2',3'-Dideoxyadenosine-5-triphosphate (BioDeep_00000019420)

   

human metabolite Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


({[({[(2S,5R)-5-(6-amino-9H-purin-9-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid

化学式: C10H16N5O11P3 (475.0059176)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 84.38%

分子结构信息

SMILES: C1CC(OC1COP(=O)(O)OP(=O)(O)OP(=O)(O)O)N2C=NC3=C(N=CN=C32)N
InChI: InChI=1S/C10H16N5O11P3/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(24-7)3-23-28(19,20)26-29(21,22)25-27(16,17)18/h4-7H,1-3H2,(H,19,20)(H,21,22)(H2,11,12,13)(H2,16,17,18)/t6-,7+/m0/s1

描述信息

2,3-Dideoxyadenosine-5-triphosphate is a metabolite of didanosine. Didanosine (2,3-dideoxyinosine, ddI, DDI) is sold under the trade names Videx and Videx EC. It is a reverse transcriptase inhibitor, effective against HIV and used in combination with other antiretroviral drug therapy as part of highly active antiretroviral therapy (HAART) (Wikipedia).

同义名列表

17 个代谢物同义名

({[({[(2S,5R)-5-(6-amino-9H-purin-9-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid; ({[(2S,5R)-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxyphosphonic acid; 2’,3’-dideoxyadenosine 5’-(tetrahydrogen triphosphate); 2,3-Dideoxyadenosine 5-(tetrahydrogen triphosphate); 2,3-Dideoxyadenosine-5-triphosphoric acid; 2’,3’-dideoxyadenosine 5’-triphosphate; 2’,3’-dideoxyadenosine triphosphate; Dideoxyadenosine triphosphoric acid; 2,3-DIDEOXYADENOSINE 5-TRIPHOSPHATE; 2,3-Dideoxyadenosine-5-triphosphate; 2,3-Dideoxyadenosine triphosphate; Dideoxyadenosine triphosphate; 2’,3’-dideoxy-ATP; 2,3-Dideoxy-ATP; 2’,3’-ddatp; 2,3-DdATP; DDATP



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(1)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xu Lan, Lei Mingdao, Guo Huilin, Gan Wei, Hu Lvjiang, Zhou Yan, Li Gang. Simultaneous determination of 2',3'-dideoxyinosine and the active metabolite, 2',3'-dideoxyadenosine-5'-triphosphate in human peripheral-blood mononuclear cell by HPLC-MS/MS and the application to cell pharmacokinetics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Oct; 1002(?):337-42. doi: 10.1016/j.jchromb.2015.08.039. [PMID: 26350426]
  • Jun'ichi Mochida, Mariko Esumi, Akiko Kitajima, Kiyoki Okada. Allelic loss analysis of tumor suppressor genes regardless of heterozygosity: von Hippel-Lindau gene loss in renal cell carcinoma. The Journal of urology. 2008 Aug; 180(2):724-8. doi: 10.1016/j.juro.2008.03.183. [PMID: 18554638]
  • Tadamasa Sasaki, Yasushi Yukawa, Tatsuya Wakasugi, Kyoji Yamada, Masahiro Sugiura. A simple in vitro RNA editing assay for chloroplast transcripts using fluorescent dideoxynucleotides: distinct types of sequence elements required for editing of ndh transcripts. The Plant journal : for cell and molecular biology. 2006 Sep; 47(5):802-10. doi: 10.1111/j.1365-313x.2006.02825.x. [PMID: 16856984]
  • Nicholas A Boyle, Vivek K Rajwanshi, Marija Prhavc, Guangyi Wang, Patrick Fagan, Fu Chen, Gregory J Ewing, Jennifer L Brooks, Tiffany Hurd, Janet M Leeds, Thomas W Bruice, P Dan Cook. Synthesis of 2',3'-dideoxynucleoside 5'-alpha-P-borano-beta,gamma-(difluoromethylene)triphosphates and their inhibition of HIV-1 reverse transcriptase. Journal of medicinal chemistry. 2005 Apr; 48(7):2695-700. doi: 10.1021/jm040101y. [PMID: 15801860]
  • Brian L Robbins, Carrie K Wilcox, Arnold Fridland, John H Rodman. Metabolism of tenofovir and didanosine in quiescent or stimulated human peripheral blood mononuclear cells. Pharmacotherapy. 2003 Jun; 23(6):695-701. doi: 10.1592/phco.23.6.695.32189. [PMID: 12820810]
  • P D Jolly, D J Tisdall, G De'ath, D A Heath, S Lun, N L Hudson, K P McNatty. Granulosa cell apoptosis, aromatase activity, cyclic adenosine 3',5'-monophosphate response to gonadotropins, and follicular fluid steroid levels during spontaneous and induced follicular atresia in ewes. Biology of reproduction. 1997 Apr; 56(4):830-6. doi: 10.1095/biolreprod56.4.830. [PMID: 9096862]