1-Cyano-2-hydroxy-3-butene (BioDeep_00000020390)

   

human metabolite Endogenous natural product


代谢物信息卡片


3-Acetyl-6-hydroxy-4-phenylbenzo[4,5]furo[2,3-b]pyridine

化学式: C5H7NO (97.0528)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=CC(CC#N)O
InChI: InChI=1S/C5H7NO/c1-2-5(7)3-4-6/h2,5,7H,1,3H2

描述信息

Potential neutriceutica

同义名列表

7 个代谢物同义名

3-Acetyl-6-hydroxy-4-phenylbenzo[4,5]furo[2,3-b]pyridine; 3-Hydroxy-4-pentenenitrile, 9ci; 1-Cyano-2-hydroxy-3-butene; 3-hydroxypent-4-enenitrile; 1-Cyano-3-buten-2-ol; Elbfluorene; Crambene



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

17 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Amy L Usborne, Aaron T Smith, Steven K Engle, David E Watson, John M Sullivan, Jennie L Walgren. Biomarkers of exocrine pancreatic injury in 2 rat acute pancreatitis models. Toxicologic pathology. 2014 Jan; 42(1):195-203. doi: 10.1177/0192623313512030. [PMID: 24285669]
  • Claudia Voelckel, Mehdi Mirzaei, Michael Reichelt, Zhiwei Luo, Dana Pascovici, Peter B Heenan, Silvia Schmidt, Bart Janssen, Paul A Haynes, Peter J Lockhart. Transcript and protein profiling identify candidate gene sets of potential adaptive significance in New Zealand Pachycladon. BMC evolutionary biology. 2010 May; 10(?):151. doi: 10.1186/1471-2148-10-151. [PMID: 20482888]
  • Eszter Bohus, Akos Rácz, Béla Noszál, Muireann Coen, Olaf Beckonert, Hector C Keun, Timothy M D Ebbels, Glenn H Cantor, John A Wijsman, Elaine Holmes, John C Lindon, Jeremy K Nicholson. Metabonomic investigations into the global biochemical sequelae of exposure to the pancreatic toxin 1-cyano-2-hydroxy-3-butene in the rat. Magnetic resonance in chemistry : MRC. 2009 Dec; 47 Suppl 1(?):S26-35. doi: 10.1002/mrc.2485. [PMID: 19639609]
  • Jennie L Walgren, Michael D Mitchell, Laurence O Whiteley, David C Thompson. Identification of novel peptide safety markers for exocrine pancreatic toxicity induced by cyanohydroxybutene. Toxicological sciences : an official journal of the Society of Toxicology. 2007 Mar; 96(1):174-83. doi: 10.1093/toxsci/kfl189. [PMID: 17169978]
  • Jennie L Walgren, Michael D Mitchell, Laurence O Whiteley, David C Thompson. Evaluation of two novel peptide safety markers for exocrine pancreatic toxicity. Toxicological sciences : an official journal of the Society of Toxicology. 2007 Mar; 96(1):184-93. doi: 10.1093/toxsci/kfl190. [PMID: 17169977]
  • Yang Cao, Sharmila Adhikari, Abel Damien Ang, Marie Véronique Clément, Matthew Wallig, Madhav Bhatia. Crambene induces pancreatic acinar cell apoptosis via the activation of mitochondrial pathway. American journal of physiology. Gastrointestinal and liver physiology. 2006 Jul; 291(1):G95-G101. doi: 10.1152/ajpgi.00520.2005. [PMID: 16603484]
  • Matthew A Wallig, Kathleen M Heinz-Taheny, Donna L Epps, Tamara Gossman. Synergy among phytochemicals within crucifers: does it translate into chemoprotection?. The Journal of nutrition. 2005 12; 135(12 Suppl):2972S-2977S. doi: 10.1093/jn/135.12.2972s. [PMID: 16317157]
  • Chu Won Nho, Elizabeth Jeffery. Crambene, a bioactive nitrile derived from glucosinolate hydrolysis, acts via the antioxidant response element to upregulate quinone reductase alone or synergistically with indole-3-carbinol. Toxicology and applied pharmacology. 2004 Jul; 198(1):40-8. doi: 10.1016/j.taap.2004.02.012. [PMID: 15207647]
  • Rong Tsao, Chris J Peterson, Joel R Coats. Glucosinolate breakdown products as insect fumigants and their effect on carbon dioxide emission of insects. BMC ecology. 2002 Mar; 2(?):5. doi: 10.1186/1472-6785-2-5. [PMID: 11914158]
  • T E Niedoborski, B P Klein, M A Wallig. Rapid isolation and purification of 1-cyano-2-hydroxy-3-butene (crambene) from Crambe abyssinica seed meal using immiscible solvent extraction and high-performance liquid chromatography. Journal of agricultural and food chemistry. 2001 Aug; 49(8):3594-9. doi: 10.1021/jf001366y. [PMID: 11513634]
  • C W Nho, E Jeffery. The synergistic upregulation of phase II detoxification enzymes by glucosinolate breakdown products in cruciferous vegetables. Toxicology and applied pharmacology. 2001 Jul; 174(2):146-52. doi: 10.1006/taap.2001.9207. [PMID: 11446830]
  • M A Wallig, S Kingston, R Staack, E H Jefferey. Induction of rat pancreatic glutathione S-transferase and quinone reductase activities by a mixture of glucosinolate breakdown derivatives found in Brussels sprouts. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1998 May; 36(5):365-73. doi: 10.1016/s0278-6915(97)00156-7. [PMID: 9662411]
  • P Kloss, E Jeffery, M Tumbleson, Y Zhang, C Parsons, M Wallig. Studies on the toxic effects of crambe meal and two of its constituents, 1-cyano-2-hydroxy-3-butene (CHB) and epi-progoitrin, in broiler chick diets. British poultry science. 1996 Dec; 37(5):971-86. doi: 10.1080/00071669608417928. [PMID: 9034587]
  • M A Davis, M A Wallig, D Eaton, K I Borroz, E H Jeffery. Differential effect of cyanohydroxybutene on glutathione synthesis in liver and pancreas of male rats. Toxicology and applied pharmacology. 1993 Dec; 123(2):257-64. doi: 10.1006/taap.1993.1244. [PMID: 7902618]
  • M A Davis, M A Wallig, E H Jeffery. In vitro metabolism of cyanohydroxybutene: formation of a glutathione-S-transferase catalyzed product. Research communications in chemical pathology and pharmacology. 1993 Mar; 79(3):343-53. doi: . [PMID: 8480079]
  • M A Wallig, A M Kore, J Crawshaw, E H Jeffery. Separation of the toxic and glutathione-enhancing effects of the naturally occurring nitrile, cyanohydroxybutene. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1992 Nov; 19(4):598-606. doi: 10.1016/0272-0590(92)90099-4. [PMID: 1385240]
  • M Maher, G Chernenko, J A Barrowman. The acute pancreatotoxic effects of the plant nitrile 1-cyano-2-hydroxy-3-butene. Pancreas. 1991 Mar; 6(2):168-74. doi: 10.1097/00006676-199103000-00007. [PMID: 1886886]
  • M A Wallig, E H Jeffery. Enhancement of pancreatic and hepatic glutathione levels in rats during cyanohydroxybutene intoxication. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1990 Jan; 14(1):144-59. doi: 10.1016/0272-0590(90)90240-k. [PMID: 2307313]
  • M A Wallig, D H Gould, J van Steenhouse, M J Fettman, C C Willhite. The relationship of vehicle to target organ toxicology induced by the naturally occurring nitrile 1-cyano-2-hydroxy-3-butene. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1989 Apr; 12(3):377-85. doi: 10.1016/0272-0590(89)90013-4. [PMID: 2731654]
  • M A Wallig, D H Gould, M J Fettman. Selective pancreato-toxicity in the rat induced by the naturally occurring plant nitrile 1-cyano-2-hydroxy-3-butene. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1988 Feb; 26(2):137-47. doi: 10.1016/0278-6915(88)90110-x. [PMID: 2452775]