Leucyl-Isoleucine (BioDeep_00000019382)

   

human metabolite Endogenous


代谢物信息卡片


2-[(2-Amino-1-hydroxy-4-methylpentylidene)amino]-3-methylpentanoate

  化学式: C12H24N2O3 (244.1787)
中文名称:
  谱图信息: 最多检出来源 Homo sapiens(feces) 11.08%

分子结构信息

SMILES: CCC(C)C(C(=O)O)NC(=O)C(CC(C)C)N
InChI: InChI=1S/C12H24N2O3/c1-5-8(4)10(12(16)17)14-11(15)9(13)6-7(2)3/h7-10H,5-6,13H2,1-4H3,(H,14,15)(H,16,17)


描述信息

Leucyl-Isoleucine is a dipeptide composed of leucine and isoleucine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis. This dipeptide has not yet been identified in human tissues or biofluids and so it is classified as an Expected metabolite.

同义名列表

10 个代谢物同义名

2-[(2-Amino-1-hydroxy-4-methylpentylidene)amino]-3-methylpentanoate; 2-(2-amino-4-methylpentanamido)-3-methylpentanoic acid; Leucine isoleucine dipeptide; Leucine-isoleucine dipeptide; L-Leucyl-L-isoleucine; Leucyl-Isoleucine; leucylisoleucine; L-I dipeptide; LI dipeptide; Leu-ile



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Ken-ichi Tanaka, Hiroya Ogo, Hiroaki Kaji, Kaori Miyatake, Erika Tokudome, Kanako Sonoda, Norio Ogawa, Masato Asanuma. Dipeptidyl compounds ameliorate the serum-deprivation-induced reduction in cell viability via the neurotrophin-activating effect in SH-SY5Y cells. Neurological research. 2012 Jul; 34(6):619-22. doi: 10.1179/1743132812y.0000000001. [PMID: 22748608]
  • Masahiro Azuma, Ryoko Sawahata, Yuusuke Akao, Takashi Ebihara, Sayuri Yamazaki, Misako Matsumoto, Masahito Hashimoto, Koichi Fukase, Yukari Fujimoto, Tsukasa Seya. The peptide sequence of diacyl lipopeptides determines dendritic cell TLR2-mediated NK activation. PloS one. 2010 Sep; 5(9):. doi: 10.1371/journal.pone.0012550. [PMID: 20824059]
  • Angèle Tingaud-Sequeira, François Chauvigné, Mercedes Fabra, Juanjo Lozano, Demetrio Raldúa, Joan Cerdà. Structural and functional divergence of two fish aquaporin-1 water channels following teleost-specific gene duplication. BMC evolutionary biology. 2008 Sep; 8(?):259. doi: 10.1186/1471-2148-8-259. [PMID: 18811940]
  • M'hamed Grati, Nisha Aggarwal, Emanuel E Strehler, Robert J Wenthold. Molecular determinants for differential membrane trafficking of PMCA1 and PMCA2 in mammalian hair cells. Journal of cell science. 2006 Jul; 119(Pt 14):2995-3007. doi: 10.1242/jcs.03030. [PMID: 16803870]
  • Sergio D Rosenzweig, Owen M Schwartz, Margaret R Brown, Thomas L Leto, Steven M Holland. Characterization of a dipeptide motif regulating IFN-gamma receptor 2 plasma membrane accumulation and IFN-gamma responsiveness. Journal of immunology (Baltimore, Md. : 1950). 2004 Sep; 173(6):3991-9. doi: 10.4049/jimmunol.173.6.3991. [PMID: 15356148]