rofecoxib (BioDeep_00000002026)
代谢物信息卡片
rofecoxib
化学式: C17H14O4S (314.06127640000005)
中文名称: 罗非昔布
谱图信息:
最多检出来源 Rattus norvegicus(viridiplantae) 12.12%
分子结构信息
SMILES: CS(=O)(=O)C1=CC=C(C=C1)C2=C(C(=O)OC2)C3=CC=CC=C3
InChI: InChI=1S/C17H14O4S/c1-22(19,20)14-9-7-12(8-10-14)15-11-21-17(18)16(15)13-5-3-2-4-6-13/h2-10H,11H2,1H3
描述信息
M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AH - Coxibs
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
D004791 - Enzyme Inhibitors > D016861 - Cyclooxygenase Inhibitors > D052246 - Cyclooxygenase 2 Inhibitors
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor > C80509 - COX-2 Inhibitor
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
COVID info from COVID-19 Disease Map
D000893 - Anti-Inflammatory Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:8887
- KEGG: C07590
- KEGGdrug: D00568
- PubChem: 5090
- Metlin: METLIN43844
- DrugBank: DB00533
- ChEMBL: CHEMBL122
- CAS: 162011-90-7
- MoNA: FiehnHILIC002972
- MoNA: FiehnHILIC002309
- MoNA: FiehnHILIC001497
- PMhub: MS000001702
- PubChem: 9792
- PDB-CCD: RCX
- NIKKAJI: J1.041.252H
- RefMet: Rofecoxib
- KNApSAcK: 8887
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- S Kwiecień, D Wojcik-Grzybek, Z Sliwowski, A Targosz, A Chmura, K Magierowska, M Strzalka, U Glowacka, A Ptak-Belowska, M Magierowski, T Brzozowski. Inhibition of endogenous nitric oxide activity impairs the colonic sparing effect of rofecoxib, the cyclooxygenase-2 inhibitor and resveratrol, the preferential cyclooxygenase-1 inhibitor in the course of experimental colitis. Role of oxidative stress biomarkers and proinflammatory cytokines.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2023 Oct; 74(5):. doi:
10.26402/jpp.2023.5.08. [PMID: 38085520] - Yongbo Wei, Wei Liu, Zexin Wang, Nannan Chen, Jingming Zhou, Tong Wu, Yuqiu Ye, Yanbing Ke, Hong Jiang, Xin Zhai, Lijun Xie. Facile Transformation from Rofecoxib to a New Near-Infrared Lipid Droplet Fluorescent Probe and Its Investigations on AIE Property, Solvatochromism and Mechanochromism.
Molecules (Basel, Switzerland).
2023 Feb; 28(4):. doi:
10.3390/molecules28041814. [PMID: 36838802] - Xinli Wang, Liwei Chen, Renfu Li, Zuoxu Xie, Ming Hu, Shitao Sun, Zhenli Li, Jinle Hao, Bin Lin, Xueyuan Chen, Lijun Xie. Development of Rofecoxib-Based Fluorophores from ACQ to AIE by Positional Regioisomerization.
ChemPlusChem.
2022 04; 87(4):e202100522. doi:
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Cell reports.
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Current pharmaceutical design.
2011; 17(16):1541-51. doi:
10.2174/138161211796197043. [PMID: 21548865] - Khaled M Elokely, Mohamed A Eldawy, Mohamed A Elkersh, Tarek F El-Moselhy. Fluorescence Spectrometric Determination of Drugs Containing α-Methylene Sulfone/Sulfonamide Functional Groups Using N-Methylnicotinamide Chloride as a Fluorogenic Agent.
International journal of analytical chemistry.
2011; 2011(?):840178. doi:
10.1155/2011/840178. [PMID: 21647288] - Ragia Hegazy, Mohamed Alashhab, Madiha Amin. Cardiorenal Effects of Newer NSAIDs (Celecoxib) versus Classic NSAIDs (Ibuprofen) in Patients with Arthritis.
Journal of toxicology.
2011; 2011(?):862153. doi:
10.1155/2011/862153. [PMID: 21776267] - Vanisree Mulabagal, Ruby L Alexander-Lindo, David L Dewitt, Muraleedharan G Nair. Health-Beneficial Phenolic Aldehyde in Antigonon leptopus Tea.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):601249. doi:
10.1093/ecam/nep041. [PMID: 19454555] - Takashi Oite. Exploring the mechanisms of renoprotection against progressive glomerulosclerosis.
Proceedings of the Japan Academy. Series B, Physical and biological sciences.
2011; 87(3):81-90. doi:
10.2183/pjab.87.81. [PMID: 21422741] - H Păunescu, O A Coman, L Coman, I Ghiţă, S R Georgescu, F Drăghia, I Fulga. Cannabinoid system and cyclooxygenases inhibitors.
Journal of medicine and life.
2011 Jan; 4(1):11-20. doi:
". [PMID: 21505570] - Kari Almendingen, Laila N Larsen, Olav Fausa, Jorunn Bratlie, Arne T Høstmark, Lars Aabakken. Selective COX-2 inhibition affects fatty acids, but not COX mRNA expression in patients with FAP.
Familial cancer.
2010 Dec; 9(4):571-80. doi:
10.1007/s10689-010-9365-2. [PMID: 20593240] - J-H Juang, C-H Kuo. Effects of cyclooxygenase-2 inhibitor and adenosine triphosphate-sensitive potassium channel opener in syngeneic mouse islet transplantation.
Transplantation proceedings.
2010 Dec; 42(10):4221-4. doi:
10.1016/j.transproceed.2010.09.086. [PMID: 21168669] - Abigail Davis, Michael Gilhooley, Mark Agius. Using non-steroidal anti-inflammatory drugs in the treatment of depression.
Psychiatria Danubina.
2010 Nov; 22 Suppl 1(?):S49-52. doi:
NULL. [PMID: 21057403] - Krishanu Sengupta, Alluri V Krishnaraju, Amar A Vishal, Artatrana Mishra, Golakoti Trimurtulu, Kadainti V S Sarma, Smriti K Raychaudhuri, Siba P Raychaudhuri. Comparative efficacy and tolerability of 5-Loxin and AflapinAgainst osteoarthritis of the knee: a double blind, randomized, placebo controlled clinical study.
International journal of medical sciences.
2010 Nov; 7(6):366-77. doi:
10.7150/ijms.7.366. [PMID: 21060724] - Piet Borgdorff, M Louis Handoko, Yeun Ying Wong, Geert Jan Tangelder. COX-2 Inhibition by Use of Rofecoxib or High Dose Aspirin Enhances ADP-Induced Platelet Aggregation in Fresh Blood.
The open cardiovascular medicine journal.
2010 Oct; 4(?):198-205. doi:
10.2174/1874192401004010198. [PMID: 21331307] - Włodzimierz Matysiak, Barbara Jodłowska-Jedrych. Does administration of non-steroidal anti-inflammatory drug determine morphological changes in adrenal cortex: ultrastructural studies.
Protoplasma.
2010 Oct; 246(1-4):109-18. doi:
10.1007/s00709-010-0194-9. [PMID: 20721677] - Jun-Yan Liu, Ning Li, Jun Yang, Nan Li, Hong Qiu, Ding Ai, Nipavan Chiamvimonvat, Yi Zhu, Bruce D Hammock. Metabolic profiling of murine plasma reveals an unexpected biomarker in rofecoxib-mediated cardiovascular events.
Proceedings of the National Academy of Sciences of the United States of America.
2010 Sep; 107(39):17017-22. doi:
10.1073/pnas.1011278107. [PMID: 20837537] - Masahide Hamaguchi, Takahiro Seno, Aihiro Yamamoto, Masataka Kohno, Masatoshi Kadoya, Hidetaka Ishino, Eishi Ashihara, Shinya Kimura, Yoshinori Tsubakimoto, Hiroki Takata, Toshikazu Yoshikawa, Taira Maekawa, Yutaka Kawahito. Loxoprofen Sodium, a Non-Selective NSAID, Reduces Atherosclerosis in Mice by Reducing Inflammation.
Journal of clinical biochemistry and nutrition.
2010 Sep; 47(2):138-47. doi:
10.3164/jcbn.10-33. [PMID: 20838569] - Bing H Wang, Micka C Bertucci, Jian Yang Ma, Anastasia Adrahtas, Raymond Y Cheung, Henry Krum. Celecoxib, but not rofecoxib or naproxen, attenuates cardiac hypertrophy and fibrosis induced in vitro by angiotensin and aldosterone.
Clinical and experimental pharmacology & physiology.
2010 Sep; 37(9):912-8. doi:
10.1111/j.1440-1681.2010.05405.x. [PMID: 20497423] - Swagata Tripathy, Suresh Chandra Dash. Etoricoxib-induced life-threatening hyperkalemia and acute kidney dysfunction against the background of telmisartan and a low sodium diet.
International journal of emergency medicine.
2010 Aug; 3(4):443-6. doi:
10.1007/s12245-010-0208-6. [PMID: 21373319] - Hsin-Wei Kuo, Shang-Shyue Tsai, Mao-Meng Tiao, Yi-Chun Liu, I-Ming Lee, Chun-Yuh Yang. Analgesic use and the risk for progression of chronic kidney disease.
Pharmacoepidemiology and drug safety.
2010 Jul; 19(7):745-51. doi:
10.1002/pds.1962. [PMID: 20582905] - Elvira L Massó González, Paola Patrignani, Stefania Tacconelli, Luis A García Rodríguez. Variability among nonsteroidal antiinflammatory drugs in risk of upper gastrointestinal bleeding.
Arthritis and rheumatism.
2010 Jun; 62(6):1592-601. doi:
10.1002/art.27412. [PMID: 20178131] - David Z I Cherney, Judith A Miller, James W Scholey, Rania Nasrallah, Richard L Hébert, Maria G Dekker, Cameron Slorach, Etienne B Sochett, Timothy J Bradley. Renal hyperfiltration is a determinant of endothelial function responses to cyclooxygenase 2 inhibition in type 1 diabetes.
Diabetes care.
2010 Jun; 33(6):1344-6. doi:
10.2337/dc09-2340. [PMID: 20332349] - Anil Kumar, Ruchika Garg, Atish K Prakash. Effect of St. John's Wort (Hypericum perforatum) treatment on restraint stress-induced behavioral and biochemical alteration in mice.
BMC complementary and alternative medicine.
2010 May; 10(?):18. doi:
10.1186/1472-6882-10-18. [PMID: 20459658] - Donatella Boschi, Clara Cena, Antonella Di Stilo, Barbara Rolando, Paola Manzini, Roberta Fruttero, Alberto Gasco. Nitrooxymethyl-substituted analogues of rofecoxib: synthesis and pharmacological characterization.
Chemistry & biodiversity.
2010 May; 7(5):1173-82. doi:
10.1002/cbdv.200900421. [PMID: 20491074] - Johannes W J Bijlsma. Patient benefit-risk in arthritis--a rheumatologist's perspective.
Rheumatology (Oxford, England).
2010 May; 49 Suppl 2(?):ii11-17. doi:
10.1093/rheumatology/keq057. [PMID: 20407136] - Shepherd R Singer, Michal Amit-Kohn, Samuel Weiss, Jonathan Rosenblum, Guy Maoz, Noah Samuels, Esther Lukasiewicz, Laurence Freedman, Ora Paltiel, Menachem Itzchaki, Meir Niska, Menachem Oberbaum. Traumeel S for pain relief following hallux valgus surgery: a randomized controlled trial.
BMC clinical pharmacology.
2010 Apr; 10(?):9. doi:
10.1186/1472-6904-10-9. [PMID: 20380750] - Estelle Marrer, Frank Dieterle. Impact of biomarker development on drug safety assessment.
Toxicology and applied pharmacology.
2010 Mar; 243(2):167-79. doi:
10.1016/j.taap.2009.12.015. [PMID: 20036272] - Kyung Hee Choi, Ah Jeong Kim, In Ja Son, Kyung-Hwan Kim, Ki-Bong Kim, Hyuk Ahn, Eun Bong Lee. Risk factors of drug interaction between warfarin and nonsteroidal anti-inflammatory drugs in practical setting.
Journal of Korean medical science.
2010 Mar; 25(3):337-41. doi:
10.3346/jkms.2010.25.3.337. [PMID: 20191029] - Rahila Ahmad Pathan, Bhulan Kumar Singh, K K Pillai, Kiran Dubey. Naproxen aggravates doxorubicin-induced cardiomyopathy in rats.
Indian journal of pharmacology.
2010 Feb; 42(1):44-9. doi:
10.4103/0253-7613.62411. [PMID: 20606837] - Anil Kumar, Beenta Kumari, Puneet Kumar. Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress.
Neuroscience bulletin.
2010 Feb; 26(1):17-27. doi:
10.1007/s12264-010-0713-x. [PMID: 20101269] - Bertold Renner, Josef Zacher, Asokumar Buvanendran, Gerrit Walter, Jochen Strauss, Kay Brune. Absorption and distribution of etoricoxib in plasma, CSF, and wound tissue in patients following hip surgery--a pilot study.
Naunyn-Schmiedeberg's archives of pharmacology.
2010 Feb; 381(2):127-36. doi:
10.1007/s00210-009-0482-0. [PMID: 20052461] - Fatih Kose, Ayberk Besen, Saime Paydas, Mustafa Balal, Gulfiliz Gonlusen, Tamer Inal, Ayse Dogan, Mustafa Kibar. Effects of selective Cox-2 inhibitor, rofecoxib, alone or combination with furosemide on renal functions and renal Cox-2 expression in rats.
Clinical and experimental nephrology.
2010 Feb; 14(1):22-7. doi:
10.1007/s10157-009-0214-2. [PMID: 19789943] - Eng-Tat Ang, Yee-Kit Tai, Shun-Qiang Lo, Raymond Seet, Tuck-Wah Soong. Neurodegenerative diseases: exercising toward neurogenesis and neuroregeneration.
Frontiers in aging neuroscience.
2010; 2(?):. doi:
10.3389/fnagi.2010.00025. [PMID: 20725635] - K Almendingen, A T Høstmark, L N Larsen, O Fausa, J Bratlie, L Aabakken. Relationship between Fecal Content of Fatty Acids and Cyclooxygenase mRNA Expression and Fatty Acid Composition in Duodenal Biopsies, Serum Lipoproteins, and Dietary Fat in Colectomized Familial Adenomatous Polyposis Patients.
Journal of nutrition and metabolism.
2010; 2010(?):862569. doi:
10.1155/2010/862569. [PMID: 21052495] - Amit Gupta, Ashish Dhir, Anil Kumar, S K Kulkarni. Protective effect of cyclooxygenase (COX)-inhibitors against drug-induced catatonia and MPTP-induced striatal lesions in rats.
Pharmacology, biochemistry, and behavior.
2009 Dec; 94(2):219-26. doi:
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Molecular pharmacology.
2009 Nov; 76(5):942-5. doi:
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Vascular pharmacology.
2009 Oct; 51(4):275-83. doi:
10.1016/j.vph.2009.07.002. [PMID: 19635586] - Thorsten J Maier, Susanne Schiffmann, Ivonne Wobst, Kerstin Birod, Carlo Angioni, Marika Hoffmann, Jakob J Lopez, Clemens Glaubitz, Dieter Steinhilber, Gerd Geisslinger, Sabine Grösch. Cellular membranes function as a storage compartment for celecoxib.
Journal of molecular medicine (Berlin, Germany).
2009 Oct; 87(10):981-93. doi:
10.1007/s00109-009-0506-8. [PMID: 19641861] - Jean-Philippe Lafrance, Donald R Miller. Selective and non-selective non-steroidal anti-inflammatory drugs and the risk of acute kidney injury.
Pharmacoepidemiology and drug safety.
2009 Oct; 18(10):923-31. doi:
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Acta orthopaedica.
2009 Oct; 80(5):597-605. doi:
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Methods and findings in experimental and clinical pharmacology.
2009 Sep; 31(7):423-32. doi:
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The Journal of pharmacology and experimental therapeutics.
2009 Sep; 330(3):964-70. doi:
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BMC neuroscience.
2009 Aug; 10(?):108. doi:
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PloS one.
2009 Aug; 4(8):e6646. doi:
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Inflammopharmacology.
2009 Aug; 17(4):211-9. doi:
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