PIP(20:0/22:6(4Z,7Z,10Z,13E,15E,19Z)-OH(17)) (BioDeep_00000204530)

   

human metabolite


代谢物信息卡片


{[(1R,5S)-2,3,4,6-tetrahydroxy-5-({hydroxy[(2R)-2-{[(4Z,7Z,10Z,13E,15E,19Z)-17-hydroxydocosa-4,7,10,13,15,19-hexaenoyl]oxy}-3-(icosanoyloxy)propoxy]phosphoryl}oxy)cyclohexyl]oxy}phosphonic acid

化学式: C51H88O17P2 (1034.5496)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: [H][C@@](COC(=O)CCCCCCCCCCCCCCCCCCC)(COP(O)(=O)O[C@H]1C(O)C(O)C(O)[C@@H](OP(O)(O)=O)C1O)OC(=O)CC\C=C/C\C=C/C\C=C/C\C=C\C=C\C(O)C\C=C/CC
InChI: InChI=1S/C51H88O17P2/c1-3-5-7-8-9-10-11-12-13-14-15-18-21-24-27-30-34-38-44(53)64-40-43(41-65-70(62,63)68-51-48(57)46(55)47(56)50(49(51)58)67-69(59,60)61)66-45(54)39-35-31-28-25-22-19-16-17-20-23-26-29-33-37-42(52)36-32-6-4-2/h6,17,19-20,22,26,28-29,31-33,37,42-43,46-52,55-58H,3-5,7-16,18,21,23-25,27,30,34-36,38-41H2,1-2H3,(H,62,63)(H2,59,60,61)/b20-17-,22-19-,29-26+,31-28-,32-6-,37-33+/t42?,43-,46?,47?,48?,49?,50-,51+/m1/s1

描述信息

PIP(20:0/22:6(4Z,7Z,10Z,13E,15E,19Z)-OH(17)) is an oxidized phosphatidylinositol phosphate (PIP). As other PIPs, oxidized phosphatidylinositol phosphates are acidic (anionic) phospholipids that consist of a phosphatidic acid backbone, linked via the phosphate group to a phosphorylated inositol (hexahydroxycyclohexane). Phosphatidylinositol phosphates are generated from phosphatidylinositols, which are phosphorylated by a number of different kinases that place the phosphate moiety on positions 4 and 5 of the inositol ring, although position 3 can also be phosphorylated. Phosphatidylinositol phosphates can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. PIP(20:0/22:6(4Z,7Z,10Z,13E,15E,19Z)-OH(17)), in particular, consists of one chain of eicosanoyl at the C-1 position and one chain of 17-hydroxy-docosahexaenoyl at the C-2 position. The most important phosphatidylinositol phosphate in both quantitative and biological terms is phosphatidylinositol 4-phosphate. Phosphatidylinositol and the phosphatidylinositol phosphates are the main source of diacylglycerols that serve as signaling molecules, via the action of phospholipase C enzymes. Phosphatidylinositol phosphates are usually present at low levels only in tissues, typically at about 1 to 3\\% of the concentration of phosphatidylinositol.

同义名列表

4 个代谢物同义名

{[(1R,5S)-2,3,4,6-tetrahydroxy-5-({hydroxy[(2R)-2-{[(4Z,7Z,10Z,13E,15E,19Z)-17-hydroxydocosa-4,7,10,13,15,19-hexaenoyl]oxy}-3-(icosanoyloxy)propoxy]phosphoryl}oxy)cyclohexyl]oxy}phosphonic acid; [(1R,5S)-2,3,4,6-tetrahydroxy-5-{[hydroxy((2R)-2-{[(4Z,7Z,10Z,13E,15E,19Z)-17-hydroxydocosa-4,7,10,13,15,19-hexaenoyl]oxy}-3-(icosanoyloxy)propoxy)phosphoryl]oxy}cyclohexyl]oxyphosphonic acid; {[(1R,5S)-2,3,4,6-tetrahydroxy-5-({hydroxy[(2R)-2-{[(4Z,7Z,13E,15E,19Z)-17-hydroxydocosa-4,7,10,13,15,19-hexaenoyl]oxy}-3-(icosanoyloxy)propoxy]phosphoryl}oxy)cyclohexyl]oxy}phosphonate; PIP(20:0/22:6(4Z,7Z,10Z,13E,15E,19Z)-OH(17))



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代谢反应

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