Peroxynitrite (BioDeep_00000019607)
Secondary id: BioDeep_00000011437, BioDeep_00001872734
human metabolite Endogenous Volatile Flavor Compounds
代谢物信息卡片
化学式: HNO3 (62.9956436)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: N(=O)OO
InChI: InChI=1S/HNO3/c2-1-4-3/h3H
描述信息
Peroxynitrite is a potent oxidant synthesized by the cell during its normal metabolism. The peroxynitrite anion (ONOO-) is a reactive species produced in the reaction between the superoxide anion (O2*-) and nitric oxide (*NO). Peroxynitrite (ONOO-) is a strong oxidation and nitration agent, which damages DNA, proteins and other cellular structures. ONOO- is involved in several pathological conditions such as inflammation, arteriosclerosis, and neurodegenerative and cardiovascular disorders. ONOO- inhibits different steps of blood platelet activation and causes the depletion of platelet thiols. (PMID 15647782) [HMDB]
Peroxynitrite is a potent oxidant synthesized by the cell during its normal metabolism. The peroxynitrite anion (ONOO-) is a reactive species produced in the reaction between the superoxide anion (O2*-) and nitric oxide (*NO). Peroxynitrite (ONOO-) is a strong oxidation and nitration agent, which damages DNA, proteins and other cellular structures. ONOO- is involved in several pathological conditions such as inflammation, arteriosclerosis, and neurodegenerative and cardiovascular disorders. ONOO- inhibits different steps of blood platelet activation and causes the depletion of platelet thiols. (PMID 15647782).
同义名列表
20 个代谢物同义名
Peroxynitrous acid, potassium salt; (1-)Oxidoperoxidonitrate; Acids, peroxynitrous; Peroxynitrosyl (NO3); Acid, peroxynitrous; Peroxynitrous acids; (-)Oxoperoxonitrate; Peroxynitrous acid; hydroxy nitrite; Peroxynitrites; Peroxonitrites; Peroxynitrate; Peroxonitrite; Peroxynitrite; Azoperoxoite; [No(oo)](-); Pernitrite; [NO(OOH)]; HNO(O2); Peroxynitrite
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:25942
- KEGG: C16845
- PubChem: 123349
- HMDB: HMDB0002179
- ChEMBL: CHEMBL1794794
- Wikipedia: Peroxynitrite
- MeSH: Peroxynitrous Acid
- foodb: FDB022889
- chemspider: 109951
- CAS: 14691-52-2
- CAS: 19059-14-4
- PMhub: MS000025433
- ChEBI: CHEBI:25941
- PubChem: 96023369
- NIKKAJI: J672.821I
- KNApSAcK: 25941
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(2)
- Amyotrophic lateral sclerosis (ALS):
L-Arginine ⟶ NO
- Amyotrophic lateral sclerosis (ALS):
L-Arginine ⟶ NO
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Xiongbo Liu, Jiali Zhu, Qiangsheng Zhang, Hao Hu, Wei Zhang, Hui Xu, Yan Huang, Jialin Xie, Hongtao Liu, Yan Feng, Jianwei Li, Chunman Jia. Multifunctional fluorescent probe for simultaneous revealing Cys and ONOO- dynamic correlation in the ferroptosis.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2024 Jul; 315(?):124248. doi:
10.1016/j.saa.2024.124248
. [PMID: 38599026] - Ruixin Liu, Haijing Jiang, Wenjie Yang, Zhijuan Zheng, Xiaoming Wang, Zhenhua Tian, Danyang Wang, Dongfang Kan, Dan Zhang, Zhixin Tang. Peroxynitrite imaging in ferroptosis-mediated drug-induced liver injury with a near-infrared fluorescence probe.
Analytica chimica acta.
2024 Jun; 1309(?):342673. doi:
10.1016/j.aca.2024.342673
. [PMID: 38772656] - Feiyan Liu, Manman Li, Weixia Li, Yingjie Ren, Mingliang Zhang, Hui Zhang, Pan Wang, Yali Wu, Kehan Wang, Xiaoyan Wang, Xiaofei Chen, Jinfa Tang. Peroxynitrite-activated fluorescent probe with two reaction triggers for pathological diagnosis and therapeutic evaluation of inflammation.
Bioorganic chemistry.
2024 Jun; 147(?):107362. doi:
10.1016/j.bioorg.2024.107362
. [PMID: 38615474] - María A Muñoz-Vargas, Jorge Taboada, Salvador González-Gordo, José M Palma, Francisco J Corpas. Characterization of leucine aminopeptidase (LAP) activity in sweet pepper fruits during ripening and its inhibition by nitration and reducing events.
Plant cell reports.
2024 Mar; 43(4):92. doi:
10.1007/s00299-024-03179-x
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Endocrine journal.
2024 Feb; 71(2):119-127. doi:
10.1507/endocrj.ej23-0355
. [PMID: 38220201] - Shijing Li, Abdul Hadi Mehmood, Xiaochan Tang, Tao Yue, Baoli Dong. Development of bishydrazide-based fluorescent probes for the imaging of cellular peroxynitrite (ONOO-) during ferroptosis.
Analytical methods : advancing methods and applications.
2024 Feb; 16(9):1409-1414. doi:
10.1039/d4ay00022f
. [PMID: 38369924] - Kittipot Sirichaiwetchakoon, Griangsak Eumkeb. Free radical scavenging and anti-isolated human LDL oxidation activities of Butea superba Roxb. extract.
BMC complementary medicine and therapies.
2024 Feb; 24(1):75. doi:
10.1186/s12906-024-04373-w
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Luminescence : the journal of biological and chemical luminescence.
2024 Feb; 39(2):e4697. doi:
10.1002/bio.4697
. [PMID: 38388787] - Luciano Cardoso Santos, Jeane Martinha Dos Anjos Cordeiro, Maria Clara da Silva Galrão Cunha, Bianca Reis Santos, Luciana Santos de Oliveira, Adriana Lopes da Silva, Erikles Macêdo Barbosa, Raquel Vieira Niella, Gustavo José Cota de Freitas, Daniel de Assis Santos, Rogéria Serakides, Natália de Melo Ocarino, Stephanie Carvalho Borges, Mário Sérgio Lima de Lavor, Juneo Freitas Silva. Kisspeptin-10 Improves Testicular Redox Status but Does Not Alter the Unfolded Protein Response (UPR) That Is Downregulated by Hypothyroidism in a Rat Model.
International journal of molecular sciences.
2024 Jan; 25(3):. doi:
10.3390/ijms25031514
. [PMID: 38338793] - Shikai Liu, Wenting Li, He Ding, Boshi Tian, Linyang Fang, Xudong Zhao, Ruoxi Zhao, Baichao An, Lianfei Ding, Lei Zhong, Piaoping Yang. Biomineralized RuO2 Nanozyme with Multi-Enzyme Activity for Ultrasound-Triggered Peroxynitrite-Boosted Ferroptosis.
Small (Weinheim an der Bergstrasse, Germany).
2023 Nov; 19(45):e2303057. doi:
10.1002/smll.202303057
. [PMID: 37434100] - Yasuko Sakihama, Takashi Kato, Sopanat Sawatdee, Yo Yakushi, Junichi Asano, Hiroyo Hayashi, Yuya Goto, Makoto Hashimoto, Yasuyuki Hashidoko. Isolation of High-Purity Betanin from Red Beet and Elucidation of Its Antioxidant Activity against Peroxynitrite: An in vitro Study.
International journal of molecular sciences.
2023 Oct; 24(20):. doi:
10.3390/ijms242015411
. [PMID: 37895092] - Pooja Singh, Saumya Jaiswal, Ajayraj Kushwaha, Priya Gahlowt, Vipul Mishra, Durgesh Kumar Tripathi, Surendra Pratap Singh, Ravi Gupta, Vijay Pratap Singh. Peroxynitrite is essential for aerenchyma formation in rice roots under waterlogging conditions.
Planta.
2023 May; 258(1):2. doi:
10.1007/s00425-023-04148-6
. [PMID: 37208534] - Nannan Wang, Xiaoyan Lu, Jiamin Wang, Han Wang, Bo Zhang, Weili Zhao, Jian Zhang. Quasi-LD-Targeted and ONOO--Responsive Fluorescent Probe for Investigating the Interaction of Nonalcoholic Fatty Liver with Drug-Induced Liver Injury.
Analytical chemistry.
2023 04; 95(14):5967-5975. doi:
10.1021/acs.analchem.2c05674
. [PMID: 36987570] - Li-Jun Yang, Jia-Bei He, Yu Jiang, Jianzhong Li, Zhen-Wei Zhou, Chuan Zhang, Xia Tao, Alex F Chen, Cheng Peng, He-Hui Xie. Berberine hydrochloride inhibits migration ability via increasing inducible NO synthase and peroxynitrite in HTR-8/SVneo cells.
Journal of ethnopharmacology.
2023 Apr; 305(?):116087. doi:
10.1016/j.jep.2022.116087
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Analytical chemistry.
2023 04; 95(13):5747-5753. doi:
10.1021/acs.analchem.3c00007
. [PMID: 36951754] - Mangmang Sang, Yibo Huang, Zhiwei Liu, Gang Li, Yan Wang, Zhenwei Yuan, Cuilian Dai, Jinrong Zheng. Peroxynitrite/Lipid Droplet Sequence-Activated Dual-Lock Fluorescent Probes Enable Precise Intraoperative Imaging of Atherosclerotic Plaques.
ACS sensors.
2023 Feb; 8(2):893-903. doi:
10.1021/acssensors.2c02590
. [PMID: 36757333] - Ayşe Nur Demiryürek, Özge Göktürk, Ahmet Saracaloglu, Seniz Demiryürek, Abdullah Tuncay Demiryürek. Protective effects of verbenalin and (+)-eudesmin against 6-hydroxydopamine-induced oxidative/nitrosative stress in SH-SY5Y cells.
Molecular biology reports.
2023 Jan; 50(1):331-338. doi:
10.1007/s11033-022-08039-z
. [PMID: 36331750] - Harrison Dulin, Nathan Hendricks, Duo Xu, Linfeng Gao, Keidy Wuang, Huiwang Ai, Rong Hai. Impact of Protein Nitration on Influenza Virus Infectivity and Immunogenicity.
Microbiology spectrum.
2022 12; 10(6):e0190222. doi:
10.1128/spectrum.01902-22
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Journal of experimental botany.
2022 11; 73(19):6853-6875. doi:
10.1093/jxb/erac341
. [PMID: 35981877] - Ling Ma, Qianqian Yang, Qi Zan, Haiyan Tian, Xiaohua Zhang, Chuan Dong, Li Fan. A benzothiazole-based fluorescence probe for imaging of peroxynitrite during ferroptosis and diagnosis of tumor tissues.
Analytical and bioanalytical chemistry.
2022 Nov; 414(27):7753-7762. doi:
10.1007/s00216-022-04307-w
. [PMID: 36053345] - Baotang Shi, Huiling Wang, Xingxia Wan, Yu Guo, Shi-Yu Liu, Quan Gong. A novel 'dual-locked' fluorescent probe for ONOO- and viscosity enables serum-based rapid disease screening.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 Oct; 278(?):121375. doi:
10.1016/j.saa.2022.121375
. [PMID: 35588605] - L Farhan Bdaiwi, L Abd ALmunim Baker, S Zuher Jalal Aldin. Investigation of the Effect of Rhubarb stalks extracts on Mice Exposed to Oxidative Stress.
Archives of Razi Institute.
2022 10; 77(5):1865-1871. doi:
10.22092/ari.2022.358160.2164
. [PMID: 37123167] - Justyna Nawrocka, Kamil Szymczak, Aleksandra Maćkowiak, Monika Skwarek-Fadecka, Urszula Małolepsza. Determination of Reactive Oxygen or Nitrogen Species and Novel Volatile Organic Compounds in the Defense Responses of Tomato Plants against Botrytis cinerea Induced by Trichoderma virens TRS 106.
Cells.
2022 09; 11(19):. doi:
10.3390/cells11193051
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European review for medical and pharmacological sciences.
2022 09; 26(18):6497-6504. doi:
10.26355/eurrev_202209_29748
. [PMID: 36196736] - Lidia A Pérez-Márquez, Marcelle D Perretti, Raúl García-Rodríguez, Fernando Lahoz, Romen Carrillo. A Fluorescent Cage for Supramolecular Sensing of 3-Nitrotyrosine in Human Blood Serum.
Angewandte Chemie (International ed. in English).
2022 Jul; 61(28):e202205403. doi:
10.1002/anie.202205403
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Biochemical pharmacology.
2022 07; 201(?):115076. doi:
10.1016/j.bcp.2022.115076
. [PMID: 35551915] - Olamide B Adelusi, Anup Ramachandran, John J Lemasters, Hartmut Jaeschke. The role of Iron in lipid peroxidation and protein nitration during acetaminophen-induced liver injury in mice.
Toxicology and applied pharmacology.
2022 06; 445(?):116043. doi:
10.1016/j.taap.2022.116043
. [PMID: 35513057] - Elisa Villa-Martínez, Selma Romina López-Vaquera, Lesvia Karina Alvarado-Coutiño, Ana María Gámez-Méndez, Amelia Ríos, Bruno Escalante. Thromboxane-dependent coronary vasoconstriction in obese mice: Role of peroxynitrite.
Prostaglandins & other lipid mediators.
2022 06; 160(?):106631. doi:
10.1016/j.prostaglandins.2022.106631
. [PMID: 35272056] - Zongtao Liu, Nianguo Dong, Haipeng Hui, Yixuan Wang, Fayun Liu, Li Xu, Ming Liu, Zhenqi Rao, Zhen Yuan, Yuqiang Shang, Jun Feng, Zhejun Cai, Fei Li. Endothelial cell-derived tetrahydrobiopterin prevents aortic valve calcification.
European heart journal.
2022 05; 43(17):1652-1664. doi:
10.1093/eurheartj/ehac037
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Biomaterials science.
2022 Feb; 10(4):1083-1089. doi:
10.1039/d1bm01675j
. [PMID: 35037671] - Jinsa Li, Shuxin Peng, Zipeng Li, Fangfang Zhao, Xiaojing Han, Jianfei Liu, Wenbo Cao, Yong Ye. Visualization of peroxynitrite in cyclophosphamide-induced oxidative stress by an activatable probe.
Talanta.
2022 Feb; 238(Pt 1):123007. doi:
10.1016/j.talanta.2021.123007
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Scientific reports.
2021 12; 11(1):23904. doi:
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2021 Dec; 262(?):120100. doi:
10.1016/j.saa.2021.120100
. [PMID: 34186297] - Yan Wang, Chun Jie Wu, Yu Du, Yu Qing Liu, Jing Ran Cai, Xue Qing Wu, Shu Qun Hu. SIRT2 tyrosine nitration by peroxynitrite in response to renal ischemia/reperfusion injury.
Free radical research.
2021 Dec; 55(11-12):1104-1118. doi:
10.1080/10715762.2021.2024529
. [PMID: 34979841] - Stanislava Vrankova, Zuzana Galandakova, Jakub Benko, Martina Cebova, Igor Riecansky, Olga Pechanova. Duration of Social Isolation Affects Production of Nitric Oxide in the Rat Brain.
International journal of molecular sciences.
2021 Sep; 22(19):. doi:
10.3390/ijms221910340
. [PMID: 34638682] - Eman Soliman, Samar M Shewaikh, Ahmed Fahmy, Shimaa Elshazly. Entacapone scavenges peroxynitrite and protects against kidney and liver injuries induced by renal ischemia/reperfusion in rats.
International urology and nephrology.
2021 Aug; 53(8):1713-1721. doi:
10.1007/s11255-021-02827-5
. [PMID: 33675481] - Anna T Backes, Kathrin Reinmuth-Selzle, Anna Lena Leifke, Kira Ziegler, Carola S Krevert, Georg Tscheuschner, Kurt Lucas, Michael G Weller, Thomas Berkemeier, Ulrich Pöschl, Janine Fröhlich-Nowoisky. Oligomerization and Nitration of the Grass Pollen Allergen Phl p 5 by Ozone, Nitrogen Dioxide, and Peroxynitrite: Reaction Products, Kinetics, and Health Effects.
International journal of molecular sciences.
2021 Jul; 22(14):. doi:
10.3390/ijms22147616
. [PMID: 34299235] - Ioana Silvia Hosu, Diana Constantinescu-Aruxandei, Florin Oancea, Mihaela Doni. The Scavenging Effect of Myoglobin from Meat Extracts toward Peroxynitrite Studied with a Flow Injection System Based on Electrochemical Reduction over a Screen-Printed Carbon Electrode Modified with Cobalt Phthalocyanine: Quantification and Kinetics.
Biosensors.
2021 Jul; 11(7):. doi:
10.3390/bios11070220
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Oncology reports.
2021 05; 45(5):. doi:
10.3892/or.2021.8022
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Proceedings of the National Academy of Sciences of the United States of America.
2021 02; 118(7):. doi:
10.1073/pnas.1921828118
. [PMID: 33579817] - Justyna Krzyżanowska-Kowalczyk, Mariusz Kowalczyk, Michał B Ponczek, Łukasz Pecio, Paweł Nowak, Joanna Kolodziejczyk-Czepas. Pulmonaria obscura and Pulmonaria officinalis Extracts as Mitigators of Peroxynitrite-Induced Oxidative Stress and Cyclooxygenase-2 Inhibitors-In Vitro and In Silico Studies.
Molecules (Basel, Switzerland).
2021 Jan; 26(3):. doi:
10.3390/molecules26030631
. [PMID: 33530389] - Michele Mariotti, Adelina Rogowska-Wrzesinska, Per Hägglund, Michael J Davies. Cross-linking and modification of fibronectin by peroxynitrous acid: Mapping and quantification of damage provides a new model for domain interactions.
The Journal of biological chemistry.
2021 Jan; 296(?):100360. doi:
10.1016/j.jbc.2021.100360
. [PMID: 33539924] - Giuliana Bruno, Sebastian Wenske, Jan-Wilm Lackmann, Michael Lalk, Thomas von Woedtke, Kristian Wende. On the Liquid Chemistry of the Reactive Nitrogen Species Peroxynitrite and Nitrogen Dioxide Generated by Physical Plasmas.
Biomolecules.
2020 12; 10(12):. doi:
10.3390/biom10121687
. [PMID: 33339444] - Yifan Zhang, Yacong He, Meiling Wu, Hansen Chen, Lu Zhang, Dan Yang, Qi Wang, Jiangang Shen. Rehmapicroside ameliorates cerebral ischemia-reperfusion injury via attenuating peroxynitrite-mediated mitophagy activation.
Free radical biology & medicine.
2020 11; 160(?):526-539. doi:
10.1016/j.freeradbiomed.2020.06.034
. [PMID: 32784031] - Laura Fási, Ahmed Dhahir Latif, István Zupkó, Sándor Lévai, Miklós Dékány, Zoltán Béni, Árpád Könczöl, György Tibor Balogh, Attila Hunyadi. AAPH or Peroxynitrite-Induced Biorelevant Oxidation of Methyl Caffeate Yields a Potent Antitumor Metabolite.
Biomolecules.
2020 11; 10(11):. doi:
10.3390/biom10111537
. [PMID: 33187226] - Şenol Kalyoncu, Bülent Yilmaz, Mustafa Demir, Meltem Tuncer, Zehra Bozdağ, Onur Ince, Mehmet Akif Bozdayi, Hasan Ulusal, Seyithan Taysi. Melatonin attenuates ovarian ischemia reperfusion injury in rats by decreasing oxidative stress index and peroxynitrite.
Turkish journal of medical sciences.
2020 10; 50(6):1513-1522. doi:
10.3906/sag-2004-135
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Cells.
2020 10; 9(10):. doi:
10.3390/cells9102330
. [PMID: 33096638] - Nabeel Ahmed, Anindita Chakrabarty, F Peter Guengerich, Goutam Chowdhury. Protective Role of Glutathione against Peroxynitrite-Mediated DNA Damage During Acute Inflammation.
Chemical research in toxicology.
2020 10; 33(10):2668-2674. doi:
10.1021/acs.chemrestox.0c00299
. [PMID: 32894672] - Hansen Chen, Binghe Guan, Bin Wang, Haiwei Pu, Xiaoyu Bai, Xi Chen, Jihong Liu, Caiming Li, Jinhua Qiu, Dan Yang, Kejian Liu, Qi Wang, Suhua Qi, Jiangang Shen. Glycyrrhizin Prevents Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke with Delayed Thrombolysis Through Targeting Peroxynitrite-Mediated HMGB1 Signaling.
Translational stroke research.
2020 10; 11(5):967-982. doi:
10.1007/s12975-019-00772-1
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Cytokine.
2020 10; 134(?):155180. doi:
10.1016/j.cyto.2020.155180
. [PMID: 32673994] - Hong-Wen Liu, Haiyang Zhang, Xiaofeng Lou, Lili Teng, Jie Yuan, Lin Yuan, Xiao-Bing Zhang, Weihong Tan. Imaging of peroxynitrite in drug-induced acute kidney injury with a near-infrared fluorescence and photoacoustic dual-modal molecular probe.
Chemical communications (Cambridge, England).
2020 Jul; 56(58):8103-8106. doi:
10.1039/d0cc01621g
. [PMID: 32555855] - Wang Yue, Zhang Huihui, Wang Jiechen, Zhao Hancheng, He Guoqiang, Huang Dan, Yang Fuwen, Zhao Meichun, Che Yanhui, Teng Zhiyuan, Liu Guanjun, Sun Guangyu. Elevated NO2 damages the photosynthetic apparatus by inducing the accumulation of superoxide anions and peroxynitrite in tobacco seedling leaves.
Ecotoxicology and environmental safety.
2020 Jun; 196(?):110534. doi:
10.1016/j.ecoenv.2020.110534
. [PMID: 32247242] - Pawel Staszek, Agnieszka Gniazdowska. Peroxynitrite induced signaling pathways in plant response to non-proteinogenic amino acids.
Planta.
2020 Jun; 252(1):5. doi:
10.1007/s00425-020-03411-4
. [PMID: 32535658] - Yun Hee Jeong, Gyeong Han Jeong, Yong-Ha Jeong, Tae Hoon Kim. Identification of sesamol byproducts produced by plasma treatment with inhibition of advanced glycation endproducts formation and ONOO- scavenging activities.
Food chemistry.
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