment of patients hospitalized with COVID-19 receiving supplemental oxygen: a targeted literature review and meta-analysis.
Scientific reports.
2022 Jun; 12(1):9622. doi:
10.1038/s41598-022-13680-6. [PMID: 35688854] - Shan Wang, Christy Huynh, Shahidul Islam, Brian Malone, Naveed Masani, D'Andrea Joseph. Assessment of Safety of Remdesivir in Covid - 19 Patients with Estimated Glomerular Filtration Rate (eGFR) < 30 ml/min per 1.73 m^2.
Journal of intensive care medicine.
2022 Jun; 37(6):764-768. doi:
10.1177/08850666211070521. [PMID: 34967255] - M D Gil-Sierra, M P Briceño-Casado, E J Alegre-Del Rey, M Sánchez-Hidalgo. Efficacy of early use of remdesivir: a systematic review of subgroup analysis.
Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia.
2022 Jun; 35(3):249-259. doi:
10.37201/req/154.2021. [PMID: 35294145] - Peter Dovjak, Hans Jürgen Heppner. Title Not Available.
MMW Fortschritte der Medizin.
2022 06; 164(11):28. doi:
10.1007/s15006-022-1234-z. [PMID: 35650486] - Steve McDonald, Simon Turner, Matthew J Page, Tari Turner. Most published systematic reviews of remdesivir for COVID-19 were redundant and lacked currency.
Journal of clinical epidemiology.
2022 Jun; 146(?):22-31. doi:
10.1016/j.jclinepi.2022.02.006. [PMID: 35192923] - Jin Gu Yoon, Jin Sae Yoo, Jungmin Lee, Hak-Jun Hyun, Hye Seong, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim, Young Rong Kim, Jung Yeon Heo, Joon-Yong Bae, Chunguang Cui, Sohyun Lee, Man-Seong Park, Joon Young Song. Viable SARS-CoV-2 shedding under remdesivir and dexamethasone treatment.
The Journal of infection.
2022 06; 84(6):834-872. doi:
10.1016/j.jinf.2022.03.022. [PMID: 35351541] - Shireesha Vuppalanchi, Raj Vuppalanchi. Editorial: liver and kidney injury from remdesivir-an issue not as much as its purpose.
Alimentary pharmacology & therapeutics.
2022 06; 55(11):1456. doi:
10.1111/apt.16921. [PMID: 35538355] - Carlos K H Wong, Ivan C H Au, Wing Yiu Cheng, Kenneth K C Man, Kristy T K Lau, Lung Yi Mak, Sing Leung Lui, Matthew S H Chung, Xi Xiong, Eric H Y Lau, Benjamin J Cowling. Editorial: liver and kidney injury from remdesivir-an issue not as much as its purpose. Authors' reply.
Alimentary pharmacology & therapeutics.
2022 06; 55(11):1457-1458. doi:
10.1111/apt.16932. [PMID: 35538354] - Florence Ader, Maude Bouscambert-Duchamp, Maya Hites, Nathan Peiffer-Smadja, France Mentré, Charles Burdet. Final results of the DisCoVeRy trial of remdesivir for patients admitted to hospital with COVID-19.
The Lancet. Infectious diseases.
2022 06; 22(6):764-765. doi:
10.1016/s1473-3099(22)00295-x. [PMID: 35643099] - Mikael Kajova, Eliisa Kekäläinen, Veli-Jukka Anttila, Juuso Paajanen. Successful treatment with a short course of remdesivir in a case of prolonged COVID-19 in a lymphoma patient.
Infectious diseases (London, England).
2022 06; 54(6):455-459. doi:
10.1080/23744235.2022.2028896. [PMID: 35086417] - Irina Rajakumar, Debra L Isaac, Nowell M Fine, Brian Clarke, Linda P Ward, Rebecca J Malott, Kanti Pabbaraju, Kara Gill, Byron M Berenger, Yi-Chan Lin, David H Evans, John M Conly. Extensive environmental contamination and prolonged severe acute respiratory coronavirus-2 (SARS CoV-2) viability in immunosuppressed recent heart transplant recipients with clinical and virologic benefit with remdesivir.
Infection control and hospital epidemiology.
2022 06; 43(6):817-819. doi:
10.1017/ice.2021.89. [PMID: 33706819] - Susanne Rüfenacht, Pascal Gantenbein, Katia Boggian, Domenica Flury, Lukas Kern, Günter Dollenmaier, Philipp Kohler, Werner C Albrich. Remdesivir in Coronavirus Disease 2019 patients treated with anti-CD20 monoclonal antibodies: a case series.
Infection.
2022 Jun; 50(3):783-790. doi:
10.1007/s15010-022-01821-y. [PMID: 35426564] - Pierluigi Russo, Evelina Tacconelli, Pier Paolo Olimpieri, Simone Celant, Antonietta Colatrella, Luca Tomassini, Giorgio Palù. Mortality in SARS-CoV-2 Hospitalized Patients Treated with Remdesivir: A Nationwide, Registry-Based Study in Italy.
Viruses.
2022 05; 14(6):. doi:
10.3390/v14061197. [PMID: 35746668] - George A Diaz, Alyssa B Christensen, Tobias Pusch, Delaney Goulet, Shu-Ching Chang, Gary L Grunkemeier, Paul A McKelvey, Ari Robicsek, Tom French, Guilford T Parsons, Glenn Doherty, Charles Laurenson, Ryan Roper, Jennifer Hadlock, Cameron J Cover, Brent Footer, Philip Robinson, Mary Micikas, Jennifer E Marfori, Charlotte Cronenweth, Yogavedya Mukkamala, Jamie Mackiewicz, Ekra Rai, Martha Dickinson Matson, Jodie Davila, Justin Rueda, Reda Tipton, Heather Algren, Brittney C Ward, Stephen Malkoski, Tyler Gluckman, Gregory B Tallman, Henry Arguinchona, Terese C Hammond, Steven Standaert, Joshua Christensen, Jose F Echaiz, Robert Choi, Daniel McClung, Albert Pacifico, Martin Fee, Farjad Sarafian, William R Berrington, Jason D Goldman. Remdesivir and Mortality in Patients With Coronavirus Disease 2019.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2022 05; 74(10):1812-1820. doi:
10.1093/cid/ciab698. [PMID: 34409431] - Lajos Szente, Tibor Renkecz, Dávid Sirok, János Stáhl, Gábor Hirka, István Puskás, Tamás Sohajda, Éva Fenyvesi. Comparative bioavailability study following a single dose intravenous and buccal administration of remdesivir in rabbits.
International journal of pharmaceutics.
2022 May; 620(?):121739. doi:
10.1016/j.ijpharm.2022.121739. [PMID: 35421532] - NULL. Title Not Available.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.
2022 05; 194(20):E713-E723. doi:
10.1503/cmaj.211698-f. [PMID: 35609913] - Sehr Naseem-Khan, Madison B Berger, Emmett M Leddin, Yazdan Maghsoud, G Andrés Cisneros. Impact of Remdesivir Incorporation along the Primer Strand on SARS-CoV-2 RNA-Dependent RNA Polymerase.
Journal of chemical information and modeling.
2022 05; 62(10):2456-2465. doi:
10.1021/acs.jcim.2c00201. [PMID: 35435671] - . Remdesivir and three other drugs for hospitalised patients with COVID-19: final results of the WHO Solidarity randomised trial and updated meta-analyses.
Lancet (London, England).
2022 05; 399(10339):1941-1953. doi:
10.1016/s0140-6736(22)00519-0. [PMID: 35512728] - Meng-Li Wu, Feng-Liang Liu, Jing Sun, Xin Li, Jian-Ru Qin, Qi-Hong Yan, Xia Jin, Xin-Wen Chen, Yong-Tang Zheng, Jin-Cun Zhao, Jian-Hua Wang. Combinational benefit of antihistamines and remdesivir for reducing SARS-CoV-2 replication and alleviating inflammation-induced lung injury in mice.
Zoological research.
2022 May; 43(3):457-468. doi:
10.24272/j.issn.2095-8137.2021.469. [PMID: 35503561] - Alexandra Schäfer, David R Martinez, John J Won, Rita M Meganck, Fernando R Moreira, Ariane J Brown, Kendra L Gully, Mark R Zweigart, William S Conrad, Samantha R May, Stephanie Dong, Rao Kalla, Kwon Chun, Venice Du Pont, Darius Babusis, Jennifer Tang, Eisuke Murakami, Raju Subramanian, Kimberly T Barrett, Blake J Bleier, Roy Bannister, Joy Y Feng, John P Bilello, Tomas Cihlar, Richard L Mackman, Stephanie A Montgomery, Ralph S Baric, Timothy P Sheahan. Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice.
Science translational medicine.
2022 05; 14(643):eabm3410. doi:
10.1126/scitranslmed.abm3410. [PMID: 35315683] - Elisabeth Mahase. Covid-19: Remdesivir has 'small effect' against death or progression to ventilation, WHO trial finds.
BMJ (Clinical research ed.).
2022 05; 377(?):o1118. doi:
10.1136/bmj.o1118. [PMID: 35508315] - Mohammed A Sarhan, Maria Casalino, Pongsatorn Paopongsawan, David Gryn, Tapas Kulkarni, Ari Bitnun, Estelle B Gauda. SARS-CoV-2 Associated Respiratory Failure in a Preterm Infant and the Outcome after Remdesivir Treatment.
The Pediatric infectious disease journal.
2022 05; 41(5):e233-e234. doi:
10.1097/inf.0000000000003504. [PMID: 35213865] - Florin Elec, Jesper Magnusson, Alina Elec, Adriana Muntean, Oana Antal, Tudor Moisoiu, Cristina Cismaru, Mihaela Lupse, Mihai Oltean. COVID-19 and kidney transplantation: the impact of remdesivir on renal function and outcome - a retrospective cohort study.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2022 May; 118(?):247-253. doi:
10.1016/j.ijid.2022.03.015. [PMID: 35301103] - Yuka Sano Wada, Jumpei Saito, Yuko Hashii, Tomomi Kishi, Masayuki Kobayashi, Taro Kamiya, Katsumi Mizuno. Remdesivir and Human Milk: A Case Study.
Journal of human lactation : official journal of International Lactation Consultant Association.
2022 05; 38(2):248-251. doi:
10.1177/08903344221076539. [PMID: 35189734] - Anjum S Kaka, Roderick MacDonald, Eric J Linskens, Lisa Langsetmo, Kathryn Vela, Wei Duan-Porter, Timothy J Wilt. Major Update 2: Remdesivir for Adults With COVID-19: A Living Systematic Review and Meta-analysis for the American College of Physicians Practice Points.
Annals of internal medicine.
2022 05; 175(5):701-709. doi:
10.7326/m21-4784. [PMID: 35226522] - Melanie D Whittington, Steven D Pearson, David M Rind, Jonathan D Campbell. The Cost-Effectiveness of Remdesivir for Hospitalized Patients With COVID-19.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research.
2022 05; 25(5):744-750. doi:
10.1016/j.jval.2021.11.1378. [PMID: 35190252] - Sabrina Wimmer, Sarai M Keestra. Public Risk-Taking and Rewards During the COVID-19 Pandemic - A Case Study of Remdesivir in the Context of Global Health Equity.
International journal of health policy and management.
2022 05; 11(5):567-578. doi:
10.34172/ijhpm.2020.166. [PMID: 32945638] - Annalucia Biancofiore, Antonio Mirijello, Maria A Puteo, Maria P Di Viesti, Maria Labonia, Massimiliano Copetti, Salvatore De Cosmo, Renato Lombardi. Remdesivir significantly reduces SARS-CoV-2 viral load on nasopharyngeal swabs in hospitalized patients with COVID-19: A retrospective case-control study.
Journal of medical virology.
2022 05; 94(5):2284-2289. doi:
10.1002/jmv.27598. [PMID: 35043405] - Omar Mourad, Zain Chagla. In high-risk outpatients with COVID-19, remdesivir reduced COVID-19-related hospitalization or all-cause death at 28 d.
Annals of internal medicine.
2022 05; 175(5):JC50. doi:
10.7326/j22-0026. [PMID: 35500263] - Amir Qaseem, Jennifer Yost, Itziar Etxeandia-Ikobaltzeta, George M Abraham, Janet A Jokela, Mary Ann Forciea, Matthew C Miller, Linda L Humphrey. Should Remdesivir Be Used for the Treatment of Patients With COVID-19? Rapid, Living Practice Points From the American College of Physicians (Version 2, Update Alert 3).
Annals of internal medicine.
2022 05; 175(5):W55-W57. doi:
10.7326/m21-4810. [PMID: 35226518] - Rachid Rafia, Marrissa Martyn-St James, Sue Harnan, Andrew Metry, Jean Hamilton, Allan Wailoo. A Cost-Effectiveness Analysis of Remdesivir for the Treatment of Hospitalized Patients With COVID-19 in England and Wales.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research.
2022 05; 25(5):761-769. doi:
10.1016/j.jval.2021.12.015. [PMID: 35197225] - Yuto Yasuda, Yutaka Hirayama, Kiyoshi Uemasu, Soichi Arasawa, Daisuke Iwashima, Ken-Ichi Takahashi. Efficacy of the combination of baricitinib, remdesivir, and dexamethasone in hypoxic adults with COVID-19: A retrospective study.
Respiratory medicine and research.
2022 May; 81(?):100903. doi:
10.1016/j.resmer.2022.100903. [PMID: 35316675] - Shinya Tsuzuki, Kayoko Hayakawa, Yukari Uemura, Tomohiro Shinozaki, Nobuaki Matsunaga, Mari Terada, Setsuko Suzuki, Yusuke Asai, Koji Kitajima, Sho Saito, Gen Yamada, Taro Shibata, Masashi Kondo, Kazuo Izumi, Masayuki Hojo, Tetsuya Mizoue, Kazuhisa Yokota, Fukumi Nakamura-Uchiyama, Fumitake Saito, Wataru Sugiura, Norio Ohmagari. Effectiveness of remdesivir in hospitalized nonsevere patients with COVID-19 in Japan: A large observational study using the COVID-19 Registry Japan.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2022 May; 118(?):119-125. doi:
10.1016/j.ijid.2022.02.039. [PMID: 35192953] - Kasha P Singh, Steven Y C Tong. In adults hospitalized with COVID-19, adding remdesivir to standard care did not reduce in-hospital mortality.
Annals of internal medicine.
2022 05; 175(5):JC51. doi:
10.7326/j22-0025. [PMID: 35500262] - Arkadiy Finn, Atin Jindal, Sarah B Andrea, Vijairam Selvaraj, Kwame Dapaah-Afriyie. Association of Treatment with Remdesivir and 30-day Hospital Readmissions in Patients Hospitalized with COVID-19.
The American journal of the medical sciences.
2022 05; 363(5):403-410. doi:
10.1016/j.amjms.2022.01.021. [PMID: 35151637] - Jagpreet Chhatwal, Anirban Basu. Cost-Effectiveness of Remdesivir for COVID-19 Treatment: What Are We Missing?.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research.
2022 05; 25(5):697-698. doi:
10.1016/j.jval.2022.02.002. [PMID: 35315330] - Megan A Dunay, Sarah L McClain, Rick L Holloway, Sarah L W Norris, Talie Bendixsen Randall, Caitlin E Mohr, Brent H Sasaki, Joseph A Coones, Nicholas J Vietri. Pre-Hospital Administration of Remdesivir During a Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Outbreak in a Skilled Nursing Facility.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2022 04; 74(8):1476-1479. doi:
10.1093/cid/ciab715. [PMID: 34410348] - Carlos K H Wong, Kristy T K Lau, Ivan C H Au, Xi Xiong, Eric H Y Lau, Benjamin J Cowling. Clinical Improvement, Outcomes, Antiviral Activity, and Costs Associated With Early Treatment With Remdesivir for Patients With Coronavirus Disease 2019 (COVID-19).
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2022 04; 74(8):1450-1458. doi:
10.1093/cid/ciab631. [PMID: 34265054] - Sohila M Elonsy, Miranda F Kamal, Mohamed M A Hamdy, Mona M Abdel Moneim. Comparative Greenness Metric Estimates for Content Uniformity Testing of Anti-Cov-2, GS-5734 in Commercial Vials: Validated Micellar Electrokinetic Chromatographic Assay.
Journal of AOAC International.
2022 Apr; 105(3):739-747. doi:
10.1093/jaoacint/qsac001. [PMID: 35015848] - Guillaume Lingas, Nadège Néant, Alexandre Gaymard, Drifa Belhadi, Gilles Peytavin, Maya Hites, Thérèse Staub, Richard Greil, Jose-Artur Paiva, Julien Poissy, Nathan Peiffer-Smadja, Dominique Costagliola, Yazdan Yazdanpanah, Florent Wallet, Amandine Gagneux-Brunon, France Mentré, Florence Ader, Charles Burdet, Jérémie Guedj, Maude Bouscambert-Duchamp. Effect of remdesivir on viral dynamics in COVID-19 hospitalized patients: a modelling analysis of the randomized, controlled, open-label DisCoVeRy trial.
The Journal of antimicrobial chemotherapy.
2022 04; 77(5):1404-1412. doi:
10.1093/jac/dkac048. [PMID: 35233617] - Iart Luca Shytaj, Mohamed Fares, Lara Gallucci, Bojana Lucic, Mahmoud M Tolba, Liv Zimmermann, Julia M Adler, Na Xing, Judith Bushe, Achim D Gruber, Ina Ambiel, Ahmed Taha Ayoub, Mirko Cortese, Christopher J Neufeldt, Bettina Stolp, Mohamed Hossam Sobhy, Moustafa Fathy, Min Zhao, Vibor Laketa, Ricardo Sobhie Diaz, Richard E Sutton, Petr Chlanda, Steeve Boulant, Ralf Bartenschlager, Megan L Stanifer, Oliver T Fackler, Jakob Trimpert, Andrea Savarino, Marina Lusic. The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication In Vitro and Decreases Viral Titers and Disease Progression in Syrian Hamsters.
mBio.
2022 04; 13(2):e0370521. doi:
10.1128/mbio.03705-21. [PMID: 35229634] - Catharine I Paules, Shannon K Gallagher, Rekha R Rapaka, Richard T Davey, Sarah B Doernberg, Robert Grossberg, Noreen A Hynes, Philip O Ponce, William R Short, Jocelyn Voell, Jing Wang, Otto O Yang, Cameron R Wolfe, David C Lye, Lori E Dodd, Constance A Benson. Remdesivir for the Prevention of Invasive Mechanical Ventilation or Death in Coronavirus Disease 2019 (COVID-19): A Post Hoc Analysis of the Adaptive COVID-19 Treatment Trial-1 Cohort Data.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2022 04; 74(7):1260-1264. doi:
10.1093/cid/ciab695. [PMID: 34379740] - Marko Lucijanic, Petra Bistrovic. Remdesivir-associated bradycardia might be a sign of good prognosis in COVID-19 patients.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2022 04; 28(4):619. doi:
10.1016/j.cmi.2021.12.017. [PMID: 34999175] - Joe Eid, Mahmoud Abdelwahab, Nora Colburn, Shandra Day, Michael Cackovic, Kara M Rood, Maged M Costantine. Early Administration of Remdesivir and Intensive Care Unit Admission in Hospitalized Pregnant Individuals With Coronavirus Disease 2019 (COVID-19).
Obstetrics and gynecology.
2022 04; 139(4):619-621. doi:
10.1097/aog.0000000000004734. [PMID: 35134032] - Elena Rensen, Stefano Pietropaoli, Florian Mueller, Christian Weber, Sylvie Souquere, Sina Sommer, Pierre Isnard, Marion Rabant, Jean-Baptiste Gibier, Fabiola Terzi, Etienne Simon-Loriere, Marie-Anne Rameix-Welti, Gérard Pierron, Giovanna Barba-Spaeth, Christophe Zimmer. Sensitive visualization of SARS-CoV-2 RNA with CoronaFISH.
Life science alliance.
2022 04; 5(4):. doi:
10.26508/lsa.202101124. [PMID: 34996842] - Matteo Ruggeri, Alessandro Signorini, Silvia Caravaggio, João Rua, Nuno Luís, Sandra Braz, Filipa Aragão. Estimation Model for Healthcare Costs and Intensive Care Units Access for Covid-19 Patients and Evaluation of the Effects of Remdesivir in the Portuguese Context: Hypothetical Study.
Clinical drug investigation.
2022 Apr; 42(4):345-354. doi:
10.1007/s40261-022-01128-8. [PMID: 35298832] - Zhengdong Yang, Deqing Xiao, Kah Hiing John Ling, Thomas Tarnowski, Rita Humeniuk, Bryan Parmentier, Yu-Hui Ann Fu, Eric Johnson, Marsha L Luna, Habibi Goudarzi, Quan Cheng. The determination of Sulfobutylether β-Cyclodextrin Sodium (SBECD) by LC-MS/MS and its application in remdesivir pharmacokinetics study for pediatric patients.
Journal of pharmaceutical and biomedical analysis.
2022 Apr; 212(?):114646. doi:
10.1016/j.jpba.2022.114646. [PMID: 35180564] - David C Schultz, Robert M Johnson, Kasirajan Ayyanathan, Jesse Miller, Kanupriya Whig, Brinda Kamalia, Mark Dittmar, Stuart Weston, Holly L Hammond, Carly Dillen, Jeremy Ardanuy, Louis Taylor, Jae Seung Lee, Minghua Li, Emily Lee, Clarissa Shoffler, Christopher Petucci, Samuel Constant, Marc Ferrer, Christoph A Thaiss, Matthew B Frieman, Sara Cherry. Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2.
Nature.
2022 04; 604(7904):134-140. doi:
10.1038/s41586-022-04482-x. [PMID: 35130559] - Zoran Sabljić, Nikolina Bašić-Jukić. Toxic myopathy and liver damage caused by concomitant therapy with remdesivir, atorvastatin, ezetimibe, and tacrolimus in a renal transplant patient with recently treated SARS-CoV-2 induced pneumonia: A case report.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2022 04; 26(2):478-479. doi:
10.1111/1744-9987.13748. [PMID: 34676979] - Debasish Das, Prabuddha Mukhopadhyay, Debtanu Banerjee. Mortality comparision in patients receiving either Remdesivir or Remdesivir plus Baricitinib combination in case of moderate to severe COVID-19 Pneumonia: A retrospective study.
The Journal of the Association of Physicians of India.
2022 Apr; 70(4):11-12. doi:
NULL. [PMID: 35443520] - Tomas Cihlar, Richard L Mackman. Journey of remdesivir from the inhibition of hepatitis C virus to the treatment of COVID-19.
Antiviral therapy.
2022 04; 27(2):13596535221082773. doi:
10.1177/13596535221082773. [PMID: 35499114] - Amira Hussain, Declan P Naughton, James Barker. Potential Effects of Ibuprofen, Remdesivir and Omeprazole on Dexamethasone Metabolism in Control Sprague Dawley Male Rat Liver Microsomes (Drugs Often Used Together Alongside COVID-19 Treatment).
Molecules (Basel, Switzerland).
2022 Mar; 27(7):. doi:
10.3390/molecules27072238. [PMID: 35408639] - Kazuhito Miyazaki, Yukihiro Yoshimura, Nobuyuki Miyata, Hiroaki Sasaki, Aya Shiba, Masaharu Aga, Yusuke Hamakawa, Yuri Taniguchi, Yuki Misumi, Yoko Agemi, Tsuneo Shimokawa, Hiroaki Okamoto, Natsuo Tachikawa. Acute pancreatitis or severe increase in pancreatic enzyme levels following remdesivir administration in COVID-19 patients: an observational study.
Scientific reports.
2022 03; 12(1):5323. doi:
10.1038/s41598-022-09170-4. [PMID: 35351942] - Alvaro A Ordonez, C Korin Bullen, Andres F Villabona-Rueda, Elizabeth A Thompson, Mitchell L Turner, Vanessa F Merino, Yu Yan, John Kim, Stephanie L Davis, Oliver Komm, Jonathan D Powell, Franco R D'Alessio, Robert H Yolken, Sanjay K Jain, Lorraine Jones-Brando. Sulforaphane exhibits antiviral activity against pandemic SARS-CoV-2 and seasonal HCoV-OC43 coronaviruses in vitro and in mice.
Communications biology.
2022 03; 5(1):242. doi:
10.1038/s42003-022-03189-z. [PMID: 35304580] - Shiv Gandhi, Jonathan Klein, Alexander J Robertson, Mario A Peña-Hernández, Michelle J Lin, Pavitra Roychoudhury, Peiwen Lu, John Fournier, David Ferguson, Shah A K Mohamed Bakhash, M Catherine Muenker, Ariktha Srivathsan, Elsio A Wunder, Nicholas Kerantzas, Wenshuai Wang, Brett Lindenbach, Anna Pyle, Craig B Wilen, Onyema Ogbuagu, Alexander L Greninger, Akiko Iwasaki, Wade L Schulz, Albert I Ko. De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report.
Nature communications.
2022 03; 13(1):1547. doi:
10.1038/s41467-022-29104-y. [PMID: 35301314] - Pierre-Vladimir Ennezat. Outpatient Remdesivir to Prevent Progression to Severe Covid-19.
The New England journal of medicine.
2022 03; 386(11):1094. doi:
10.1056/nejmc2200591. [PMID: 35172052] - Robert L Gottlieb, Kavita Juneja, Joshua A Hill. Outpatient Remdesivir to Prevent Progression to Severe Covid-19. Reply.
The New England journal of medicine.
2022 03; 386(11):1094. doi:
10.1056/nejmc2200591. [PMID: 35172053] - Jungang Chen, Lu Dai, Samantha Kendrick, Steven R Post, Zhiqiang Qin. The Anti-COVID-19 Drug Remdesivir Promotes Oncogenic Herpesvirus Reactivation through Regulation of Intracellular Signaling Pathways.
Antimicrobial agents and chemotherapy.
2022 03; 66(3):e0239521. doi:
10.1128/aac.02395-21. [PMID: 35041508] - Carla Obradors, Benjamin Mitschke, Miles H Aukland, Markus Leutzsch, Oleg Grossmann, Sebastian Brunen, Sebastian A Schwengers, Benjamin List. Direct and Catalytic C-Glycosylation of Arenes: Expeditious Synthesis of the Remdesivir Nucleoside.
Angewandte Chemie (International ed. in English).
2022 03; 61(11):e202114619. doi:
10.1002/anie.202114619. [PMID: 34856043] - Ariel Izcovich, Reed Alexander Siemieniuk, Jessica Julia Bartoszko, Long Ge, Dena Zeraatkar, Elena Kum, Anila Qasim, Assem M Khamis, Bram Rochwerg, Thomas Agoritsas, Derek K Chu, Shelley L McLeod, Reem A Mustafa, Per Vandvik, Romina Brignardello-Petersen. Adverse effects of remdesivir, hydroxychloroquine and lopinavir/ritonavir when used for COVID-19: systematic review and meta-analysis of randomised trials.
BMJ open.
2022 03; 12(3):e048502. doi:
10.1136/bmjopen-2020-048502. [PMID: 35236729] - Prasanta Raghab Mohapatra. Remdesivir for Outpatient Management: Time to Wait, Not to Act.
The American journal of medicine.
2022 03; 135(3):e80. doi:
10.1016/j.amjmed.2021.07.009. [PMID: 35249635] - Faiha M Al-Ardhi, Ladislav Novotny, Adel Alhunayan, Naser F Al-Tannak. Comparison of remdesivir and favipiravir - the anti-Covid-19 agents mimicking purine RNA constituents.
Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia.
2022 Mar; 166(1):12-20. doi:
10.5507/bp.2021.063. [PMID: 34782799] - Jianghong Fan, Yuching Yang, Manuela Grimstein, Xinyuan Zhang, Eliford Kitabi, Justin C Earp, Vikram Arya, Kellie S Reynolds, Hao Zhu, Yaning Wang. Whole Body PBPK Modeling of Remdesivir and Its Metabolites to Aid in Estimating Active Metabolite Exposure in the Lung and Liver in Patients With Organ Dysfunction.
Clinical pharmacology and therapeutics.
2022 03; 111(3):624-634. doi:
10.1002/cpt.2445. [PMID: 34656075] - Maryam Nabati, Homa Parsaee. Potential Cardiotoxic Effects of Remdesivir on Cardiovascular System: A Literature Review.
Cardiovascular toxicology.
2022 03; 22(3):268-272. doi:
10.1007/s12012-021-09703-9. [PMID: 34643857] - Martinot Martin. Should remdesivir be recommended in France in the early stage of COVID-19.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2022 Mar; 116(?):281-282. doi:
10.1016/j.ijid.2021.12.359. [PMID: 34986405]
