Ethoxyacetic acid (BioDeep_00000021042)

 

Secondary id: BioDeep_00000616794

human metabolite PANOMIX_OTCML-2023 Endogenous Volatile Flavor Compounds natural product


代谢物信息卡片


ETHOXYACETIC ACID (egmee (110-80-5))

化学式: C4H8O3 (104.0473418)
中文名称: 乙氧基乙酸, 乙氧乙酸
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 92.31%

分子结构信息

SMILES: CCOCC(=O)O
InChI: InChI=1S/C4H8O3/c1-2-7-3-4(5)6/h2-3H2,1H3,(H,5,6)

描述信息

Ethoxyacetic acid is found in herbs and spices. Ethoxyacetic acid is a component of perilla leaf extract (Perilla frutescens
Component of perilla leaf extract (Perilla frutescens). Ethoxyacetic acid is found in herbs and spices.
Ethoxyacetic acid is an endogenous metabolite.

同义名列表

14 个代谢物同义名

ETHOXYACETIC ACID (egmee (110-80-5)); Glycolic acid ethyl ether; Ethoxy-acetic acid anion; acetic acid, ethoxy-; Ethoxy-acetate anion; O-Ethylglycolic acid; 2-Ethoxy-acetic acid; 2-Ethoxyacetic acid; Ethoxy-acetic acid; Ethoxy acetic acid; ETHOXYACETIC ACID; 2-Ethoxyacetate; Ethoxyacetate; Ethoxyacetic acid



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Anne-Claire Binter, Elise Bannier, Grégory Simon, Dave Saint-Amour, Jean-Christophe Ferré, Christian Barillot, Christine Monfort, Sylvaine Cordier, Cécile Chevrier, Fabienne Pelé. Prenatal exposure to glycol ethers and motor inhibition function evaluated by functional MRI at the age of 10 to 12 years in the PELAGIE mother-child cohort. Environment international. 2019 12; 133(Pt A):105163. doi: 10.1016/j.envint.2019.105163. [PMID: 31518935]
  • Tomáš Hložek, Miroslava Bursová, Pavel Coufal, Radomír Čabala. Identification and quantification of acidosis inducing metabolites in cases of alcohols intoxication by GC-MS for emergency toxicology. Journal of pharmaceutical and biomedical analysis. 2015 Oct; 114(?):16-21. doi: 10.1016/j.jpba.2015.04.039. [PMID: 26001161]
  • Ronan Garlantézec, Luc Multigner, Laurence Labat, Nathalie Bonvallot, Juha Pulkkinen, Brigitte Dananché, Christine Monfort, Florence Rouget, Sylvaine Cordier. Urinary biomarkers of exposure to glycol ethers and chlorinated solvents during pregnancy: determinants of exposure and comparison with indirect methods of exposure assessment. Occupational and environmental medicine. 2012 Jan; 69(1):62-70. doi: 10.1136/oem.2010.062315. [PMID: 21705463]
  • Didik Priyandoko, Tetsuro Ishii, Sunil C Kaul, Renu Wadhwa. Ashwagandha leaf derived withanone protects normal human cells against the toxicity of methoxyacetic acid, a major industrial metabolite. PloS one. 2011 May; 6(5):e19552. doi: 10.1371/journal.pone.0019552. [PMID: 21573189]
  • Rui-Sheng Wang, Katsumi Ohtani, Megumi Suda, Kyoko Kitagawa, Keiichi Nakayama, Toshihiro Kawamoto, Tamie Nakajima. Reproductive toxicity of ethylene glycol monoethyl ether in Aldh2 knockout mice. Industrial health. 2007 Aug; 45(4):574-8. doi: 10.2486/indhealth.45.574. [PMID: 17878629]
  • Nanqin Li, Ih Chu, Raymond Poon, Mike G Wade. Gas chromatography analysis of urinary alkoxyacetic acids as biomarkers of exposure to aliphatic alkyl ethers. Journal of analytical toxicology. 2006 May; 30(4):252-7. doi: 10.1093/jat/30.4.252. [PMID: 16803663]
  • Rui-Sheng Wang, Megumi Suda, Xing Gao, Bingling Wang, Tamie Nakajima, Takeshi Honma. Health effects of exposure to ethylene glycol monoethyl ether in female workers. Industrial health. 2004 Oct; 42(4):447-51. doi: 10.2486/indhealth.42.447. [PMID: 15540629]
  • Hong Soon Choi, Jun Ho Park, Jae Seok Song, Yong Bong Cho. Determination of urinary metabolites of alkyl cellosolves by solid phase extraction and GC/FID. Journal of occupational health. 2004 Jul; 46(4):260-5. doi: 10.1539/joh.46.260. [PMID: 15308824]
  • David J Lockley, Douglas Howes, Faith M Williams. Percutaneous penetration and metabolism of 2-ethoxyethanol. Toxicology and applied pharmacology. 2002 Apr; 180(2):74-82. doi: 10.1006/taap.2002.9373. [PMID: 11969374]
  • Wilbur Johnson. Final report on the safety assessment of ethoxyethanol and ethoxyethanol acetate. International journal of toxicology. 2002; 21 Suppl 1(?):9-62. doi: 10.1080/10915810290096388. [PMID: 12042060]
  • T S Shih, J S Chou, C Y Chen, T J Smith. Improved method to measure urinary alkoxyacetic acids. Occupational and environmental medicine. 1999 Jul; 56(7):460-7. doi: 10.1136/oem.56.7.460. [PMID: 10472317]
  • J Liesivuori, J Laitinen, H Savolainen. Rat model for renal effects of 2-alkoxyalcohols and their acetates. Archives of toxicology. 1999 Jun; 73(4-5):229-32. doi: 10.1007/s002040050611. [PMID: 10463388]
  • L Aasmoe, M Mathiesen, G Sager. Elimination of methoxyacetic acid and ethoxyacetic acid in rat. Xenobiotica; the fate of foreign compounds in biological systems. 1999 Apr; 29(4):417-24. doi: 10.1080/004982599238597. [PMID: 10375010]
  • W G Chung, I J Yu, C S Park, K H Lee, H K Roh, Y N Cha. Decreased formation of ethoxyacetic acid from ethylene glycol monoethyl ether and reduced atrophy of testes in male rats upon combined administration with toluene and xylene. Toxicology letters. 1999 Jan; 104(1-2):143-50. doi: 10.1016/s0378-4274(98)00357-9. [PMID: 10048760]
  • L Aasmoe, J Aarbakke. Gender difference in the elimination of 2-methoxyethanol, methoxyacetic acid and ethoxyacetic acid in rat. Xenobiotica; the fate of foreign compounds in biological systems. 1997 Dec; 27(12):1237-44. doi: 10.1080/004982597239822. [PMID: 9460229]
  • NULL. Reproductive toxicology. Ethoxyacetic acid. Environmental health perspectives. 1997 Feb; 105 Suppl 1(?):211-2. doi: NULL. [PMID: 9114290]
  • B Söhnlein, S Letzel, D Weltle, H W Rüdiger, J Angerer. Occupational chronic exposure to organic solvents. XIV. Examinations concerning the evaluation of a limit value for 2-ethoxyethanol and 2-ethoxyethyl acetate and the genotoxic effects of these glycol ethers. International archives of occupational and environmental health. 1993; 64(7):479-84. doi: 10.1007/bf00381095. [PMID: 8482587]
  • H Veulemans, O Steeno, R Masschelein, D Groeseneken. Exposure to ethylene glycol ethers and spermatogenic disorders in man: a case-control study. British journal of industrial medicine. 1993 Jan; 50(1):71-8. doi: 10.1136/oem.50.1.71. [PMID: 8431394]
  • L K Lowry, D A Stumpp, C Orbaugh, F Rieders. Applications of biological monitoring in occupational health practice: practical application of urinary 2-ethoxyacetic acid to assess exposure to 2-ethoxyethyl acetate in large format silk-screening operations. International archives of occupational and environmental health. 1993; 65(1 Suppl):S47-51. doi: 10.1007/bf00381307. [PMID: 8406938]
  • T Sakai, T Araki, Y Masuyama. Determination of urinary alkoxyacetic acids by a rapid and simple method for biological monitoring of workers exposed to glycol ethers and their acetates. International archives of occupational and environmental health. 1993; 64(7):495-8. doi: 10.1007/bf00381097. [PMID: 8482589]
  • J M Ratcliffe, S M Schrader, D E Clapp, W E Halperin, T W Turner, R W Hornung. Semen quality in workers exposed to 2-ethoxyethanol. British journal of industrial medicine. 1989 Jun; 46(6):399-406. doi: 10.1136/oem.46.6.399. [PMID: 2818974]
  • D Groeseneken, H Veulemans, R Masschelein, E Van Vlem. An improved method for the determination in urine of alkoxyacetic acids. International archives of occupational and environmental health. 1989; 61(4):249-54. doi: 10.1007/bf00381422. [PMID: 2722248]
  • D Groeseneken, H Veulemans, R Masschelein, E Van Vlem. Comparative urinary excretion of ethoxyacetic acid in man and rat after single low doses of ethylene glycol monoethyl ether. Toxicology letters. 1988 Apr; 41(1):57-68. doi: 10.1016/0378-4274(88)90008-2. [PMID: 3358271]
  • L K Lowry. The biological exposure index: its use in assessing chemical exposures in the workplace. Toxicology. 1987 Dec; 47(1-2):55-69. doi: 10.1016/0300-483x(87)90160-0. [PMID: 3686532]
  • D Groeseneken, H Veulemans, R Masschelein, E Van Vlem. Ethoxyacetic acid: a metabolite of ethylene glycol monoethyl ether acetate in man. British journal of industrial medicine. 1987 Jul; 44(7):488-93. doi: 10.1136/oem.44.7.488. [PMID: 3620374]
  • H Veulemans, D Groeseneken, R Masschelein, E Van Vlem. Field study of the urinary excretion of ethoxyacetic acid during repeated daily exposure to the ethyl ether of ethylene glycol and the ethyl ether of ethylene glycol acetate. Scandinavian journal of work, environment & health. 1987 Jun; 13(3):239-42. doi: 10.5271/sjweh.2058. [PMID: 3616552]
  • P M Foster, S C Lloyd, D M Blackburn. Comparison of the in vivo and in vitro testicular effects produced by methoxy-, ethoxy- and N-butoxy acetic acids in the rat. Toxicology. 1987 Jan; 43(1):17-30. doi: 10.1016/0300-483x(87)90071-0. [PMID: 3810650]
  • D Groeseneken, H Veulemans, R Masschelein. Urinary excretion of ethoxyacetic acid after experimental human exposure to ethylene glycol monoethyl ether. British journal of industrial medicine. 1986 Sep; 43(9):615-9. doi: 10.1136/oem.43.9.615. [PMID: 3756113]
  • D Groeseneken, E van Vlem, H Veulemans, R Masschelein. Gas chromatographic determination of methoxyacetic and ethoxyacetic acid in urine. British journal of industrial medicine. 1986 Jan; 43(1):62-5. doi: 10.1136/oem.43.1.62. [PMID: 3947564]
  • A W Smallwood, K E DeBord, L K Lowry. Analyses of ethylene glycol monoalkyl ethers and their proposed metabolites in blood and urine. Environmental health perspectives. 1984 Aug; 57(?):249-53. doi: 10.1289/ehp.8457249. [PMID: 6499809]
  • P M Foster, D M Creasy, J R Foster, T J Gray. Testicular toxicity produced by ethylene glycol monomethyl and monoethyl ethers in the rat. Environmental health perspectives. 1984 Aug; 57(?):207-17. doi: 10.1289/ehp.8457207. [PMID: 6499806]