Phenolphthalin (BioDeep_00000002278)

代谢物信息卡片

Phenolphthalin

化学式: C20H16O4 (320.1048536)
中文名称: 酚酞啉[用于氧化还原反应指示剂]
谱图信息: 最多检出来源 Viridiplantae(plant) 50%

分子结构信息

SMILES: C1=CC=C(C(=C1)C(C2=CC=C(C=C2)O)C3=CC=C(C=C3)O)C(=O)O
InChI: InChI=1S/C20H16O4/c21-15-9-5-13(6-10-15)19(14-7-11-16(22)12-8-14)17-3-1-2-4-18(17)20(23)24/h1-12,19,21-22H,(H,23,24)

描述信息

D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D010635 - Phenolphthaleins
CONFIDENCE standard compound; INTERNAL_ID 1288; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3788; ORIGINAL_PRECURSOR_SCAN_NO 3786
CONFIDENCE standard compound; INTERNAL_ID 1288; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3838; ORIGINAL_PRECURSOR_SCAN_NO 3835
CONFIDENCE standard compound; INTERNAL_ID 1288; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3790; ORIGINAL_PRECURSOR_SCAN_NO 3789
CONFIDENCE standard compound; INTERNAL_ID 1288; DATASET 20200303_ENTACT_RP_MIX507; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3797; ORIGINAL_PRECURSOR_SCAN_NO 3795
CONFIDENCE standard compound; INTERNAL_ID 1288; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3856; ORIGINAL_PRECURSOR_SCAN_NO 3855
CONFIDENCE standard compound; INTERNAL_ID 1288; DATASET 20200303_ENTACT_RP_MIX504; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 3849; ORIGINAL_PRECURSOR_SCAN_NO 3846

同义名列表

1 个代谢物同义名

Phenolphthalin

数据库引用编号

18 个数据库交叉引用编号

ChEBI: CHEBI:34915
KEGG: C14223
KEGGdrug: D94774
PubChem: 66494
Metlin: METLIN69890
ChEMBL: CHEMBL1528560
MeSH: Phenolphthalein
CAS: 81-90-3
MoNA: LU128855
MoNA: LU128856
MoNA: LU128851
MoNA: LU128854
MoNA: LU128853
MoNA: LU128852
PMhub: MS000002271
PubChem: 7847033
NIKKAJI: J8.609F
RefMet: Phenolphthalin

分类词条

Benzoic acids

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Michael Gold, Sonya Abdulla, Anneke Andriessen, Vivian Bucay, Ariel Haus, Qin Xiaolei, Todd Schlesinger, Weimin Song, Hua Zhong. INDIVIDUAL ARTICLE: Real-World Patient Cases Using Botanical Serum-Containing Corrective Gel as an Adjunct to Aesthetic Facial Laser or Microneedling Radiofrequency (MRF) Treatment. Journal of drugs in dermatology : JDD. 2024 Mar; 23(3):SF400676s3-SF400676s14. doi: 10.36849/jdd.sf400676. [PMID: 38443134]
Aleksey S Antipov, Julia G Kokunko, Svetlana A Krasnova, Victor A Utkin. Dynamic Smoothing, Filtering and Differentiation of Signals Defining the Path of the UAV. Sensors (Basel, Switzerland). 2022 Dec; 22(23):. doi: 10.3390/s22239472. [PMID: 36502174]
Sungwook Hong, Chaewon Kim, Soyoung Jeon, Eunhye Lee. Preparation of Artificial Blood from the Extract of Legume Root Nodules, and the Creation of Artificial Latent Fingermarks in Blood Using Artificial Blood. Journal of forensic sciences. 2018 Jan; 63(1):234-238. doi: 10.1111/1556-4029.13488. [PMID: 28271501]
Susanna Every-Palmer, Giles Newton-Howes, Mike J Clarke. Pharmacological treatment for antipsychotic-related constipation. The Cochrane database of systematic reviews. 2017 01; 1(?):CD011128. doi: 10.1002/14651858.cd011128.pub2. [PMID: 28116777]
Phyllis Wilson, Claude Masse. Detection of Synthetic Drugs as Adulterants in Natural and Herbal Slimming Products by LC-ESI-MS/MS with Polarity Switching. Journal of AOAC International. 2016 Jul; 99(4):929-940. doi: 10.5740/jaoacint.15-0295. [PMID: 27143234]
Daniel Petersen, Frank Kovacs. Phenolphthalein false-positive reactions from legume root nodules. Journal of forensic sciences. 2014 Mar; 59(2):481-4. doi: 10.1111/1556-4029.12352. [PMID: 24313711]
Satoshi Endo, Toshiyuki Matsunaga, Atsuko Matsumoto, Yuki Arai, Satoshi Ohno, Ossama El-Kabbani, Kazuo Tajima, Yasuo Bunai, Shigeru Yamano, Akira Hara, Yukio Kitade. Rabbit 3-hydroxyhexobarbital dehydrogenase is a NADPH-preferring reductase with broad substrate specificity for ketosteroids, prostaglandin D₂, and other endogenous and xenobiotic carbonyl compounds. Biochemical pharmacology. 2013 Nov; 86(9):1366-75. doi: 10.1016/j.bcp.2013.08.024. [PMID: 23994167]
H Wang, Y Wu, Y Zhao, W Sun, L Ding, B Guo, B Chen. Rapid screening of illicit additives in weight loss dietary supplements with desorption corona beam ionisation (DCBI) mass spectrometry. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2012 Aug; 29(8):1194-201. doi: 10.1080/19440049.2012.692395. [PMID: 22784191]
H Filiz Ayyildiz, Huseyin Kara, S T H Sherazi. A novel approach for determination of free fatty acids in vegetable oils by a flow injection system with manual injection. Lipids. 2011 Dec; 46(12):1181-90. doi: 10.1007/s11745-011-3610-9. [PMID: 21904794]
J Vaysse, S Balayssac, V Gilard, D Desoubdzanne, M Malet-Martino, R Martino. Analysis of adulterated herbal medicines and dietary supplements marketed for weight loss by DOSY 1H-NMR. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment. 2010 Jul; 27(7):903-16. doi: 10.1080/19440041003705821. [PMID: 20437283]
. The toxicology and carcinogenesis study of phenolphthalein (CAS No. 77-09-8) in genetically modified haploinsufficient p16(Ink4a)/p19(Arf) mice (feed study). National Toxicology Program genetically modified model report. 2007 Dec; ?(12):1-85. doi: . [PMID: 18784766]
Shanan S Tobe, Nigel Watson, Niamh Nic Daéid. Evaluation of six presumptive tests for blood, their specificity, sensitivity, and effect on high molecular-weight DNA. Journal of forensic sciences. 2007 Jan; 52(1):102-9. doi: 10.1111/j.1556-4029.2006.00324.x. [PMID: 17209919]
Yi Hong Fan, Bin Lu, Mei Wang, Gui Bao Ni, Ming Tao Chen, Yi Xu. Expression and significance of nerve growth factor receptor p75 in rats' cathartic colonic wall. Chinese journal of digestive diseases. 2006; 7(4):225-9. doi: 10.1111/j.1443-9573.2006.00274.x. [PMID: 17054585]
Jochen Beyer, Frank T Peters, Hans H Maurer. Screening procedure for detection of stimulant laxatives and/or their metabolites in human urine using gas chromatography-mass spectrometry after enzymatic cleavage of conjugates and extractive methylation. Therapeutic drug monitoring. 2005 Apr; 27(2):151-7. doi: 10.1097/01.ftd.0000150878.36296.04. [PMID: 15795644]
Martin Bertau, Gerhard Jörg. Saccharides as efficacious solubilisers for highly lipophilic compounds in aqueous media. Bioorganic & medicinal chemistry. 2004 Jun; 12(11):2973-83. doi: 10.1016/j.bmc.2004.03.041. [PMID: 15142556]
B J Collins, T B Grizzle, J K Dunnick. Toxicokinetics of phenolphthalein in male and female rats and mice. Toxicological sciences : an official journal of the Society of Toxicology. 2000 Aug; 56(2):271-81. doi: 10.1093/toxsci/56.2.271. [PMID: 10910984]
C E Garner, H B Matthews, L T Burka. Phenolphthalein metabolite inhibits catechol-O-methyltransferase-mediated metabolism of catechol estrogens: a possible mechanism for carcinogenicity. Toxicology and applied pharmacology. 2000 Jan; 162(2):124-31. doi: 10.1006/taap.1999.8830. [PMID: 10637136]
C Gruy-Kapral, M Emmett, C A Santa Ana, J L Porter, J S Fordtran, K D Fine. Effect of single dose resin-cathartic therapy on serum potassium concentration in patients with end-stage renal disease. Journal of the American Society of Nephrology : JASN. 1998 Oct; 9(10):1924-30. doi: 10.1681/asn.v9101924. [PMID: 9773794]
R J Griffin, V B Godfrey, L T Burka. Metabolism and disposition of phenolphthalein in male and female F344 rats and B6C3F1 mice. Toxicological sciences : an official journal of the Society of Toxicology. 1998 Apr; 42(2):73-81. doi: 10.1006/toxs.1997.2422. [PMID: 9579019]
H H Wenzl, K D Fine, C A Santa Ana, J L Porter, J S Fordtran. Effect of fludrocortisone and spironolactone on sodium and potassium losses in secretory diarrhea. Digestive diseases and sciences. 1997 Jan; 42(1):119-28. doi: 10.1023/a:1018897307835. [PMID: 9009126]
J K Dunnick, J R Hailey. Phenolphthalein exposure causes multiple carcinogenic effects in experimental model systems. Cancer research. 1996 Nov; 56(21):4922-6. doi: . [PMID: 8895745]
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R A Ahrens, S L Garland, H N Kigutha, E Russek. The disaccharide effect of sucrose feeding on glucuronide excretion and bile concentration of injected phenolphthalein in guinea pigs. The Journal of nutrition. 1985 Feb; 115(2):288-91. doi: 10.1093/jn/115.2.288. [PMID: 3968593]
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P KRAMER, C E POPE. FACTITIOUS DIARRHEA INDUCED BY PHENOLPHTHALEIN. Archives of internal medicine. 1964 Nov; 114(?):634-6. doi: 10.1001/archinte.1964.03860110104010. [PMID: 14215990]
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