Risbitin (BioDeep_00000227807)

Main id: BioDeep_00000007565

 

human metabolite PANOMIX_OTCML-2023 natural product


Metabolite Card


(1S,2R,3R,7R)-1-methyl-7-(prop-1-en-2-yl)-1,2,3,4,5,6,7,8-octahydronaphthalene-2,3-diol

Formula: C14H22O2 (222.162)
Chinese Names: 瑞希汀
Spectrum Hits: Top Source () 0%

Molecular Structure

SMILES: C=C(C)[C@@H]1CCC2=C(C1)[C@H](C)[C@@H](O)[C@H](O)C2
InChI: InChI=1S/C14H22O2/c1-8(2)10-4-5-11-7-13(15)14(16)9(3)12(11)6-10/h9-10,13-16H,1,4-7H2,2-3H3/t9-,10+,13+,14+/m0/s1

Description

Risbitin, also known as rishitin, (1s-(1alpha,2beta,3alpha,7beta))-isomer, is a member of the class of compounds known as 1,2-diols. 1,2-diols are polyols containing an alcohol group at two adjacent positions. Risbitin is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Risbitin can be found in potato, which makes risbitin a potential biomarker for the consumption of this food product.

Synonyms

6 synonym names

(1S,2R,3R,7R)-1-methyl-7-(prop-1-en-2-yl)-1,2,3,4,5,6,7,8-octahydronaphthalene-2,3-diol; Rishitin, (1S-(1alpha,2beta,3alpha,7beta))-isomer; rishitin; Risbitin; Rishitin; Rishitin



Cross Reference

13 cross reference id

Classification Terms

Related Pathways

Reactome(0)

BioCyc(0)

PlantCyc(0)

Biological Process

0 related biological process reactions.

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

38 organism taxonomy source information

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

Sub-cellular location Genes
Cytoplasm 2 ALOX5, PRKX
Peripheral membrane protein 2 ALOX5, CYP1B1
Endoplasmic reticulum membrane 2 CYP1B1, HMGCR
Nucleus 1 PRKX
cytosol 1 ALOX5
nucleoplasm 3 ALOX5, ATP2B1, PRKX
Cell membrane 2 ATP2B1, NOX1
Multi-pass membrane protein 3 ATP2B1, HMGCR, NOX1
Synapse 1 ATP2B1
glutamatergic synapse 1 ATP2B1
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 1 ALOX5
plasma membrane 2 ATP2B1, NOX1
synaptic vesicle membrane 1 ATP2B1
Membrane 4 ATP2B1, CYP1B1, HMGCR, NOX1
basolateral plasma membrane 1 ATP2B1
extracellular exosome 1 ATP2B1
endoplasmic reticulum 1 HMGCR
extracellular space 1 ALOX5
perinuclear region of cytoplasm 1 ALOX5
mitochondrion 1 CYP1B1
intracellular membrane-bounded organelle 2 ATP2B1, CYP1B1
Microsome membrane 1 CYP1B1
extracellular region 1 ALOX5
anchoring junction 1 NOX1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Nucleus membrane 1 ALOX5
nuclear membrane 1 ALOX5
Early endosome 1 NOX1
Cytoplasm, perinuclear region 1 ALOX5
peroxisomal membrane 1 HMGCR
lateral plasma membrane 1 ATP2B1
cell projection 2 ATP2B1, NOX1
Basolateral cell membrane 1 ATP2B1
nuclear envelope 1 ALOX5
Nucleus envelope 1 ALOX5
Presynaptic cell membrane 1 ATP2B1
Peroxisome membrane 1 HMGCR
ficolin-1-rich granule lumen 1 ALOX5
secretory granule lumen 1 ALOX5
nuclear matrix 1 ALOX5
immunological synapse 1 ATP2B1
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
NADPH oxidase complex 1 NOX1
Cell projection, invadopodium membrane 1 NOX1
Nucleus intermembrane space 1 ALOX5
photoreceptor ribbon synapse 1 ATP2B1


Literature Reference

  • Maurizio Camagna, Makoto Ojika, Daigo Takemoto. Detoxification of the solanaceous phytoalexins rishitin, lubimin, oxylubimin and solavetivone via a cytochrome P450 oxygenase. Plant signaling & behavior. 2020; 15(2):1707348. doi: 10.1080/15592324.2019.1707348. [PMID: 31884882]
  • Gaétan Le Floch, Nicole Benhamou, Emina Mamaca, Maria-Isabel Salerno, Yves Tirilly, Patrice Rey. Characterisation of the early events in atypical tomato root colonisation by a biocontrol agent, Pythium oligandrum. Plant physiology and biochemistry : PPB. 2005 Jan; 43(1):1-11. doi: 10.1016/j.plaphy.2004.10.005. [PMID: 15763660]
  • M K Yao, H Désilets, M T Charles, R Boulanger, R J Tweddell. Effect of mycorrhization on the accumulation of rishitin and solavetivone in potato plantlets challenged with Rhizoctonia solani. Mycorrhiza. 2003 Dec; 13(6):333-6. doi: 10.1007/s00572-003-0267-0. [PMID: 14505123]
  • K Loser, K Weltring. Induction of a polyubiquitin gene (ubi1) by potato phytoalexins and heat shock in Gibberella pulicaris. Current genetics. 1998 Dec; 34(5):404-9. doi: 10.1007/s002940050414. [PMID: 9871124]
  • M Lee, W W Currier. Suppression of the hypersensitive response in potato by acetyl salicylic acid. Biochemical and biophysical research communications. 1996 May; 222(2):309-11. doi: 10.1006/bbrc.1996.0740. [PMID: 8670201]
  • G D Lyon. Metabolism of the phytoalexin rishitin by Botrytis spp. Journal of general microbiology. 1976 Sep; 96(1):225-6. doi: 10.1099/00221287-96-1-225. [PMID: 988112]