Monosialoganglioside GM1 (BioDeep_00000229412)
human metabolite
代谢物信息卡片
(2S,4S,5R,6S)-2-{[(2S,3R,4R,5S,6R)-2-{[(2R,3S,4R,5R,6R)-4,5-dihydroxy-6-{[(4E)-3-hydroxy-2-[(1-hydroxyoctadecylidene)amino]octadec-4-en-1-yl]oxy}-2-(hydroxymethyl)oxan-3-yl]oxy}-3-hydroxy-5-{[(2S,3R,4R,5R,6R)-5-hydroxy-3-[(1-hydroxyethylidene)amino]-6-(hydroxymethyl)-4-{[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-6-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-5-[(1-hydroxyethylidene)amino]-6-(1,2,3-trihydroxypropyl)oxane-2-carboxylic acid
化学式: C73H131N3O31 (1545.8766096)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCCCC(=O)NC(COC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)CO)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)CO)O)O)O)NC(=O)C)OC5(CC(C(C(O5)C(C(CO)O)O)NC(=O)C)O)C(=O)O)O)O)O)C(C=CCCCCCCCCCCCCC)O
InChI: InChI=1S/C73H131N3O31/c1-5-7-9-11-13-15-17-19-20-22-24-26-28-30-32-34-52(87)76-44(45(84)33-31-29-27-25-23-21-18-16-14-12-10-8-6-2)41-98-69-61(94)59(92)63(50(39-80)101-69)103-71-62(95)67(107-73(72(96)97)35-46(85)53(74-42(3)82)66(106-73)55(88)47(86)36-77)64(51(40-81)102-71)104-68-54(75-43(4)83)65(57(90)49(38-79)99-68)105-70-60(93)58(91)56(89)48(37-78)100-70/h31,33,44-51,53-71,77-81,84-86,88-95H,5-30,32,34-41H2,1-4H3,(H,74,82)(H,75,83)(H,76,87)(H,96,97)/b33-31+/t44?,45?,46-,47?,48+,49+,50+,51+,53+,54+,55?,56-,57-,58-,59+,60+,61+,62+,63+,64-,65+,66-,67+,68-,69+,70-,71-,73-/m0/s1
描述信息
同义名列表
9 个代谢物同义名
(2S,4S,5R,6S)-2-{[(2S,3R,4R,5S,6R)-2-{[(2R,3S,4R,5R,6R)-4,5-dihydroxy-6-{[(4E)-3-hydroxy-2-[(1-hydroxyoctadecylidene)amino]octadec-4-en-1-yl]oxy}-2-(hydroxymethyl)oxan-3-yl]oxy}-3-hydroxy-5-{[(2S,3R,4R,5R,6R)-5-hydroxy-3-[(1-hydroxyethylidene)amino]-6-(hydroxymethyl)-4-{[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-6-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-5-[(1-hydroxyethylidene)amino]-6-(1,2,3-trihydroxypropyl)oxane-2-carboxylic acid; (2S,4S,5R,6S)-2-{[(2S,3R,4R,5S,6R)-2-{[(2R,3S,4R,5R,6R)-4,5-dihydroxy-6-{[(4E)-3-hydroxy-2-[(1-hydroxyoctadecylidene)amino]octadec-4-en-1-yl]oxy}-2-(hydroxymethyl)oxan-3-yl]oxy}-3-hydroxy-5-{[(2S,3R,4R,5R,6R)-5-hydroxy-3-[(1-hydroxyethylidene)amino]-6-(hydroxymethyl)-4-{[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}oxan-2-yl]oxy}-6-(hydroxymethyl)oxan-4-yl]oxy}-4-hydroxy-5-[(1-hydroxyethylidene)amino]-6-(1,2,3-trihydroxypropyl)oxane-2-carboxylate; Ceramide, monosialosyl tetraglycosyl; Tetraglycosyl ceramide, monosialosyl; Monosialosyl tetraglycosyl ceramide; Monosialoganglioside, GM1a; GM1a Monosialoganglioside; Monosialoganglioside GM1; g(m1) Ganglioside
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 5497107
- HMDB: HMDB0304760
- MeSH: G(M1) Ganglioside
- foodb: FDB097529
- chemspider: 4593688
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jason A Weesner, Ida Annunziata, Diantha van de Vlekkert, Camenzind G Robinson, Yvan Campos, Ashutosh Mishra, Leigh E Fremuth, Elida Gomero, Huimin Hu, Alessandra d'Azzo. Altered GM1 catabolism affects NMDAR-mediated Ca2+ signaling at ER-PM junctions and increases synaptic spine formation in a GM1-gangliosidosis model.
Cell reports.
2024 May; 43(5):114117. doi:
10.1016/j.celrep.2024.114117. [PMID: 38630590] - Yongkang Lyu, Shuo Chen, Yu Zhao, Hongxiu Yuan, Chenyang Zhang, Changzhe Zhang, Qingtian Meng. Effect of GM1 concentration change on plasma membrane: molecular dynamics simulation and analysis.
Physical chemistry chemical physics : PCCP.
2024 Apr; 26(16):12552-12563. doi:
10.1039/d3cp06161b. [PMID: 38595108] - Ryosuke Midorikawa, Yoshihiko Wakazono, Kogo Takamiya. Aβ peptide enhances GluA1 internalization via lipid rafts in Alzheimer's-related hippocampal LTP dysfunction.
Journal of cell science.
2024 Apr; 137(8):. doi:
10.1242/jcs.261281. [PMID: 38668720] - Rajendra P Giri, Subhadip Chowdhury, Mrinmay K Mukhopadhyay, Abhijit Chakrabarti, Milan K Sanyal. Ganglioside GM1 Drives Hemin and Protoporphyrin Adsorption in Phospholipid Membranes: A Structural Study.
The journal of physical chemistry. B.
2024 Mar; 128(11):2745-2754. doi:
10.1021/acs.jpcb.3c08239. [PMID: 38447189] - E Nicholas Petersen, Mahmud Arif Pavel, Samuel S Hansen, Manasa Gudheti, Hao Wang, Zixuan Yuan, Keith R Murphy, William Ja, Heather A Ferris, Erik Jorgensen, Scott B Hansen. Mechanical activation of TWIK-related potassium channel by nanoscopic movement and rapid second messenger signaling.
eLife.
2024 Feb; 12(?):. doi:
10.7554/elife.89465. [PMID: 38407149] - Natalia Santos, Luthary Segura, Amber Lewis, Thuong Pham, Kwan H Cheng. Multiscale Modeling of Macromolecular Interactions between Tau-Amylin Oligomers and Asymmetric Lipid Nanodomains That Link Alzheimer's and Diabetic Diseases.
Molecules (Basel, Switzerland).
2024 Feb; 29(3):. doi:
10.3390/molecules29030740. [PMID: 38338484] - Amaury Stommen, Marine Ghodsi, Anne-Sophie Cloos, Louise Conrard, Andra C Dumitru, Patrick Henriet, Christophe E Pierreux, David Alsteens, Donatienne Tyteca. Piezo1 Regulation Involves Lipid Domains and the Cytoskeleton and Is Favored by the Stomatocyte-Discocyte-Echinocyte Transformation.
Biomolecules.
2023 Dec; 14(1):. doi:
10.3390/biom14010051. [PMID: 38254651] - Jing Hu, Sara Linse, Emma Sparr. Ganglioside Micelles Affect Amyloid β Aggregation by Coassembly.
ACS chemical neuroscience.
2023 Dec; 14(24):4335-4343. doi:
10.1021/acschemneuro.3c00524. [PMID: 38050745] - Erika Miyamoto, Toshinori Sato, Teruhiko Matsubara. Cyclization of Peptides Enhances the Inhibitory Activity against Ganglioside-Induced Aβ Fibril Formation.
ACS chemical neuroscience.
2023 12; 14(23):4199-4207. doi:
10.1021/acschemneuro.3c00589. [PMID: 37971427] - Maria L Allende, Y Terry Lee, Colleen Byrnes, Cuiling Li, Galina Tumetova, Jenna Y Bakir, Elena-Raluca Nicoli, Virginia K James, Jennifer S Brodbelt, Cynthia J Tifft, Richard L Proia. Sialidase NEU3 action on GM1 ganglioside is neuroprotective in GM1 Gangliosidosis.
Journal of lipid research.
2023 Oct; ?(?):100463. doi:
10.1016/j.jlr.2023.100463. [PMID: 37871851] - Tanushree Das, Chaitali Mukhopadhyay. Comparison and Possible Binding Orientations of SARS-CoV-2 Spike N-Terminal Domain for Gangliosides GM3 and GM1.
The journal of physical chemistry. B.
2023 08; 127(31):6940-6948. doi:
10.1021/acs.jpcb.3c02286. [PMID: 37523476] - Fodil Azzaz, Morgane Mazzarino, Henri Chahinian, Nouara Yahi, Coralie Di Scala, Jacques Fantini. Structure of the Myelin Sheath Proteolipid Plasmolipin (PLLP) in a Ganglioside-Containing Lipid Raft.
Frontiers in bioscience (Landmark edition).
2023 08; 28(8):157. doi:
10.31083/j.fbl2808157. [PMID: 37664934] - Maho Yagi-Utsumi, Satoru G Itoh, Hisashi Okumura, Katsuhiko Yanagisawa, Koichi Kato, Katsuyuki Nishimura. The Double-Layered Structure of Amyloid-β Assemblage on GM1-Containing Membranes Catalytically Promotes Fibrillization.
ACS chemical neuroscience.
2023 Aug; 14(15):2648-2657. doi:
10.1021/acschemneuro.3c00192. [PMID: 37482658] - David Davidović, Mercedes Kukulka, Maria J Sarmento, Ilya Mikhalyov, Natalia Gretskaya, Barbora Chmelová, Joana C Ricardo, Martin Hof, Lukasz Cwiklik, Radek Šachl. Which Moiety Drives Gangliosides to Form Nanodomains?.
The journal of physical chemistry letters.
2023 Jun; ?(?):5791-5797. doi:
10.1021/acs.jpclett.3c00761. [PMID: 37327454] - Zhongwu Guo. Ganglioside GM1 and the Central Nervous System.
International journal of molecular sciences.
2023 May; 24(11):. doi:
10.3390/ijms24119558. [PMID: 37298512] - Ngoc Nguyen, Amber Lewis, Thuong Pham, Donald Sikazwe, Kwan H Cheng. Exploring the Role of Anionic Lipid Nanodomains in the Membrane Disruption and Protein Folding of Human Islet Amyloid Polypeptide Oligomers on Lipid Membrane Surfaces Using Multiscale Molecular Dynamics Simulations.
Molecules (Basel, Switzerland).
2023 May; 28(10):. doi:
10.3390/molecules28104191. [PMID: 37241931] - Geetanjali Negi, Anurag Sharma, Monika Chaudhary, Divya Gupta, Krishnan H Harshan, Nagma Parveen. SARS-CoV-2 Binding to Terminal Sialic Acid of Gangliosides Embedded in Lipid Membranes.
ACS infectious diseases.
2023 May; ?(?):. doi:
10.1021/acsinfecdis.3c00106. [PMID: 37145972] - Wei Wang, Xue-Wei Cao, Fu-Jun Wang, Jian Zhao. Cytotoxic effects of recombinant proteins enhanced by momordin Ic are dependent on cholesterol and ganglioside GM1.
Toxicon : official journal of the International Society on Toxinology.
2023 Apr; 229(?):107129. doi:
10.1016/j.toxicon.2023.107129. [PMID: 37086901] - Marin Kuharić, Vedrana Ivić, Milorad Zjalić, Anita Matić, Ines Drenjančević, Sandor G Vari, Aleksandar Včev, Marija Heffer. HIPPOCAMPAL GANGLIOSIDE COMPOSITION IS ALTERED BY METFORMIN AND LIRAGLUTIDE TREATMENT IN A HIGH-FAT HIGH-SUGAR DIET RAT MODEL.
Acta clinica Croatica.
2023 Apr; 62(1):184-192. doi:
10.20471/acc.2023.62.01.21. [PMID: 38304364] - Beatrice Barletti, Giacomo Lucchesi, Stefano Muscat, Silvia Errico, Denise Barbut, Andrea Danani, Michael Zasloff, Gianvito Grasso, Fabrizio Chiti, Gabriella Caminati. Reorganization of the outer layer of a model of the plasma membrane induced by a neuroprotective aminosterol.
Colloids and surfaces. B, Biointerfaces.
2023 Feb; 222(?):113115. doi:
10.1016/j.colsurfb.2022.113115. [PMID: 36603410] - Qiangde Duan, Shengmei Pang, Lili Feng, Baoliang Li, Linfen Lv, Yuxuan Liang, Guoqiang Zhu. Both LTA and LTB Subunits Are Equally Important to Heat-Labile Enterotoxin (LT)-Enhanced Bacterial Adherence.
International journal of molecular sciences.
2023 Jan; 24(2):. doi:
10.3390/ijms24021245. [PMID: 36674760] - Yutaka Itokazu, Robert K Yu. Ganglioside Microdomains on Cellular and Intracellular Membranes Regulate Neuronal Cell Fate Determination.
Advances in neurobiology.
2023; 29(?):281-304. doi:
10.1007/978-3-031-12390-0_10. [PMID: 36255679] - Li Long, Lingling Lv, Jie Qiu, Dongchan Sun, Shangfeng Wei, Xianqin Wan, Chao Gao. Comprehensive evaluation of fruit quality for premium Wangmo Castanea mollissima plants.
PloS one.
2023; 18(12):e0295691. doi:
10.1371/journal.pone.0295691. [PMID: 38085713] - Madhura Mohole, Durba Sengupta, Amitabha Chattopadhyay. Synergistic and Competitive Lipid Interactions in the Serotonin1A Receptor Microenvironment.
ACS chemical neuroscience.
2022 12; 13(23):3403-3415. doi:
10.1021/acschemneuro.2c00422. [PMID: 36351047] - Giulia Lunghi, Maria Fazzari, Maria Grazia Ciampa, Laura Mauri, Erika Di Biase, Elena Chiricozzi, Sandro Sonnino. Regulation of signal transduction by gangliosides in lipid rafts: focus on GM3-IR and GM1-TrkA interactions.
FEBS letters.
2022 12; 596(24):3124-3132. doi:
10.1002/1873-3468.14532. [PMID: 36331354] - Ling Han, Linh Nguyen, Edward N Schmidt, Mansoore Esmaili, Elena N Kitova, Michael Overduin, Matthew S Macauley, John S Klassen. How Choice of Model Membrane Affects Protein-Glycosphingolipid Interactions: Insights from Native Mass Spectrometry.
Analytical chemistry.
2022 11; 94(46):16042-16049. doi:
10.1021/acs.analchem.2c03067. [PMID: 36367338] - Thuong Pham, Kwan H Cheng. Exploring the binding kinetics and behaviors of self-aggregated beta-amyloid oligomers to phase-separated lipid rafts with or without ganglioside-clusters.
Biophysical chemistry.
2022 11; 290(?):106874. doi:
10.1016/j.bpc.2022.106874. [PMID: 36067650] - Jhinuk Saha, Priyankar Bose, Shailendra Dhakal, Preetam Ghosh, Vijayaraghavan Rangachari. Ganglioside-Enriched Phospholipid Vesicles Induce Cooperative Aβ Oligomerization and Membrane Disruption.
Biochemistry.
2022 10; 61(20):2206-2220. doi:
10.1021/acs.biochem.2c00495. [PMID: 36173882] - Arghya Chakravorty, Samuel D McCalpin, Bikash R Sahoo, Ayyalusamy Ramamoorthy, Charles L Brooks. Free Gangliosides Can Alter Amyloid-β Aggregation.
The journal of physical chemistry letters.
2022 Oct; 13(40):9303-9308. doi:
10.1021/acs.jpclett.2c02362. [PMID: 36174129] - Shanshan Jin, Tongtong Wang, Yan Zhao, Xue Liu, Yichen Wang, Lingchuan Jiang, Qiusheng Zhang. The heat-labile toxin B subunit of E. coli fused with VP6 from GCRV (Grass carp reovirus) was expressed and folded into an active protein in rice calli.
Protein expression and purification.
2022 09; 197(?):106099. doi:
10.1016/j.pep.2022.106099. [PMID: 35525405] - Jason Andrew Weesner, Ida Annunziata, Tianhong Yang, Walter Acosta, Elida Gomero, Huimin Hu, Diantha van de Vlekkert, Jorge Ayala, Xiaohui Qiu, Leigh Ellen Fremuth, David N Radin, Carole L Cramer, Alessandra d'Azzo. Preclinical Enzyme Replacement Therapy with a Recombinant β-Galactosidase-Lectin Fusion for CNS Delivery and Treatment of GM1-Gangliosidosis.
Cells.
2022 08; 11(16):. doi:
10.3390/cells11162579. [PMID: 36010656] - Lonnie Schneider, Maryam Rezaeezade-Roukerd, Jenna Faulkner, Ethan Reichert, Hussam Abou-Al-Shaar, Alexandra Flis, Andres M Rubiano, Gregory W J Hawryluk. The human anti-ganglioside GM1 autoantibody response following traumatic and surgical central nervous system insults.
Neuroscience research.
2022 Aug; 181(?):105-114. doi:
10.1016/j.neures.2022.03.009. [PMID: 35405180] - Pankaj D Patil, Yuchen Jin, Yan-Yeung Luk. Chemical control over Asialo-GM1: A dual ligand for pili and Lectin A that activates swarming motility and facilitates adherence of Pseudomonas aeruginosa.
Colloids and surfaces. B, Biointerfaces.
2022 Jul; 215(?):112478. doi:
10.1016/j.colsurfb.2022.112478. [PMID: 35390596] - Tom Hutteau-Hamel, Amine Mellouk, Nicolas Trainel, Anne-Marie Cassard, Pierre Bobé. Hypercholesterolemia Negatively Regulates P2X7-Induced Cellular Function in CD4+ and CD8+ T-Cell Subsets from B6 Mice Fed a High-Fat Diet.
International journal of molecular sciences.
2022 Jun; 23(12):. doi:
10.3390/ijms23126730. [PMID: 35743168] - Michael K Racke, Justin K Niles, Raymond A Lorenz, Harvey W Kaufman. Changes in ganglioside antibody positivity rates during the COVID-19 pandemic.
Journal of neuroimmunology.
2022 06; 367(?):577877. doi:
10.1016/j.jneuroim.2022.577877. [PMID: 35490444] - Erik B Watkins, Andrew J C Dennison, Jaroslaw Majewski. Binding of Cholera Toxin B-Subunit to a Ganglioside GM1-Functionalized PEG-Tethered Lipid Membrane.
Langmuir : the ACS journal of surfaces and colloids.
2022 06; 38(22):6959-6966. doi:
10.1021/acs.langmuir.2c00499. [PMID: 35604017] - Hoang Linh Nguyen, Huynh Quang Linh, Pawel Krupa, Giovanni La Penna, Mai Suan Li. Amyloid β Dodecamer Disrupts the Neuronal Membrane More Strongly than the Mature Fibril: Understanding the Role of Oligomers in Neurotoxicity.
The journal of physical chemistry. B.
2022 05; 126(20):3659-3672. doi:
10.1021/acs.jpcb.2c01769. [PMID: 35580354] - Amanda L Gross, Heather L Gray-Edwards, Cassie N Bebout, Nathan L Ta, Kayly Nielsen, Brandon L Brunson, Kalajan R Lopez Mercado, Devin E Osterhoudt, Ana Rita Batista, Stacy Maitland, Thomas N Seyfried, Miguel Sena-Esteves, Douglas R Martin. Intravenous delivery of adeno-associated viral gene therapy in feline GM1 gangliosidosis.
Brain : a journal of neurology.
2022 04; 145(2):655-669. doi:
10.1093/brain/awab309. [PMID: 34410345] - Eleonora Sgambati, Alessia Tani, Manuela Leri, Giovanni Delfino, Sandra Zecchi-Orlandini, Monica Bucciantini, Daniele Nosi. Correlation between Sialylation Status and Cell Susceptibility to Amyloid Toxicity.
Cells.
2022 02; 11(4):. doi:
10.3390/cells11040601. [PMID: 35203252] - Elena Chiricozzi. Plasma membrane glycosphingolipid signaling: a turning point.
Glycoconjugate journal.
2022 02; 39(1):99-105. doi:
10.1007/s10719-021-10008-w. [PMID: 34398373] - Danny Galleguillos, Qian Wang, Noam Steinberg, Asifa Zaidi, Gaurav Shrivastava, Kamaldeep Dhami, Gour C Daskhan, Edward N Schmidt, Zoë Dworsky-Fried, Fabrizio Giuliani, Matthew Churchward, Christopher Power, Kathryn Todd, Anna Taylor, Matthew S Macauley, Simonetta Sipione. Anti-inflammatory role of GM1 and other gangliosides on microglia.
Journal of neuroinflammation.
2022 Jan; 19(1):9. doi:
10.1186/s12974-021-02374-x. [PMID: 34991625] - Maria J Sarmento, Michael C Owen, Joana C Ricardo, Barbora Chmelová, David Davidović, Ilya Mikhalyov, Natalia Gretskaya, Martin Hof, Mariana Amaro, Robert Vácha, Radek Šachl. The impact of the glycan headgroup on the nanoscopic segregation of gangliosides.
Biophysical journal.
2021 12; 120(24):5530-5543. doi:
10.1016/j.bpj.2021.11.017. [PMID: 34798138] - Katarina Ilic, Xiao Lin, Ayse Malci, Mario Stojanović, Borna Puljko, Marko Rožman, Željka Vukelić, Marija Heffer, Dirk Montag, Ronald L Schnaar, Svjetlana Kalanj-Bognar, Rodrigo Herrera-Molina, Kristina Mlinac-Jerkovic. Plasma Membrane Calcium ATPase-Neuroplastin Complexes Are Selectively Stabilized in GM1-Containing Lipid Rafts.
International journal of molecular sciences.
2021 Dec; 22(24):. doi:
10.3390/ijms222413590. [PMID: 34948386] - Ellen Hertz, Marcus Saarinen, Per Svenningsson. GM1 Is Cytoprotective in GPR37-Expressing Cells and Downregulates Signaling.
International journal of molecular sciences.
2021 Nov; 22(23):. doi:
10.3390/ijms222312859. [PMID: 34884663] - Samavi Farnush Bint E Naser, Hui Su, Han-Yuan Liu, Zachary A Manzer, Zhongmou Chao, Arpita Roy, Anna-Maria Pappa, Alberto Salleo, Róisín M Owens, Susan Daniel. Detection of Ganglioside-Specific Toxin Binding with Biomembrane-Based Bioelectronic Sensors.
ACS applied bio materials.
2021 11; 4(11):7942-7950. doi:
10.1021/acsabm.1c00878. [PMID: 35006775] - Hyun-Ro Lee, Siyoung Q Choi. Sphingomyelinase-Mediated Multitimescale Clustering of Ganglioside GM1 in Heterogeneous Lipid Membranes.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
2021 10; 8(20):e2101766. doi:
10.1002/advs.202101766. [PMID: 34473415] - Stefano Pro, Fabiana Ursitti, Gian Luca Pruneddu, Matteo Di Capua, Massimiliano Valeriani. Childhood-Onset Multifocal Motor Neuropathy with IgM Antibodies to Gangliosides GM1: A Case Report with Poor Outcome.
Neuropediatrics.
2021 10; 52(5):406-409. doi:
10.1055/s-0040-1722677. [PMID: 33511596] - Hebah Fatafta, Mohammed Khaled, Michael C Owen, Abdallah Sayyed-Ahmad, Birgit Strodel. Amyloid-β peptide dimers undergo a random coil to β-sheet transition in the aqueous phase but not at the neuronal membrane.
Proceedings of the National Academy of Sciences of the United States of America.
2021 09; 118(39):. doi:
10.1073/pnas.2106210118. [PMID: 34544868] - Ji Hun Wi, Cheol Ho Heo, HyeRan Gwak, Cheulhee Jung, So Yeon Kim. Probing Physical Properties of the Cellular Membrane in Senescent Cells by Fluorescence Imaging.
The journal of physical chemistry. B.
2021 09; 125(36):10182-10194. doi:
10.1021/acs.jpcb.1c05403. [PMID: 34473497] - Silvia Errico, Hassan Ramshini, Claudia Capitini, Claudio Canale, Martina Spaziano, Denise Barbut, Martino Calamai, Michael Zasloff, Reinier Oropesa-Nuñez, Michele Vendruscolo, Fabrizio Chiti. Quantitative Measurement of the Affinity of Toxic and Nontoxic Misfolded Protein Oligomers for Lipid Bilayers and of its Modulation by Lipid Composition and Trodusquemine.
ACS chemical neuroscience.
2021 09; 12(17):3189-3202. doi:
10.1021/acschemneuro.1c00327. [PMID: 34382791] - Senthil Arumugam, Stefanie Schmieder, Weria Pezeshkian, Ulrike Becken, Christian Wunder, Dan Chinnapen, John Hjort Ipsen, Anne K Kenworthy, Wayne Lencer, Satyajit Mayor, Ludger Johannes. Ceramide structure dictates glycosphingolipid nanodomain assembly and function.
Nature communications.
2021 06; 12(1):3675. doi:
10.1038/s41467-021-23961-9. [PMID: 34135326] - Ida Cariati, Roberto Bonanni, Mario Marini, Anna Maria Rinaldi, Beatrice Zarrilli, Virginia Tancredi, Claudio Frank, Giovanna D'Arcangelo, Marco Diociaiuti. Role of Electrostatic Interactions in Calcitonin Prefibrillar Oligomer-Induced Amyloid Neurotoxicity and Protective Effect of Neuraminidase.
International journal of molecular sciences.
2021 Apr; 22(8):. doi:
10.3390/ijms22083947. [PMID: 33920464] - Yu-Lin Guo, Wen-Jun Duan, Dan-Hua Lu, Xiao-Hui Ma, Xiao-Xiao Li, Zhao Li, Wei Bi, Hiroshi Kurihara, Hai-Zhi Liu, Yi-Fang Li, Rong-Rong He. Autophagy-dependent removal of α-synuclein: a novel mechanism of GM1 ganglioside neuroprotection against Parkinson's disease.
Acta pharmacologica Sinica.
2021 Apr; 42(4):518-528. doi:
10.1038/s41401-020-0454-y. [PMID: 32724177] - Benita C Percival, Yvonne L Latour, Cynthia J Tifft, Martin Grootveld. Rapid Identification of New Biomarkers for the Classification of GM1 Type 2 Gangliosidosis Using an Unbiased 1H NMR-Linked Metabolomics Strategy.
Cells.
2021 03; 10(3):. doi:
10.3390/cells10030572. [PMID: 33807817] - Elena Chiricozzi, Erika Di Biase, Giulia Lunghi, Maria Fazzari, Nicoletta Loberto, Massimo Aureli, Laura Mauri, Sandro Sonnino. Turning the spotlight on the oligosaccharide chain of GM1 ganglioside.
Glycoconjugate journal.
2021 02; 38(1):101-117. doi:
10.1007/s10719-021-09974-y. [PMID: 33620588] - Jhinuk Saha, Dexter N Dean, Shailendra Dhakal, Kelli A Stockmal, Sarah E Morgan, Kristy D Dillon, Munir F Adamo, Yona Levites, Vijayaraghavan Rangachari. Biophysical characteristics of lipid-induced Aβ oligomers correlate to distinctive phenotypes in transgenic mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 02; 35(2):e21318. doi:
10.1096/fj.202002025rr. [PMID: 33508158] - Hasna Ahyayauch, Massimo Masserini, Félix M Goñi, Alicia Alonso. The interaction of Aβ42 peptide in monomer, oligomer or fibril forms with sphingomyelin/cholesterol/ganglioside bilayers.
International journal of biological macromolecules.
2021 Jan; 168(?):611-619. doi:
10.1016/j.ijbiomac.2020.11.112. [PMID: 33217464] - Teruhiko Matsubara, Kazutoshi IIjima, Takahiro Kojima, Miwa Hirai, Erika Miyamoto, Toshinori Sato. Heterogeneous Ganglioside-Enriched Nanoclusters with Different Densities in Membrane Rafts Detected by a Peptidyl Molecular Probe.
Langmuir : the ACS journal of surfaces and colloids.
2021 01; 37(2):646-654. doi:
10.1021/acs.langmuir.0c02387. [PMID: 33398996] - Jingjing Ge, Xiaoling Jiao, Fanlin Qi, Hui Li. Neural Function Recovery and Safety of Mild Hypothermia Therapy Combined with Monosialotetrahexosylganglioside on Neonatal Asphyxia Complicated by Hypoxic Ischemic Encephalopathy.
Computational and mathematical methods in medicine.
2021; 2021(?):6186011. doi:
10.1155/2021/6186011. [PMID: 34987600] - Consuelo Gajate, Faustino Mollinedo. Lipid Raft Isolation by Sucrose Gradient Centrifugation and Visualization of Raft-Located Proteins by Fluorescence Microscopy: The Use of Combined Techniques to Assess Fas/CD95 Location in Rafts During Apoptosis Triggering.
Methods in molecular biology (Clifton, N.J.).
2021; 2187(?):147-186. doi:
10.1007/978-1-0716-0814-2_9. [PMID: 32770506] - Nahuel Peinetti, Mariana Micaela Cuello Rubio, Liliana Del Valle Sosa, María Victoria Scalerandi, Roxana Valeria Alasino, Victoria Peyret, Juan Pablo Nicola, Dante Miguel Beltramo, Amado Alfredo Quintar, Cristina Alicia Maldonado. Testosterone-loaded GM1 micelles targeted to the intracellular androgen receptor for the specific induction of genomic androgen signaling.
International journal of pharmaceutics.
2020 Dec; 591(?):119985. doi:
10.1016/j.ijpharm.2020.119985. [PMID: 33069891] - Ikuko Koyama-Honda, Takahiro K Fujiwara, Rinshi S Kasai, Kenichi G N Suzuki, Eriko Kajikawa, Hisae Tsuboi, Taka A Tsunoyama, Akihiro Kusumi. High-speed single-molecule imaging reveals signal transduction by induced transbilayer raft phases.
The Journal of cell biology.
2020 12; 219(12):. doi:
10.1083/jcb.202006125. [PMID: 33053147] - Hasna Ahyayauch, Aritz B García-Arribas, Massimo E Masserini, Sergio Pantano, Félix M Goñi, Alicia Alonso. β-Amyloid (1-42) peptide adsorbs but does not insert into ganglioside-containing phospholipid membranes in the liquid-disordered state: modelling and experimental studies.
International journal of biological macromolecules.
2020 Dec; 164(?):2651-2658. doi:
10.1016/j.ijbiomac.2020.08.165. [PMID: 32846182] - Yuko Yamagishi, Motoi Kuwahara, Hidekazu Suzuki, Masahiro Sonoo, Satoshi Kuwabara, Takanori Yokota, Kyoichi Nomura, Atsuro Chiba, Ryuji Kaji, Takashi Kanda, Ken-Ichi Kaida, Tatsuro Mutoh, Ryo Yamasaki, Hiroshi Takashima, Makoto Matsui, Kazutoshi Nishiyama, Gen Sobue, Susumu Kusunoki. Serum IgG anti-GD1a antibody and mEGOS predict outcome in Guillain-Barré syndrome.
Journal of neurology, neurosurgery, and psychiatry.
2020 12; 91(12):1339-1342. doi:
10.1136/jnnp-2020-323960. [PMID: 33041261] - Cristina Petrelli, Roberto Scendoni, Marco Paglioriti, Francesco Ottavio Logullo. Acute Motor Axonal Neuropathy Related to COVID-19 Infection: A New Diagnostic Overview.
Journal of clinical neuromuscular disease.
2020 Dec; 22(2):120-121. doi:
10.1097/cnd.0000000000000322. [PMID: 33214404] - Ravi Holani, Anshu Babbar, Graham A D Blyth, Fernando Lopes, Humberto Jijon, Derek M McKay, Morley D Hollenberg, Eduardo R Cobo. Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production.
Gut microbes.
2020 11; 12(1):1785802. doi:
10.1080/19490976.2020.1785802. [PMID: 32658599] - Sophie R Cook, Cerys Bladen, Johanna Smith, Emily Maguire, Jordan Copner, Gareth D Fenn, Kim Wager, Helen Waller-Evans, Emyr Lloyd-Evans. Visualisation of cholesterol and ganglioside GM1 in zebrafish models of Niemann-Pick type C disease and Smith-Lemli-Opitz syndrome using light sheet microscopy.
Histochemistry and cell biology.
2020 Nov; 154(5):565-578. doi:
10.1007/s00418-020-01925-2. [PMID: 33079236] - Upneet Kaur, Jennifer C Lee. Unroofing site-specific α-synuclein-lipid interactions at the plasma membrane.
Proceedings of the National Academy of Sciences of the United States of America.
2020 08; 117(32):18977-18983. doi:
10.1073/pnas.2006291117. [PMID: 32719116] - Jacques Fantini, Henri Chahinian, Nouara Yahi. Synergistic antiviral effect of hydroxychloroquine and azithromycin in combination against SARS-CoV-2: What molecular dynamics studies of virus-host interactions reveal.
International journal of antimicrobial agents.
2020 Aug; 56(2):106020. doi:
10.1016/j.ijantimicag.2020.106020. [PMID: 32405156] - Jacques Fantini, Henri Chahinian, Nouara Yahi. Synergistic antiviral effect of hydroxychloroquine and azithromycin in combination against SARS-CoV-2: What molecular dynamics studies of virus-host interactions reveal.
International journal of antimicrobial agents.
2020 Aug; 56(2):106020. doi:
10.1016/j.ijantimicag.2020.106020. [PMID: 32862840] - Monica Bucciantini, Manuela Leri, Massimo Stefani, Ronald Melki, Sandra Zecchi-Orlandini, Daniele Nosi. The Amphipathic GM1 Molecule Stabilizes Amyloid Aggregates, Preventing their Cytotoxicity.
Biophysical journal.
2020 07; 119(2):326-336. doi:
10.1016/j.bpj.2020.06.005. [PMID: 32579964] - Giulia Mancini, Nicoletta Loberto, Debora Olioso, Maria Cristina Dechecchi, Giulio Cabrini, Laura Mauri, Rosaria Bassi, Domitilla Schiumarini, Elena Chiricozzi, Giuseppe Lippi, Emanuela Pesce, Sandro Sonnino, Nicoletta Pedemonte, Anna Tamanini, Massimo Aureli. GM1 as Adjuvant of Innovative Therapies for Cystic Fibrosis Disease.
International journal of molecular sciences.
2020 Jun; 21(12):. doi:
10.3390/ijms21124486. [PMID: 32599772] - Wei He, Yun Su, H Benjamin Peng, Penger Tong. Dynamic heterogeneity and non-Gaussian statistics for ganglioside GM1s and acetylcholine receptors on live cell membrane.
Molecular biology of the cell.
2020 06; 31(13):1380-1391. doi:
10.1091/mbc.e19-08-0473. [PMID: 32348189] - Maria Fazzari, Matteo Audano, Giulia Lunghi, Erika Di Biase, Nicoletta Loberto, Laura Mauri, Nico Mitro, Sandro Sonnino, Elena Chiricozzi. The oligosaccharide portion of ganglioside GM1 regulates mitochondrial function in neuroblastoma cells.
Glycoconjugate journal.
2020 06; 37(3):293-306. doi:
10.1007/s10719-020-09920-4. [PMID: 32266604] - Erika Di Biase, Giulia Lunghi, Maria Fazzari, Margherita Maggioni, Diego Yuri Pomè, Manuela Valsecchi, Maura Samarani, Pamela Fato, Maria Grazia Ciampa, Simona Prioni, Laura Mauri, Sandro Sonnino, Elena Chiricozzi. Gangliosides in the differentiation process of primary neurons: the specific role of GM1-oligosaccharide.
Glycoconjugate journal.
2020 06; 37(3):329-343. doi:
10.1007/s10719-020-09919-x. [PMID: 32198666] - Yuki Fujii, Marco Gerdol, Sarkar M A Kawsar, Imtiaj Hasan, Francesca Spazzali, Tatsusada Yoshida, Yukiko Ogawa, Sultana Rajia, Kenichi Kamata, Yasuhiro Koide, Shigeki Sugawara, Masahiro Hosono, Jeremy R H Tame, Hideaki Fujita, Alberto Pallavicini, Yasuhiro Ozeki. A GM1b/asialo-GM1 oligosaccharide-binding R-type lectin from purplish bifurcate mussels Mytilisepta virgata and its effect on MAP kinases.
The FEBS journal.
2020 06; 287(12):2612-2630. doi:
10.1111/febs.15154. [PMID: 31769916] - S Schwarz, A Lehmbecker, W Tongtako, K Hahn, Y Wang, F Felmy, I Zdora, G Brogden, K Branitzki-Heinemann, M von Köckritz-Blickwede, W Baumgärtner, I Gerhauser. Neurotrophic effects of GM1 ganglioside, NGF, and FGF2 on canine dorsal root ganglia neurons in vitro.
Scientific reports.
2020 03; 10(1):5380. doi:
10.1038/s41598-020-61852-z. [PMID: 32214122] - Youssef M Mousa, Ihab M Abdallah, Misako Hwang, Douglas R Martin, Amal Kaddoumi. Amylin and pramlintide modulate γ-secretase level and APP processing in lipid rafts.
Scientific reports.
2020 02; 10(1):3751. doi:
10.1038/s41598-020-60664-5. [PMID: 32111883] - Aldo A Vilcaes, Eduardo Garbarino-Pico, Vanina Torres Demichelis, Jose L Daniotti. Ganglioside Synthesis by Plasma Membrane-Associated Sialyltransferase in Macrophages.
International journal of molecular sciences.
2020 Feb; 21(3):. doi:
10.3390/ijms21031063. [PMID: 32033474] - Zarrin Shahzadi, Chaitali Mukhopadhyay. Effect of Transmembrane Electric Field on GM1 Containing DMPC-Cholesterol Monolayer: A Computational Study.
The Journal of membrane biology.
2020 02; 253(1):11-24. doi:
10.1007/s00232-019-00101-5. [PMID: 31728569] - Elena Chiricozzi, Giulia Lunghi, Erika Di Biase, Maria Fazzari, Sandro Sonnino, Laura Mauri. GM1 Ganglioside Is A Key Factor in Maintaining the Mammalian Neuronal Functions Avoiding Neurodegeneration.
International journal of molecular sciences.
2020 Jan; 21(3):. doi:
10.3390/ijms21030868. [PMID: 32013258] - Enamul Haque Mojumdar, Carl Grey, Emma Sparr. Self-Assembly in Ganglioside‒Phospholipid Systems: The Co-Existence of Vesicles, Micelles, and Discs.
International journal of molecular sciences.
2019 Dec; 21(1):. doi:
10.3390/ijms21010056. [PMID: 31861839] - F Perissinotto, V Rondelli, P Parisse, N Tormena, A Zunino, L Almásy, D G Merkel, L Bottyán, Sz Sajti, L Casalis. GM1 Ganglioside role in the interaction of Alpha-synuclein with lipid membranes: Morphology and structure.
Biophysical chemistry.
2019 12; 255(?):106272. doi:
10.1016/j.bpc.2019.106272. [PMID: 31698188] - Rodolfo Tonin, Anna Caciotti, Elena Procopio, Rita Fischetto, Federica Deodato, Maria Margherita Mancardi, Maja Di Rocco, Anna Ardissone, Alessandro Salviati, Antonio Marangi, Pietro Strisciuglio, Giusi Mangone, Arianna Casini, Silvia Ricci, Agata Fiumara, Rossella Parini, Francesco Saverio Pavone, Renzo Guerrini, Martino Calamai, Amelia Morrone. Pre-diagnosing and managing patients with GM1 gangliosidosis and related disorders by the evaluation of GM1 ganglioside content.
Scientific reports.
2019 11; 9(1):17684. doi:
10.1038/s41598-019-53995-5. [PMID: 31776384] - Antonella Rigo, Isacco Ferrarini, Erika Lorenzetto, Elena Darra, Irene Liparulo, Christian Bergamini, Cinzia Sissa, Elisabetta Cavalieri, Fabrizio Vinante. BID and the α-bisabolol-triggered cell death program: converging on mitochondria and lysosomes.
Cell death & disease.
2019 11; 10(12):889. doi:
10.1038/s41419-019-2126-8. [PMID: 31767857] - Mehdi Azouz, Christophe Cullin, Sophie Lecomte, Michel Lafleur. Membrane domain modulation of Aβ1-42 oligomer interactions with supported lipid bilayers: an atomic force microscopy investigation.
Nanoscale.
2019 Nov; 11(43):20857-20867. doi:
10.1039/c9nr06361g. [PMID: 31657431] - Damiano Verardo, Björn Agnarsson, Vladimir P Zhdanov, Fredrik Höök, Heiner Linke. Single-Molecule Detection with Lightguiding Nanowires: Determination of Protein Concentration and Diffusivity in Supported Lipid Bilayers.
Nano letters.
2019 09; 19(9):6182-6191. doi:
10.1021/acs.nanolett.9b02226. [PMID: 31369284] - Michael C Owen, Andreas Karner, Radek Šachl, Johannes Preiner, Mariana Amaro, Robert Vácha. Force Field Comparison of GM1 in a DOPC Bilayer Validated with AFM and FRET Experiments.
The journal of physical chemistry. B.
2019 09; 123(35):7504-7517. doi:
10.1021/acs.jpcb.9b05095. [PMID: 31397569] - Markus S Miettinen, Reinhard Lipowsky. Bilayer Membranes with Frequent Flip-Flops Have Tensionless Leaflets.
Nano letters.
2019 08; 19(8):5011-5016. doi:
10.1021/acs.nanolett.9b01239. [PMID: 31056917] - Marius M Kostelic, Alex M Ryan, Deseree J Reid, Jibriel M Noun, Michael T Marty. Expanding the Types of Lipids Amenable to Native Mass Spectrometry of Lipoprotein Complexes.
Journal of the American Society for Mass Spectrometry.
2019 Aug; 30(8):1416-1425. doi:
10.1007/s13361-019-02174-x. [PMID: 30972726] - Magdalena Komiazyk, Malgorzata Palczewska, Izabela Sitkiewicz, Slawomir Pikula, Patrick Groves. Neutralization of cholera toxin by Rosaceae family plant extracts.
BMC complementary and alternative medicine.
2019 Jun; 19(1):140. doi:
10.1186/s12906-019-2540-6. [PMID: 31221152] - Yuhei Tachi, Yuko Okamoto, Hisashi Okumura. Conformational Change of Amyloid-β 40 in Association with Binding to GM1-Glycan Cluster.
Scientific reports.
2019 05; 9(1):6853. doi:
10.1038/s41598-019-43117-6. [PMID: 31048748] - M Ewald, S Henry, E Lambert, C Feuillie, C Bobo, C Cullin, S Lecomte, M Molinari. High speed atomic force microscopy to investigate the interactions between toxic Aβ1-42 peptides and model membranes in real time: impact of the membrane composition.
Nanoscale.
2019 Apr; 11(15):7229-7238. doi:
10.1039/c8nr08714h. [PMID: 30924478] - Elena Chiricozzi, Erika Di Biase, Margherita Maggioni, Giulia Lunghi, Maria Fazzari, Diego Yuri Pomè, Riccardo Casellato, Nicoletta Loberto, Laura Mauri, Sandro Sonnino. GM1 promotes TrkA-mediated neuroblastoma cell differentiation by occupying a plasma membrane domain different from TrkA.
Journal of neurochemistry.
2019 04; 149(2):231-241. doi:
10.1111/jnc.14685. [PMID: 30776097] - Zhaocai Jiang, Weina Ju, Shen Luo, Yu Yang. Diffuse large B-cell lymphoma involving peripheral nervous system with IgM antibodies against GM1 and GD1b: A case report.
Medicine.
2019 Apr; 98(15):e15049. doi:
10.1097/md.0000000000015049. [PMID: 30985655] - Matthias Müller, Daniel Lauster, Helen H K Wildenauer, Andreas Herrmann, Stephan Block. Mobility-Based Quantification of Multivalent Virus-Receptor Interactions: New Insights Into Influenza A Virus Binding Mode.
Nano letters.
2019 03; 19(3):1875-1882. doi:
10.1021/acs.nanolett.8b04969. [PMID: 30719917] - Raisa Kociurzynski, Sophie D Beck, Jean-Baptiste Bouhon, Winfried Römer, Volker Knecht. Binding of SV40's Viral Capsid Protein VP1 to Its Glycosphingolipid Receptor GM1 Induces Negative Membrane Curvature: A Molecular Dynamics Study.
Langmuir : the ACS journal of surfaces and colloids.
2019 03; 35(9):3534-3544. doi:
10.1021/acs.langmuir.8b03765. [PMID: 30802059] - Yuki Manabe, Takashi Hirata, Tatsuya Sugawara. Inhibitory Effect of Carotenoids on Ligand-induced Lipid Raft Translocation of Immunoreceptors.
Journal of oleo science.
2019 Feb; 68(2):149-158. doi:
10.5650/jos.ess18204. [PMID: 30651415] - Yong Wei, Zi Jian Xiong, Jun Li, Chunxia Zou, Christopher W Cairo, John S Klassen, Gilbert G Privé. Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters.
Communications biology.
2019; 2(?):52. doi:
10.1038/s42003-018-0262-9. [PMID: 30729188]