CE(16:1(9Z)) (BioDeep_00000019332)

描述信息

CE(16:1(9Z)), also known as (Z)-cholesterol 9-hexadecenoate or 1-palmitoleoyl-cholesterol, is an important plasma cholesteryl ester. A cholesteryl ester is an ester of cholesterol. Fatty acid esters of cholesterol constitute about two-thirds of the cholesterol in the plasma. Cholesterol is a sterol (a combination steroid and alcohol) and a lipid found in the cell membranes of all body tissues and transported in the blood plasma of all animals. The accumulation of cholesterol esters in the arterial intima (the innermost layer of an artery, in direct contact with the flowing blood) is a characteristic feature of atherosclerosis. Atherosclerosis is a disease affecting arterial blood vessels. It is a chronic inflammatory response in the walls of arteries, in large part to the deposition of lipoproteins (plasma proteins that carry cholesterol and triglycerides). Cholesteryl palmitoleate is one of the two more prevalent esters that are a component of dehydroepiandrosterone fatty acid esters (DHEA-FA). DHEA-FA is formed from DHEA by lecithin-cholesterol acyltransferase, localized on high-density lipoprotein (HDL). Once DHEA-FA is formed, it is subsequently transferred to very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL), like cholesteryl esters. Cholesteryl palmitoleate constitutes 20\\% of the total lipoidal pregnenolone (an important precursor steroid) in follicular fluid. The fatty acid components of the resulting lipoidal pregnenolone derivatives resemble those of cholesteryl esters formed in plasma by the enzymatic activity of lecithin–cholesterol acyltransferase (LCAT) (PMID: 2770299, 8943795). CE(16:1(9Z)) is considered to be practically insoluble (in water) and basic.

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