PIP(20:4(5E,8Z,12Z,14Z)-OH(11R)/16:1(9Z)) (BioDeep_00000203536)

   

human metabolite


代谢物信息卡片


{[(1R,3S)-3-({[(2R)-2-[(9Z)-hexadec-9-enoyloxy]-3-{[(5E,8Z,11S,12Z,14Z)-11-hydroxyicosa-5,8,12,14-tetraenoyl]oxy}propoxy](hydroxy)phosphoryl}oxy)-2,4,5,6-tetrahydroxycyclohexyl]oxy}phosphonic acid

化学式: C45H78O17P2 (952.4714)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: [H][C@@](COC(=O)CCC\C=C\C\C=C/C[C@H](O)\C=C/C=C\CCCCC)(COP(O)(=O)O[C@H]1C(O)C(O)C(O)[C@@H](OP(O)(O)=O)C1O)OC(=O)CCCCCCC\C=C/CCCCCC
InChI: InChI=1S/C45H78O17P2/c1-3-5-7-9-11-12-13-14-15-16-20-25-29-33-39(48)60-37(35-59-64(56,57)62-45-42(51)40(49)41(50)44(43(45)52)61-63(53,54)55)34-58-38(47)32-28-24-21-17-19-23-27-31-36(46)30-26-22-18-10-8-6-4-2/h12-13,17-18,21-23,26-27,30,36-37,40-46,49-52H,3-11,14-16,19-20,24-25,28-29,31-35H2,1-2H3,(H,56,57)(H2,53,54,55)/b13-12-,21-17+,22-18-,27-23-,30-26-/t36-,37-,40?,41?,42?,43?,44-,45+/m1/s1

描述信息

PIP(20:4(5E,8Z,12Z,14Z)-OH(11R)/16:1(9Z)) is an oxidized phosphatidylinositol phosphate (PIP). As other PIPs, oxidized phosphatidylinositol phosphates are acidic (anionic) phospholipids that consist of a phosphatidic acid backbone, linked via the phosphate group to a phosphorylated inositol (hexahydroxycyclohexane). Phosphatidylinositol phosphates are generated from phosphatidylinositols, which are phosphorylated by a number of different kinases that place the phosphate moiety on positions 4 and 5 of the inositol ring, although position 3 can also be phosphorylated. Phosphatidylinositol phosphates can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. PIP(20:4(5E,8Z,12Z,14Z)-OH(11R)/16:1(9Z)), in particular, consists of one chain of 11-Hydroxyeicosatetraenoyl at the C-1 position and one chain of 9Z-hexadecenoyl at the C-2 position. The most important phosphatidylinositol phosphate in both quantitative and biological terms is phosphatidylinositol 4-phosphate. Phosphatidylinositol and the phosphatidylinositol phosphates are the main source of diacylglycerols that serve as signaling molecules, via the action of phospholipase C enzymes. Phosphatidylinositol phosphates are usually present at low levels only in tissues, typically at about 1 to 3\\% of the concentration of phosphatidylinositol.

同义名列表

4 个代谢物同义名

{[(1R,3S)-3-({[(2R)-2-[(9Z)-hexadec-9-enoyloxy]-3-{[(5E,8Z,11S,12Z,14Z)-11-hydroxyicosa-5,8,12,14-tetraenoyl]oxy}propoxy](hydroxy)phosphoryl}oxy)-2,4,5,6-tetrahydroxycyclohexyl]oxy}phosphonic acid; {[(1R,3S)-3-({[(2R)-2-[(9Z)-hexadec-9-enoyloxy]-3-{[(5E,8Z,11S,12Z,14Z)-11-hydroxyicosa-5,8,12,14-tetraenoyl]oxy}propoxy](hydroxy)phosphoryl}oxy)-2,4,5,6-tetrahydroxycyclohexyl]oxy}phosphonate; [(1R,3S)-3-{[(2R)-2-[(9Z)-hexadec-9-enoyloxy]-3-{[(5E,8Z,11S,12Z,14Z)-11-hydroxyicosa-5,8,12,14-tetraenoyl]oxy}propoxy(hydroxy)phosphoryl]oxy}-2,4,5,6-tetrahydroxycyclohexyl]oxyphosphonic acid; PIP(20:4(5E,8Z,12Z,14Z)-OH(11R)/16:1(9Z))



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代谢反应

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1 个相关的物种来源信息

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