Sapogenins (BioDeep_00000227123)
human metabolite
代谢物信息卡片
(1R,2R,2S,4S,5S,7S,8R,9S,12S,13S)-5,7,9,13-tetramethyl-5-oxaspiro[oxane-2,6-pentacyclo[10.8.0.0²,⁹.0⁴,⁸.0¹³,¹⁸]icosane]
化学式: C27H44O2 (400.3341124)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCCC6)C)C)C)OC1
InChI: InChI=1S/C27H44O2/c1-17-10-14-27(28-16-17)18(2)24-23(29-27)15-22-20-9-8-19-7-5-6-12-25(19,3)21(20)11-13-26(22,24)4/h17-24H,5-16H2,1-4H3/t17-,18-,19?,20+,21-,22-,23-,24-,25-,26-,27+/m0/s1
描述信息
Any of the aglycon moieties of saponins; they may be steroids or triterpenes. (ChEBI) Sapogenins are the aglycones, or non-saccharide, portions of the family of natural products known as saponins. Sapogenins contain steroid or other triterpene frameworks as their key organic feature. Sapogenins is found in soft-necked garlic.
Any of the aglycon moieties of saponins; they may be steroids or triterpenes. (ChEBI)
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 21139920
- HMDB: HMDB0302215
- Wikipedia: Sapogenin
- MeSH: Sapogenins
- foodb: FDB003694
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yang Ruan, Guoqing Ren, Mingchun Wang, Weichao Lv, Kuniyoshi Shimizu, Chaofeng Zhang. The dual role of 20(S)-protopanaxadiol in alleviating pulmonary fibrosis through the gut-lung axis.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jul; 129(?):155699. doi:
10.1016/j.phymed.2024.155699. [PMID: 38733907] - Zhu Zhu, Yao Cheng, Xu Han, Tiantian Wang, Hantao Zhang, Qi Yao, Feiyan Chen, Ling Gu, Dongqing Yang, Lin Chen, Yunan Zhao. 20(S)-Protopanaxadiol Exerts Antidepressive Effects in Chronic Corticosterone-Induced Rodent Animal Models as an Activator of Brain-Type Creatine Kinase.
Journal of agricultural and food chemistry.
2024 May; 72(18):10376-10390. doi:
10.1021/acs.jafc.4c00415. [PMID: 38661058] - A Berenice Aguilar-Guadarrama, Mónica Aideé Díaz-Román, Maribel Osorio-García, Myrna Déciga-Campos, María Yolanda Rios. Chemical Constituents from Agave applanata and Its Antihyperglycemic, Anti-inflammatory, and Antimicrobial Activities Associated with Its Tissue Repair Capability.
Planta medica.
2024 May; 90(5):397-410. doi:
10.1055/a-2270-5527. [PMID: 38365219] - Nasser A Alsabaani, Kawther Amawi, Samy M Eleawa, Wisam Nabeel Ibrahim, Walid Aldhaban, Ahmad Mohammad Alaraj, Badr Alkhalaf, Waqas Sami, Hisham Alshaikhli, Mahmoud A Alkhateeb. Nrf-2-dependent antioxidant and anti-inflammatory effects underlie the protective effect of esculeoside A against retinal damage in streptozotocin-induced diabetic rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2024 Apr; 173(?):116461. doi:
10.1016/j.biopha.2024.116461. [PMID: 38503237] - Kang-Xi Zhang, Yue Zhu, Shu-Xia Song, Qing-Yun Bu, Xiao-Yan You, Hong Zou, Guo-Ping Zhao. Ginsenoside Rb1, Compound K and 20(S)-Protopanaxadiol Attenuate High-Fat Diet-Induced Hyperlipidemia in Rats via Modulation of Gut Microbiota and Bile Acid Metabolism.
Molecules (Basel, Switzerland).
2024 Mar; 29(5):. doi:
10.3390/molecules29051108. [PMID: 38474620] - Jie Xia, Yuan Zhang, Qing Wang, Teng Zhang. Cycloastragenol restrains keratinocyte hyperproliferation by promoting autophagy via the miR-145/STC1/Notch1 axis in psoriasis.
Immunopharmacology and immunotoxicology.
2024 Jan; ?(?):1-11. doi:
10.1080/08923973.2023.2300310. [PMID: 38194243] - Manami Sakanishi, Soo Yeon Chung, Kentaro Fujiwara, Mareshige Kojoma, Toshiya Muranaka, Hikaru Seki. Disruption of a licorice cellulose synthase-derived glycosyltransferase gene demonstrates its in planta role in soyasaponin biosynthesis.
Plant cell reports.
2023 Dec; 43(1):15. doi:
10.1007/s00299-023-03095-6. [PMID: 38135741] - Long You, Ting Shen, Weicheng Hu, Jae Youl Cho. Protopanaxatriol activates EGFR and HER2 to strengthen the molecules of skin protection in human keratinocytes.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Oct; 123(?):155167. doi:
10.1016/j.phymed.2023.155167. [PMID: 37952408] - Masaru Nakayasu, Kyoko Takamatsu, Keiko Kanai, Sachiko Masuda, Shinichi Yamazaki, Yuichi Aoki, Arisa Shibata, Wataru Suda, Ken Shirasu, Kazufumi Yazaki, Akifumi Sugiyama. Tomato root-associated Sphingobium harbors genes for catabolizing toxic steroidal glycoalkaloids.
mBio.
2023 Sep; ?(?):e0059923. doi:
10.1128/mbio.00599-23. [PMID: 37772873] - Feng Zhu, Xiao Zhang, Bing-Yuan Du, Xiang-Xia Zhu, Gui-Fang Zhao, Ying Sun, Qing-Qiang Yao, Hong-Bao Liang, Jing-Chun Yao, Zhong Liu, Gui-Min Zhang, Guo-Fei Qin. Using UPLC-LTQ-Orbitrap-MS and HPLC-CAD to Identify Impurities in Cycloastragenol, Which Is a Pre-Clinical Candidate for COPD.
Molecules (Basel, Switzerland).
2023 Aug; 28(17):. doi:
10.3390/molecules28176382. [PMID: 37687212] - Liming Dong, Ning Jiang, Jie Bai, Yiman Li, Zhihui Song, Xinmin Liu, Chao Zhang. Neuroprotective Effects of Dammarane Sapogenins Against lipopolysaccharide-induced Cognitive Impairment, Neuroinflammation and Synaptic Dysfunction.
Neurochemical research.
2023 Jul; ?(?):. doi:
10.1007/s11064-023-03997-7. [PMID: 37490197] - Xiao-Hui Li, Wei Jiang, Yan Guo, Qian Li, Jin-Fu Wan. Steroidal sapogenins from the aerial parts of Paris polyphylla var. yunnanensis and activity evaluation.
Fitoterapia.
2023 Jun; 167(?):105498. doi:
10.1016/j.fitote.2023.105498. [PMID: 37004742] - Wen-Ling Liao, Chun-Ping Huang, Hao-Pei Wang, Yu-Jie Lei, Hui-Ju Lin, Yu-Chuen Huang. Diosgenin, a Natural Steroidal Sapogenin, Alleviates the Progression of Diabetic Retinopathy in Diabetic Mice.
In vivo (Athens, Greece).
2023 Mar; 37(2):661-666. doi:
10.21873/invivo.13126. [PMID: 36881067] - Xiao-San Li, Xiao-Yan Liang, Ming-Shang Liu, Qi-Lin Wang, He-Hui Zhan, Zhi-Peng Xu, Li Liu, Yong-Mei Huang, Mao-Xun Yang, Hui Luo. Five New C21 -Steroidal Sapogenins from the Acid Hydrolysate of Cynanchum otophyllum Roots.
Chemistry & biodiversity.
2023 Mar; 20(3):e202300082. doi:
10.1002/cbdv.202300082. [PMID: 36729050] - Dayana Resino-Ruiz, Yisel Gonzalez-Madariaga, Leisy Nieto, Yilka Mena Linares, Jose Orestes Guerra León, Arlena Vázquez Martín, Arianna Valido Díaz, Francisco Torrens, Juan A Castillo-Garit. Anti-inflammatory Activity: In silico and In vivo of Sapogenins Present in Agave brittoniana subsp. brachypus (Trel.).
Anti-inflammatory & anti-allergy agents in medicinal chemistry.
2023; 22(1):42-48. doi:
10.2174/1871523022666230419103027. [PMID: 37114792] - Huajian Li, Shaoping Wang, Hong Wang, Haoran Li, Yanan Li, Pingping Dong, Xianming Lan, Jiayu Zhang, Long Dai. Comprehensive Study of In vivo and In vitro Metabolites of Cycloastragenol Based on UHPLC-Q-Exactive Orbitrap Mass Spectrometer.
Current drug metabolism.
2023; 23(14):1090-1114. doi:
10.2174/1389200224666230202150436. [PMID: 36733242] - Min He, Siyuan Guo, Yan Yin, Chi Zhang, Xianan Zhang. A novel sterol glycosyltransferase catalyses steroidal sapogenin 3-O glucosylation from Paris polyphylla var. yunnanensis.
Molecular biology reports.
2022 Dec; ?(?):. doi:
10.1007/s11033-022-08199-y. [PMID: 36562935] - Ting Chen, Ziqing Li, Shichun Li, Yingxiang Zou, Xinyi Gao, Shi Shu, Zhifei Wang. Cycloastragenol suppresses M1 and promotes M2 polarization in LPS-stimulated BV-2 cells and ischemic stroke mice.
International immunopharmacology.
2022 Dec; 113(Pt A):109290. doi:
10.1016/j.intimp.2022.109290. [PMID: 36252498] - Melis Küçüksolak, Göklem Üner, Petek Ballar Kırmızıbayrak, Erdal Bedir. Neuroprotective metabolites via fungal biotransformation of a novel sapogenin, cyclocephagenol.
Scientific reports.
2022 11; 12(1):18481. doi:
10.1038/s41598-022-22799-5. [PMID: 36323752] - Chaiwat Monmai, Jin-Suk Kim, So-Hyeon Baek. Transgenic Rice Seed Extracts Exert Immunomodulatory Effects by Modulating Immune-Related Biomarkers in RAW264.7 Macrophage Cells.
Nutrients.
2022 Oct; 14(19):. doi:
10.3390/nu14194143. [PMID: 36235795] - Soledad García-Morales, Ilenia Janeth Corzo-Jiménez, Natalina Frine Silva-Córdova, Andrés Michelle Soto-Cordero, Diego Iván Rodríguez-Mejía, Joaliné Pardo-Núñez, Janet María León-Morales. Comparative study of steroidal sapogenins content in leaves of five Agave species.
Journal of the science of food and agriculture.
2022 Oct; 102(13):5653-5659. doi:
10.1002/jsfa.11912. [PMID: 35368099] - Jin Yan, Zhiwen Li, Fangdao Zhu, Shaoming Chi, Qin Wang, Meizhu Rong, Weiyou Xie, Yan Zhao. Inclusion complex of 20(S)-protopanaxatriol with modified β-cyclodextrin: Characterization, solubility, and interaction with bovine serum albumin.
Analytical biochemistry.
2022 Sep; 653(?):114753. doi:
10.1016/j.ab.2022.114753. [PMID: 35691377] - Amila A Dissanayake, Juma A Mmongoyo, Muraleedharan G Nair. Zanzibar yam (Dioscorea sansibarensis Pax) isolates exhibit cyclooxygenase enzyme and lipid peroxidation inhibitory activities.
Natural product research.
2022 Sep; 36(18):4725-4729. doi:
10.1080/14786419.2021.2004598. [PMID: 34781791] - Ye-Wei Huang, Meng Zhang, Li-Tian Wang, Yan Nie, Jin-Bo Yang, Wen-Luer Meng, Xuan-Jun Wang, Jun Sheng. 20(S)-Protopanaxadiol decreases atherosclerosis in ApoE KO mice by increasing the levels of LDLR and inhibiting its binding with PCSK9.
Food & function.
2022 Jul; 13(13):7020-7028. doi:
10.1039/d2fo00392a. [PMID: 35723202] - Yi-Min Fan, Jun Jin, Jun-You Jian, Wei Gu, Chun-Mao Yuan, Zhan-Xing Hu, Xiao-Jiang Hao, Lie-Jun Huang. Three New Pregnanes Isolated from the Cynanchum auriculatum.
Chemistry & biodiversity.
2022 Jun; 19(6):e202200243. doi:
10.1002/cbdv.202200243. [PMID: 35560497] - Feiyan Chen, Chu Li, Huiying Cao, Hantao Zhang, Cai Lu, Ruimei Li, Zhu Zhu, Lin Chen, Yunan Zhao. Identification of Adenylate Kinase 5 as a Protein Target of Ginsenosides in Brain Tissues Using Mass Spectrometry-Based Drug Affinity Responsive Target Stability (DARTS) and Cellular Thermal Shift Assay (CETSA) Techniques.
Journal of agricultural and food chemistry.
2022 Mar; 70(8):2741-2751. doi:
10.1021/acs.jafc.1c07819. [PMID: 35184563] - Junda Chen, Yu Zhang, Xiao Guan, Hongwei Cao, Lin Li, Jie Yu, Hanlin Liu. Characterization of Saponins from Differently Colored Quinoa Cultivars and Their In Vitro Gastrointestinal Digestion and Fermentation Properties.
Journal of agricultural and food chemistry.
2022 Feb; 70(6):1810-1818. doi:
10.1021/acs.jafc.1c06200. [PMID: 35119265] - Fan C Wang, Philip L Hudson, Keith Burk, Alejandro G Marangoni. Encapsulation of cycloastragenol in phospholipid vesicles enhances transport and delivery across the skin barrier.
Journal of colloid and interface science.
2022 Feb; 608(Pt 2):1222-1228. doi:
10.1016/j.jcis.2021.10.143. [PMID: 34735856] - He Zhang, Yuyao Zhang, Xiaolei Tang, Wenjie Su, Chunhui Yang, Daian Pan, Daqing Zhao, Bin Qi, Xiangyan Li. Hemostatic Effect of 20(S)-Panaxadiol by Induced Platelet Aggregation Depending on Calcium Signaling Pathway.
BioMed research international.
2022; 2022(?):8265898. doi:
10.1155/2022/8265898. [PMID: 36177062] - Yve V S Magedans, Michael A Phillips. Soapbark Triterpenes: Quillaja brasiliensis Cell Culture Sapogenin and Free Sterol Analysis by GCMS.
Methods in molecular biology (Clifton, N.J.).
2022; 2469(?):119-128. doi:
10.1007/978-1-0716-2185-1_10. [PMID: 35508834] - Xueyi Zhu, Yuxue Cao, Mingyue Su, Mengmeng Chen, Congcong Li, La Yi, Jingjing Qin, Wuniqiemu Tulake, Fangzhou Teng, Yuanyuan Zhong, Weifeng Tang, Shiyuan Wang, Jingcheng Dong. Cycloastragenol alleviates airway inflammation in asthmatic mice by inhibiting autophagy.
Molecular medicine reports.
2021 11; 24(5):. doi:
10.3892/mmr.2021.12445. [PMID: 34542166] - Su-Nyeong Jang, So-Young Park, Hyunyoung Lee, Hyojin Jeong, Ji-Hyeon Jeon, Im-Sook Song, Mi Jeong Kwon, Kwang-Hyeon Liu. In vitro modulatory effects of ginsenoside compound K, 20(S)-protopanaxadiol and 20(S)-protopanaxatriol on uridine 5'-diphospho-glucuronosyltransferase activity and expression.
Xenobiotica; the fate of foreign compounds in biological systems.
2021 Oct; 51(10):1087-1094. doi:
10.1080/00498254.2021.1963503. [PMID: 34338601] - Chen Chen, Yaohui Ni, Baocheng Jiang, Song Yan, Bohui Xu, Boyi Fan, Huilian Huang, Guangtong Chen. Anti-aging derivatives of cycloastragenol produced by biotransformation.
Natural product research.
2021 Aug; 35(16):2685-2690. doi:
10.1080/14786419.2019.1662011. [PMID: 31496283] - Xiaodong Li, Yinmei Wang, Zhenjun Fan, Yan Wang, Pingping Wang, Xing Yan, Zhihua Zhou. High-level sustainable production of the characteristic protopanaxatriol-type saponins from Panax species in engineered Saccharomyces cerevisiae.
Metabolic engineering.
2021 07; 66(?):87-97. doi:
10.1016/j.ymben.2021.04.006. [PMID: 33865981] - Jiahuan Wu, Zhanwei Zeng, Yuyun Li, Huiyi Qin, Changqing Zuo, Chenhui Zhou, Daohua Xu. Cycloastragenol protects against glucocorticoid-induced osteogenic differentiation inhibition by activating telomerase.
Phytotherapy research : PTR.
2021 Apr; 35(4):2034-2044. doi:
10.1002/ptr.6946. [PMID: 33165990] - Seda Duman, Güner Ekiz, Sinem Yılmaz, Hasan Yusufoglu, Petek Ballar Kırmızıbayrak, Erdal Bedir. Telomerase activators from 20(27)-octanor-cycloastragenol via biotransformation by the fungal endophytes.
Bioorganic chemistry.
2021 04; 109(?):104708. doi:
10.1016/j.bioorg.2021.104708. [PMID: 33621779] - Deepa K Ingawale, Satish K Mandlik, Snehal S Patel. Hecogenin and fluticasone combination attenuates TNBS-induced ulcerative colitis in rats via downregulation of pro-inflammatory mediators and oxidative stress.
Immunopharmacology and immunotoxicology.
2021 Apr; 43(2):160-170. doi:
10.1080/08923973.2021.1872617. [PMID: 33435764] - Se-A Kim, Eun-Bi Jeong, Deok-Kun Oh. Complete Bioconversion of Protopanaxadiol-Type Ginsenosides to Compound K by Extracellular Enzymes from the Isolated Strain Aspergillus tubingensis.
Journal of agricultural and food chemistry.
2021 Jan; 69(1):315-324. doi:
10.1021/acs.jafc.0c07424. [PMID: 33372793] - Zhen-Zhen Lai, Hui-Li Yang, Jia-Wei Shi, Hui-Hui Shen, Yan Wang, Kai-Kai Chang, Tao Zhang, Jiang-Feng Ye, Jian-Song Sun, Xue-Min Qiu, Ming-Qing Li. Protopanaxadiol improves endometriosis associated infertility and miscarriage in sex hormones receptors-dependent and independent manners.
International journal of biological sciences.
2021; 17(8):1878-1894. doi:
10.7150/ijbs.58657. [PMID: 34131393] - Liu Liu, Haobin Li, Kaiwen Hu, Qinglong Xu, Xiaoan Wen, Keguang Cheng, Caiping Chen, Haoliang Yuan, Liang Dai, Hongbin Sun. Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid.
European journal of medicinal chemistry.
2021 Jan; 209(?):112932. doi:
10.1016/j.ejmech.2020.112932. [PMID: 33131725] - Eun-Bi Jeong, Se-A Kim, Kyung-Chul Shin, Deok-Kun Oh. Biotransformation of Protopanaxadiol-Type Ginsenosides in Korean Ginseng Extract into Food-Available Compound K by an Extracellular Enzyme from Aspergillus niger.
Journal of microbiology and biotechnology.
2020 Oct; 30(10):1560-1567. doi:
10.4014/jmb.2007.07003. [PMID: 32807754] - Jingya Ruan, Fan Sun, Ying Zhang, Dandan Zheng, Guilin Xiang, Wei Zhao, Yi Zhang, Tao Wang. New 20(S)-protopanaxadiol type saponins from the leaves of Panax notoginseng and their potential anti-inflammatory activities.
Steroids.
2020 10; 162(?):108696. doi:
10.1016/j.steroids.2020.108696. [PMID: 32649999] - Ning Jiang, Haixia Wang, Jingwei Lv, Qiong Wang, Cong Lu, Yujiao Li, Xinmin Liu. Dammarane sapogenins attenuates stress-induced anxiety-like behaviors by upregulating ERK/CREB/BDNF pathways.
Phytotherapy research : PTR.
2020 Oct; 34(10):2721-2729. doi:
10.1002/ptr.6713. [PMID: 32431006] - Vaderament-A Nchiozem-Ngnitedem, Leonidah Kerubo Omosa, Kibrom Gebreheiwot Bedane, Solomon Derese, Lukas Brieger, Carsten Strohmann, Michael Spiteller. Anti-inflammatory steroidal sapogenins and a conjugated chalcone-stilbene from Dracaena usambarensis Engl.
Fitoterapia.
2020 Oct; 146(?):104717. doi:
10.1016/j.fitote.2020.104717. [PMID: 32877711] - Dan Zhang, Wei Li, Zhong-Jian Chen, Fu-Gang Wei, Yun-Long Liu, Li-Zhi Gao. SMRT- and Illumina-based RNA-seq analyses unveil the ginsinoside biosynthesis and transcriptomic complexity in Panax notoginseng.
Scientific reports.
2020 09; 10(1):15310. doi:
10.1038/s41598-020-72291-1. [PMID: 32943706] - Ning Jiang, Lv Jingwei, Haixia Wang, Hong Huang, Qiong Wang, Guirong Zeng, Shanshan Li, Xinmin Liu. Ginsenoside 20(S)-protopanaxadiol attenuates depressive-like behaviour and neuroinflammation in chronic unpredictable mild stress-induced depressive rats.
Behavioural brain research.
2020 09; 393(?):112710. doi:
10.1016/j.bbr.2020.112710. [PMID: 32464121] - Jia-Ning Zhao, Ru-Feng Wang, Shu-Juan Zhao, Zheng-Tao Wang. Advance in glycosyltransferases, the important bioparts for production of diversified ginsenosides.
Chinese journal of natural medicines.
2020 Sep; 18(9):643-658. doi:
10.1016/s1875-5364(20)60003-6. [PMID: 32928508] - Jian Song, Zhen-Yu Cui, Li-Hua Lian, Xin Han, Li-Shuang Hou, Ge Wang, Lu Gao, Yue Zhu, Yu-Chen Jiang, Jia-Yi Dou, Zhong-He Hu, Yu-Qing Zhao, Ji-Xing Nan, Yan-Ling Wu. 20S-Protopanaxatriol Ameliorates Hepatic Fibrosis, Potentially Involving FXR-Mediated Inflammatory Signaling Cascades.
Journal of agricultural and food chemistry.
2020 Aug; 68(31):8195-8204. doi:
10.1021/acs.jafc.0c01978. [PMID: 32662640] - Man Li, Shi-Chun Li, Bao-Kai Dou, Ying-Xiang Zou, Hao-Zhen Han, Dong-Xiang Liu, Zun-Ji Ke, Zhi-Fei Wang. Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia.
Acta pharmacologica Sinica.
2020 Aug; 41(8):1025-1032. doi:
10.1038/s41401-020-0386-6. [PMID: 32203080] - Yu-Shan Ren, Hong-Hua Li, Jing-Chun Yao, Yu-Jun Tan, Li-Hong Pan, Tao Peng, Li-Li Zhao, Gui-Min Zhang, Jiang Yue, Xue-Mei Hu, Zhong Liu, Jie Li. Application quantitative proteomics approach to identify differentially expressed proteins associated with cardiac protection mediated by cycloastragenol in acute myocardial infarction rats.
Journal of proteomics.
2020 06; 222(?):103691. doi:
10.1016/j.jprot.2020.103691. [PMID: 32068187] - Chun-Xia Zhang, Xiao-Yan Wang, Zhao-Zhou Lin, Hong-da Wang, Yue-Xin Qian, Wei-Wei Li, Wen-Zhi Yang, De-An Guo. Highly selective monitoring of in-source fragmentation sapogenin product ions in positive mode enabling group-target ginsenosides profiling and simultaneous identification of seven Panax herbal medicines.
Journal of chromatography. A.
2020 May; 1618(?):460850. doi:
10.1016/j.chroma.2020.460850. [PMID: 31983414] - Izabella Jastrzebska. Synthesis and application of steroidal 22,16β-carbolactones: A review.
The Journal of steroid biochemistry and molecular biology.
2020 05; 199(?):105592. doi:
10.1016/j.jsbmb.2020.105592. [PMID: 31953168] - Yannick Hövelmann, Annika Jagels, Robin Schmid, Florian Hübner, Hans-Ulrich Humpf. Identification of potential human urinary biomarkers for tomato juice intake by mass spectrometry-based metabolomics.
European journal of nutrition.
2020 Mar; 59(2):685-697. doi:
10.1007/s00394-019-01935-4. [PMID: 30820652] - Joaquin Navarro Del Hierro, Vieri Piazzini, Guillermo Reglero, Diana Martin, Maria Camilla Bergonzi. In Vitro Permeability of Saponins and Sapogenins from Seed Extracts by the Parallel Artificial Membrane Permeability Assay: Effect of in Vitro Gastrointestinal Digestion.
Journal of agricultural and food chemistry.
2020 Feb; 68(5):1297-1305. doi:
10.1021/acs.jafc.9b07182. [PMID: 31934761] - Anna Kiełbasa, Aneta Krakowska-Sieprawska, Tomasz Kowalkowski, Katarzyna Rafińska, Bogusław Buszewski. Distribution of sapogenins in morphological Medicago sativa L. parts: Comparison of various extraction techniques.
Journal of separation science.
2020 Feb; 43(3):671-680. doi:
10.1002/jssc.201900964. [PMID: 31670460] - Joanie Vaillancourt, Véronique Turcotte, Patrick Caron, Lyne Villeneuve, Louis Lacombe, Frédéric Pouliot, Éric Lévesque, Chantal Guillemette. Glucuronidation of Abiraterone and Its Pharmacologically Active Metabolites by UGT1A4, Influence of Polymorphic Variants and Their Potential as Inhibitors of Steroid Glucuronidation.
Drug metabolism and disposition: the biological fate of chemicals.
2020 02; 48(2):75-84. doi:
10.1124/dmd.119.088229. [PMID: 31727674] - Joaquín Navarro Del Hierro, Carolina Cueva, Alba Tamargo, Estefanía Núñez-Gómez, M Victoria Moreno-Arribas, Guillermo Reglero, Diana Martin. In Vitro Colonic Fermentation of Saponin-Rich Extracts from Quinoa, Lentil, and Fenugreek. Effect on Sapogenins Yield and Human Gut Microbiota.
Journal of agricultural and food chemistry.
2020 Jan; 68(1):106-116. doi:
10.1021/acs.jafc.9b05659. [PMID: 31841325] - Di Sun, Shi-Yan Guo, Li Yang, Ya-Ru Wang, Xiao-Hui Wei, Sha Song, Yi-Wei Yang, Yong Gan, Zheng-Tao Wang. Silicone elastomer gel impregnated with 20(S)-protopanaxadiol-loaded nanostructured lipid carriers for ordered diabetic ulcer recovery.
Acta pharmacologica Sinica.
2020 Jan; 41(1):119-128. doi:
10.1038/s41401-019-0288-7. [PMID: 31534201] - Wissem Mhiri, Merve Ceylan, Neslihan Turgut-Kara, Barbaros Nalbantoğlu, Özgür Çakır. Transcriptomic analysis reveals responses to Cycloastragenol in Arabidopsis thaliana.
PloS one.
2020; 15(12):e0242986. doi:
10.1371/journal.pone.0242986. [PMID: 33301486] - Jamie Love, Casey R Simons. Acid hydrolysis of saponins extracted in tincture.
PloS one.
2020; 15(12):e0244654. doi:
10.1371/journal.pone.0244654. [PMID: 33382809] - Güner Ekiz, Sinem Yılmaz, Hasan Yusufoglu, Petek Ballar Kırmızıbayrak, Erdal Bedir. Microbial Transformation of Cycloastragenol and Astragenol by Endophytic Fungi Isolated from Astragalus Species.
Journal of natural products.
2019 11; 82(11):2979-2985. doi:
10.1021/acs.jnatprod.9b00336. [PMID: 31713424] - Ning Jiang, Jing-Wei Lv, Hai-Xia Wang, Cong Lu, Qiong Wang, Tian-Ji Xia, Yu Bao, Shan-Shan Li, Xin-Min Liu. Dammarane sapogenins alleviates depression-like behaviours induced by chronic social defeat stress in mice through the promotion of the BDNF signalling pathway and neurogenesis in the hippocampus.
Brain research bulletin.
2019 11; 153(?):239-249. doi:
10.1016/j.brainresbull.2019.09.007. [PMID: 31542427] - Haijun Lin, Baocheng Jiang, Chen Chen, Yan Song, Min Yang, Huilian Huang, Guangtong Chen. Microbial transformation of the anti-aging agent cycloastragenol by Mucor racemosus.
Natural product research.
2019 Nov; 33(21):3103-3108. doi:
10.1080/14786419.2018.1519822. [PMID: 30449165] - Conghui Liu, Ruibing Feng, Jian Zou, Fangbo Xia, Jian-Bo Wan. 20(S)-Protopanaxadiol Saponins Mainly Contribute to the Anti-Atherogenic Effects of Panax notoginseng in ApoE Deficient Mice.
Molecules (Basel, Switzerland).
2019 Oct; 24(20):. doi:
10.3390/molecules24203723. [PMID: 31623159] - Ning Jiang, Jing-Wei Lv, Hai-Xia Wang, Qiong Wang, Cong Lu, Yu-Jie Yang, Hong Huang, Tian-Ji Xia, Guang-Hua Lv, Xin-Min Liu. Antidepressant-like effects of 20(S)-protopanaxadiol in a mouse model of chronic social defeat stress and the related mechanisms.
Phytotherapy research : PTR.
2019 Oct; 33(10):2726-2736. doi:
10.1002/ptr.6446. [PMID: 31353678] - Jing Liu, Dongxiao Gao, Juhua Dan, Dan Liu, Lei Peng, Ruoyu Zhou, Ying Luo. The protective effect of cycloastragenol on aging mouse circadian rhythmic disorder induced by d-galactose.
Journal of cellular biochemistry.
2019 10; 120(10):16408-16415. doi:
10.1002/jcb.28587. [PMID: 31310357] - Jung Yeon Han, So-Hyeon Baek, Hye Jeong Jo, Do Won Yun, Yong Eui Choi. Genetically modified rice produces ginsenoside aglycone (protopanaxadiol).
Planta.
2019 Oct; 250(4):1103-1110. doi:
10.1007/s00425-019-03204-4. [PMID: 31168665] - Hui Zhang, Hongbing Liu, Pan Qi, Silin Wang, Haibin Hu, Jingxin Gou, Yu Zhang, Haibing He, Xing Tang, Tian Yin, Yue Yuan. Enhanced the Bioavailability of Sterile 20(S)-Protopanaxadiol Nanocrystalline Suspension Coated by Bovine Serum Albumin for Intramuscular Injection: In Vitro and In Vivo Evaluation.
AAPS PharmSciTech.
2019 Sep; 20(7):305. doi:
10.1208/s12249-019-1498-5. [PMID: 31506831] - Tiehua Zhang, Yuan Liang, Peng Zuo, Mi Yan, Siyuan Jing, Tiezhu Li, Yongjun Wang, Jie Zhang, Zhengyi Wei. Identification of 20(R, S)-protopanaxadiol and 20(R, S)-protopanaxatriol for potential selective modulation of glucocorticoid receptor.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Sep; 131(?):110642. doi:
10.1016/j.fct.2019.110642. [PMID: 31247261] - Chang-Hao Cui, Byeong-Min Jeon, Yaoyao Fu, Wan-Taek Im, Sun-Chang Kim. High-density immobilization of a ginsenoside-transforming β-glucosidase for enhanced food-grade production of minor ginsenosides.
Applied microbiology and biotechnology.
2019 Sep; 103(17):7003-7015. doi:
10.1007/s00253-019-09951-4. [PMID: 31289903] - Guoliang Deng, Wenjun Chen, Peng Wang, Tianying Zhan, Wei Zheng, Zhengbing Gu, Xiaomei Wang, Xiaoyun Ji, Yang Sun. Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice.
International immunopharmacology.
2019 Sep; 74(?):105682. doi:
10.1016/j.intimp.2019.105682. [PMID: 31203155] - Liying Zhang, Congcong Xu, Jingjing Mao, Weiwei Wang, Han Han, Yiqiong Pu, Tong Zhang. Formulation and Characterization of Novel Dry Suspension and Dry Emulsion of 20(S)-Protopanaxadiol.
AAPS PharmSciTech.
2019 Aug; 20(7):275. doi:
10.1208/s12249-019-1487-8. [PMID: 31388863] - Minxia Zhang, Jiaqi Zhao, Jianjun Deng, Zhiguang Duan, Chenhui Zhu, Daidi Fan. The protective effect of protopanaxatriol-type saponin on intestinal health in antibiotic-treated mice.
Food & function.
2019 Jul; 10(7):4124-4133. doi:
10.1039/c9fo00242a. [PMID: 31237597] - E Ramos-Morales, L Lyons, G de la Fuente, R Braganca, C J Newbold. Not all saponins have a greater antiprotozoal activity than their related sapogenins.
FEMS microbiology letters.
2019 07; 366(13):. doi:
10.1093/femsle/fnz144. [PMID: 31271417] - Rui Yuan, Tong Su, Chao Zhang, Xiao Song, Yao-Hui Yuan, Rui-Teng Li, Yi-Jing Liu. [Study on transformation rules of terrestrosin D in course of Tribuli Fructus stir-frying based on simulated processing technology].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2019 Jul; 44(14):3049-3054. doi:
10.19540/j.cnki.cjcmm.20190321.304. [PMID: 31602852] - Chuhe Liu, Hongli Li, Zhenyu Zhou, Junxiao Li, Hui Chen, Yalei Liu, Cheng Huang, Shengjie Fan. Protopanaxadiol alleviates obesity in high-fat diet-fed mice via activation of energy-sensing neuron in the paraventricular nucleus of hypothalamus.
Biochemical and biophysical research communications.
2019 06; 513(4):1092-1099. doi:
10.1016/j.bbrc.2019.04.031. [PMID: 31010683] - Vered Tzin, John H Snyder, Dong Sik Yang, David V Huhman, Bonnie S Watson, Stacy N Allen, Yuhong Tang, Karel Miettinen, Philipp Arendt, Jacob Pollier, Alain Goossens, Lloyd W Sumner. Integrated metabolomics identifies CYP72A67 and CYP72A68 oxidases in the biosynthesis of Medicago truncatula oleanate sapogenins.
Metabolomics : Official journal of the Metabolomic Society.
2019 05; 15(6):85. doi:
10.1007/s11306-019-1542-1. [PMID: 31144047] - Zhihua Wang, Unchol Kim, Yanting Jiao, Chaowen Li, Yingying Guo, Xiaoyao Ma, Min Jiang, Zhihong Jiang, Yuanyuan Hou, Gang Bai. Quantitative Proteomics Combined with Affinity MS Revealed the Molecular Mechanism of Ginsenoside Antitumor Effects.
Journal of proteome research.
2019 05; 18(5):2100-2108. doi:
10.1021/acs.jproteome.8b00972. [PMID: 30860844] - Jian Li, Lan Ma, Shuting Zhang, Cailian Zuo, Na Song, Shusheng Zhu, Jinsong Wu. Transcriptome analysis of 1- and 3-year-old Panax notoginseng roots and functional characterization of saponin biosynthetic genes DS and CYP716A47-like.
Planta.
2019 Apr; 249(4):1229-1237. doi:
10.1007/s00425-018-03083-1. [PMID: 30607503] - Xue Wang, Hua-Ying Xia, Hong-You Qin, Xiang-Ping Kang, Hai-Yan Hu, Jing Zheng, Jia-Ye Jiang, Ling-Ai Yao, Yan-Wu Xu, Tong Zhang, Xue-Li Zhang. 20(S)-protopanaxadiol induces apoptosis in human umbilical vein endothelial cells by activating the PERK-eIF2alpha-ATF4 signaling pathway.
Journal of cellular biochemistry.
2019 04; 120(4):5085-5096. doi:
10.1002/jcb.27785. [PMID: 30259568] - Bo Peng, Rong He, Qihua Xu, Yifei Yang, Qin Hu, Hongping Hou, Xinmin Liu, Jianrong Li. Ginsenoside 20(S)-protopanaxadiol inhibits triple-negative breast cancer metastasis in vivo by targeting EGFR-mediated MAPK pathway.
Pharmacological research.
2019 04; 142(?):1-13. doi:
10.1016/j.phrs.2019.02.003. [PMID: 30735802] - Teresa Herrera, Joaquín Navarro Del Hierro, Tiziana Fornari, Guillermo Reglero, Diana Martin. Acid hydrolysis of saponin-rich extracts of quinoa, lentil, fenugreek and soybean to yield sapogenin-rich extracts and other bioactive compounds.
Journal of the science of food and agriculture.
2019 Apr; 99(6):3157-3167. doi:
10.1002/jsfa.9531. [PMID: 30536393] - Mohamed Ben-Eltriki, Mohamed Hassona, Gray Meckling, Hans Adomat, Subrata Deb, Emma S Tomlinson Guns. Pharmacokinetic interaction of calcitriol with 20(S)-protopanaxadiol in mice: Determined by LC/MS analysis.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2019 Mar; 130(?):173-180. doi:
10.1016/j.ejps.2019.01.016. [PMID: 30654110] - Quanfu Huang, Qiuguo Wang, Dong Li, Xiao Wei, Yijuan Jia, Zheng Zhang, Bo Ai, Xiaonian Cao, Tao Guo, Yongde Liao. Co-administration of 20(S)-protopanaxatriol (g-PPT) and EGFR-TKI overcomes EGFR-TKI resistance by decreasing SCD1 induced lipid accumulation in non-small cell lung cancer.
Journal of experimental & clinical cancer research : CR.
2019 Mar; 38(1):129. doi:
10.1186/s13046-019-1120-4. [PMID: 30876460] - Jianqiang Zhang, Qian Zhang, Yangrong Xu, Huixiang Li, Fenglan Zhao, Chaoming Wang, Zhi Liu, Pan Liu, Yanan Liu, Qingguo Meng, Feng Zhao. Synthesis and In Vitro Anti-inflammatory Activity of C20 Epimeric Ocotillol-Type Triterpenes and Protopanaxadiol.
Planta medica.
2019 Mar; 85(4):292-301. doi:
10.1055/a-0770-0994. [PMID: 30380571] - Yin-Ping Guo, Man-Yun Chen, Li Shao, Wei Zhang, Tai Rao, Hong-Hao Zhou, Wei-Hua Huang. Quantification of Panax notoginseng saponins metabolites in rat plasma with in vivo gut microbiota-mediated biotransformation by HPLC-MS/MS.
Chinese journal of natural medicines.
2019 Mar; 17(3):231-240. doi:
10.1016/s1875-5364(19)30026-3. [PMID: 30910060] - Hong Ri Jin, Charles H Du, Chong-Zhi Wang, Chun-Su Yuan, Wei Du. Ginseng metabolite protopanaxadiol interferes with lipid metabolism and induces endoplasmic reticulum stress and p53 activation to promote cancer cell death.
Phytotherapy research : PTR.
2019 Mar; 33(3):610-617. doi:
10.1002/ptr.6249. [PMID: 30537241] - Li Yang, Chun-Yang Wang, Xiao-Nv Xie, Yi-Cheng Wang, Jing-Bo Peng, Wei-Hua Huang, Yao Chen, Dong-Sheng Ouyang, Zhi-Rong Tan. LC-MS/MS determination of ginsenoside compound K and its metabolite 20 (S)-protopanaxadiol in human plasma and urine: applications in a clinical study.
Bioanalysis.
2019 Mar; 11(5):365-380. doi:
10.4155/bio-2018-0185. [PMID: 30873858] - Lina Jin, Xue Fu, Shuangshuang Yao, Jian Yang, Guang Ning, Zhiguo Zhang. Protective effects of protopanaxatriol on acute liver injury induced by concanavalin A.
Naunyn-Schmiedeberg's archives of pharmacology.
2019 01; 392(1):81-87. doi:
10.1007/s00210-018-1567-4. [PMID: 30269219] - Min-Hwan Kim, Ki-Taek Kim, Seo-Yeon Sohn, Jae-Young Lee, Chang Hyung Lee, Hee Yang, Bo Kyung Lee, Ki Won Lee, Dae-Duk Kim. Formulation And Evaluation Of Nanostructured Lipid Carriers (NLCs) Of 20(S)-Protopanaxadiol (PPD) By Box-Behnken Design.
International journal of nanomedicine.
2019; 14(?):8509-8520. doi:
10.2147/ijn.s215835. [PMID: 31749618] - Jing Yang, Beibei Zhang, Zifei Qin, Shishi Li, Jinjin Xu, Zhihong Yao, Xiaojian Zhang, Frank J Gonzalez, Xinsheng Yao. Efflux excretion of bisdemethoxycurcumin-O-glucuronide in UGT1A1-overexpressing HeLa cells: Identification of breast cancer resistance protein (BCRP) and multidrug resistance-associated proteins 1 (MRP1) as the glucuronide transporters.
BioFactors (Oxford, England).
2018 Nov; 44(6):558-569. doi:
10.1002/biof.1452. [PMID: 30334318] - Jing Wang, Meng-Ling Wu, Shou-Pei Cao, Hui Cai, Zhi-Ming Zhao, Yao-Hong Song. Cycloastragenol ameliorates experimental heart damage in rats by promoting myocardial autophagy via inhibition of AKT1-RPS6KB1 signaling.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Nov; 107(?):1074-1081. doi:
10.1016/j.biopha.2018.08.016. [PMID: 30257319] - Elena Moreno-Castillo, Daniel P Ramírez-Echemendía, Giselle Hernández-Campoalegre, Dayana Mesa-Tejeda, Francisco Coll-Manchado, Yamilet Coll-García. In silico identification of new potentially active brassinosteroid analogues.
Steroids.
2018 10; 138(?):35-42. doi:
10.1016/j.steroids.2018.06.009. [PMID: 29997046] - Wu Song, Lin Wei, Yanwei Du, Yimei Wang, Shuang Jiang. Protective effect of ginsenoside metabolite compound K against diabetic nephropathy by inhibiting NLRP3 inflammasome activation and NF-κB/p38 signaling pathway in high-fat diet/streptozotocin-induced diabetic mice.
International immunopharmacology.
2018 Oct; 63(?):227-238. doi:
10.1016/j.intimp.2018.07.027. [PMID: 30107367] - Jun Wang, Hongshuai Yang, Yang Liu, Kelsang Norbo, Kewu Zeng, Mingbo Zhao, Hong Liang, Pengfei Tu, Qingying Zhang. Azukisapogenol Triterpene Glycosides from Oxytropis chiliophylla Royle.
Molecules (Basel, Switzerland).
2018 Sep; 23(10):. doi:
10.3390/molecules23102448. [PMID: 30257447] - Kyo Bin Kang, Murukarthick Jayakodi, Yun Sun Lee, Van Binh Nguyen, Hyun-Seung Park, Hyun Jo Koo, Ik Young Choi, Dae Hyun Kim, You Jin Chung, Byeol Ryu, Dong Young Lee, Sang Hyun Sung, Tae-Jin Yang. Identification of candidate UDP-glycosyltransferases involved in protopanaxadiol-type ginsenoside biosynthesis in Panax ginseng.
Scientific reports.
2018 08; 8(1):11744. doi:
10.1038/s41598-018-30262-7. [PMID: 30082711] - Jin-Qi Li, Jia-Feng Wang, Jie Li, Shu-Han Zhang, Dan He, Rong-Sheng Tong, Shu-Ya She. Simultaneous determination of 20(S)-protopanaxadiol and its three metabolites in rat plasma by LC-MS/MS: application to their pharmacokinetic studies.
Biomedical chromatography : BMC.
2018 Aug; 32(8):e4252. doi:
10.1002/bmc.4252. [PMID: 29607527] - Guangfei Wei, Fugang Wei, Can Yuan, Zhongjian Chen, Yong Wang, Jiang Xu, Yongqing Zhang, Linlin Dong, Shilin Chen. Integrated Chemical and Transcriptomic Analysis Reveals the Distribution of Protopanaxadiol- and Protopanaxatriol-Type Saponins in Panax notoginseng.
Molecules (Basel, Switzerland).
2018 Jul; 23(7):. doi:
10.3390/molecules23071773. [PMID: 30029488] - Ning Jiang, Bei-Yue Zhang, Li-Ming Dong, Jing-Wei Lv, Cong Lu, Qiong Wang, Lin-Xi Fan, Hong-Xia Zhang, Rui-Le Pan, Xin-Min Liu. Antidepressant effects of dammarane sapogenins in chronic unpredictable mild stress-induced depressive mice.
Phytotherapy research : PTR.
2018 Jun; 32(6):1023-1029. doi:
10.1002/ptr.6040. [PMID: 29468732]