Crofelemer (BioDeep_00000228205)

human metabolite PANOMIX_OTCML-2023 Chemicals and Drugs

代谢物信息卡片

化学式: C63H98N18O13S (1346.7281097999999)
中文名称: P物质
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(C)CC(C(=O)NC(CCSC)C(=O)N)NC(=O)CNC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCC(=O)N)NC(=O)C(CCC(=O)N)NC(=O)C3CCCN3C(=O)C(CCCCN)NC(=O)C4CCCN4C(=O)C(CCCN=C(N)N)N
InChI: InChI=1S/C63H98N18O13S/c1-37(2)33-45(57(89)74-41(53(68)85)27-32-95-3)73-52(84)36-72-54(86)46(34-38-15-6-4-7-16-38)78-58(90)47(35-39-17-8-5-9-18-39)79-56(88)42(23-25-50(66)82)75-55(87)43(24-26-51(67)83)76-59(91)49-22-14-31-81(49)62(94)44(20-10-11-28-64)77-60(92)48-21-13-30-80(48)61(93)40(65)19-12-29-71-63(69)70/h4-9,15-18,37,40-49H,10-14,19-36,64-65H2,1-3H3,(H2,66,82)(H2,67,83)(H2,68,85)(H,72,86)(H,73,84)(H,74,89)(H,75,87)(H,76,91)(H,77,92)(H,78,90)(H,79,88)(H4,69,70,71)/t40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1

描述信息

Oligomeric proanthocyanidin. Crofelemer is an inhibitor of secretory diarrhea via inhibition of the CFTR chloride transporter. Crofelemer is not an antimicrobial, and therefore does not drive the emergence of resistance, it does not inhibit motility, and therefore does not cause constipation or rebound diarrhea, and it is not systemically absorbed, reducing the potential for adverse drug interactions and toxicity.
A - Alimentary tract and metabolism > A07 - Antidiarrheals, intestinal antiinflammatory/antiinfective agents
D018377 - Neurotransmitter Agents > D015320 - Tachykinins
Oligomeric proanthocyanidin
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).
Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).

同义名列表

14 个代谢物同义名

(2S)-2-({[(2S)-1-[(2S)-6-amino-2-({[(2S)-1-[(2S)-2-amino-5-carbamimidamidopentanoyl]pyrrolidin-2-yl](hydroxy)methylidene}amino)hexanoyl]pyrrolidin-2-yl](hydroxy)methylidene}amino)-N-[(1S)-3-(C-hydroxycarbonimidoyl)-1-{[(1S)-1-{[(1S)-1-[({[(1S)-1-{[(1S)-1-(C-hydroxycarbonimidoyl)-3-(methylsulfanyl)propyl]-C-hydroxycarbonimidoyl}-3-methylbutyl]-C-hydroxycarbonimidoyl}methyl)-C-hydroxycarbonimidoyl]-2-phenylethyl]-C-hydroxycarbonimidoyl}-2-phenylethyl]-C-hydroxycarbonimidoyl}propyl]pentanediimidic acid; P, Euler-gaddum substance; Substance p, euler-gaddum; Substance p, hypothalamic; P, Hypothalamic substance; Euler gaddum substance p; Substance P acetate salt; Hypothalamic substance p; Euler-gaddum substance p; P, Substance; Substance P; Crofelemer; SP(1-11); Neurokinin P

数据库引用编号

12 个数据库交叉引用编号

ChEBI: CHEBI:80308
PubChem: 36511
HMDB: HMDB0303403
ChEMBL: CHEMBL235363
MeSH: Substance P
KNApSAcK: C00057959
foodb: FDB013189
chemspider: 33558
CAS: 11035-08-8
CAS: 12769-48-1
CAS: 33507-63-0
medchemexpress: HY-P0201

分类词条

Polypeptides

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

9606 Homo sapiens: -

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Lu-Min Liao, Ling Zou, Kui-Wu Li, Jing-Ru Ruan, Jiao-Jiao Wang, Jin-Yu Chen, Shan-Shan Zhu, Hao-Ran Chu. Moxibustion ameliorates visceral hypersensitivity by regulating hypothalamus-spinal cord-colon axis in rats with irritable bowel syndrome with diarrhea. Zhen ci yan jiu = Acupuncture research. 2024 Jan; 49(1):47-56. doi: 10.13702/j.1000-0607.20221092. [PMID: 38239138]
Qianzi Liu, Minxuan Yu, Menglin Liao, Zhiyue Ran, Xiaofeng Tang, Jun Hu, Beiju Su, Gang Fu, Qingqing Wu. The ratio of alpha-calcitonin gene-related peptide to substance P is associated with the transition of bone metabolic states during aging and healing. Journal of molecular histology. 2023 Dec; 54(6):689-702. doi: 10.1007/s10735-023-10167-0. [PMID: 37857924]
Alan Hegron, Chloe J Peach, Raquel Tonello, Philipp Seemann, Shavonne Teng, Rocco Latorre, Harald Huebner, Dorothee Weikert, Jeanette Rientjes, Nicholas A Veldhuis, Daniel P Poole, Dane D Jensen, Alex R B Thomsen, Brian L Schmidt, Wendy L Imlach, Peter Gmeiner, Nigel W Bunnett. Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief. Proceedings of the National Academy of Sciences of the United States of America. 2023 05; 120(22):e2220979120. doi: 10.1073/pnas.2220979120. [PMID: 37216510]
Yuanyuan Ding, Baowen Dang, Yonghui Zhang, Shiting Hu, Yuejin Wang, Chenrui Zhao, Tao Zhang, Zijun Gao. Paeonol attenuates Substance P-induced urticaria by inhibiting Src kinase phosphorylation in mast cells. Cellular immunology. 2023 May; 388-389(?):104728. doi: 10.1016/j.cellimm.2023.104728. [PMID: 37224634]
Yu-Jun Hou, Kai Wang, Hui-Ling Jiang, Ying Chen, Jun-Peng Yao, Ying Li, Si-Yuan Zhou. [Study on the mechanism of electroacupuncture repairing intestinal barrier via regulating mast cell in rats with diarrhea-predominant irritable bowel syndrome]. Zhen ci yan jiu = Acupuncture research. 2023 Mar; 48(3):281-6. doi: 10.13702/j.1000-0607.20220147. [PMID: 36951081]
Bin Chen, Hong Liu, Liang-Zhi Zhang, Jing Liu, Zhen-Feng Hong, Zhong-Biao Xiu, Hong-Jia Zhao. [Visual acupotomy intervention mitigates pain reaction by improving intervertebral disc degeneration and inhibiting apoptosis of nucleus pulposus cells in rabbits with cervical spondylosis]. Zhen ci yan jiu = Acupuncture research. 2022 Nov; 47(11):1005-11. doi: 10.13702/j.1000-0607.20220300. [PMID: 36453678]
Di Zhang, Bei Jing, Zhenni Chen, Xin Li, Huimei Shi, Yachun Zheng, Shiquan Chang, Guoping Zhao. Ferulic acid alleviates sciatica by inhibiting peripheral sensitization through the RhoA/p38MAPK signalling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Nov; 106(?):154420. doi: 10.1016/j.phymed.2022.154420. [PMID: 36115115]
Zheng Wang, Bin Liu, Kaifeng Lin, Chunguang Duan, Chunmei Wang. The presence and degradation of nerve fibers in articular cartilage of neonatal rats. Journal of orthopaedic surgery and research. 2022 Jun; 17(1):331. doi: 10.1186/s13018-022-03221-2. [PMID: 35761305]
Theresa Tschoner, Melanie Feist. Substance P concentrations in the blood plasma and serum of adult cattle and calves during different painful procedures and conditions - a systematic review. BMC veterinary research. 2022 Jun; 18(1):232. doi: 10.1186/s12917-022-03304-6. [PMID: 35717202]
Xian-Zhu Wang, Kai-Yang Xue, Ping-Nan Chen, Cai-Hong Xiao, Jin Cui, Jing Fu. Ma's bamboo-based medicinal moxibustion therapy of low back pain in lumbar disc herniation: study protocol for a randomized controlled trial. Trials. 2022 May; 23(1):446. doi: 10.1186/s13063-022-06382-x. [PMID: 35643520]
Simone König, Christian Engl, Malte Bayer, Fabiola Escolano-Lozano, Heike Rittner, Cora Rebhorn, Frank Birklein. Substance P Serum Degradation in Complex Regional Pain Syndrome - Another Piece of the Puzzle?. The journal of pain. 2022 03; 23(3):501-507. doi: 10.1016/j.jpain.2021.10.005. [PMID: 34678467]
Antonio Tornero-Martínez, Maria Del Carmen Silva-Lucero, Edén Cano Sampedro, Eva Ramón-Gallegos, Claudia Pérez-Cruz, Brenda Pérez-Grijalva, Rosalva Mora-Escobedo. Aloe vera and Fermented Extracts Exhibit an Anti-Inflammatory Effect on Human Glioblastoma/Astrocytoma U373 MG Cells. Plant foods for human nutrition (Dordrecht, Netherlands). 2022 Mar; 77(1):37-43. doi: 10.1007/s11130-022-00957-4. [PMID: 35292934]
Erkan Kilinc, Seyit Ankarali, Ibrahim Ethem Torun, Yasar Dagistan. Receptor mechanisms mediating the anti-neuroinflammatory effects of endocannabinoid system modulation in a rat model of migraine. The European journal of neuroscience. 2022 02; 55(4):1015-1031. doi: 10.1111/ejn.14897. [PMID: 32639078]
Hyunmin Ko, Young Il Kim, Hyung Joon Ahn. Effects of Substance P for Liver Regeneration in Rat Hepatectomy Models: A Preliminary Experimental Animal Study. Annals of transplantation. 2022 Feb; 27(?):e934801. doi: 10.12659/aot.934801. [PMID: 35102131]
Ivonne Maciel Arciniega-Martínez, Aldo Arturo Reséndiz Albor, Luz María Cárdenas Jaramillo, Juan Manuel Gutiérrez-Meza, Ramcés Falfán-Valencia, Belen Mendoza Arroyo, Mariazell Yépez-Ortega, Judith Pacheco-Yépez, Edgar Abarca-Rojano. CD4+/IL‑4+ lymphocytes of the lamina propria and substance P promote colonic protection during acute stress. Molecular medicine reports. 2022 Feb; 25(2):. doi: 10.3892/mmr.2021.12579. [PMID: 34958108]
Baorui Xing, Nana Feng, Juan Zhang, Yunmei Li, Xiuxiu Hou, Hao Wu, Wendong Liu, Guangpu Han. Pinocembrin relieves hip fracture-induced pain by repressing spinal substance P signaling in aged rats. Journal of neurophysiology. 2022 02; 127(2):397-404. doi: 10.1152/jn.00517.2021. [PMID: 34986062]
Francisco Silva, Alice D'Onofrio, Carolina Mendes, Catarina Pinto, Ana Marques, Maria Paula Cabral Campello, Maria Cristina Oliveira, Paula Raposinho, Ana Belchior, Salvatore Di Maria, Fernanda Marques, Carla Cruz, Josué Carvalho, António Paulo. Radiolabeled Gold Nanoseeds Decorated with Substance P Peptides: Synthesis, Characterization and In Vitro Evaluation in Glioblastoma Cellular Models. International journal of molecular sciences. 2022 Jan; 23(2):. doi: 10.3390/ijms23020617. [PMID: 35054798]
Seungheon Lee, Mi Ae Kim, Jong-Moon Park, Keunwan Park, Young Chang Sohn. Multiple tachykinins and their receptors characterized in the gastropod mollusk Pacific abalone: Expression, signaling cascades, and potential role in regulating lipid metabolism. Frontiers in endocrinology. 2022; 13(?):994863. doi: 10.3389/fendo.2022.994863. [PMID: 36187101]
Jianning Guo, Cong Qi, Yu Liu, Xiaoyao Guo, Yujiao Meng, Jingxia Zhao, Jing Fu, Tingting Di, Lu Zhang, Xinwei Guo, Qingwu Liu, Yazhuo Wang, Ping Li, Yan Wang. Terrestrosin D ameliorates skin lesions in an imiquimod-induced psoriasis-like murine model by inhibiting the interaction between Substance P and Dendritic cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jan; 95(?):153864. doi: 10.1016/j.phymed.2021.153864. [PMID: 34923236]
Simon Haunhorst, Wilhelm Bloch, Miriam Ringleb, Lena Fennen, Heiko Wagner, Holger H W Gabriel, Christian Puta. Acute effects of heavy resistance exercise on biomarkers of neuroendocrine-immune regulation in healthy adults: a systematic review. Exercise immunology review. 2022; 28(?):36-52. doi: . [PMID: 35452397]
Jia Li, Xiao Wang, Shining Xun, Qiuting Guo, Yao Wang, Yanzuo Jia, Wenfei Wang, Yujiao Wang, Taotao Li, Tiantian Tang, Junbo Zou, Mei Wang, Ming Yang, Fang Wang, Xiaofei Zhang, Changli Wang. Study of the Mechanism of Antiemetic Effect of Lavandula angustifolia Mill. Essential Oil Based on Ca2+/CaMKII/ERK1/2 Pathway. Drug design, development and therapy. 2022; 16(?):2407-2422. doi: 10.2147/dddt.s366597. [PMID: 35923932]
Nan Wang, Jue Wang, Yongjing Zhang, Shiling Hu, Tianxiao Zhang, Yuanyuan Wu, Xiuzhen Sun, Tao Zhang, Shuanying Yang, Langchong He. Substance P-induced lung inflammation in mice is mast cell dependent. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology. 2022 01; 52(1):46-58. doi: 10.1111/cea.13902. [PMID: 33999474]
Wenzheng Zhang, Naixia Hu, Ya Zhang, Anying Wang. Elevated Substance P Is a Risk Factor for Postoperative Delirium in Patients with Hip Fracture. BioMed research international. 2022; 2022(?):5320218. doi: 10.1155/2022/5320218. [PMID: 35402619]
Tiancheng Xu, Zhi Yu, Yun Liu, Mengjiang Lu, Meirong Gong, Qian Li, Youbing Xia, Bin Xu. Hypoglycemic Effect of Electroacupuncture at ST25 Through Neural Regulation of the Pancreatic Intrinsic Nervous System. Molecular neurobiology. 2022 Jan; 59(1):703-716. doi: 10.1007/s12035-021-02609-1. [PMID: 34757591]
Riffat Mehboob. Neurokinin-1 Receptor as a potential drug target for COVID-19 treatment. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Nov; 143(?):112159. doi: 10.1016/j.biopha.2021.112159. [PMID: 34536760]
Alexander Widiapradja, Ainsley O Kasparian, Samuel L McCaffrey, Lauren L Kolb, John D Imig, Jessica L Lacey, Giselle C Melendez, Scott P Levick. Replacement of Lost Substance P Reduces Fibrosis in the Diabetic Heart by Preventing Adverse Fibroblast and Macrophage Phenotype Changes. Cells. 2021 10; 10(10):. doi: 10.3390/cells10102659. [PMID: 34685639]
Leszek Królicki, Frank Bruchertseifer, Jolanta Kunikowska, Henryk Koziara, Dariusz Pawlak, Radosław Kuliński, Rafał Rola, Adrian Merlo, Alfred Morgenstern. Dose escalation study of targeted alpha therapy with [225Ac]Ac-DOTA-substance P in recurrence glioblastoma - safety and efficacy. European journal of nuclear medicine and molecular imaging. 2021 10; 48(11):3595-3605. doi: 10.1007/s00259-021-05350-y. [PMID: 33860346]
Juanjuan Zhao, Guomin Ai, Sheng Yang, Xiaoxia Zhang, Guishan Zhang. Detection, Structural Elucidation, and Biological Effects of Diverse N-Acyl-homoserine Lactone Signaling Molecules in the Plant-Promoting Endophytic Bacterium Rhizobium oryzihabitans M15. Journal of agricultural and food chemistry. 2021 Aug; 69(33):9693-9705. doi: 10.1021/acs.jafc.1c03895. [PMID: 34428903]
Stefi V Raju, Arnab Mukherjee, Purabi Sarkar, Praveen Kumar Issac, Christy Lite, Bilal Ahmad Paray, Mohammad K Al-Sadoon, Abdul Rahman Al-Mfarij, Jesu Arockiaraj. RM12 similar to substance P from tachykinin of freshwater murrel Channa striatus influence intracellular ROS in vitro fish erythrocytes and developmental toxicity and antioxidant enzymes in vivo zebrafish embryo. Fish physiology and biochemistry. 2021 Aug; 47(4):1073-1085. doi: 10.1007/s10695-021-00950-9. [PMID: 34021418]
Guannan Yang, Chen Bai, Tiegang Liu, Jianzhen He, Xiaohong Gu. The effect of Raphanus sativus L. seeds on regulation of intestinal motility in rats consuming a high-calorie diet. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Aug; 140(?):111705. doi: 10.1016/j.biopha.2021.111705. [PMID: 34118598]
Chenxia Han, Dan Du, Yongjian Wen, Jiawang Li, Rui Wang, Tao Jin, Jingyu Yang, Na Shi, Kun Jiang, Lihui Deng, Xianghui Fu, Rajarshi Mukherjee, John A Windsor, Jiwon Hong, Anthony R Phillips, Robert Sutton, Wei Huang, Tingting Liu, Qing Xia. Chaiqin chengqi decoction ameliorates acute pancreatitis in mice via inhibition of neuron activation-mediated acinar cell SP/NK1R signaling pathways. Journal of ethnopharmacology. 2021 Jun; 274(?):114029. doi: 10.1016/j.jep.2021.114029. [PMID: 33731310]
Mengyue Guan, Sun Ying, Yuguang Wang. Increased expression of transient receptor potential channels and neurogenic factors associates with cough severity in a guinea pig model. BMC pulmonary medicine. 2021 Jun; 21(1):187. doi: 10.1186/s12890-021-01556-w. [PMID: 34078339]
Henrike Arfsten, Georg Goliasch, Philipp E Bartko, Suriya Prausmüller, Georg Spinka, Anna Cho, Johannes Novak, Julia Mascherbauer, Helmuth Haslacher, Guido Strunk, Martin Hülsmann, Noemi Pavo. Neprilysin inhibition does not alter dynamic of proenkephalin-A 119-159 and pro-substance P in heart failure. ESC heart failure. 2021 06; 8(3):2016-2024. doi: 10.1002/ehf2.13278. [PMID: 33742565]
Theo Crosson, Jo-Chiao Wang, Benjamin Doyle, Hannah Merrison, Mohammad Balood, Alexandre Parrin, Maud Pascal, Barbara C Mindt, Corey R Seehus, Alp Ozcan, Xuan Huang, Elise Semenara, Nicole Y Y Lai, Abdelilah Majdoubi, Raja-Elie E Abdulnour, Trevor Rajchgot, Moutih Rafei, Simmie L Foster, Jacques Thibodeau, Jörg H Fritz, Bruce D Levy, Clifford J Woolf, Sebastien Talbot. FcεR1-expressing nociceptors trigger allergic airway inflammation. The Journal of allergy and clinical immunology. 2021 06; 147(6):2330-2342. doi: 10.1016/j.jaci.2020.12.644. [PMID: 33453289]
Antonio Guzmán, Gregorio Encina, Antonio R Fernández de Henestrosa, Cristina Vila, Araceli Tortajada, Ana-Paz Marín. Twenty six-week repeat dose oral rat toxicity study of cizolirtine, a substance-P and calcitonin gene-related peptide release modulator. Regulatory toxicology and pharmacology : RTP. 2021 Jun; 122(?):104916. doi: 10.1016/j.yrtph.2021.104916. [PMID: 33711392]
Kristina Rodionova, Karl F Hilgers, Peter Linz, Johannes Schätzl, Giulia Raschke, Christian Ott, Roland E Schmieder, Mario Schiffer, Kerstin Amann, Roland Veelken, Tilmann Ditting. Neurogenic substance P-influences on action potential production in afferent neurons of the kidney?. Pflugers Archiv : European journal of physiology. 2021 04; 473(4):633-646. doi: 10.1007/s00424-021-02552-z. [PMID: 33786667]
Ellen M S Xerfan, Monica L Andersen, Anamaria S Facina, Sergio Tufik, Jane Tomimori. The role of sleep in telogen effluvium and trichodynia: A commentary in the context of the current pandemic. Journal of cosmetic dermatology. 2021 Apr; 20(4):1088-1090. doi: 10.1111/jocd.13929. [PMID: 33387387]
Mee-Ra Rhyu, Yiseul Kim, Vijay Lyall. Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1. International journal of molecular sciences. 2021 Mar; 22(7):. doi: 10.3390/ijms22073360. [PMID: 33806052]
Ying Zhou, Hui Ye, Weifeng Lu. Serum Substance P Concentration in Children With Traumatic Brain Injury: A First Report. World neurosurgery. 2021 03; 147(?):e200-e205. doi: 10.1016/j.wneu.2020.12.009. [PMID: 33307260]
Vardan T Karamyan. Between two storms, vasoactive peptides or bradykinin underlie severity of COVID-19?. Physiological reports. 2021 03; 9(5):e14796. doi: 10.14814/phy2.14796. [PMID: 33687143]
E E Aguirre-Siancas, E Colona-Vallejos, E Ruiz-Ramirez, M Becerra-Bravo, L Alzamora-Gonzales. [Substance P, proinflammatory cytokines, transient receptor potential vanilloid subtype 1 and COVID-19: A working hypothesis]. Neurologia (Barcelona, Spain). 2021 Mar; 36(2):184-185. doi: 10.1016/j.nrl.2020.10.004. [PMID: 33160723]
Theoharis C Theoharides. Potential association of mast cells with coronavirus disease 2019. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2021 03; 126(3):217-218. doi: 10.1016/j.anai.2020.11.003. [PMID: 33161155]
Yoo Jung Yi, Do Hee Kim, Suchan Chang, Yeonhee Ryu, Sang Chan Kim, Hee Young Kim. Electroacupuncture at Neurogenic Spots in Referred Pain Areas Attenuates Hepatic Damages in Bile Duct-Ligated Rats. International journal of molecular sciences. 2021 Feb; 22(4):. doi: 10.3390/ijms22041974. [PMID: 33671269]
Fatma Hanci, Yasemin Baranoglu Kilinc, Erkan Kilinc, Sevim Turay, Mustafa Dilek, Nimet Kabakus. Plasma levels of vasoactive neuropeptides in pediatric patients with migraine during attack and attack-free periods. Cephalalgia : an international journal of headache. 2021 02; 41(2):166-175. doi: 10.1177/0333102420957588. [PMID: 32903061]
Manjung Kim, Jaehee Kim. Effects of Acupressure on Pain, Flexibility, and Substance P in Middle-Age Women with Chronic Neck Pain. Journal of alternative and complementary medicine (New York, N.Y.). 2021 Feb; 27(2):160-167. doi: 10.1089/acm.2020.0413. [PMID: 33296258]
Martin Feickert, Bjoern B Burckhardt. Mass spectrometric studies on the peptide integrity of substance P and related human tachykinins in human biofluids. Peptides. 2021 02; 136(?):170458. doi: 10.1016/j.peptides.2020.170458. [PMID: 33248147]
Darko Roviš, Vanja Vasiljev, Zala Jenko-Pražnikar, Ana Petelin, Gorazd Drevenšek, Dolores Peruč, Maša Černelič-Bizjak. Mental health and drug use severity: the role of substance P, neuropeptide Y, self-reported childhood history of trauma, parental bonding and current resiliency. Journal of mental health (Abingdon, England). 2021 Feb; 30(1):88-96. doi: 10.1080/09638237.2019.1644492. [PMID: 31347421]
Riffat Mehboob, Anna Maria Lavezzi. Neuropathological explanation of minimal COVID-19 infection rate in newborns, infants and children - a mystery so far. New insight into the role of Substance P. Journal of the neurological sciences. 2021 01; 420(?):117276. doi: 10.1016/j.jns.2020.117276. [PMID: 33360484]
Livia L Camargo, Alexandre Denadai-Souza, Lidia M Yshii, Carla Lima, Simone A Teixeira, Anderson R A Cerqueira, Mayara C F Gewehr, Elizabeth S Fernandes, André A Schenka, Marcelo N Muscará, Emer S Ferro, Soraia K P Costa. The potential anti-inflammatory and anti-nociceptive effects of rat hemopressin (PVNFKFLSH) in experimental arthritis. European journal of pharmacology. 2021 Jan; 890(?):173636. doi: 10.1016/j.ejphar.2020.173636. [PMID: 33053380]
Quynh N Mai, Priyank Shenoy, Tim Quach, Jeffri S Retamal, Arisbel B Gondin, Holly R Yeatman, Luigi Aurelio, Joshua W Conner, Daniel P Poole, Meritxell Canals, Cameron J Nowell, Bim Graham, Thomas P Davis, Stephen J Briddon, Stephen J Hill, Christopher J H Porter, Nigel W Bunnett, Michelle L Halls, Nicholas A Veldhuis. A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes. The Journal of biological chemistry. 2021 Jan; 296(?):100345. doi: 10.1016/j.jbc.2021.100345. [PMID: 33515548]
Carolina L Haass-Koffler, Roberta Perciballi, Zoe E Brown, Mary R Lee, William H Zywiak, Jonathan Kurtis, Robert M Swift, Lorenzo Leggio. Brief Report: Relationship Between Cotinine Levels and Peripheral Endogenous Concentrations of Oxytocin, β-Endorphin, and Orexin in Individuals With Both Alcohol and Nicotine Use Disorders. The American journal on addictions. 2021 01; 30(1):88-91. doi: 10.1111/ajad.13064. [PMID: 32488890]
Andrew N Bubak, Vicki Traina-Dorge, Christina N Como, Brittany Feia, Catherine M Pearce, Laura Doyle-Meyers, Arpita Das, Jayme Looper, Ravi Mahalingam, Maria A Nagel. Elevated serum substance P during simian varicella virus infection in rhesus macaques: implications for chronic inflammation and adverse cerebrovascular events. Journal of neurovirology. 2020 12; 26(6):945-951. doi: 10.1007/s13365-020-00907-3. [PMID: 32964407]
Martin Feickert, Bjoern B Burckhardt. Validated mass spectrometric assay for the quantification of substance P and human hemokinin-1 in plasma samples: A design of experiments concept for comprehensive method development. Journal of pharmaceutical and biomedical analysis. 2020 Nov; 191(?):113542. doi: 10.1016/j.jpba.2020.113542. [PMID: 32871415]
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