Dideoxycytidine 5'-Triphosphate (BioDeep_00000019421)

   

human metabolite


代谢物信息卡片


{[hydroxy({[hydroxy({[(2S,5R)-5-(2-hydroxy-4-imino-1,4-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy})phosphoryl]oxy})phosphoryl]oxy}phosphonic acid

化学式: C9H16N3O12P3 (450.9946846)
中文名称: 扎西他滨三磷酸三钠盐
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)N2C=CC(=NC2=O)N
InChI: InChI=1S/C9H16N3O12P3/c10-7-3-4-12(9(13)11-7)8-2-1-6(22-8)5-21-26(17,18)24-27(19,20)23-25(14,15)16/h3-4,6,8H,1-2,5H2,(H,17,18)(H,19,20)(H2,10,11,13)(H2,14,15,16)/t6-,8+/m0/s1

描述信息

Dideoxycytidine 5-Triphosphate belongs to the class of organic compounds known as pyrimidine 2,3-dideoxyribonucleoside diphosphates. These are pyrimidine nucleotides with diphosphate group linked to the ribose moiety lacking a hydroxyl group at positions 2 and 3.

同义名列表

12 个代谢物同义名

{[hydroxy({[hydroxy({[(2S,5R)-5-(2-hydroxy-4-imino-1,4-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy})phosphoryl]oxy})phosphoryl]oxy}phosphonic acid; [hydroxy({hydroxy[(2S,5R)-5-(2-hydroxy-4-iminopyrimidin-1-yl)oxolan-2-yl]methoxyphosphoryl}oxy)phosphoryl]oxyphosphonic acid; 2,3-DIDEOXYCYTIDINE 5-triphosphoric acid; 23-Dideoxycytidine 5-triphosphoric acid; Dideoxycytidine 5-triphosphoric acid; 2,3-Dideoxycytidine 5-triphosphate; 23-Dideoxycytidine 5-triphosphate; Dideoxycytidine 5-Triphosphate; CHEMBL190153; DDCTP-2,3; 2,3-DDCTP; ddCTP



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Klaus Klumpp, Genadiy Kalayanov, Han Ma, Sophie Le Pogam, Vincent Leveque, Wen-Rong Jiang, Nicole Inocencio, Anniek De Witte, Sonal Rajyaguru, Ezra Tai, Sushmita Chanda, Michael R Irwin, Christian Sund, Anna Winqist, Tatiana Maltseva, Staffan Eriksson, Elena Usova, Mark Smith, Andre Alker, Isabel Najera, Nick Cammack, Joseph A Martin, Nils Gunnar Johansson, David B Smith. 2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups. The Journal of biological chemistry. 2008 Jan; 283(4):2167-75. doi: 10.1074/jbc.m708929200. [PMID: 18003608]
  • Nicholas A Boyle, Vivek K Rajwanshi, Marija Prhavc, Guangyi Wang, Patrick Fagan, Fu Chen, Gregory J Ewing, Jennifer L Brooks, Tiffany Hurd, Janet M Leeds, Thomas W Bruice, P Dan Cook. Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase. Journal of medicinal chemistry. 2005 Apr; 48(7):2695-700. doi: 10.1021/jm040101y. [PMID: 15801860]
  • K De Groote, L Naesens, J Balzarini, M I Baes, P E Declercq. Effects of 2',3'-dideoxycytidine and 2',3'-dideoxycytidine 5'-triphosphate on phospholipid metabolism in permeabilized rat hepatocytes. Biochemical pharmacology. 1997 Sep; 54(6):713-9. doi: 10.1016/s0006-2952(97)00244-x. [PMID: 9310348]
  • S M Daluge, D J Purifoy, P M Savina, M H St Clair, N R Parry, I K Dev, P Novak, K M Ayers, J E Reardon, G B Roberts. 5-Chloro-2',3'-dideoxy-3'-fluorouridine (935U83), a selective anti-human immunodeficiency virus agent with an improved metabolic and toxicological profile. Antimicrobial agents and chemotherapy. 1994 Jul; 38(7):1590-603. doi: 10.1128/aac.38.7.1590. [PMID: 7526782]
  • G V Betageri, C D Black, J Szebeni, L M Wahl, J N Weinstein. Fc-receptor-mediated targeting of antibody-bearing liposomes containing dideoxycytidine triphosphate to human monocyte/macrophages. The Journal of pharmacy and pharmacology. 1993 Jan; 45(1):48-53. doi: 10.1111/j.2042-7158.1993.tb03678.x. [PMID: 8094446]