Hydrocotarnine (BioDeep_00000019006)

   

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


1,2,3,4-tetrahydro-8-Methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinoline, 9ci

化学式: C12H15NO3 (221.1052)
中文名称:
谱图信息: 最多检出来源 Mus musculus(otcml) 5.07%

分子结构信息

SMILES: CN1CCC2=CC3=C(C(=C2C1)OC)OCO3
InChI: InChI=1S/C12H15NO3/c1-13-4-3-8-5-10-12(16-7-15-10)11(14-2)9(8)6-13/h5H,3-4,6-7H2,1-2H3

描述信息

Hydrocotarnine is an alkaloid from opium (Papaver somniferum).
Alkaloid from opium (Papaver somniferum).
Hydrocotarnine is a Cbl inhibitor, and results in inflammasome-mediated IL-18 secretion in colitis. Hydrocotarnine increases expression of GLUT1 and cellular glucose uptake in glycolytic metabolism. Hydrocotarnine acts as an agent that provides analgesic effect in cancer research[1][2][3].

同义名列表

10 个代谢物同义名

1,2,3,4-tetrahydro-8-Methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinoline, 9ci; 1,2,3,4-tetrahydro-8-Methoxy-2-methyl-6,7-methylenedioxyisoquinoline; 5,6,7,8-Tetrahydro-4-methoxy-6-methyl-1,3-dioxolo[4,5-g]isoquinoline; 4-methoxy-6-methyl-2H,5H,6H,7H,8H-[1,3]dioxolo[4,5-g]isoquinoline; Hydrocotarnine hydrochloride monohydrate; Hydrocotarnine hydrochloride (JP15); Hydrocotarnine hydrochloride; Hydrocotarnine hydrobromide; Hydrocotarnine; Hydrocotarnin



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

16 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Hideya Kokubun, Motohiro Matoba, Yasuhiko Yamada, Kazuo Yago. [Solutions for the clinical problems of analgesics for cancer pain treatment in Japan]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2011 Jan; 131(1):113-27. doi: 10.1248/yakushi.131.113. [PMID: 21212621]
  • Hideya Kokubun, Misako Fukawa, Motohiro Matoba, Sumio Hoka, Yasuhiko Yamada, Kazuo Yago. Pharmacokinetics and variation in the clearance of oxycodone and hydrocotarnine in patients with cancer pain. Biological & pharmaceutical bulletin. 2007 Nov; 30(11):2173-7. doi: 10.1248/bpb.30.2173. [PMID: 17978495]
  • Sue Paterson, Rosa Cordero. Comparison of the various opiate alkaloid contaminants and their metabolites found in illicit heroin with 6-monoacetyl morphine as indicators of heroin ingestion. Journal of analytical toxicology. 2006 May; 30(4):267-73. doi: 10.1093/jat/30.4.267. [PMID: 16803666]
  • Hideya Kokubun, Makiko Ouki, Motohiro Matoba, Hiroaki Kubo, Sumio Hoka, Kazuo Yago. Determination of oxycodone and hydrocotarnine in cancer patient serum by high-performance liquid chromatography with electrochemical detection. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2005 Mar; 21(3):337-9. doi: 10.2116/analsci.21.337. [PMID: 15790123]
  • B Göber, S Pfeifer, K Pankow, R Kraft. [Biotransformation and Stability of Hydrocotarnine and Diazocarbonylhydrocotarnine and -hydrohydrastinine derivatives (author's transl)]. Die Pharmazie. 1979 Dec; 34(12):830-7. doi: NULL. [PMID: 545353]