Madecassoside (BioDeep_00000019008)

Main id: BioDeep_00000230718

 

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


6-({[3,4-dihydroxy-6-(hydroxymethyl)-5-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl]oxy}methyl)-3,4,5-trihydroxyoxan-2-yl 8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid

化学式: C48H78O20 (974.5086188)
中文名称: 羟基积雪草苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CCC2(C(=O)OC3OC(COC4OC(CO)C(OC5OC(C)C(O)C(O)C5O)C(O)C4O)C(O)C(O)C3O)CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(CO)C5C(O)CC43C)C2C1C
InChI: InChI=1S/C48H78O20/c1-19-10-11-48(13-12-46(6)22(28(48)20(19)2)8-9-27-44(4)14-24(52)39(61)45(5,18-50)38(44)23(51)15-47(27,46)7)43(62)68-42-35(59)32(56)30(54)26(66-42)17-63-40-36(60)33(57)37(25(16-49)65-40)67-41-34(58)31(55)29(53)21(3)64-41/h8,19-21,23-42,49-61H,9-18H2,1-7H3

描述信息

Madecassoside is found in green vegetables. Madecassoside is isolated from whole plants of Centella asiatica (Ji Xue Cao).
Isolated from whole plants of Centella asiatica (Ji Xue Cao). Madecassoside is found in green vegetables.
Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects.
Madecassoside is a pentacyclic triterpene isolated from Centella asiatica and has anti-inflammatory properties. Antioxidant and anti-aging effects.

同义名列表

5 个代谢物同义名

6-({[3,4-dihydroxy-6-(hydroxymethyl)-5-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl]oxy}methyl)-3,4,5-trihydroxyoxan-2-yl 8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid; 6-({[3,4-dihydroxy-6-(hydroxymethyl)-5-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl]oxy}methyl)-3,4,5-trihydroxyoxan-2-yl 8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylate; 6-({[3,4-dihydroxy-6-(hydroxymethyl)-5-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]oxan-2-yl]oxy}methyl)-3,4,5-trihydroxyoxan-2-yl 8,10,11-trihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,7,8,8a,10,11,12,12b,13,14b-tetradecahydro-1H-picene-4a-carboxylate; asiaticoside A; Madecassoside



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Zaynab Mando, Huda Mando, Adlin Afzan, Khozirah Shaari, Zurina Hassan, Mohamad Nurul Azmi Mohamad Taib, Fauziahanim Zakaria. Biomarker triterpenoids of Centella asiatica as potential antidepressant agents: Combining in vivo and in silico studies. Behavioural brain research. 2024 May; 466(?):114976. doi: 10.1016/j.bbr.2024.114976. [PMID: 38599249]
  • Zicheng Ling, Sirui Zhou, Yancheng Zhou, Wanyu Zhong, Zhonghao Su, Zhenxia Qin. Protective role of madecassoside from Centella asiatica against protein L-isoaspartyl methyltransferase deficiency-induced neurodegeneration. Neuropharmacology. 2024 Mar; 246(?):109834. doi: 10.1016/j.neuropharm.2023.109834. [PMID: 38181970]
  • Run-Run Shan, Ju-Tao Yu, Shao-Fei Zhang, Man-Man Xie, Rui Hou, Chun-Ya Xie, Ze-Hui Dong, Qin Yang, Xiao-Wei Hu, Yu-Hang Dong, Yao Zhang, Xiu-Feng Luo, Zong-Yu Cui, Xiao-Ying Liu, Yun-Chang Xie, Jia-Gen Wen, Ming-Ming Liu, Juan Jin, Qi Chen, Xiao-Ming Meng. Madecassoside alleviates acute kidney injury by regulating JNK-mediated oxidative stress and programmed cell death. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 123(?):155252. doi: 10.1016/j.phymed.2023.155252. [PMID: 38056145]
  • Narumon Changsan, Teerapol Srichana, Apichart Atipairin, Somchai Sawatdee. Wound healing efficacy of a polymeric spray film solution containing Centella asiatica leaf extract on acute wounds. Journal of wound care. 2023 Dec; 32(Sup12):S22-S32. doi: 10.12968/jowc.2023.32.sup12.s22. [PMID: 38063299]
  • Temitope Akinwumi Ajani, Kenechukwu Obikeze, Zandisiwe E Magwebu, Samuel Egieyeh, Chesa G Chauke. In-silico and in-vitro screening of Asiatic acid and Asiaticoside A against Cathepsin S enzyme. BMC pharmacology & toxicology. 2023 11; 24(1):67. doi: 10.1186/s40360-023-00701-x. [PMID: 38007481]
  • Sung Woo Choi, Wonjun Cho, Heeseung Oh, A M Abd El-Aty, Soon Auck Hong, Mineui Hong, Ji Hoon Jeong, Tae Woo Jung. Madecassoside ameliorates hepatic steatosis in high-fat diet-fed mice through AMPK/autophagy-mediated suppression of ER stress. Biochemical pharmacology. 2023 11; 217(?):115815. doi: 10.1016/j.bcp.2023.115815. [PMID: 37741512]
  • Swee Ching Tan, Ramkumar Rajendran, Subrat Kumar Bhattamisra, Purushotham Krishnappa, Fabian Davamani, Ebenezer Chitra, Stephen Ambu, Brian Furman, Mayuren Candasamy. Effect of madecassoside in reducing oxidative stress and blood glucose in streptozotocin-nicotinamide-induced diabetes in rats. The Journal of pharmacy and pharmacology. 2023 Jul; ?(?):. doi: 10.1093/jpp/rgad063. [PMID: 37402616]
  • Joan Eilstein, Vimal Nair, Kieran Moore, Steve Thomas Pannakal, Sébastien Grégoire, Prashant Ekhar, Richard H Guy, M Begoña Delgado-Charro, Nita Roy. Non-destructive, reverse iontophoretic extraction of phytochemicals from Mangifera indica, Centella asiatica, Punica granatum, and Citrus sinensis. Phytochemical analysis : PCA. 2023 Jun; 34(4):408-413. doi: 10.1002/pca.3219. [PMID: 36971356]
  • Shinjini Bandopadhyay, Sujata Mandal, Mimosa Ghorai, Niraj Kumar Jha, Manoj Kumar, Radha, Arabinda Ghosh, Jarosław Proćków, José M Pérez de la Lastra, Abhijit Dey. Therapeutic properties and pharmacological activities of asiaticoside and madecassoside: A review. Journal of cellular and molecular medicine. 2023 Feb; ?(?):. doi: 10.1111/jcmm.17635. [PMID: 36756687]
  • Sujata Mandal, Tuyelee Das, Samapika Nandy, Mimosa Ghorai, Suchismita Chatterjee Saha, Abilash Valsala Gopalakrishnan, Manoj Kumar, Radha, Arabinda Ghosh, Nobendu Mukerjee, Mahipal S Shekhawat, Devendra Kumar Pandey, Abhijit Dey. Biotechnological and endophytic-mediated production of centellosides in Centella asiatica. Applied microbiology and biotechnology. 2023 Feb; 107(2-3):473-489. doi: 10.1007/s00253-022-12316-z. [PMID: 36481800]
  • Tussapon Boonyarattanasoonthorn, Teetat Kongratanapasert, Arnatchai Maiuthed, Robert Hamlin, Anusak Kijtawornrat, Phisit Khemawoot. Bioenhancing effects of piperine and curcumin on triterpenoid pharmacokinetics and neurodegenerative metabolomes from Centella asiatica extract in beagle dogs. Scientific reports. 2022 12; 12(1):20789. doi: 10.1038/s41598-022-24935-7. [PMID: 36456663]
  • Tussapon Boonyarattanasoonthorn, Anusak Kijtawornrat, Phanit Songvut, Nitra Nuengchamnong, Visarut Buranasudja, Phisit Khemawoot. Increase water solubility of Centella asiatica extract by indigenous bioenhancers could improve oral bioavailability and disposition kinetics of triterpenoid glycosides in beagle dogs. Scientific reports. 2022 02; 12(1):2909. doi: 10.1038/s41598-022-06967-1. [PMID: 35190633]
  • Nur Aziah Hanapi, Ahmad Saifuddin Mohamad Arshad, Jafri Malin Abdullah, Tengku Sifzizul Tengku Muhammad, Siti R Yusof. Blood-Brain Barrier Permeability of Asiaticoside, Madecassoside and Asiatic Acid in Porcine Brain Endothelial Cell Model. Journal of pharmaceutical sciences. 2021 02; 110(2):698-706. doi: 10.1016/j.xphs.2020.09.015. [PMID: 32949562]
  • Boju Sun, Misa Hayashi, Maya Kudo, Lili Wu, Lingling Qin, Ming Gao, Tonghua Liu. Madecassoside Inhibits Body Weight Gain via Modulating SIRT1-AMPK Signaling Pathway and Activating Genes Related to Thermogenesis. Frontiers in endocrinology. 2021; 12(?):627950. doi: 10.3389/fendo.2021.627950. [PMID: 33767670]
  • Minjie Liang, Guangming Li, Xueqin Guan, Sisi Liu, Liguang Fang, Tianfu Li, Jun Dong, Quan Zhou. Intravoxel Incoherent Motion Imaging Study of Madecassoside in Improving Lipopolysaccharide-Induced Cognitive Impairment in Rats. Journal of magnetic resonance imaging : JMRI. 2020 06; 51(6):1836-1843. doi: 10.1002/jmri.27003. [PMID: 31785074]
  • Komal Rani, Mitali Tyagi, Mohit Mazumder, Akanksha Singh, Annaian Shanmugam, Krishna Dalal, Manoj Pillai, Gourinath Samudrala, Saroj Kumar, Alagiri Srinivasan. Accelerated identification of serine racemase inhibitor from Centella asiatica. Scientific reports. 2020 03; 10(1):4640. doi: 10.1038/s41598-020-61494-1. [PMID: 32170206]
  • Saowanee Wannasarit, Sirima Mahattanadul, Ousanee Issarachot, Panupong Puttarak, Ruedeekorn Wiwattanapatapee. Raft-forming gastro-retentive formulations based on Centella asiatica extract-solid dispersions for gastric ulcer treatment. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2020 Feb; 143(?):105204. doi: 10.1016/j.ejps.2019.105204. [PMID: 31870812]
  • Nur Nadia Mohd Razali, Chin Theng Ng, Lai Yen Fong. Cardiovascular Protective Effects of Centella asiatica and Its Triterpenes: A Review. Planta medica. 2019 Nov; 85(16):1203-1215. doi: 10.1055/a-1008-6138. [PMID: 31539918]
  • Sisi Liu, Guangming Li, Haijie Tang, Rui Pan, Huili Wang, Fujun Jin, Xueqin Yan, Yanyan Xing, Guiling Chen, Yongmei Fu, Jun Dong. Madecassoside ameliorates lipopolysaccharide-induced neurotoxicity in rats by activating the Nrf2-HO-1 pathway. Neuroscience letters. 2019 09; 709(?):134386. doi: 10.1016/j.neulet.2019.134386. [PMID: 31330225]
  • Yingrak Boondam, Phanit Songvut, Mayuree H Tantisira, Sompol Tapechum, Kanokwan Tilokskulchai, Narawut Pakaprot. Inverted U-shaped response of a standardized extract of Centella asiatica (ECa 233) on memory enhancement. Scientific reports. 2019 06; 9(1):8404. doi: 10.1038/s41598-019-44867-z. [PMID: 31182820]
  • Xiaohui Lu, Runming Zeng, Jing Lin, Jun Hu, Zhijie Rong, Weicai Xu, Zewa Liu, Wanting Zeng. Pharmacological basis for use of madecassoside in gouty arthritis: anti-inflammatory, anti-hyperuricemic, and NLRP3 inhibition. Immunopharmacology and immunotoxicology. 2019 Apr; 41(2):277-284. doi: 10.1080/08923973.2019.1590721. [PMID: 31084401]
  • Qingqing Wang, Lingya Yao, Ke Xu, Haiming Jin, Kai Chen, Ziyi Wang, Qian Liu, Zhen Cao, Jacob Kenny, Yuhao Liu, Jennifer Tickner, Huazi Xu, Jiake Xu. Madecassoside inhibits estrogen deficiency-induced osteoporosis by suppressing RANKL-induced osteoclastogenesis. Journal of cellular and molecular medicine. 2019 01; 23(1):380-394. doi: 10.1111/jcmm.13942. [PMID: 30338925]
  • Renu Arora, Ritesh Kumar, Amit Agarwal, K H Reeta, Y K Gupta. Comparison of three different extracts of Centella asiatica for anti-amnesic, antioxidant and anticholinergic activities: in vitro and in vivo study. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Sep; 105(?):1344-1352. doi: 10.1016/j.biopha.2018.05.156. [PMID: 30021372]
  • Patcharaporn Hengjumrut, Tosapol Anukunwithaya, Mayuree H Tantisira, Boonyong Tantisira, Phisit Khemawoot. Comparative pharmacokinetics between madecassoside and asiaticoside presented in a standardised extract of Centella asiatica, ECa 233 and their respective pure compound given separately in rats. Xenobiotica; the fate of foreign compounds in biological systems. 2018 Jan; 48(1):18-27. doi: 10.1080/00498254.2016.1273562. [PMID: 28001462]
  • Tosapol Anukunwithaya, Mayuree H Tantisira, Boonyong Tantisira, Phisit Khemawoot. Pharmacokinetics of a Standardized Extract of Centella asiatica ECa 233 in Rats. Planta medica. 2017 May; 83(8):710-717. doi: 10.1055/s-0042-122344. [PMID: 27992940]
  • Jinjin Lin, Hui Jiang, Xianting Ding. Synergistic combinations of five single drugs from Centella asiatica for neuronal differentiation. Neuroreport. 2017 Jan; 28(1):23-27. doi: 10.1097/wnr.0000000000000698. [PMID: 27893605]
  • Shu Qing Li, Yong Sheng Xie, Qing Wen Meng, Jing Zhang, Tao Zhang. Neuroprotective properties of Madecassoside from Centella asiatica after hypoxic-ischemic injury. Pakistan journal of pharmaceutical sciences. 2016 Nov; 29(6):2047-2051. doi: ". [PMID: 28375122]
  • Robert Azerad. Chemical structures, production and enzymatic transformations of sapogenins and saponins from Centella asiatica (L.) Urban. Fitoterapia. 2016 Oct; 114(?):168-187. doi: 10.1016/j.fitote.2016.07.011. [PMID: 27491750]
  • Zhonghao Su, Jin Ye, Zhenxia Qin, Xianting Ding. Protective effects of madecassoside against Doxorubicin induced nephrotoxicity in vivo and in vitro. Scientific reports. 2015 Dec; 5(?):18314. doi: 10.1038/srep18314. [PMID: 26658818]
  • Ting Wang, Zhifeng Wei, Yannong Dou, Yan Yang, Dandan Leng, Lingyi Kong, Yue Dai, Yufeng Xia. Intestinal interleukin-10 mobilization as a contributor to the anti-arthritis effect of orally administered madecassoside: a unique action mode of saponin compounds with poor bioavailability. Biochemical pharmacology. 2015 Mar; 94(1):30-8. doi: 10.1016/j.bcp.2015.01.004. [PMID: 25600909]
  • Ting Wang, Dan-Dan Leng, Fei-Fei Gao, Chun-Jie Jiang, Yu-Feng Xia, Yue Dai. A LC-ESI-MS method for the simultaneous determination of madecassoside and its metabolite madecassic acid in rat plasma: comparison pharmacokinetics in normal and collagen-induced arthritic rats. Chinese journal of natural medicines. 2014 Dec; 12(12):943-51. doi: 10.1016/s1875-5364(14)60138-2. [PMID: 25556066]
  • Yuejuan Zheng, Xin Jiang, Feng Gao, Junxiang Song, Jinxia Sun, Lixin Wang, Xiaoxia Sun, Zhenhui Lu, Huiyong Zhang. Identification of plant-derived natural products as potential inhibitors of the Mycobacterium tuberculosis proteasome. BMC complementary and alternative medicine. 2014 Oct; 14(?):400. doi: 10.1186/1472-6882-14-400. [PMID: 25315519]
  • Yuan Luo, Yi-Ping Yang, Jie Liu, Wan-Hua Li, Jun Yang, Xin Sui, Xin Yuan, Zhi-Yong Nie, Yan-Qin Liu, Ding Chen, Shao-Hui Lin, Yong-An Wang. Neuroprotective effects of madecassoside against focal cerebral ischemia reperfusion injury in rats. Brain research. 2014 May; 1565(?):37-47. doi: 10.1016/j.brainres.2014.04.008. [PMID: 24735651]
  • Qian Shen, Lu-shan Yu, Hui Zhou, Su Zeng. [Simultaneous determination of madecassoside, asiaticoside and their aglycones in Centella asiatica (L.) urban extracts by RP-HPLC]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. 2014 03; 43(2):135-40. doi: 10.3785/j.issn.1008-9292.2014.03.002. [PMID: 24782366]
  • Dan-dan Leng, Wen-jing Han, Yao Rui, Yue Dai, Yu-feng Xia. In vivo disposition and metabolism of madecassoside, a major bioactive constituent in Centella asiatica (L.) Urb. Journal of ethnopharmacology. 2013 Nov; 150(2):601-8. doi: 10.1016/j.jep.2013.09.004. [PMID: 24091240]
  • Chang-Liang Xu, Rong Qu, Jin Zhang, Lu-Fan Li, Shi-Ping Ma. Neuroprotective effects of madecassoside in early stage of Parkinson's disease induced by MPTP in rats. Fitoterapia. 2013 Oct; 90(?):112-8. doi: 10.1016/j.fitote.2013.07.009. [PMID: 23876367]
  • Jacinda T James, Fidele Tugizimana, Paul A Steenkamp, Ian A Dubery. Metabolomic analysis of methyl jasmonate-induced triterpenoid production in the medicinal herb Centella asiatica (L.) urban. Molecules (Basel, Switzerland). 2013 Apr; 18(4):4267-81. doi: 10.3390/molecules18044267. [PMID: 23579994]
  • P Puttarak, P Panichayupakaranant. Factors affecting the content of pentacyclic triterpenes in Centella asiatica raw materials. Pharmaceutical biology. 2012 Dec; 50(12):1508-12. doi: 10.3109/13880209.2012.685946. [PMID: 22966846]
  • Difei Bian, Mei Liu, Ying Li, Yufeng Xia, Zhunan Gong, Yue Dai. Madecassoside, a triterpenoid saponin isolated from Centella asiatica herbs, protects endothelial cells against oxidative stress. Journal of biochemical and molecular toxicology. 2012 Oct; 26(10):399-406. doi: 10.1002/jbt.21434. [PMID: 22829481]
  • Jie Song, Huan Xu, Qian Lu, Zhao Xu, Difei Bian, Yufeng Xia, Zhifeng Wei, Zhunan Gong, Yue Dai. Madecassoside suppresses migration of fibroblasts from keloids: involvement of p38 kinase and PI3K signaling pathways. Burns : journal of the International Society for Burn Injuries. 2012 Aug; 38(5):677-84. doi: 10.1016/j.burns.2011.12.017. [PMID: 22360962]
  • Wen-Jing Han, Yu-Feng Xia, Yue Dai. Development and validation of high-performance liquid chromatography/electrospray ionization mass spectrometry for assay of madecassoside in rat plasma and its application to pharmacokinetic study. Biomedical chromatography : BMC. 2012 Jan; 26(1):26-32. doi: 10.1002/bmc.1620. [PMID: 21413047]
  • Wei Cao, Xiao-Qiang Li, Xiao-Nan Zhang, Ying Hou, Ai-Guo Zeng, Yan-Hua Xie, Si-Wang Wang. Madecassoside suppresses LPS-induced TNF-alpha production in cardiomyocytes through inhibition of ERK, p38, and NF-kappaB activity. International immunopharmacology. 2010 Jul; 10(7):723-9. doi: 10.1016/j.intimp.2010.03.015. [PMID: 20381648]
  • Ok Tae Kim, Sun Hee Kim, Kiyoshi Ohyama, Toshiya Muranaka, Yong Eui Choi, Hyeon Yong Lee, Min Young Kim, Baik Hwang. Upregulation of phytosterol and triterpene biosynthesis in Centella asiatica hairy roots overexpressed ginseng farnesyl diphosphate synthase. Plant cell reports. 2010 Apr; 29(4):403-11. doi: 10.1007/s00299-010-0831-y. [PMID: 20195611]
  • Jong-Heon Won, Ji-Sun Shin, Hee-Juhn Park, Hyun-Ju Jung, Duck-Jae Koh, Baek-Geon Jo, Jin-Yong Lee, Kijoo Yun, Kyung-Tae Lee. Anti-inflammatory effects of madecassic acid via the suppression of NF-kappaB pathway in LPS-induced RAW 264.7 macrophage cells. Planta medica. 2010 Feb; 76(3):251-7. doi: 10.1055/s-0029-1186142. [PMID: 19774506]
  • Hongzhong Li, Xia Gong, Li Zhang, Zhuo Zhang, Fuling Luo, Qixin Zhou, Jin Chen, Jingyuan Wan. Madecassoside attenuates inflammatory response on collagen-induced arthritis in DBA/1 mice. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2009 Jun; 16(6-7):538-46. doi: 10.1016/j.phymed.2008.11.002. [PMID: 19135346]
  • Mei Liu, Yue Dai, Xiujuan Yao, Ying Li, Yubin Luo, Yufeng Xia, Zhunan Gong. Anti-rheumatoid arthritic effect of madecassoside on type II collagen-induced arthritis in mice. International immunopharmacology. 2008 Nov; 8(11):1561-6. doi: 10.1016/j.intimp.2008.06.011. [PMID: 18652917]
  • Mei Liu, Yue Dai, Ying Li, Yubin Luo, Fang Huang, Zhunan Gong, Qingyu Meng. Madecassoside isolated from Centella asiatica herbs facilitates burn wound healing in mice. Planta medica. 2008 Jun; 74(8):809-15. doi: 10.1055/s-2008-1074533. [PMID: 18484522]
  • Mingzhe Gao, Xiaoyan Yuan, Hongbin Xiao. [Preparation of asiaticoside and madecassoside from the extract of Centella asiatica (L.) Urb using preparative high performance liquid chromatography]. Se pu = Chinese journal of chromatography. 2008 May; 26(3):362-5. doi: ". [PMID: 18724677]
  • Guang-Xing Bian, Gui-Gui Li, Yun Yang, Rui-Ting Liu, Jian-Ping Ren, Li-Qing Wen, Shao-Ming Guo, Qiu-Jun Lu. Madecassoside reduces ischemia-reperfusion injury on regional ischemia induced heart infarction in rat. Biological & pharmaceutical bulletin. 2008 Mar; 31(3):458-63. doi: 10.1248/bpb.31.458. [PMID: 18310910]
  • Feng-Lun Zhang, Ying-Jie Wei, Jia Zhu, Zhu-Nan Gong. Simultaneous quantitation of three major triterpenoid glycosides in Centella asiatica extracts by high performance liquid chromatography with evaporative light scattering detection. Biomedical chromatography : BMC. 2008 Feb; 22(2):119-24. doi: 10.1002/bmc.901. [PMID: 17703474]
  • Gui-Gui Li, Guang-Xing Bian, Jian-Ping Ren, Li-Qing Wen, Min Zhang, Qiu-Jun Lü. [Protective effect of madecassoside against reperfusion injury after regional ischemia in rabbit heart in vivo]. Yao xue xue bao = Acta pharmaceutica Sinica. 2007 May; 42(5):475-80. doi: NULL. [PMID: 17703767]
  • Jingchun Gao, Feng Huang, Jinchao Zhang, Guoyuan Zhu, Mengsu Yang, Peigen Xiao. Cytotoxic cycloartane triterpene saponins from Actaea asiatica. Journal of natural products. 2006 Oct; 69(10):1500-2. doi: 10.1021/np060113h. [PMID: 17067171]
  • J H Sampson, A Raman, G Karlsen, H Navsaria, I M Leigh. In vitro keratinocyte antiproliferant effect of Centella asiatica extract and triterpenoid saponins. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2001 May; 8(3):230-5. doi: 10.1078/0944-7113-00032. [PMID: 11417919]
  • F Bonté, M Dumas, C Chaudagne, A Meybeck. [Comparative activity of asiaticoside and madecassoside on type I and III collagen synthesis by cultured human fibroblasts]. Annales pharmaceutiques francaises. 1995; 53(1):38-42. doi: NULL. [PMID: 7741425]