(±)-Leptophos (BioDeep_00000021402)

   

human metabolite Endogenous


代谢物信息卡片


O-4-Bromo-2,5-dichlorophenyl O-methyl phenylphosphonothioic acid

化学式: C13H10BrCl2O2PS (409.869953)
中文名称: 对溴磷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COP(=S)(C1=CC=CC=C1)OC2=CC(=C(C=C2Cl)Br)Cl
InChI: InChI=1S/C13H10BrCl2O2PS/c1-17-19(20,9-5-3-2-4-6-9)18-13-8-11(15)10(14)7-12(13)16/h2-8H,1H3

描述信息

(±)-Leptophos is an Agricultural insecticide, now supersede
D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals

同义名列表

6 个代谢物同义名

O-4-Bromo-2,5-dichlorophenyl O-methyl phenylphosphonothioic acid; O-4-bromo-2,5-dichlorophenyl O-methyl phenylphosphonothioate; (±)-Leptophos; LEPTOPHOS; Phosvel; Leptophos



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • John E Casida. The greening of pesticide-environment interactions: some personal observations. Environmental health perspectives. 2012 Apr; 120(4):487-93. doi: 10.1289/ehp.1104405. [PMID: 22472325]
  • Hiroyuki Kojima, Fumihiro Sata, Shinji Takeuchi, Tatsuya Sueyoshi, Tadanori Nagai. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb; 280(3):77-87. doi: 10.1016/j.tox.2010.11.008. [PMID: 21115097]
  • Daniel Jun, Lucie Musilova, Miroslav Pohanka, Young-Sik Jung, Pavel Bostik, Kamil Kuca. Reactivation of human acetylcholinesterase and butyrylcholinesterase inhibited by leptophos-oxon with different oxime reactivators in vitro. International journal of molecular sciences. 2010 Aug; 11(8):2856-63. doi: 10.3390/ijms11082856. [PMID: 21152278]
  • Larry L Needham. Assessing exposure to organophosphorus pesticides by biomonitoring in epidemiologic studies of birth outcomes. Environmental health perspectives. 2005 Apr; 113(4):494-8. doi: 10.1289/ehp.7490. [PMID: 15811842]
  • Jui-Hung Yen, Chia Chun Tsai, Yei Shung Wang. Separation and toxicity of enantiomers of organophosphorus insecticide leptophos. Ecotoxicology and environmental safety. 2003 Jun; 55(2):236-42. doi: 10.1016/s0147-6513(02)00066-0. [PMID: 12742374]
  • T Yamauchi, K Katoh, N Konno, M Fukushima. Delayed neurotoxicity and toxicokinetics of leptophos in hens given repeatedly by low-dose intravenous injections. The Journal of toxicological sciences. 1989 Feb; 14(1):11-21. doi: 10.2131/jts.14.11. [PMID: 2472490]
  • Y Yamaguchi. [Pharmacokinetics of the organophosphorous insecticide leptophos in the hen]. Nihon eiseigaku zasshi. Japanese journal of hygiene. 1989 Feb; 43(6):1159-68. doi: 10.1265/jjh.43.1159. [PMID: 2473232]
  • D J Hoffman, L Sileo, H C Murray. Subchronic organophosphorus ester-induced delayed neurotoxicity in mallards. Toxicology and applied pharmacology. 1984 Aug; 75(1):128-36. doi: 10.1016/0041-008x(84)90083-8. [PMID: 6205472]
  • E E Enan, A H El-Sebae, O H Enan, S El-Fiki. In-vivo interaction of some organophosphorus insecticides with different biochemical targets in white rats. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 1982; 17(5):549-70. doi: 10.1080/03601238209372341. [PMID: 6184393]
  • M B Abou-Donia. Metabolism and pharmacokinetics of a single oral dose of O-4-bromo-2,5-dichlorophenyl O-methyl phenylphosphonothioate (Leptophos) in hens. Toxicology and applied pharmacology. 1980 Aug; 55(1):131-45. doi: 10.1016/0041-008x(80)90229-x. [PMID: 6158766]
  • M A Hussain, P C Oloffs. Neurotoxic effects of leptophos (PhosvelR) in chickens and rats following chronic low-level feeding. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 1979; 14(4):367-82. doi: 10.1080/03601237909372135. [PMID: 89138]
  • N Konno, H Kinebuchi. Residues of phosvel in plasma and in adipose tissue of hens after single oral administration. Toxicology and applied pharmacology. 1978 Aug; 45(2):541-7. doi: 10.1016/0041-008x(78)90116-3. [PMID: 81542]
  • A H El-Sebae, N S Ahmed, S A Soliman. Effect of pre-exposure on acute toxicity of organophosphorus insecticides to white mice. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 1978; 13(1):11-24. doi: 10.1080/03601237809372074. [PMID: 75904]
  • D E Bradway, T M Shafik, E M Lores. Comparison of cholinesterase activity, residue levels, and urinary metabolite excretion of rats exposed to organophosphorus pesticides. Journal of agricultural and food chemistry. 1977 Nov; 25(6):1353-8. doi: 10.1021/jf60214a007. [PMID: 72085]
  • D M Whitacre, M Badie, B A Schwemmer, L I Diaz. Metabolism of 14C-leptophos and 14C-4-bromo-2,5-dichlorophenol in rats: a multiple dosing study. Bulletin of environmental contamination and toxicology. 1976 Dec; 16(6):689-96. doi: 10.1007/bf01685574. [PMID: 65192]
  • M B Abou-Donia. Pharmacokinetics of a neurotoxic oral dose of leptophos in hens. Archives of toxicology. 1976 Oct; 36(2):103-10. doi: 10.1007/bf00351968. [PMID: 64240]