Nuzhenide (BioDeep_00000227648)

Main id: BioDeep_00000230566

 

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


methyl (2S,3E)-3-ethylidene-4-(2-oxo-2-{[(2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-[2-(4-hydroxyphenyl)ethoxy]oxan-2-yl]methoxy}ethyl)-2-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,4-dihydro-2H-pyran-5-carboxylate

化学式: C31H42O17 (686.2421882000001)
中文名称: 特女贞苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C/C=C([C@@H]1O[C@]([C@@H]([C@@H](O)[C@@H]2O)O)([H])O[C@@H]2CO)\[C@@H](C(C(OC)=O)=CO1)CC(OC[C@H]([C@H]([C@H](O)[C@H]3O)O)O[C@H]3OCCC4=CC=C(O)C=C4)=O
InChI: InChI=1S/C31H42O17/c1-3-16-17(18(28(41)42-2)12-45-29(16)48-31-27(40)24(37)22(35)19(11-32)46-31)10-21(34)44-13-20-23(36)25(38)26(39)30(47-20)43-9-8-14-4-6-15(33)7-5-14/h3-7,12,17,19-20,22-27,29-33,35-40H,8-11,13H2,1-2H3/b16-3+/t17?,19-,20-,22-,23-,24+,25+,26-,27-,29+,30-,31+/m1/s1

描述信息

Nuzhenide is a member of the class of compounds known as saccharolipids. Saccharolipids are compounds in which fatty acids are linked directly to a sugar backbone, forming structures that are compatible with membrane bilayers. In the saccharolipids, a sugar substitutes for the glycerol backbone that is present in glycerolipids and glycerophospholipids. The most familiar saccharolipids contain an acylated glucosamine. In contrast to others glycolipids, the fatty acid is not glycosidically linked to the sugar moiety. Nuzhenide is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Nuzhenide can be found in olive, which makes nuzhenide a potential biomarker for the consumption of this food product.
Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of?Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA)[1].
Specnuezhenide ((8E)-Nuezhenide) is isolated from the fruits of?Ligustrum lucidum. Specnuezhenide ((8E)-Nuezhenide) can inhibit IL-1β-induced inflammation in chondrocytes via inhibition of NF-κB and wnt/β-catenin signaling. Specnuezhenide ((8E)-Nuezhenide) exerts anti-inflammatory effects in a rat model of osteoarthritis (OA)[1].

同义名列表

6 个代谢物同义名

methyl (2S,3E)-3-ethylidene-4-(2-oxo-2-{[(2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-[2-(4-hydroxyphenyl)ethoxy]oxan-2-yl]methoxy}ethyl)-2-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-3,4-dihydro-2H-pyran-5-carboxylate; methyl (5E,6S)-5-ethylidene-4-(2-oxo-2-{[(2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-[2-(4-hydroxyphenyl)ethoxy]oxan-2-yl]methoxy}ethyl)-6-{[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-4,6-dihydropyran-3-carboxylate; Specnuezhenide; Nuezhenide; Nuzhenide; (8E)-Nuezhenide



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

33 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nan Tang, Ying-Yun Ren, Hao-Tian Wu, Xi-Ting Lv, Xiao-Ting Liu, Qi-Lin Li, Guo-En Wang, Yan-Hua Wu. Specnuezhenide ameliorates ultraviolet-induced skin photoaging in mice by regulating the Sirtuin 3/8-Oxoguanine DNA glycosylase signal. Photodermatology, photoimmunology & photomedicine. 2023 May; ?(?):. doi: 10.1111/phpp.12880. [PMID: 37147870]
  • Dongmei Hu, Shaojie Huang, Yi Ding, Xian Zhao, Wei Zhang, Haixia Chen, Jingwen Wang. Specnuezhenide reduces carbon tetrachloride-induced liver injury in mice through inhibition of oxidative stress and hepatocyte apoptosis. The Journal of pharmacy and pharmacology. 2022 Feb; 74(2):191-199. doi: 10.1093/jpp/rgab164. [PMID: 34923584]
  • Qin-Qin Wang, Shan Han, Xin-Xing Li, Renyikun Yuan, Youqiong Zhuo, Xinxin Chen, Chenwei Zhang, Yangling Chen, Hongwei Gao, Li-Chun Zhao, Shilin Yang. Nuezhenide Exerts Anti-Inflammatory Activity through the NF-κB Pathway. Current molecular pharmacology. 2021; 14(1):101-111. doi: 10.2174/1874467213666200611141337. [PMID: 32525787]
  • Jing Yang, Jian Jia, Yongkang Yang, Yaning Zhao, Qin Li. Protective effect of Specnuezhenide on islet β cell of rats with gestational diabetes mellitus. Cellular and molecular biology (Noisy-le-Grand, France). 2020 Apr; 66(1):60-64. doi: 10.14715/cmb/2019.66.1.10. [PMID: 32359385]
  • Xuexiao Cao, Huanhuan Li, Meng Wang, Xiaoliang Ren, Yanru Deng. Analysis of five active ingredients of Er-Zhi-Wan, a traditional Chinese medicine water-honeyed pill, using the biopharmaceutics classification system. Biomedical chromatography : BMC. 2020 Feb; 34(2):e4757. doi: 10.1002/bmc.4757. [PMID: 31755125]
  • Fengwei He, Li Chen, Qian Liu, Xiao Wang, Jia Li, Jinqian Yu. Preparative Separation of Phenylethanoid and Secoiridoid Glycosides from Ligustri Lucidi Fructus by High-Speed Counter-Current Chromatography Coupled with Ultrahigh Pressure Extraction. Molecules (Basel, Switzerland). 2018 Dec; 23(12):. doi: 10.3390/molecules23123353. [PMID: 30567348]
  • Yan Ding, Zhengcai Ju, Chao Ma. A validated LC-MS/MS method for the determination of specnuezhenide and salidroside in rat plasma and its application to a pharmacokinetic study. Biomedical chromatography : BMC. 2018 Dec; 32(12):e4353. doi: 10.1002/bmc.4353. [PMID: 30062793]
  • Ying Nie, Weifeng Yao. A Comprehensive Quality Evaluation Method Based on C30-HPLC and an Analytic Hierarchy Process for the Chinese Herbal Formula, Erzhiwan. Molecules (Basel, Switzerland). 2018 Aug; 23(8):. doi: 10.3390/molecules23082045. [PMID: 30111749]
  • Jianming Wu, Xiao Ke, Wei Fu, Xiaoping Gao, Hongcheng Zhang, Wei Wang, Na Ma, Manxi Zhao, Xiaofeng Hao, Zhirong Zhang. Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway. Molecules (Basel, Switzerland). 2016 Dec; 21(12):. doi: 10.3390/molecules21121756. [PMID: 28009852]
  • Chang-Qin Li, Chen Yao, Rong-Yao Zhu, Yong-Xin Huang, Wen-Yi Kang, Jin-Mei Wang. [Spectrum-effect relationship in antioxidant activity of Ligustri Lucidi Fructus based on DPPH, ABTS and FRAP assays]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 May; 41(9):1670-1677. doi: 10.4268/cjcmm20160917. [PMID: 28891617]
  • Yan-Peng Li, Si-Jia Wang, Yi-Mei Zang, Zhong-Sheng Hu, Chun-Sheng Liu. Sources of varieties and quality of circular Fructus Ligustri Lucidi. Chinese journal of natural medicines. 2016 Mar; 14(3):236-40. doi: 10.1016/s1875-5364(16)30022-x. [PMID: 27025372]
  • Hui-Fen Li, Xue-Lan Zhang. [Comparation of gastrointestinal absorption studies of specnuezhenide with salidroside in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2014 Mar; 39(6):1107-10. doi: . [PMID: 24956860]
  • Qianfeng Chen, Lijuan Yang, Guolin Zhang, Fei Wang. Bioactivity-guided Isolation of antiosteoporotic compounds from Ligustrum lucidum. Phytotherapy research : PTR. 2013 Jul; 27(7):973-9. doi: 10.1002/ptr.4820. [PMID: 22893624]
  • Mu He, Weifeng Yao, Li Zhang, Anwei Ding. [Simultaneous determination of four compounds in Erzhiwan by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Mar; 37(5):594-6. doi: . [PMID: 22693900]
  • Na Guo, Youhua Yu, Keyume Ablajan, Li Li, Bin Fan, Juan Peng, Han Yan, Fang Ma, Yinglan Nie. Seasonal variations in metabolite profiling of the fruits of Ligustrum lucidum Ait. Rapid communications in mass spectrometry : RCM. 2011 Jun; 25(12):1701-14. doi: 10.1002/rcm.5036. [PMID: 21598330]
  • L Shi, Y Ma, Z Cai. Quantitative determination of salidroside and specnuezhenide in the fruits of Ligustrum lucidum Ait by high performance liquid chromatography. Biomedical chromatography : BMC. 1998 Jan; 12(1):27-30. doi: 10.1002/(sici)1099-0801(199801/02)12:1<27::aid-bmc715>3.0.co;2-e. [PMID: 9470971]
  • M Niikawa, H Hayashi, T Sato, H Nagase, H Kito. Isolation of substances from glossy privet (Ligustrum lucidum Ait.) inhibiting the mutagenicity of benzo[a]pyrene in bacteria. Mutation research. 1993 Sep; 319(1):1-9. doi: 10.1016/0165-1218(93)90025-9. [PMID: 7690454]
  • J M Patel, C Harper, B N Gupta, R T Drew. Changes in serum enzymes after inhalation exposure of p-xylene. Bulletin of environmental contamination and toxicology. 1979 Jan; 21(1-2):17-24. doi: 10.1007/bf01685379. [PMID: 36187]
  • T Asakawa, C Johnson, J Ruiz, I Scheinbaum, T R Russell, R Ho, E W Sutherland. Activation by 'feedback regulator' and some properties of guanylate cyclase of plasma membrane of rat epididymal fat cells. Biochemical and biophysical research communications. 1976 Oct; 72(4):1335-42. doi: 10.1016/s0006-291x(76)80161-1. [PMID: 11790]