3-Hydroxyhippuric acid (BioDeep_00000022685)

   

human metabolite Endogenous blood metabolite PANOMIX_OTCML-2023


代谢物信息卡片


2-[(3-Hydroxyphenyl)formamido]acetic acid

化学式: C9H9NO4 (195.0531554)
中文名称: 3-羟基马尿酸
谱图信息: 最多检出来源 Homo sapiens(blood) 5.17%

分子结构信息

SMILES: C1=CC(=CC(=C1)O)C(=O)NCC(=O)O
InChI: InChI=1S/C9H9NO4/c11-7-3-1-2-6(4-7)9(14)10-5-8(12)13/h1-4,11H,5H2,(H,10,14)(H,12,13)

描述信息

3-Hydroxyhippuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: acyl-CoA + glycine < -- > CoA + N-acylglycine. 3-Hydroxyhippuric acid is an organic acid found in normal human urine. 3-Hydroxyhippuric acid is a metabolite of rutin detected in urine after consumption of tomato juice (a source of rutin). 3-Hydroxyhippuric acid has its origin in dietary procyanidins (a major source of polyphenols consisting of elementary flavan-3-ol (epi)catechin units). 3-Hydroxyhippuric acid is a microbial aromatic acid metabolite derived from dietary polyphenols and flavonoids, found in normal human urine (PMID: 12592675, 2338430, 17015248, 14556848, 12742116). It is a marker of gut Clostridium species. Higher levels are associated with higher levels of Clostridia (PMID: 27123458).
3-Hydroxyhippuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction:
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3-Hydroxyhippuric acid is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids.

同义名列表

14 个代谢物同义名

2-[(3-Hydroxyphenyl)formamido]acetic acid; 2-[(3-Hydroxybenzoyl)amino]acetic acid; 2-[(3-Hydroxyphenyl)formamido]acetate; N-m-Hydroxylbenzoylglycine; 3-Hydroxybenzoylglycine; m-Hydroxyhippuric acid; 3-Hydroxyhippuric acid; 3-hydroxyhippuric acid; 3-Hydroxyhippic acid; m-Hydroxyhippic acid; m-Hydroxyhippurate; 3-Hydroxyhippurate; 3-Hydroxyhippate; m-Hydroxyhippate



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yin-Pan Chau, Philip C M Au, Gloria H Y Li, Chor-Wing Sing, Vincent K F Cheng, Kathryn C B Tan, Annie W C Kung, Ching-Lung Cheung. Serum Metabolome of Coffee Consumption and its Association With Bone Mineral Density: The Hong Kong Osteoporosis Study. The Journal of clinical endocrinology and metabolism. 2020 03; 105(3):. doi: 10.1210/clinem/dgz210. [PMID: 31750515]
  • Xiyue Xiong, Dan Liu, Yichao Wang, Ting Zeng, Ying Peng. Urinary 3-(3-Hydroxyphenyl)-3-hydroxypropionic Acid, 3-Hydroxyphenylacetic Acid, and 3-Hydroxyhippuric Acid Are Elevated in Children with Autism Spectrum Disorders. BioMed research international. 2016; 2016(?):9485412. doi: 10.1155/2016/9485412. [PMID: 27123458]
  • Suming Chen, Li Chen, Jianing Wang, Jian Hou, Qing He, Jian'an Liu, Jiyun Wang, Shaoxiang Xiong, Guoqiang Yang, Zongxiu Nie. 2,3,4,5-Tetrakis(3',4'-dihydroxylphenyl)thiophene: a new matrix for the selective analysis of low molecular weight amines and direct determination of creatinine in urine by MALDI-TOF MS. Analytical chemistry. 2012 Dec; 84(23):10291-7. doi: 10.1021/ac3021278. [PMID: 23113720]
  • Doris M Jacobs, Jens C Fuhrmann, Ferdinand A van Dorsten, Dietrich Rein, Sonja Peters, Ewoud J J van Velzen, Boudewijn Hollebrands, Richard Draijer, John van Duynhoven, Ursula Garczarek. Impact of short-term intake of red wine and grape polyphenol extract on the human metabolome. Journal of agricultural and food chemistry. 2012 Mar; 60(12):3078-85. doi: 10.1021/jf2044247. [PMID: 22372405]
  • Daniele Del Rio, Angelique Stalmach, Luca Calani, Alan Crozier. Bioavailability of coffee chlorogenic acids and green tea flavan-3-ols. Nutrients. 2010 08; 2(8):820-33. doi: 10.3390/nu2080820. [PMID: 22254058]
  • Sonia de Pascual-Teresa, Diego A Moreno, Cristina García-Viguera. Flavanols and anthocyanins in cardiovascular health: a review of current evidence. International journal of molecular sciences. 2010 Apr; 11(4):1679-703. doi: 10.3390/ijms11041679. [PMID: 20480037]
  • Suri Roowi, William Mullen, Christine A Edwards, Alan Crozier. Yoghurt impacts on the excretion of phenolic acids derived from colonic breakdown of orange juice flavanones in humans. Molecular nutrition & food research. 2009 May; 53 Suppl 1(?):S68-75. doi: 10.1002/mnfr.200800287. [PMID: 19415668]
  • Andreas R Rechner, Gunter Kuhnle, Henglong Hu, Andrea Roedig-Penman, Maarten H van den Braak, Kevin P Moore, Catherine A Rice-Evans. The metabolism of dietary polyphenols and the relevance to circulating levels of conjugated metabolites. Free radical research. 2002 Nov; 36(11):1229-41. doi: 10.1080/246-1071576021000016472. [PMID: 12592675]
  • A R Rechner, J P Spencer, G Kuhnle, U Hahn, C A Rice-Evans. Novel biomarkers of the metabolism of caffeic acid derivatives in vivo. Free radical biology & medicine. 2001 Jun; 30(11):1213-22. doi: 10.1016/s0891-5849(01)00506-8. [PMID: 11368919]