Sampangine (BioDeep_00000022908)

   

human metabolite


代谢物信息卡片


10,16-diazatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(16),2,4,6,9,11,13(17),14-octaen-8-one

化学式: C15H8N2O (232.06365979999998)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C2C(=C1)C3=NC=CC4=C3C(=NC=C4)C2=O
InChI: InChI=1S/C15H8N2O/c18-15-11-4-2-1-3-10(11)13-12-9(5-7-16-13)6-8-17-14(12)15/h1-8H

描述信息

Sampangine is an alkaloid from the stem bark of Cananga odorata (ylang ylang
Alkaloid from the stem bark of Cananga odorata (ylang ylang).

同义名列表

5 个代谢物同义名

10,16-diazatetracyclo[7.7.1.0²,⁷.0¹³,¹⁷]heptadeca-1(16),2,4,6,9,11,13(17),14-octaen-8-one; 7H-Naphtho[1,2,3,-ij][2,7]naphthyridin-7-one, 9ci; 1,6-Diaza-benzo[de]anthracen-7-one; 1,6-Diaza-benzo(de)anthracen-7-one; Sampangine



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zhuang Li, Na Liu, Jie Tu, Changjin Ji, Guiyan Han, Chunquan Sheng. Discovery of Simplified Sampangine Derivatives with Potent Antifungal Activities against Cryptococcal Meningitis. ACS infectious diseases. 2019 08; 5(8):1376-1384. doi: 10.1021/acsinfecdis.9b00086. [PMID: 31070884]
  • Zhuang Li, Na Liu, Jie Tu, Changjin Ji, Guiyan Han, Yan Wang, Chunquan Sheng. Discovery of novel simplified isoxazole derivatives of sampangine as potent anti-cryptococcal agents. Bioorganic & medicinal chemistry. 2019 03; 27(5):832-840. doi: 10.1016/j.bmc.2019.01.029. [PMID: 30711309]
  • Yang-Nim Park, Thyagarajan Srikantha, Karla J Daniels, Melissa R Jacob, Ameeta K Agarwal, Xing-Cong Li, David R Soll. Protocol for Identifying Natural Agents That Selectively Affect Adhesion, Thickness, Architecture, Cellular Phenotypes, Extracellular Matrix, and Human White Blood Cell Impenetrability of Candida albicans Biofilms. Antimicrobial agents and chemotherapy. 2017 11; 61(11):. doi: 10.1128/aac.01319-17. [PMID: 28893778]
  • Zhiwei Huang, Kaifu Chen, Tao Xu, Jianhuai Zhang, Yongxiang Li, Wei Li, Ameeta K Agarwal, Alice M Clark, John D Phillips, Xuewen Pan. Sampangine inhibits heme biosynthesis in both yeast and human. Eukaryotic cell. 2011 Nov; 10(11):1536-44. doi: 10.1128/ec.05170-11. [PMID: 21908598]
  • Ana Silvia Suassuna Carneiro Lúcio, Jackson Roberto Guedes da Silva Almeida, José Maria Barbosa-Filho, João Carlos Lima Rodrigues Pita, Marianna Vieira Sobral Castello Branco, Margareth de Fátima Formiga Melo Diniz, Maria de Fátima Agra, Emidio V L da-Cunha, Marcelo Sobral da Silva, Josean Fechine Tavares. Azaphenanthrene alkaloids with antitumoral activity from Anaxagorea dolichocarpa Sprague & Sandwith (Annonaceae). Molecules (Basel, Switzerland). 2011 Aug; 16(8):7125-31. doi: 10.3390/molecules16087125. [PMID: 21860364]
  • Ende Pan, Shugeng Cao, Peggy J Brodie, Martin W Callmander, Richard Randrianaivo, Stephan Rakotonandrasana, Etienne Rakotobe, Vincent E Rasamison, Karen TenDyke, Yongchun Shen, Edward M Suh, David G I Kingston. Isolation and synthesis of antiproliferative eupolauridine alkaloids of Ambavia gerrardii from the Madagascar Dry Forest. Journal of natural products. 2011 May; 74(5):1169-74. doi: 10.1021/np200093n. [PMID: 21504145]
  • Ameeta K Agarwal, Tao Xu, Melissa R Jacob, Qin Feng, Michael C Lorenz, Larry A Walker, Alice M Clark. Role of heme in the antifungal activity of the azaoxoaporphine alkaloid sampangine. Eukaryotic cell. 2008 Feb; 7(2):387-400. doi: 10.1128/ec.00323-07. [PMID: 18156292]
  • Jérôme Kluza, Romain Mazinghien, Klara Degardin, Amélie Lansiaux, Christian Bailly. Induction of apoptosis by the plant alkaloid sampangine in human HL-60 leukemia cells is mediated by reactive oxygen species. European journal of pharmacology. 2005 Nov; 525(1-3):32-40. doi: 10.1016/j.ejphar.2005.09.050. [PMID: 16289142]
  • Adewole L Okunade, Memory P F Elvin-Lewis, Walter H Lewis. Natural antimycobacterial metabolites: current status. Phytochemistry. 2004 Apr; 65(8):1017-32. doi: 10.1016/j.phytochem.2004.02.013. [PMID: 15110681]
  • Jérôme Kluza, Alice M Clark, Christian Bailly. Apoptosis induced by the alkaloid sampangine in HL-60 leukemia cells: correlation between the effects on the cell cycle progression and changes of mitochondrial potential. Annals of the New York Academy of Sciences. 2003 Dec; 1010(?):331-4. doi: 10.1196/annals.1299.059. [PMID: 15033745]
  • I Muhammad, D C Dunbar, S Takamatsu, L A Walker, A M Clark. Antimalarial, cytotoxic, and antifungal alkaloids from Duguetia hadrantha. Journal of natural products. 2001 May; 64(5):559-62. doi: 10.1021/np000436s. [PMID: 11374943]
  • K Y Orabi, L A Walker, A M Clark, C D Hufford. Characterization of the major metabolite of sampangine in rats. Journal of natural products. 2000 May; 63(5):685-7. doi: 10.1021/np990552z. [PMID: 10843589]