Calusterone (BioDeep_00000019586)

 

Secondary id: BioDeep_00000009918, BioDeep_00000858779

human metabolite Volatile Flavor Compounds


代谢物信息卡片


(1S,2R,9S,10R,11S,14S,15S)-14-hydroxy-2,9,14,15-tetramethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one

化学式: C21H32O2 (316.24021719999996)
中文名称: 卡普睾酮, 勃拉睾酮
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 2.63%

分子结构信息

SMILES: C1[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@](C)(O)CC[C@@]4([H])[C@]3([H])[C@H](C)CC2=CC(=O)C1
InChI: InChI=1S/C21H32O2/c1-13-11-14-12-15(22)5-8-19(14,2)16-6-9-20(3)17(18(13)16)7-10-21(20,4)23/h12-13,16-18,23H,5-11H2,1-4H3/t13-,16+,17+,18-,19+,20+,21+/m1/s1

描述信息

Calusterone is an androgenic steroid. Calusterone induce given orally induce a marked decrease (between 30 and 70\\% depending on the dose) in the binding capacity of oestradiol-17beta to specific uterine receptors in vivo. As an androgen, calusterone has been used as a therapeutic agent in postmenopausal women with metastatic breast cancer; the addition of a potent hormonal agent to effective cytotoxic chemotherapy improves the results of treatment of women with metastatic breast cancer. Calusterone is tested in sport screening; fast and sensitive method for the comprehensive screening of anabolic agents and other banned doping substances using gas chromatography/tandem mass spectrometry (GC/MS/MS) with an external ionization ion trap mass spectrometer have been developed for the parent substances and their metabolites. (PMID: 17610244, 12375280, 153787, 2325376, 12375280) [HMDB]
Calusterone is an androgenic steroid. Calusterone induce given orally induce a marked decrease (between 30 and 70\\% depending on the dose) in the binding capacity of oestradiol-17beta to specific uterine receptors in vivo. As an androgen, calusterone has been used as a therapeutic agent in postmenopausal women with metastatic breast cancer; the addition of a potent hormonal agent to effective cytotoxic chemotherapy improves the results of treatment of women with metastatic breast cancer. Calusterone is tested in sport screening; fast and sensitive method for the comprehensive screening of anabolic agents and other banned doping substances using gas chromatography/tandem mass spectrometry (GC/MS/MS) with an external ionization ion trap mass spectrometer have been developed for the parent substances and their metabolites. (PMID: 17610244, 12375280, 153787, 2325376, 12375280).
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D045930 - Anabolic Agents
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C2360 - Anabolic Steroid
Same as: D03144

同义名列表

30 个代谢物同义名

(1S,2R,9S,10R,11S,14S,15S)-14-hydroxy-2,9,14,15-tetramethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-5-one; 17-beta-Hydroxy-7-beta,17-alpha-dimethylandrost-4-ene-3-one; 17beta-Hydroxy-7beta-17alpha-dimethylandrost-4-ene-3-one; 17-beta-Hydroxy-7-beta-17-dimethyl androst-4-en-3-one; (7b,17b)-17-Hydroxy-7,17-dimethyl-androst-4-en-3-one; 17-Dimethyl-17beta-hydroxy-7beta-androst-4-en-3-one; 17beta-hydroxy-7alpha,17-dimethylandrost-4-en-3-one; 17beta-Hydroxy-7beta-17-dimethylandrost-4-en-3-one; 17b-Hydroxy-7b,17-dimethyl-androst-4-en-3-one; 17b-Hydroxy-7b,17-dimethylandrost-4-en-3-one; 17-Hydroxy-7,17-dimethylandrost-4-en-3-one; 7-beta,17-alpha-Dimethyl testosterone; 7 beta,17 alpha-Dimethyltestosterone; 7-beta-17-alpha-Dimethyltestosterone; 7alpha,17alpha-Dimethyltestosterone; 7beta,17alpha-Dimethyltestosterone; 7beta,17beta-Dimethyltestosterone; 7-beta,17-Dimethyltestosterone; 17beta-Dimethyl testosterone; 7beta-Dimethyltestosterone; Dimethyltestosterone; Calusteronum; Calusterona; Calusterone; Bolasterone; Calusteron; ST 21:2;O2; Methosarb; U19763; Bolasterone



数据库引用编号

22 个数据库交叉引用编号

分类词条

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代谢反应

0 个相关的代谢反应过程信息。

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INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Nola H Yu, Emmie N M Ho, David K K Leung, Terence S M Wan. Screening of anabolic steroids in horse urine by liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2005 Apr; 37(5):1031-8. doi: 10.1016/j.jpba.2004.08.041. [PMID: 15862683]
  • R Gonzalo-Lumbreras, R Izquierdo-Hornillos. Optimization of the high-performance liquid chromatographic separation of a complex mixture containing urinary steroids, boldenone and bolasterone: application to urine samples. Journal of chromatography. B, Biomedical sciences and applications. 2000 May; 742(1):47-57. doi: 10.1016/s0378-4347(00)00084-0. [PMID: 10892583]
  • Y Z Zhang, X Liu, C J Zhang, L Ye. [Studies on urinary metabolites of calusterone in man]. Yao xue xue bao = Acta pharmaceutica Sinica. 1993; 28(12):918-23. doi: NULL. [PMID: 8030416]