Saccharin sodium (BioDeep_00000226751)
human metabolite
代谢物信息卡片
sodium 2,3-dihydro-1λ⁶,2-benzothiazole-1,1,3-trione
化学式: C7H5NNaO3S+ (205.988784)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C(=C1)C(=O)NS2(=O)=O.[Na+]
InChI: +1
描述信息
D000074385 - Food Ingredients > D005503 - Food Additives
D010592 - Pharmaceutic Aids > D005421 - Flavoring Agents
Sweetener
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- PubChem: 21583979
- HMDB: HMDB0301770
- MeSH: Saccharin
- foodb: FDB000919
- chemspider: 10605692
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shuang Qiao, Wendy Huang, Darina Kuzma, Aleshia Kormendi. Acesulfame and other artificial sweeteners in a wastewater treatment plant in Alberta, Canada: Occurrence, degradation, and emission.
Chemosphere.
2024 May; 356(?):141893. doi:
10.1016/j.chemosphere.2024.141893. [PMID: 38582168] - Linhong Jiang, Zhenyang Yu, Yanbin Zhao, Daqiang Yin. Obesogenic potentials of environmental artificial sweeteners with disturbances on both lipid metabolism and neural responses.
The Science of the total environment.
2024 Apr; 919(?):170755. doi:
10.1016/j.scitotenv.2024.170755. [PMID: 38340820] - Vinicius Diniz, Susanne Rath. Adsorption of aqueous phase contaminants of emerging concern by activated carbon: Comparative fixed-bed column study and in situ regeneration methods.
Journal of hazardous materials.
2023 Jul; 459(?):132197. doi:
10.1016/j.jhazmat.2023.132197. [PMID: 37543021] - Yang Yue, Li Li, Baocheng Qu, Ying Liu, Xuankai Wang, Houyu Wang, Siyu Chen. Levels, consumption, and variations of eight artificial sweeteners in the wastewater treatment plants of Dalian city, China.
The Science of the total environment.
2023 May; ?(?):163867. doi:
10.1016/j.scitotenv.2023.163867. [PMID: 37201820] - Husni Mohammed Hasan, Suad Yousif Alkass, Daniele Suzete Persike de Oliveira. Impact of Long-Term Cyclamate and Saccharin Consumption on Biochemical Parameters in Healthy Individuals and Type 2 Diabetes Mellitus Patients.
Medicina (Kaunas, Lithuania).
2023 Apr; 59(4):. doi:
10.3390/medicina59040698. [PMID: 37109657] - V M Svistushkin, G N Nikiforova, A V Toldanov, A V Zolotova, E A Shevchik, A N Nikiforova. [Possibilities of usage of modern herbal medicinal product in the treatment of patients with acute viral rhinosinusitis].
Vestnik otorinolaringologii.
2023; 88(5):49-57. doi:
10.17116/otorino20238805149. [PMID: 37970770] - Juan Cruz Carrizo, Sung Vo Duy, Gabriel Munoz, Guido Marconi, María Valeria Amé, Sébastien Sauvé. Suspect screening of pharmaceuticals, illicit drugs, pesticides, and other emerging contaminants in Argentinean Piaractus mesopotamicus, a fish species used for local consumption and export.
Chemosphere.
2022 Dec; 309(Pt 1):136769. doi:
10.1016/j.chemosphere.2022.136769. [PMID: 36209849] - Aishwarya Murali, Varun Giri, Hunter James Cameron, Saskia Sperber, Franziska Maria Zickgraf, Volker Haake, Peter Driemert, Tilmann Walk, Hennicke Kamp, Ivonne McM Rietjens, Bennard van Ravenzwaay. Investigating the gut microbiome and metabolome following treatment with artificial sweeteners acesulfame potassium and saccharin in young adult Wistar rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2022 Jul; 165(?):113123. doi:
10.1016/j.fct.2022.113123. [PMID: 35588986] - Sofie Stampe, Magnus Leth-Møller, Eva Greibe, Elke Hoffmann-Lücke, Michael Pedersen, Per Ovesen. Artificial Sweeteners in Breast Milk: A Clinical Investigation with a Kinetic Perspective.
Nutrients.
2022 Jun; 14(13):. doi:
10.3390/nu14132635. [PMID: 35807817] - Giorgio Gasparini, Davide Castioni, Giovanna Spina, Filippo Familiari, Olimpio Galasso, Michele Mercurio. The use of a surgical helmet system with a high-efficiency particulate air filter as possible protection equipment during the coronavirus disease 2019 pandemic: a double-blinded randomized control study.
International orthopaedics.
2022 Jun; 46(6):1233-1240. doi:
10.1007/s00264-022-05371-8. [PMID: 35292837] - Aylin Bayındır Gümüş, Alev Keser, Esra Tunçer, Tuğba Altuntaş Yıldız, İlknur Kepenekci Bayram. Effect of saccharin, a non-nutritive sweeteners, on insulin and blood glucose levels in healthy young men: A crossover trial.
Diabetes & metabolic syndrome.
2022 Jun; 16(6):102500. doi:
10.1016/j.dsx.2022.102500. [PMID: 35598544] - Yosuke Masubuchi, Jinhui Ma, Tomohiro Suzuki, Itaru Kojima, Takeshi Inagaki, Hiroshi Shibata. T1R3 homomeric sweet taste receptor negatively regulates insulin-induced glucose transport through Gαs-mediated microtubules disassembly in 3T3-L1 adipocytes.
Endocrine journal.
2022 May; 69(5):487-493. doi:
10.1507/endocrj.ej21-0661. [PMID: 34803124] - Harry J G M Crijns, Arif Elvan, Nadea Al-Windy, Ype S Tuininga, Erik Badings, Ismail Aksoy, Isabelle C Van Gelder, Prashanti Madhavapeddi, A John Camm, Peter R Kowey, Jeremy N Ruskin, Luiz Belardinelli. Open-Label, Multicenter Study of Flecainide Acetate Oral Inhalation Solution for Acute Conversion of Recent-Onset, Symptomatic Atrial Fibrillation to Sinus Rhythm.
Circulation. Arrhythmia and electrophysiology.
2022 03; 15(3):e010204. doi:
10.1161/circep.121.010204. [PMID: 35196871] - Ebru Ozer Ozturk, Mehmet Aslan, Tuba Bayındır. The effect of COVID-19 on nasal mucociliary clearance.
Acta oto-laryngologica.
2022 Mar; 142(3-4):329-332. doi:
10.1080/00016489.2022.2048072. [PMID: 35294841] - Emmanuella Enuwosa, Lata Gautam, Linda King, Havovi Chichger. Saccharin and Sucralose Protect the Glomerular Microvasculature In Vitro against VEGF-Induced Permeability.
Nutrients.
2021 Aug; 13(8):. doi:
10.3390/nu13082746. [PMID: 34444906] - Angelina F Osabutey, A-Young Kim, Bo Yoon Seo, Linh Xuan Mai, Young Ho Koh. Alteration of unfolded protein responses and autophagy signaling represented the molecular basis underlying saccharin toxicity to Drosophila (Diptera: Drosophilidae).
Archives of insect biochemistry and physiology.
2021 Aug; 107(4):e21826. doi:
10.1002/arch.21826. [PMID: 34212404] - Shehala, Kirti Baranwal, Tulika Malviya, Lalit Mohan Dwivedi, Mani Prabha, Vandana Singh. Efficient sensing of saccharin through interference synthesis of gum ghatti capped silver nanoparticles.
International journal of biological macromolecules.
2021 Jul; 182(?):2003-2018. doi:
10.1016/j.ijbiomac.2021.05.124. [PMID: 34029584] - Samara Mejri, Maryline Magnin-Robert, Beatrice Randoux, Alina Ghinet, Patrice Halama, Ali Siah, Philippe Reignault. Saccharin Provides Protection and Activates Defense Mechanisms in Wheat Against the Hemibiotrophic Pathogen Zymoseptoria tritici.
Plant disease.
2021 Apr; 105(4):780-786. doi:
10.1094/pdis-05-20-1106-re. [PMID: 32830594] - Valerie Weinborn, Arlie L Lehmkuhler, Sarah J Zyba, Marjorie J Haskell, Fanny B Morel, Mamane Zeilani, Alyson E Mitchell. Measurement of Saccharin and trans-Resveratrol Metabolites in Urine as Adherence Markers for Small Quantity Lipid-Based Nutrient Supplement Consumption.
Journal of agricultural and food chemistry.
2021 Jan; 69(3):1107-1114. doi:
10.1021/acs.jafc.0c06144. [PMID: 33439009] - Jianhui Zhu, Jiaxin Liu, Zhengyi Li, Ranhui Xi, Yuqing Li, Xian Peng, Xin Xu, Xin Zheng, Xuedong Zhou. The Effects of Nonnutritive Sweeteners on the Cariogenic Potential of Oral Microbiome.
BioMed research international.
2021; 2021(?):9967035. doi:
10.1155/2021/9967035. [PMID: 34258285] - Jun Yuan, Xiaoteng Yan, Xing Chen, Xinqi Jiang, Keqi Ye, Qingping Xiong, Jing Kong, Yange Huang, Changxing Jiang, Tingting Xu, Guoyong Xie. A mild and efficient extraction method for polysaccharides from Sinonovacula constricta and study of their structural characteristic and antioxidant activities.
International journal of biological macromolecules.
2020 Jan; 143(?):913-921. doi:
10.1016/j.ijbiomac.2019.10.032. [PMID: 31678104] - A Pierre, Y Regin, A Van Schuerbeek, E M Fritz, K Muylle, T Beckers, I J Smolders, N Singewald, D De Bundel. Effects of disrupted ghrelin receptor function on fear processing, anxiety and saccharin preference in mice.
Psychoneuroendocrinology.
2019 12; 110(?):104430. doi:
10.1016/j.psyneuen.2019.104430. [PMID: 31542636] - Juliana Paschoalin De Souza Nogueira, Fei He, Heather F Mangian, Patricia Massae Oba, Maria R C De Godoy. Dietary supplementation of a fiber-prebiotic and saccharin-eugenol blend in extruded diets fed to dogs.
Journal of animal science.
2019 Nov; 97(11):4519-4531. doi:
10.1093/jas/skz293. [PMID: 31634399] - Omar Hasan Azeez, Suad Yousif Alkass, Daniele Suzete Persike. Long-Term Saccharin Consumption and Increased Risk of Obesity, Diabetes, Hepatic Dysfunction, and Renal Impairment in Rats.
Medicina (Kaunas, Lithuania).
2019 Oct; 55(10):. doi:
10.3390/medicina55100681. [PMID: 31601053] - Yaohui Huang, Gislaine Kuminek, Lilly Roy, Katie L Cavanagh, Qiuxiang Yin, Naír Rodríguez-Hornedo. Cocrystal Solubility Advantage Diagrams as a Means to Control Dissolution, Supersaturation, and Precipitation.
Molecular pharmaceutics.
2019 09; 16(9):3887-3895. doi:
10.1021/acs.molpharmaceut.9b00501. [PMID: 31318567] - Kavita Ngekure M X, Jingle Jiang, Hamdard Enayatullah, Wael Ennab, Sheeraz Mustafa, Saif Rodeni, Quanwei Wei, Fangxiong Shi. Sweet taste receptor agonists alter ovarian functions and ovarian cycles in aged mice.
Reproductive biology.
2019 Sep; 19(3):230-236. doi:
10.1016/j.repbio.2019.07.007. [PMID: 31399370] - Alperen Vural, İrfan Kara, Furkan Şan, Mehmet İlhan Şahin, Eray Eroğlu, Gökmen Zararsız, İbrahim Ketenci, Yaşar Ünlü, İsmail Koçyiğit. Mucociliary clearance in patients with continuous ambulatory peritoneal dialysis.
Nefrologia.
2019 Sep; 39(5):545-551. doi:
10.1016/j.nefro.2019.02.008. [PMID: 31164245] - K Davididou, E Chatzisymeon, L Perez-Estrada, I Oller, S Malato. Photo-Fenton treatment of saccharin in a solar pilot compound parabolic collector: Use of olive mill wastewater as iron chelating agent, preliminary results.
Journal of hazardous materials.
2019 06; 372(?):137-144. doi:
10.1016/j.jhazmat.2018.03.016. [PMID: 29567303] - Kelly A Higgins, Richard D Mattes. A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity.
The American journal of clinical nutrition.
2019 05; 109(5):1288-1301. doi:
10.1093/ajcn/nqy381. [PMID: 30997499] - Amine Bahi, Jean-Luc Dreyer. No effect of sex on ethanol intake and preference after dopamine transporter (DAT) knockdown in adult mice.
Psychopharmacology.
2019 Apr; 236(4):1349-1365. doi:
10.1007/s00213-018-5144-9. [PMID: 30539268] - Liat Shbiro, Danielle Hen-Shoval, Noa Hazut, Kayla Rapps, Shira Dar, Gil Zalsman, Raphael Mechoulam, Aron Weller, Gal Shoval. Effects of cannabidiol in males and females in two different rat models of depression.
Physiology & behavior.
2019 03; 201(?):59-63. doi:
10.1016/j.physbeh.2018.12.019. [PMID: 30571957] - Nomcebo Mchunu, Chika Ifeanyi Chukwuma, Mohammed Auwal Ibrahim, Olajumoke A Oyebode, Siphiwe Ndumiso Dlamini, Md Shahidul Islam. Commercially available non-nutritive sweeteners modulate the antioxidant status of type 2 diabetic rats.
Journal of food biochemistry.
2019 03; 43(3):e12775. doi:
10.1111/jfbc.12775. [PMID: 31353552] - Travis W Grim, Scarlet Jinhong Park, Cullen L Schmid, Robert B Laprairie, Michael Cameron, Laura M Bohn. The effect of quinine in two bottle choice procedures in C57BL6 mice: Opioid preference, somatic withdrawal, and pharmacokinetic outcomes.
Drug and alcohol dependence.
2018 10; 191(?):195-202. doi:
10.1016/j.drugalcdep.2018.05.034. [PMID: 30138791] - Grégory Jacquillet, Edward S Debnam, Robert J Unwin, Joanne Marks. Acute saccharin infusion has no effect on renal glucose handling in normal rats in vivo.
Physiological reports.
2018 07; 6(14):e13804. doi:
10.14814/phy2.13804. [PMID: 30009546] - Eric Augier, Estelle Barbier, Russell S Dulman, Valentina Licheri, Gaëlle Augier, Esi Domi, Riccardo Barchiesi, Sean Farris, Daniel Nätt, R Dayne Mayfield, Louise Adermark, Markus Heilig. A molecular mechanism for choosing alcohol over an alternative reward.
Science (New York, N.Y.).
2018 06; 360(6395):1321-1326. doi:
10.1126/science.aao1157. [PMID: 29930131] - Oytun Erbaş, Mümin Alper Erdoğan, Asghar Khalilnezhad, Volkan Solmaz, Fulya Tuzcu Gürkan, Gürkan Yiğittürk, Hüseyin Avni Eroglu, Dilek Taskiran. Evaluation of long-term effects of artificial sweeteners on rat brain: a biochemical, behavioral, and histological study.
Journal of biochemical and molecular toxicology.
2018 Jun; 32(6):e22053. doi:
10.1002/jbt.22053. [PMID: 29660801] - Zhongquan Li, Fang Zhang, Junbo Zhao, Xiaopan Liu, Xiuping Chen, Yue Su, Yinlong Guo. High-throughput quantification of sodium saccharin in foods by ambient flame ionization mass spectrometry.
Talanta.
2018 May; 182(?):241-246. doi:
10.1016/j.talanta.2018.01.071. [PMID: 29501147] - Yuri A Blednov, Adriana J Da Costa, Tamara Tarbox, Olga Ponomareva, Robert O Messing, R Adron Harris. Apremilast Alters Behavioral Responses to Ethanol in Mice: I. Reduced Consumption and Preference.
Alcoholism, clinical and experimental research.
2018 05; 42(5):926-938. doi:
10.1111/acer.13616. [PMID: 29469962] - Laura Sánchez-Marín, David Ladrón de Guevara-Miranda, M Carmen Mañas-Padilla, Francisco Alén, Román D Moreno-Fernández, Caridad Díaz-Navarro, José Pérez-Del Palacio, María García-Fernández, Carmen Pedraza, Francisco J Pavón, Fernando Rodríguez de Fonseca, Luis J Santín, Antonia Serrano, Estela Castilla-Ortega. Systemic blockade of LPA1/3 lysophosphatidic acid receptors by ki16425 modulates the effects of ethanol on the brain and behavior.
Neuropharmacology.
2018 05; 133(?):189-201. doi:
10.1016/j.neuropharm.2018.01.033. [PMID: 29378212] - Brendan J Tunstall, Chelsea P Ho, Jianjing Cao, Janaína C M Vendruscolo, Brooke E Schmeichel, Rachel D Slack, Gianluigi Tanda, Alexandra J Gadiano, Rana Rais, Barbara S Slusher, George F Koob, Amy H Newman, Leandro F Vendruscolo. Atypical dopamine transporter inhibitors attenuate compulsive-like methamphetamine self-administration in rats.
Neuropharmacology.
2018 03; 131(?):96-103. doi:
10.1016/j.neuropharm.2017.12.006. [PMID: 29217282] - Jingle Jiang, Lina Qi, Quanwei Wei, Fangxiong Shi. Effects of daily exposure to saccharin sodium and rebaudioside A on the ovarian cycle and steroidogenesis in rats.
Reproductive toxicology (Elmsford, N.Y.).
2018 03; 76(?):35-45. doi:
10.1016/j.reprotox.2017.12.006. [PMID: 29262312] - Ling Ma, Yarui Liu, Jiayao Xu, Hongwen Sun, Hao Chen, Yiming Yao, Peng Zhang, Fengju Shen, Aldredo C Alder. Mass loading of typical artificial sweeteners in a pig farm and their dissipation and uptake by plants in neighboring farmland.
The Science of the total environment.
2017 Dec; 605-606(?):735-744. doi:
10.1016/j.scitotenv.2017.06.027. [PMID: 28675883] - Caomhan Logue, Le Roy C Dowey, J J Strain, Hans Verhagen, Stephen McClean, Alison M Gallagher. Application of Liquid Chromatography-Tandem Mass Spectrometry To Determine Urinary Concentrations of Five Commonly Used Low-Calorie Sweeteners: A Novel Biomarker Approach for Assessing Recent Intakes?.
Journal of agricultural and food chemistry.
2017 Jun; 65(22):4516-4525. doi:
10.1021/acs.jafc.7b00404. [PMID: 28506059] - Elnaz Karimian Azari, Kathleen R Smith, Fanchao Yi, Timothy F Osborne, Roberto Bizzotto, Andrea Mari, Richard E Pratley, George A Kyriazis. Inhibition of sweet chemosensory receptors alters insulin responses during glucose ingestion in healthy adults: a randomized crossover interventional study.
The American journal of clinical nutrition.
2017 04; 105(4):1001-1009. doi:
10.3945/ajcn.116.146001. [PMID: 28251932] - Nicoletta A Miele, Rossella Di Monaco, Francesca Dell'Amura, Michele F Rega, Delia Picone, Silvana Cavella. A preliminary study on the application of natural sweet proteins in agar-based gels.
Journal of texture studies.
2017 04; 48(2):103-113. doi:
10.1111/jtxs.12215. [PMID: 28370108] - Tao Zhang, Zhiwei Gan, Chuanzi Gao, Ling Ma, Yanxi Li, Xiao Li, Hongwen Sun. Occurrence of artificial sweeteners in human liver and paired blood and urine samples from adults in Tianjin, China and their implications for human exposure.
Environmental science. Processes & impacts.
2016 Sep; 18(9):1169-76. doi:
10.1039/c6em00130k. [PMID: 27383923] - Caleb J Browne, Paul J Fletcher. Decreased Incentive Motivation Following Knockout or Acute Blockade of the Serotonin Transporter: Role of the 5-HT2C Receptor.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2016 09; 41(10):2566-76. doi:
10.1038/npp.2016.63. [PMID: 27125304] - Christopher O Boyson, Elizabeth N Holly, Andrew R Burke, Sandra Montagud-Romero, Joseph F DeBold, Klaus A Miczek. Maladaptive choices by defeated rats: link between rapid approach to social threat and escalated cocaine self-administration.
Psychopharmacology.
2016 Sep; 233(17):3173-86. doi:
10.1007/s00213-016-4363-1. [PMID: 27376946] - Rongyan Li, Jiadong Zheng, Mingshan Jiang, Yuanli Liu, Xiaofa Qin, Xiuhong Wang. Increased Digestive Proteases and Decreased β-Glucuronidase in Feces of Rats Treated with Sucralose and Saccharin-Another Critical Evidence That These Dietary Chemicals May Be Important Causative Factors for Inflammatory Bowel Disease.
Inflammatory bowel diseases.
2016 08; 22(8):E29-30. doi:
10.1097/mib.0000000000000859. [PMID: 27416049] - Kristian Daly, Alistair C Darby, Neil Hall, Mark C Wilkinson, Pisut Pongchaikul, David Bravo, Soraya P Shirazi-Beechey. Bacterial sensing underlies artificial sweetener-induced growth of gut Lactobacillus.
Environmental microbiology.
2016 07; 18(7):2159-71. doi:
10.1111/1462-2920.12942. [PMID: 26058469] - Ngoc Han Tran, Jie Gan, Viet Tung Nguyen, Huiting Chen, Luhua You, Ankur Duarah, Lifeng Zhang, Karina Yew-Hoong Gin. Sorption and biodegradation of artificial sweeteners in activated sludge processes.
Bioresource technology.
2015 Dec; 197(?):329-38. doi:
10.1016/j.biortech.2015.08.083. [PMID: 26342347] - Kristina I Rother, Allison C Sylvetsky, S S Schiffman. Non-nutritive sweeteners in breast milk: perspective on potential implications of recent findings.
Archives of toxicology.
2015 Nov; 89(11):2169-71. doi:
10.1007/s00204-015-1611-9. [PMID: 26462668] - Mohamed El-Sayed Alkafafy, Zein Shaban Ibrahim, Mohamed Mohamed Ahmed, Samir Ahmed El-Shazly. Impact of aspartame and saccharin on the rat liver: Biochemical, molecular, and histological approach.
International journal of immunopathology and pharmacology.
2015 Jun; 28(2):247-55. doi:
10.1177/0394632015586134. [PMID: 26015492] - Hila M Ene, Nirit Z Kara, Haim Einat. The effects of the atypical antipsychotic asenapine in a strain-specific battery of tests for mania-like behaviors.
Behavioural pharmacology.
2015 Jun; 26(4):331-7. doi:
10.1097/fbp.0000000000000128. [PMID: 25590966] - Michael S Sinclair, Isabel Perea-Martinez, Marianne Abouyared, Steven J St John, Nirupa Chaudhari. Oxytocin decreases sweet taste sensitivity in mice.
Physiology & behavior.
2015 Mar; 141(?):103-10. doi:
10.1016/j.physbeh.2014.12.048. [PMID: 25554481] - Allison C Sylvetsky, Alexandra L Gardner, Viviana Bauman, Jenny E Blau, H Martin Garraffo, Peter J Walter, Kristina I Rother. Nonnutritive Sweeteners in Breast Milk.
Journal of toxicology and environmental health. Part A.
2015; 78(16):1029-32. doi:
10.1080/15287394.2015.1053646. [PMID: 26267522] - Armorel Diane van Eyk. The effect of five artificial sweeteners on Caco-2, HT-29 and HEK-293 cells.
Drug and chemical toxicology.
2015; 38(3):318-27. doi:
10.3109/01480545.2014.966381. [PMID: 25317478] - Jotham Suez, Tal Korem, David Zeevi, Gili Zilberman-Schapira, Christoph A Thaiss, Ori Maza, David Israeli, Niv Zmora, Shlomit Gilad, Adina Weinberger, Yael Kuperman, Alon Harmelin, Ilana Kolodkin-Gal, Hagit Shapiro, Zamir Halpern, Eran Segal, Eran Elinav. Artificial sweeteners induce glucose intolerance by altering the gut microbiota.
Nature.
2014 Oct; 514(7521):181-6. doi:
10.1038/nature13793. [PMID: 25231862] - Alessandra T Peana, Giulia Muggironi, Liliana Spina, Michela Rosas, Sanjay B Kasture, Elisabetta Cotti, Elio Acquas. Effects of Withania somnifera on oral ethanol self-administration in rats.
Behavioural pharmacology.
2014 Oct; 25(7):618-28. doi:
10.1097/fbp.0000000000000078. [PMID: 25115596] - Yoshiaki Ohtsu, Yuko Nakagawa, Masahiro Nagasawa, Shigeki Takeda, Hirokazu Arakawa, Itaru Kojima. Diverse signaling systems activated by the sweet taste receptor in human GLP-1-secreting cells.
Molecular and cellular endocrinology.
2014 Aug; 394(1-2):70-9. doi:
10.1016/j.mce.2014.07.004. [PMID: 25017733] - Janina S G Diogo, Liliana S O Silva, Angelina Pena, Celeste M Lino. Risk assessment of additives through soft drinks and nectars consumption on Portuguese population: a 2010 survey.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2013 Dec; 62(?):548-53. doi:
10.1016/j.fct.2013.09.006. [PMID: 24036138] - Jesselea Carlin, Tiffany E Hill-Smith, Irwin Lucki, Teresa M Reyes. Reversal of dopamine system dysfunction in response to high-fat diet.
Obesity (Silver Spring, Md.).
2013 Dec; 21(12):2513-21. doi:
10.1002/oby.20374. [PMID: 23512420] - Zhiwei Gan, Hongwen Sun, Biting Feng, Ruonan Wang, Yanwei Zhang. Occurrence of seven artificial sweeteners in the aquatic environment and precipitation of Tianjin, China.
Water research.
2013 Sep; 47(14):4928-37. doi:
10.1016/j.watres.2013.05.038. [PMID: 23866151] - Martine Duclos, Amel Ouerdani, Pierre Mormède, Jan Pieter Konsman. Food restriction-induced hyperactivity: addiction or adaptation to famine?.
Psychoneuroendocrinology.
2013 Jun; 38(6):884-97. doi:
10.1016/j.psyneuen.2012.09.012. [PMID: 23059205] - Bojana M Andrejić, Vesna M Mijatović, Isidora N Samojlik, Olga J Horvat, Jelena D Ćalasan, Matilda A Đolai. The influence of chronic intake of saccharin on rat hepatic and pancreatic function and morphology: gender differences.
Bosnian journal of basic medical sciences.
2013 May; 13(2):94-9. doi:
10.17305/bjbms.2013.2372. [PMID: 23725505] - Xavier Viñals, Rafael Maldonado, Patricia Robledo. Effects of repeated treatment with MDMA on working memory and behavioural flexibility in mice.
Addiction biology.
2013 Mar; 18(2):263-73. doi:
10.1111/j.1369-1600.2011.00421.x. [PMID: 22260267] - Yuko Nakagawa, Masahiro Nagasawa, Hideo Mogami, Martin Lohse, Yuzo Ninomiya, Itaru Kojima. Multimodal function of the sweet taste receptor expressed in pancreatic β-cells: generation of diverse patterns of intracellular signals by sweet agonists.
Endocrine journal.
2013; 60(10):1191-206. doi:
10.1507/endocrj.ej13-0282. [PMID: 23933592] - Yuan Gao, Jing Gao, Ziling Liu, Hongliang Kan, Hui Zu, Wanjin Sun, Jianjun Zhang, Shuai Qian. Coformer selection based on degradation pathway of drugs: a case study of adefovir dipivoxil-saccharin and adefovir dipivoxil-nicotinamide cocrystals.
International journal of pharmaceutics.
2012 Nov; 438(1-2):327-35. doi:
10.1016/j.ijpharm.2012.09.027. [PMID: 22989978] - Dale R Walters, Linda Paterson. Parents lend a helping hand to their offspring in plant defence.
Biology letters.
2012 Oct; 8(5):871-3. doi:
10.1098/rsbl.2012.0416. [PMID: 22696290] - Bo Liu, Matthew Ha, Xuan-Yu Meng, Mohammed Khaleduzzaman, Zhe Zhang, Xia Li, Meng Cui. Functional characterization of the heterodimeric sweet taste receptor T1R2 and T1R3 from a New World monkey species (squirrel monkey) and its response to sweet-tasting proteins.
Biochemical and biophysical research communications.
2012 Oct; 427(2):431-7. doi:
10.1016/j.bbrc.2012.09.083. [PMID: 23000410] - Maartje C P Geraedts, Freddy J Troost, Wim H M Saris. Addition of sucralose enhances the release of satiety hormones in combination with pea protein.
Molecular nutrition & food research.
2012 Mar; 56(3):417-24. doi:
10.1002/mnfr.201100297. [PMID: 22378494] - Andrey P Kozlov, Michael E Nizhnikov, Elena I Varlinskaya, Norman E Spear. The role of social isolation in ethanol effects on the preweanling rat.
Behavioural brain research.
2012 Feb; 227(1):43-57. doi:
10.1016/j.bbr.2011.10.029. [PMID: 22051944] - Harumi Oozawa, Hiroyuki Kimura, Tsuneyuki Noda, Koichiro Hamada, Taketoshi Morimoto, Yuichi Majima. Effect of prehydration on nasal mucociliary clearance in low relative humidity.
Auris, nasus, larynx.
2012 Feb; 39(1):48-52. doi:
10.1016/j.anl.2011.04.002. [PMID: 21601396] - Marina Rukhadze, Diana Dzidziguri, Nana Giorgobiani, Salome Kerkenjia. Imitation of biomembranes on the basis of cholic acid and endogenic thermostable protein complex in biopartitioning micellar chromatography.
Biomedical chromatography : BMC.
2011 Dec; 25(12):1364-8. doi:
10.1002/bmc.1610. [PMID: 21381065] - Vanita Gupta, Madhu Bala, Jagdish Prasad, Surinder Singh, Manish Gupta. Leaves of Hippophae rhamnoides prevent taste aversion in gamma-irradiated rats.
Journal of dietary supplements.
2011 Dec; 8(4):355-68. doi:
10.3109/19390211.2011.621929. [PMID: 22432774] - Jae-Yong Kim, Juyi Seo, Kyung-Hyun Cho. Aspartame-fed zebrafish exhibit acute deaths with swimming defects and saccharin-fed zebrafish have elevation of cholesteryl ester transfer protein activity in hypercholesterolemia.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2011 Nov; 49(11):2899-905. doi:
10.1016/j.fct.2011.08.001. [PMID: 21855599] - Ismael Abdelaziz, Abd El Rahiem A Ashour. Effect of saccharin on albino rats' blood indices and the therapeutic action of vitamins C and E.
Human & experimental toxicology.
2011 Feb; 30(2):129-37. doi:
10.1177/0960327110368695. [PMID: 20382728] - Felix S Seibert, Benno Riesselmann, Timm H Westhoff. A sweet cause of polyuria.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2011 Feb; 57(2):355-6. doi:
10.1053/j.ajkd.2010.11.016. [PMID: 21251550] - Ignaz J Buerge, Martina Keller, Hans-Rudolf Buser, Markus D Müller, Thomas Poiger. Saccharin and other artificial sweeteners in soils: estimated inputs from agriculture and households, degradation, and leaching to groundwater.
Environmental science & technology.
2011 Jan; 45(2):615-21. doi:
10.1021/es1031272. [PMID: 21142066] - Min-Sook Jung, Jeong-Soo Kim, Min-Soo Kim, Amjad Alhalaweh, Wonkyung Cho, Sung-Joo Hwang, Sitaram P Velaga. Bioavailability of indomethacin-saccharin cocrystals.
The Journal of pharmacy and pharmacology.
2010 Nov; 62(11):1560-8. doi:
10.1111/j.2042-7158.2010.01189.x. [PMID: 21039541] - Deepak A Deshpande, Wayne C H Wang, Elizabeth L McIlmoyle, Kathryn S Robinett, Rachel M Schillinger, Steven S An, James S K Sham, Stephen B Liggett. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction.
Nature medicine.
2010 Nov; 16(11):1299-304. doi:
10.1038/nm.2237. [PMID: 20972434] - Anthony Sclafani, Mahsa Bahrani, Steven Zukerman, Karen Ackroff. Stevia and saccharin preferences in rats and mice.
Chemical senses.
2010 Jun; 35(5):433-43. doi:
10.1093/chemse/bjq033. [PMID: 20413452] - Oz Malkesman, Maria Luisa Scattoni, Daniel Paredes, Tyson Tragon, Brandon Pearson, Galit Shaltiel, Guang Chen, Jacqueline N Crawley, Husseini K Manji. The female urine sniffing test: a novel approach for assessing reward-seeking behavior in rodents.
Biological psychiatry.
2010 May; 67(9):864-71. doi:
10.1016/j.biopsych.2009.10.018. [PMID: 20034613] - Ke Chen, Jianqun Yan, Yi Suo, Jinrong Li, Qian Wang, Bo Lv. Nutritional status alters saccharin intake and sweet receptor mRNA expression in rat taste buds.
Brain research.
2010 Apr; 1325(?):53-62. doi:
10.1016/j.brainres.2010.02.026. [PMID: 20156422] - Tadahiro Ohkuri, Keiko Yasumatsu, Nao Horio, Masafumi Jyotaki, Robert F Margolskee, Yuzo Ninomiya. Multiple sweet receptors and transduction pathways revealed in knockout mice by temperature dependence and gurmarin sensitivity.
American journal of physiology. Regulatory, integrative and comparative physiology.
2009 Apr; 296(4):R960-71. doi:
10.1152/ajpregu.91018.2008. [PMID: 19211717] - Yukihiro Fujita, Rhonda D Wideman, Madeleine Speck, Ali Asadi, David S King, Travis D Webber, Masakazu Haneda, Timothy J Kieffer. Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo.
American journal of physiology. Endocrinology and metabolism.
2009 Mar; 296(3):E473-9. doi:
10.1152/ajpendo.90636.2008. [PMID: 19106249] - A Haksar, A Sharma, R Chawla, Raj Kumar, S S Lahiri, F Islam, M P Arora, R K Sharma, R P Tripathi, Rajesh Arora. Mint oil (Mentha spicata Linn.) offers behavioral radioprotection: a radiation-induced conditioned taste aversion study.
Phytotherapy research : PTR.
2009 Feb; 23(2):293-6. doi:
10.1002/ptr.2604. [PMID: 18853399] - John M Freeman, Eileen P G Vining, Eric H Kossoff, Paula L Pyzik, Xiaobu Ye, Steven N Goodman. A blinded, crossover study of the efficacy of the ketogenic diet.
Epilepsia.
2009 Feb; 50(2):322-5. doi:
10.1111/j.1528-1167.2008.01740.x. [PMID: 18717710] - A Sterk, P Schlegel, A J Mul, M Ubbink-Blanksma, E M A M Bruininx. Effects of sweeteners on individual feed intake characteristics and performance in group-housed weanling pigs.
Journal of animal science.
2008 Nov; 86(11):2990-7. doi:
10.2527/jas.2007-0591. [PMID: 18539824] - Tino Just, Hans Wilhelm Pau, Ulrike Engel, Thomas Hummel. Cephalic phase insulin release in healthy humans after taste stimulation?.
Appetite.
2008 Nov; 51(3):622-7. doi:
10.1016/j.appet.2008.04.271. [PMID: 18556090] - K J Jiang, H C Jiao, Z G Song, L Yuan, J P Zhao, H Lin. Corticosterone administration and dietary glucose supplementation enhance fat accumulation in broiler chickens.
British poultry science.
2008 Sep; 49(5):625-31. doi:
10.1080/00071660802337241. [PMID: 18836910] - Aleksandra Orlita, Matylda Sidwa-Gorycka, Jolanta Kumirska, Edmund Maliński, Ewa M Siedlecka, Jerzy Gajdus, Ewa Lojkowska, Piotr Stepnowski. Identification of Ruta graveolens L. metabolites accumulated in the presence of abiotic elicitors.
Biotechnology progress.
2008 Jan; 24(1):128-33. doi:
10.1021/bp070261d. [PMID: 18052337] - Nikolaos G Chalkias, Emmanuel P Giannelis. A nanohybrid membrane with lipid bilayer-like properties utilized as a conductimetric saccharin sensor.
Biosensors & bioelectronics.
2007 Oct; 23(3):370-6. doi:
10.1016/j.bios.2007.04.014. [PMID: 17548189] - Alexey N Pronin, Hong Xu, Huixian Tang, Lan Zhang, Qing Li, Xiaodong Li. Specific alleles of bitter receptor genes influence human sensitivity to the bitterness of aloin and saccharin.
Current biology : CB.
2007 Aug; 17(16):1403-8. doi:
10.1016/j.cub.2007.07.046. [PMID: 17702579] - Kazuyuki Tonosaki, Yasunori Hori, Yasutake Shimizu, Keiichi Tonosaki. Relationships between insulin release and taste.
Biomedical research (Tokyo, Japan).
2007 Apr; 28(2):79-83. doi:
10.2220/biomedres.28.79. [PMID: 17510492] - Meenakshi Tripathi, Subhash K Khanna, Mukul Das. Usage of saccharin in food products and its intake by the population of Lucknow, India.
Food additives and contaminants.
2006 Dec; 23(12):1265-75. doi:
10.1080/02652030600944395. [PMID: 17118869] - Randall Bennett, Bobbi Adams, Amanda French, Yasmin Neggers, John B Vincent. High-dose chromium(III) supplementation has no effects on body mass and composition while altering plasma hormone and triglycerides concentrations.
Biological trace element research.
2006 Oct; 113(1):53-66. doi:
10.1385/bter:113:1:53. [PMID: 17114815] - You-Qing Cai, Guo-Qiang Cai, Guo-Xiang Liu, Qing Cai, Jia-Hao Shi, Jun Shi, Sun-Kai Ma, Xia Sun, Zhe-Jin Sheng, Zhen-Tong Mei, Dafu Cui, Lihe Guo, Zhugang Wang, Jian Fei. Mice with genetically altered GABA transporter subtype I (GAT1) expression show altered behavioral responses to ethanol.
Journal of neuroscience research.
2006 Aug; 84(2):255-67. doi:
10.1002/jnr.20884. [PMID: 16683252] - Anupum Haksar, Ashok Sharma, Raman Chawla, Raj Kumar, Rajesh Arora, Surender Singh, J Prasad, M Gupta, R P Tripathi, M P Arora, F Islam, R K Sharma. Zingiber officinale exhibits behavioral radioprotection against radiation-induced CTA in a gender-specific manner.
Pharmacology, biochemistry, and behavior.
2006 Jun; 84(2):179-88. doi:
10.1016/j.pbb.2006.04.008. [PMID: 16797061]