3H-1,2-Dithiole-3-thione (BioDeep_00000021838)

   

human metabolite


代谢物信息卡片


1,2-Dithia-4-cyclopentene-3-thione

化学式: C3H2S3 (133.9318652)
中文名称: 3H-13H-1,2-二硫基-3-硫酮
谱图信息: 最多检出来源 Anoectochilus roxburghii(viridiplantae) 87.5%

分子结构信息

SMILES: C1=CSSC1=S
InChI: InChI=1S/C3H2S3/c4-3-1-2-5-6-3/h1-2H

描述信息

3H-1,2-Dithiole-3-thione is found in brassicas. 3H-1,2-Dithiole-3-thione is isolated from Brassica oleracea var. capitata and other crucifers. Potential nutriceutica
Isolated from Brassica oleracea variety capitata and other crucifers. Potential nutriceutical. 3H-1,2-Dithiole-3-thione is found in brassicas.
D000970 - Antineoplastic Agents

同义名列表

7 个代谢物同义名

1,2-Dithia-4-cyclopentene-3-thione; 3-H-1,2-Dithiole-2-thione (D3T); 3H-1,2-Dithiole-3-thione; 1,2-Dithiolene-3-thione; 1,2-dithiole-3-thione; 1,2-Dithiol-3-thione; D3T Compound



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Chuan-Teng Liu, Jui-Hung Jimmy Yen, Dennis A Brown, Ying-Chyi Song, Mei-Yun Chu, Yu-Hsiang Hung, Yi-Huan Tang, Po-Yuan Wu, Hung-Rong Yen. Targeting Nrf2 with 3 H-1,2-dithiole-3-thione to moderate OXPHOS-driven oxidative stress attenuates IL-17A-induced psoriasis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Mar; 159(?):114294. doi: 10.1016/j.biopha.2023.114294. [PMID: 36706632]
  • Katalin Éva Sikura, László Potor, Tamás Szerafin, Abolfazl Zarjou, Anupam Agarwal, Paolo Arosio, Maura Poli, Zoltán Hendrik, Gábor Méhes, Melinda Oros, Niké Posta, Lívia Beke, Ibolya Fürtös, György Balla, József Balla. Potential Role of H-Ferritin in Mitigating Valvular Mineralization. Arteriosclerosis, thrombosis, and vascular biology. 2019 03; 39(3):413-431. doi: 10.1161/atvbaha.118.312191. [PMID: 30700131]
  • Zi-Zhang Chen, Yun-Dong Xie, Li-Hua Shao, Qiu-Tang Wang, Yan-Hong Xu, Xiao-Li Bian. 5-(4-Hydroxyphenyl)-3H-1,2-dithiole-3-thione-based fibrates as potential hypolipidemic and hepatoprotective agents. Bioorganic & medicinal chemistry letters. 2018 12; 28(23-24):3787-3792. doi: 10.1016/j.bmcl.2018.10.003. [PMID: 30337230]
  • Christophe O Soulage, Laura Sardón Puig, Laurent Soulère, Bader Zarrouki, Michel Guichardant, Michel Lagarde, Nicolas J Pillon. Skeletal muscle insulin resistance is induced by 4-hydroxy-2-hexenal, a by-product of n-3 fatty acid peroxidation. Diabetologia. 2018 03; 61(3):688-699. doi: 10.1007/s00125-017-4528-4. [PMID: 29299636]
  • Gergely Becs, Abolfazl Zarjou, Anupam Agarwal, Katalin Éva Kovács, Ádám Becs, Mónika Nyitrai, Enikő Balogh, Emese Bányai, John W Eaton, Paolo Arosio, Maura Poli, Viktória Jeney, József Balla, György Balla. Pharmacological induction of ferritin prevents osteoblastic transformation of smooth muscle cells. Journal of cellular and molecular medicine. 2016 Feb; 20(2):217-30. doi: 10.1111/jcmm.12682. [PMID: 26499096]
  • Nicolas J Pillon, Marine L Croze, Roxane E Vella, Laurent Soulère, Michel Lagarde, Christophe O Soulage. The lipid peroxidation by-product 4-hydroxy-2-nonenal (4-HNE) induces insulin resistance in skeletal muscle through both carbonyl and oxidative stress. Endocrinology. 2012 May; 153(5):2099-111. doi: 10.1210/en.2011-1957. [PMID: 22396448]
  • Joan Smith Sonneborn. Alternative strategy for Alzheimer's disease: stress response triggers. International journal of Alzheimer's disease. 2012; 2012(?):684283. doi: 10.1155/2012/684283. [PMID: 22655213]
  • Ana Cecilia A X De-Oliveira, Renato S Carvalho, Flavio H M Paixão, Hellen S Tavares, Luciana S Gueiros, Carolina M Siqueira, Francisco J R Paumgartten. Up- and down-modulation of liver cytochrome P450 activities and associated events in two murine malaria models. Malaria journal. 2010 Mar; 9(?):81. doi: 10.1186/1475-2875-9-81. [PMID: 20307316]
  • Daniela Giustarini, Elena Perrino, Valerio Tazzari, Ranieri Rossi. HPLC determination of novel dithiolethione containing drugs and its application for in vivo studies in rats. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Feb; 878(3-4):340-6. doi: 10.1016/j.jchromb.2009.11.047. [PMID: 20006565]
  • Quynh T Tran, Lijing Xu, Vinhthuy Phan, Shirlean B Goodwin, Mostafizur Rahman, Victor X Jin, Carrie H Sutter, Bill D Roebuck, Thomas W Kensler, E Olusegun George, Thomas R Sutter. Chemical genomics of cancer chemopreventive dithiolethiones. Carcinogenesis. 2009 Mar; 30(3):480-6. doi: 10.1093/carcin/bgn292. [PMID: 19126641]
  • Zhenquan Jia, Bhaba R Misra, Hong Zhu, Yunbo Li, Hara P Misra. Upregulation of cellular glutathione by 3H-1,2-dithiole-3-thione as a possible treatment strategy for protecting against acrolein-induced neurocytotoxicity. Neurotoxicology. 2009 Jan; 30(1):1-9. doi: 10.1016/j.neuro.2008.11.007. [PMID: 19073213]
  • Hyun-Min Park, Jeong-Min Cho, Hyang-Rim Lee, Gi-seoung Shim, Mi-Kyoung Kwak. Renal protection by 3H-1,2-dithiole-3-thione against cisplatin through the Nrf2-antioxidant pathway. Biochemical pharmacology. 2008 Sep; 76(5):597-607. doi: 10.1016/j.bcp.2008.06.021. [PMID: 18656455]
  • Neal C Burton, Thomas W Kensler, Tomás R Guilarte. In vivo modulation of the Parkinsonian phenotype by Nrf2. Neurotoxicology. 2006 Dec; 27(6):1094-100. doi: 10.1016/j.neuro.2006.07.019. [PMID: 16959318]
  • Xiang Yu, Patricia A Egner, Junko Wakabayashi, Nobunao Wakabayashi, Masayuki Yamamoto, Thomas W Kensler. Nrf2-mediated induction of cytoprotective enzymes by 15-deoxy-Delta12,14-prostaglandin J2 is attenuated by alkenal/one oxidoreductase. The Journal of biological chemistry. 2006 Sep; 281(36):26245-52. doi: 10.1074/jbc.m604620200. [PMID: 16857669]
  • Yong Huang, Jian Yan, Ronald Lubet, Thomas W Kensler, Thomas R Sutter. Identification of novel transcriptional networks in response to treatment with the anticarcinogen 3H-1,2-dithiole-3-thione. Physiological genomics. 2006 Jan; 24(2):144-53. doi: 10.1152/physiolgenomics.00258.2005. [PMID: 16317079]
  • Steven P Anderson, Paul Howroyd, Jie Liu, Xun Qian, Rainer Bahnemann, Cynthia Swanson, Mi-Kyoung Kwak, Thomas W Kensler, J Christopher Corton. The transcriptional response to a peroxisome proliferator-activated receptor alpha agonist includes increased expression of proteome maintenance genes. The Journal of biological chemistry. 2004 Dec; 279(50):52390-8. doi: 10.1074/jbc.m409347200. [PMID: 15375163]
  • J Christopher Corton, Udayan Apte, Steven P Anderson, Pallavi Limaye, Lawrence Yoon, John Latendresse, Corrie Dunn, Jeffrey I Everitt, Kenneth A Voss, Cynthia Swanson, Carie Kimbrough, Jean S Wong, Sarjeet S Gill, Roshantha A S Chandraratna, Mi-Kyoung Kwak, Thomas W Kensler, Thomas M Stulnig, Knut R Steffensen, Jan-Ake Gustafsson, Harihara M Mehendale. Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors. The Journal of biological chemistry. 2004 Oct; 279(44):46204-12. doi: 10.1074/jbc.m406739200. [PMID: 15302862]
  • Mi-Kyoung Kwak, Nobunao Wakabayashi, Ken Itoh, Hozumi Motohashi, Masayuki Yamamoto, Thomas W Kensler. Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival. The Journal of biological chemistry. 2003 Mar; 278(10):8135-45. doi: 10.1074/jbc.m211898200. [PMID: 12506115]
  • Eric Le Ferrec, Dominique Lagadic-Gossmann, Claudine Rauch, Caroline Bardiau, Karine Maheo, Frederic Massiere, Marc Le Vee, Andre Guillouzo, Fabrice Morel. Transcriptional induction of CYP1A1 by oltipraz in human Caco-2 cells is aryl hydrocarbon receptor- and calcium-dependent. The Journal of biological chemistry. 2002 Jul; 277(27):24780-7. doi: 10.1074/jbc.m111319200. [PMID: 11959854]
  • M K Kwak, P A Egner, P M Dolan, M Ramos-Gomez, J D Groopman, K Itoh, M Yamamoto, T W Kensler. Role of phase 2 enzyme induction in chemoprotection by dithiolethiones. Mutation research. 2001 Sep; 480-481(?):305-15. doi: 10.1016/s0027-5107(01)00190-7. [PMID: 11506823]
  • L A Cohen, Z Zhao, B Pittman, C Aliaga, R Lubet. Feeding thiol-containing compounds, derived from vegetables, fails to inhibit N-methylnitrosourea-induced mammary tumorigenesis. Cancer detection and prevention. 2001; 25(3):254-61. doi: NULL. [PMID: 11425267]
  • E Elmore, T T Luc, H R Li, J A Buckmeier, V E Steele, G J Kelloff, J L Redpath. Correlation of chemopreventive efficacy data from the human epidermal cell assay with in vivo data. Anticancer research. 2000 Jan; 20(1A):27-32. doi: NULL. [PMID: 10769631]
  • G P Doherty, M K Leith, X Wang, T J Curphey, A Begleiter. Induction of DT-diaphorase by 1,2-dithiole-3-thiones in human tumour and normal cells and effect on anti-tumour activity of bioreductive agents. British journal of cancer. 1998 Apr; 77(8):1241-52. doi: 10.1038/bjc.1998.209. [PMID: 9579829]
  • D J Meyer, J M Harris, K S Gilmore, B Coles, T W Kensler, B Ketterer. Quantitation of tissue- and sex-specific induction of rat GSH transferase subunits by dietary 1,2-dithiole-3-thiones. Carcinogenesis. 1993 Apr; 14(4):567-72. doi: 10.1093/carcin/14.4.567. [PMID: 8472316]
  • J D Groopman, P DeMatos, P A Egner, A Love-Hunt, T W Kensler. Molecular dosimetry of urinary aflatoxin-N7-guanine and serum aflatoxin-albumin adducts predicts chemoprotection by 1,2-dithiole-3-thione in rats. Carcinogenesis. 1992 Jan; 13(1):101-6. doi: 10.1093/carcin/13.1.101. [PMID: 1733561]
  • J D Groopman, B D Roebuck, T W Kensler. Molecular dosimetry of aflatoxin DNA adducts in humans and experimental rat models. Progress in clinical and biological research. 1992; 374(?):139-55. doi: NULL. [PMID: 1320272]