Neferine (BioDeep_00000021674)
Main id: BioDeep_00000230514
human metabolite PANOMIX_OTCML-2023
代谢物信息卡片
4-[(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl]-2-({6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)phenol
化学式: C38H44N2O6 (624.3199204)
中文名称: 甲基莲心碱
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCC2=CC(=C(C=C2C1CC3=CC=C(C=C3)OC)OC4=C(C=CC(=C4)CC5C6=CC(=C(C=C6CCN5C)OC)OC)O)OC
InChI: InChI=1S/C38H44N2O6/c1-39-15-14-27-21-36(44-5)38(23-30(27)31(39)17-24-7-10-28(42-3)11-8-24)46-34-19-25(9-12-33(34)41)18-32-29-22-37(45-6)35(43-4)20-26(29)13-16-40(32)2/h7-12,19-23,31-32,41H,13-18H2,1-6H3
描述信息
Neferine is found in coffee and coffee products. Neferine is an alkaloid from the seed embryo of Nelumbo nucifera (East Indian lotus
Alkaloid from the seed embryo of Nelumbo nucifera (East Indian lotus). Neferine is found in coffee and coffee products.
Neferine is a major bisbenzylisoquinline alkaloid. Neferine strongly inhibits NF-κB activation.
Neferine is a major bisbenzylisoquinline alkaloid. Neferine strongly inhibits NF-κB activation.
同义名列表
7 个代谢物同义名
4-[(6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-1-yl)methyl]-2-({6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-1,2,3,4-tetrahydroisoquinolin-7-yl}oxy)phenol; 4-[(6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl)methyl]-2-({6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl}oxy)phenol; 12-O-Methylliensinine; CID 398793; Neferine; Neferin; (-)-Neferine
数据库引用编号
9 个数据库交叉引用编号
- PubChem: 398793
- HMDB: HMDB0034104
- ChEMBL: CHEMBL1986816
- KNApSAcK: C00053535
- foodb: FDB012368
- chemspider: 353522
- CAS: 2292-16-2
- PMhub: MS000068591
- medchemexpress: HY-N0441
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Huang Hongmei, Yang Maojun, L I Ting, Wang Dandan, L I Ying, Tang Xiaochi, Yuan Lu, G U Shi, X U Yong. Neferine inhibits the progression of diabetic nephropathy by modulating the miR-17-5p/nuclear factor E2-related factor 2 axis.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2024 Feb; 44(1):44-53. doi:
10.19852/j.cnki.jtcm.20231204.004. [PMID: 38213238] - Peng-Cheng Zhong, Zhi-Wen Liu, Qi-Chang Xing, Jia Chen, Rui-Pei Yang. Neferine inhibits the development of lung cancer cells by downregulating TGF-β to regulate MST1/ROS-induced pyroptosis.
The Kaohsiung journal of medical sciences.
2023 Sep; ?(?):. doi:
10.1002/kjm2.12752. [PMID: 37698291] - Cheng Lu, Bing Jiang, Jie Xu, Xuan Zhang, Nianxin Jiang. Neferine protected cardiomyocytes against hypoxia/oxygenation injury through SIRT1/Nrf2/HO-1 signaling.
Journal of biochemical and molecular toxicology.
2023 Aug; 37(8):e23398. doi:
10.1002/jbt.23398. [PMID: 37421224] - Ming-Yue Wang, Shao-Shi Zhang, Meng-Fei An, Yue-Fei Xia, Mao-Si Fan, Ze-Rui Sun, Li-Juan Zhang, Yun-Li Zhao, Jun Sheng, Xuan-Jun Wang. Neferine ameliorates nonalcoholic steatohepatitis through regulating AMPK pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Jun; 114(?):154798. doi:
10.1016/j.phymed.2023.154798. [PMID: 37031639] - Weiquan Zeng, Xiuli Zhang, Yao Lu, Ying Wen, Qiurong Xie, Xuan Yang, Shuyu He, Zhi Guo, Jiapeng Li, Aling Shen, Jun Peng. Neferine ameliorates hypertensive vascular remodeling modulating multiple signaling pathways in spontaneously hypertensive rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Feb; 158(?):114203. doi:
10.1016/j.biopha.2022.114203. [PMID: 36916429] - Po Hu, Peng Wan, Anna Xu, Binghui Yan, Chunmei Liu, Qixuan Xu, Zhenhuan Wei, Jingyi Xu, Siqi Liu, Guangming Yang, Yang Pan. Neferine, a novel ROCK1-targeting inhibitor, blocks EMT process and induces apoptosis in non-small cell lung cancer.
Journal of cancer research and clinical oncology.
2023 Feb; 149(2):553-566. doi:
10.1007/s00432-022-04280-y. [PMID: 35984492] - Tonggang Zhu, Xue Xiao, Yufu Dong, Chengbo Yuan. Neferine alleviates ovalbumin-induced asthma via MAPK signaling pathways in mice.
Allergologia et immunopathologia.
2023; 51(3):135-142. doi:
10.15586/aei.v51i3.840. [PMID: 37169571] - Jirakhamon Sengking, Chio Oka, Nuttapong Yawoot, Jiraporn Tocharus, Waraluck Chaichompoo, Apichart Suksamrarn, Chainarong Tocharus. Protective Effect of Neferine in Permanent Cerebral Ischemic Rats via Anti-Oxidative and Anti-Apoptotic Mechanisms.
Neurotoxicity research.
2022 Oct; 40(5):1348-1359. doi:
10.1007/s12640-022-00568-6. [PMID: 36018507] - Eun-Ae Kim, Ji Hoon Jang, Eon-Gi Sung, In-Hwan Song, Joo-Young Kim, Ho-Yong Sohn, Tae-Jin Lee. Neferine increases sensitivities to multiple anticancer drugs via downregulation of Bcl-2 expression in renal cancer cells.
Genes & genomics.
2022 02; 44(2):165-173. doi:
10.1007/s13258-021-01201-0. [PMID: 35034280] - Lohanathan Bharathi Priya, Chih-Yang Huang, Rouh-Mei Hu, Balamuralikrishnan Balasubramanian, Rathinasamy Baskaran. An updated review on pharmacological properties of neferine-A bisbenzylisoquinoline alkaloid from Nelumbo nucifera.
Journal of food biochemistry.
2021 12; 45(12):e13986. doi:
10.1111/jfbc.13986. [PMID: 34779018] - Nabila Jahan, Apu Chowdhury, Ting Li, Ke Xu, Fen Wei, Sicen Wang. Neferine improves oxidative stress and apoptosis in benign prostate hyperplasia via Nrf2-ARE pathway.
Redox report : communications in free radical research.
2021 Dec; 26(1):1-9. doi:
10.1080/13510002.2021.1871814. [PMID: 33416009] - Lin Hu, Yu Wang, Chang Shu, Jingjing Yu, Yueyue Chen, Yali Li, Ran Tao, Huiyuan Yang, Lei Dou. Pharmacokinetics, bioavailability and metabolism of neferine in rat by LC-MS/MS and LC-HRMS.
Biomedical chromatography : BMC.
2021 Nov; 35(11):e5193. doi:
10.1002/bmc.5193. [PMID: 34128252] - Yang Yang, Peng Yang, Cong Huang, Yuming Wu, Zhe Zhou, Xuejun Wang, Shengqi Wang. Inhibitory effect on SARS-CoV-2 infection of neferine by blocking Ca2+ -dependent membrane fusion.
Journal of medical virology.
2021 10; 93(10):5825-5832. doi:
10.1002/jmv.27117. [PMID: 34061377] - Jingxuan Wang, Yan Hu, Jieying Yuan, Yan Zhang, Yifan Wang, Yingshun Yang, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Zhizheng Zhuang, Fan Wu. Chemomodulatory effect of neferine on DMBA-induced squamous cell carcinogenesis: Biochemical and molecular approach.
Environmental toxicology.
2021 Apr; 36(4):460-471. doi:
10.1002/tox.23051. [PMID: 33156559] - Hong Li, Long Gao, Jie Min, Yucheng Yang, Ren Zhang. Neferine suppresses autophagy-induced inflammation, oxidative stress and adipocyte differentiation in Graves' orbitopathy.
Journal of cellular and molecular medicine.
2021 02; 25(4):1949-1957. doi:
10.1111/jcmm.15931. [PMID: 33443817] - Linhan Yang, Ying Xiong, Zhongli Sun, Xiaoying Lin, Huaikun Ni. Neferine Inhibits 7,12-Dimethylbenz(a)anthracene-Induced Mammary Tumorigenesis by Suppression of Cell Proliferation and Induction of Apoptosis via Modulation of the PI3K/AKT/NF-κB Signaling Pathway.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.
2021; 40(3):51-61. doi:
10.1615/jenvironpatholtoxicoloncol.2021038118. [PMID: 34587404] - Juan Li, Haiyan Chou, Lei Li, Hao Li, Zhengjun Cui. Wound healing activity of neferine in experimental diabetic rats through the inhibition of inflammatory cytokines and nrf-2 pathway.
Artificial cells, nanomedicine, and biotechnology.
2020 Dec; 48(1):96-106. doi:
10.1080/21691401.2019.1699814. [PMID: 31852261] - Xiao-Li Wu, Min-Zhen Deng, Zhi-Jie Gao, Yuan-Ye Dang, Yu-Cui Li, Chu-Wen Li. Neferine alleviates memory and cognitive dysfunction in diabetic mice through modulation of the NLRP3 inflammasome pathway and alleviation of endoplasmic-reticulum stress.
International immunopharmacology.
2020 Jul; 84(?):106559. doi:
10.1016/j.intimp.2020.106559. [PMID: 32402951] - Miey Park, Jinyoung Han, Hae-Jeung Lee. Anti-Adipogenic Effect of Neferine in 3T3-L1 Cells and Primary White Adipocytes.
Nutrients.
2020 Jun; 12(6):. doi:
10.3390/nu12061858. [PMID: 32580414] - Jingjing Chen, Mimi Tang, Manhua Liu, Yueping Jiang, Bin Liu, Shao Liu. Neferine and lianzixin extracts have protective effects on undifferentiated caffeine-damaged PC12 cells.
BMC complementary medicine and therapies.
2020 Mar; 20(1):76. doi:
10.1186/s12906-020-2872-2. [PMID: 32143612] - Shuaizeng Yin, Qin Ran, Jin Yang, Yuhua Zhao, Chenyu Li. Nootropic effect of neferine on aluminium chloride-induced Alzheimer's disease in experimental models.
Journal of biochemical and molecular toxicology.
2020 Feb; 34(2):e22429. doi:
10.1002/jbt.22429. [PMID: 31860774] - Shenao Chen, Bingxiang Chu, Yao Chen, Xun Cheng, Di Guo, Lihua Chen, Jiacheng Wang, Zhiyan Li, Zhenghua Hong, Dun Hong. Neferine suppresses osteoclast differentiation through suppressing NF-κB signal pathway but not MAPKs and promote osteogenesis.
Journal of cellular physiology.
2019 12; 234(12):22960-22971. doi:
10.1002/jcp.28857. [PMID: 31127627] - Yang-Shuo Tang, Yan-Hua Zhao, Yong Zhong, Xiao-Zhao Li, Jia-Xi Pu, Yan-Cheng Luo, Qiao-Ling Zhou. Neferine inhibits LPS-ATP-induced endothelial cell pyroptosis via regulation of ROS/NLRP3/Caspase-1 signaling pathway.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2019 Sep; 68(9):727-738. doi:
10.1007/s00011-019-01256-6. [PMID: 31172209] - Zhisheng Liu, Shenglin Zhang, Tingting Wang, Hui Shao, Junjie Gao, Ye Wang, Yunjie Ge. Neferine inhibits MDA-MB-231 cells growth and metastasis by regulating miR-374a/FGFR-2.
Chemico-biological interactions.
2019 Aug; 309(?):108716. doi:
10.1016/j.cbi.2019.06.029. [PMID: 31207222] - Eun-Ae Kim, Eon-Gi Sung, In-Hwan Song, Joo-Young Kim, Hwa-Jung Sung, Ho-Yong Sohn, Jong-Yi Park, Tae-Jin Lee. Neferine-induced apoptosis is dependent on the suppression of Bcl-2 expression via downregulation of p65 in renal cancer cells.
Acta biochimica et biophysica Sinica.
2019 Jul; 51(7):734-742. doi:
10.1093/abbs/gmz061. [PMID: 31187116] - Yalan Zhang, Yuhang Xiao, Qixing Dong, Wenjuan Ouyang, Qun Qin. Neferine in the Lotus Plumule Potentiates the Antitumor Effect of Imatinib in Primary Chronic Myeloid Leukemia Cells In Vitro.
Journal of food science.
2019 Apr; 84(4):904-910. doi:
10.1111/1750-3841.14484. [PMID: 30866043] - Kalaiselvi Sivalingam, Vinoth Amirthalingam, Karunagaran Ganasan, Chih-Yang Huang, Vijaya Padma Viswanadha. Neferine suppresses diethylnitrosamine-induced lung carcinogenesis in Wistar rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2019 Jan; 123(?):385-398. doi:
10.1016/j.fct.2018.11.014. [PMID: 30423403] - Abidullah Khan, Hongliang Bai, Maoguo Shu, Mingxia Chen, Amin Khan, Zhuanli Bai. Antioxidative and antiphotoaging activities of neferine upon UV-A irradiation in human dermal fibroblasts.
Bioscience reports.
2018 12; 38(6):. doi:
10.1042/bsr20181414. [PMID: 30355644] - Abidullah Khan, Hongliang Bai, Enqi Liu, Mingxia Chen, Chunshui Yu, Rui Wang, Amin Khan, Zhuanli Bai. Protective effect of neferine against UV-B-mediated oxidative damage in human epidermal keratinocytes.
The Journal of dermatological treatment.
2018 Nov; 29(7):733-741. doi:
10.1080/09546634.2018.1441490. [PMID: 29532689] - Shibu Marthandam Asokan, Ravichandran Mariappan, Shanmugavadivu Muthusamy, Bharath Kumar Velmurugan. Pharmacological benefits of neferine - A comprehensive review.
Life sciences.
2018 Apr; 199(?):60-70. doi:
10.1016/j.lfs.2018.02.032. [PMID: 29499283] - Lohanathan Bharathi Priya, Rathinasamy Baskaran, Chih-Yang Huang, Viswanadha Vijaya Padma. Neferine modulates IGF-1R/Nrf2 signaling in doxorubicin treated H9c2 cardiomyoblasts.
Journal of cellular biochemistry.
2018 02; 119(2):1441-1452. doi:
10.1002/jcb.26305. [PMID: 28731223] - Xiaxia Wu, Yanling Guo, Xiangjing Min, Lixia Pei, Xiuping Chen. Neferine, a Bisbenzylisoquinoline Alkaloid, Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis.
The American journal of Chinese medicine.
2018; 46(6):1263-1279. doi:
10.1142/s0192415x18500660. [PMID: 30149754] - Guang-Ming Yang, Jie Sun, Yang Pan, Jun-Li Zhang, Min Xiao, Min-Sheng Zhu. Isolation and identification of a tribenzylisoquinoline alkaloid from Nelumbo nucifera Gaertn, a novel potential smooth muscle relaxant.
Fitoterapia.
2018 Jan; 124(?):58-65. doi:
10.1016/j.fitote.2017.10.020. [PMID: 29108933] - Rathinasamy Baskaran, Lohanathan Bharathi Priya, Palanisamy Kalaiselvi, Paramasivan Poornima, Chih-Yang Huang, Viswanadha Vijaya Padma. Neferine from Nelumbo nucifera modulates oxidative stress and cytokines production during hypoxia in human peripheral blood mononuclear cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Sep; 93(?):730-736. doi:
10.1016/j.biopha.2017.07.003. [PMID: 28700977] - Hui Li, Yuling Tang, Long Wen, Xianglong Kong, Xuelian Chen, Ping Liu, Zhiguo Zhou, Wenhang Chen, Chenggen Xiao, Ping Xiao, Xiangcheng Xiao. Neferine reduces cisplatin-induced nephrotoxicity by enhancing autophagy via the AMPK/mTOR signaling pathway.
Biochemical and biophysical research communications.
2017 03; 484(3):694-701. doi:
10.1016/j.bbrc.2017.01.180. [PMID: 28161641] - Rathinasamy Baskaran, Paramasivan Poornima, Lohanathan Bharathi Priya, Chih-Yang Huang, Viswanadha Vijaya Padma. Neferine prevents autophagy induced by hypoxia through activation of Akt/mTOR pathway and Nrf2 in muscle cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2016 Oct; 83(?):1407-1413. doi:
10.1016/j.biopha.2016.08.063. [PMID: 27583981] - Xue Liu, Xiuhui Song, Jianjun Lu, Xueying Chen, Ershun Liang, Xiaoqiong Liu, Mingxiang Zhang, Yun Zhang, Zhanhui Du, Yuxia Zhao. Neferine inhibits proliferation and collagen synthesis induced by high glucose in cardiac fibroblasts and reduces cardiac fibrosis in diabetic mice.
Oncotarget.
2016 Sep; 7(38):61703-61715. doi:
10.18632/oncotarget.11225. [PMID: 27533252] - Limei Xu, Xiyu Zhang, Yinuo Li, Shuhua Lu, Shan Lu, Jieyin Li, Yuqiong Wang, Xiaoxue Tian, Jian-Jun Wei, Changshun Shao, Zhaojian Liu. Neferine induces autophagy of human ovarian cancer cells via p38 MAPK/ JNK activation.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2016 Jul; 37(7):8721-9. doi:
10.1007/s13277-015-4737-8. [PMID: 26738868] - Yangyang Yu, Shennan Sun, Shifeng Wang, Qiao Zhang, Ming Li, Feng Lan, Shiyou Li, Chunsheng Liu. Liensinine- and Neferine-Induced Cardiotoxicity in Primary Neonatal Rat Cardiomyocytes and Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes.
International journal of molecular sciences.
2016 Jan; 17(2):. doi:
10.3390/ijms17020186. [PMID: 26840304] - Yumi Sugimoto, Katsumi Nishimura, Atsuko Itoh, Takao Tanahashi, Hiroshi Nakajima, Hideo Oshiro, Shujian Sun, Takahiro Toda, Jun Yamada. Serotonergic mechanisms are involved in antidepressant-like effects of bisbenzylisoquinolines liensinine and its analogs isolated from the embryo of Nelumbo nucifera Gaertner seeds in mice.
The Journal of pharmacy and pharmacology.
2015 Dec; 67(12):1716-22. doi:
10.1111/jphp.12473. [PMID: 26246025] - Yong Zhao, Bent Håvard Hellum, Aihua Liang, Odd Georg Nilsen. Inhibitory Mechanisms of Human CYPs by Three Alkaloids Isolated from Traditional Chinese Herbs.
Phytotherapy research : PTR.
2015 Jun; 29(6):825-34. doi:
10.1002/ptr.5285. [PMID: 25640685] - Guoxin Hu, Ren-ai Xu, Yao-yao Dong, Yi-yan Wang, Wen-wen Yao, Zhi-chuan Chen, Dongxin Chen, Tiao Bu, Ren-shan Ge. Simultaneous determination of liensinine, isoliensinine and neferine in rat plasma by UPLC-MS/MS and application of the technique to pharmacokinetic studies.
Journal of ethnopharmacology.
2015 Apr; 163(?):94-8. doi:
10.1016/j.jep.2015.01.020. [PMID: 25636663] - Mo-Si Chen, Jia-Hua Zhang, Jia-Ling Wang, Lu Gao, Xiao-Xu Chen, Jun-Hua Xiao. Anti-fibrotic effects of neferine on carbon tetrachloride-induced hepatic fibrosis in mice.
The American journal of Chinese medicine.
2015; 43(2):231-40. doi:
10.1142/s0192415x15500159. [PMID: 25800905] - Qi Shen, Minjuan Zuo, Li Ma, Ye Tian, Lu Wang, Huidi Jiang, Quan Zhou, Hui Zhou, Lushan Yu, Su Zeng. Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity.
Chemico-biological interactions.
2014 Dec; 224(?):89-99. doi:
10.1016/j.cbi.2014.10.014. [PMID: 25451576] - Jie Dong, Shao Liu, Xing-lei Zhu, Xiao-tian Zhang, Yao Jiang. [Ti-AI intermetallic compound membrane refining Chinese medicinal materials extract].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2014 Sep; 37(9):1673-5. doi:
". [PMID: 25857171] - Paramasivan Poornima, Ching Feng Weng, Viswanadha Vijaya Padma. Neferine, an alkaloid from lotus seed embryo, inhibits human lung cancer cell growth by MAPK activation and cell cycle arrest.
BioFactors (Oxford, England).
2014 Jan; 40(1):121-31. doi:
10.1002/biof.1115. [PMID: 23983146] - Paramasivan Poornima, Ching Feng Weng, Viswanadha Vijaya Padma. Neferine from Nelumbo nucifera induces autophagy through the inhibition of PI3K/Akt/mTOR pathway and ROS hyper generation in A549 cells.
Food chemistry.
2013 Dec; 141(4):3598-605. doi:
10.1016/j.foodchem.2013.05.138. [PMID: 23993526] - Lushan Yu, Qi Shen, Quan Zhou, Huidi Jiang, Huichang Bi, Min Huang, Hui Zhou, Su Zeng. In vitro characterization of ABC transporters involved in the absorption and distribution of liensinine and its analogs.
Journal of ethnopharmacology.
2013 Nov; 150(2):485-91. doi:
10.1016/j.jep.2013.08.061. [PMID: 24036064] - Yong Xie, Yi Zhang, Long-Tao Zhang, Shao-Xiao Zeng, Ze-Bin Guo, Bao-Dong Zheng. Protective effects of alkaloid compounds from Nelumbinis Plumula on tert-butyl hydroperoxide-induced oxidative stress.
Molecules (Basel, Switzerland).
2013 Aug; 18(9):10285-300. doi:
10.3390/molecules180910285. [PMID: 24064445] - Chang-He Niu, Yong Wang, Jing-Di Liu, Jia-Ling Wang, Jun-Hua Xiao. Protective effects of neferine on amiodarone-induced pulmonary fibrosis in mice.
European journal of pharmacology.
2013 Aug; 714(1-3):112-9. doi:
10.1016/j.ejphar.2013.06.004. [PMID: 23792144] - Jin-Soo Yoon, Hwa-Mi Kim, Anandam Kasin Yadunandam, Nan-Hee Kim, Hyun-Ah Jung, Jae-Sue Choi, Chi-Yeon Kim, Gun-Do Kim. Neferine isolated from Nelumbo nucifera enhances anti-cancer activities in Hep3B cells: molecular mechanisms of cell cycle arrest, ER stress induced apoptosis and anti-angiogenic response.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2013 Aug; 20(11):1013-22. doi:
10.1016/j.phymed.2013.03.024. [PMID: 23746959] - Ya-Jun Zhou, Ji-Zhou Xiang, Hongjin Yuan, Hui Liu, Qiang Tang, Hong-Zhen Hao, Zhao Yin, Jialing Wang, Zhang-Yin Ming. Neferine exerts its antithrombotic effect by inhibiting platelet aggregation and promoting dissociation of platelet aggregates.
Thrombosis research.
2013 Aug; 132(2):202-10. doi:
10.1016/j.thromres.2013.05.018. [PMID: 23773522] - Gurusamy Lalitha, Paramasivan Poornima, Arjunan Archanah, Viswanadha Vijaya Padma. Protective effect of neferine against isoproterenol-induced cardiac toxicity.
Cardiovascular toxicology.
2013 Jun; 13(2):168-79. doi:
10.1007/s12012-012-9196-5. [PMID: 23274852] - Guilin Li, Hong Xu, Shuanghua Zhu, Wenyuan Xu, Shulan Qin, Shuangmei Liu, Guihua Tu, Haiying Peng, Shuyi Qiu, Shicheng Yu, Qicheng Zhu, Bo Fan, Chaoran Zheng, Guodong Li, Shangdong Liang. Effects of neferine on CCL5 and CCR5 expression in SCG of type 2 diabetic rats.
Brain research bulletin.
2013 Jan; 90(?):79-87. doi:
10.1016/j.brainresbull.2012.10.002. [PMID: 23063706] - Hui-Jun Pan, Xu-Qiang Nie, Duo Liu, Ka Bian. [Effects of four kinds of Chinese medicine monomer on growth of PANC-1 xenograft tumor and studying of molecular mechanism].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2013 Jan; 38(2):245-8. doi:
. [PMID: 23672050] - Yong Zhao, Bent Håvard Hellum, Aihua Liang, Odd Georg Nilsen. The in vitro inhibition of human CYP1A2, CYP2D6 and CYP3A4 by tetrahydropalmatine, neferine and berberine.
Phytotherapy research : PTR.
2012 Feb; 26(2):277-83. doi:
10.1002/ptr.3554. [PMID: 21678521] - J Wang, Q Kan, J Li, X Zhang, Y Qi. Effect of neferine on liver ischemia-reperfusion injury in rats.
Transplantation proceedings.
2011 Sep; 43(7):2536-9. doi:
10.1016/j.transproceed.2011.04.013. [PMID: 21911119] - Chenghui Huang, Yaping Li, Peiguo Cao, Zhaoxia Xie, Zhiqiang Qin. Synergistic effect of hyperthermia and neferine on reverse multidrug resistance in adriamycin-resistant SGC7901/ADM gastric cancer cells.
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