D-erythro-Eritadenine (BioDeep_00000018972)

 

Secondary id: BioDeep_00000615953

human metabolite Endogenous


代谢物信息卡片


6-Amino-alpha,beta-dihydroxy-9H-purine-9-butanoic acid

化学式: C9H11N5O4 (253.08110059999998)
中文名称: D-二十碳四烯
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=NC(=C2C(=N1)N(C=N2)CC(C(C(=O)O)O)O)N
InChI: InChI=1S/C9H11N5O4/c10-7-5-8(12-2-11-7)14(3-13-5)1-4(15)6(16)9(17)18/h2-4,6,15-16H,1H2,(H,17,18)(H2,10,11,12)

描述信息

D-erythro-Eritadenine is found in mushrooms. D-erythro-Eritadenine is isolated from the edible shitake mushroo
D004791 - Enzyme Inhibitors

同义名列表

17 个代谢物同义名

6-Amino-alpha,beta-dihydroxy-9H-purine-9-butanoic acid; 4-(6-amino-9H-purin-9-yl)-2,3-dihydroxybutanoic acid; 4-(6-Amino-9H-purin-9-yl)-4-deoxy-D-erythronic acid; D-4-(6-Amino-9H-purin-9-yl)-4-deoxyerythronic acid; Eritadenine, monosodium salt, (S-(r*,r*))-isomer; Eritadenine, monosodium salt, (R-(r*,r*))-isomer; 4-(6-Amino-9H-purin-9-yl)-2,3-dihydroxybutanoate; Eritadenine, (S-(r*,r*))-isomer; Eritadenine, (S-(r*,s*))-isomer; Eritadenine, (R-(r*,s*))-isomer; D-erythro-Eritadenine; D-Erythro-form; D-Eritadenine; Eritadenine; Lentinacin; Lentysine; dea



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Diego Morales, María Tabernero, Carlota Largo, Gonzalo Polo, Adriana Jiménez Piris, Cristina Soler-Rivas. Effect of traditional and modern culinary processing, bioaccessibility, biosafety and bioavailability of eritadenine, a hypocholesterolemic compound from edible mushrooms. Food & function. 2018 Dec; 9(12):6360-6368. doi: 10.1039/c8fo01704b. [PMID: 30456394]
  • Ning Zhang, Haixia Chen, Yu Zhang, Lishuai Ma, Xufeng Xu. Comparative studies on chemical parameters and antioxidant properties of stipes and caps of shiitake mushroom as affected by different drying methods. Journal of the science of food and agriculture. 2013 Sep; 93(12):3107-13. doi: 10.1002/jsfa.6151. [PMID: 23553427]
  • Taro Yamada, Junichi Komoto, Kaiyan Lou, Akiharu Ueki, Duy H Hua, Kimio Sugiyama, Yoshimi Takata, Hirofumi Ogawa, Fusao Takusagawa. Structure and function of eritadenine and its 3-deaza analogues: potent inhibitors of S-adenosylhomocysteine hydrolase and hypocholesterolemic agents. Biochemical pharmacology. 2007 Apr; 73(7):981-9. doi: 10.1016/j.bcp.2006.12.014. [PMID: 17214973]
  • Shin-ichiro Fukada, Minoru Setoue, Tatsuya Morita, Kimio Sugiyama. Dietary eritadenine suppresses guanidinoacetic Acid-induced hyperhomocysteinemia in rats. The Journal of nutrition. 2006 Nov; 136(11):2797-802. doi: 10.1093/jn/136.11.2797. [PMID: 17056803]
  • Atsushi Sekiya, Shin-Ichiro Fukada, Tatsuya Morita, Hirokazu Kawagishi, Kimio Sugiyama. Suppression of methionine-induced hyperhomocysteinemia by dietary eritadenine in rats. Bioscience, biotechnology, and biochemistry. 2006 Aug; 70(8):1987-91. doi: 10.1271/bbb.60075. [PMID: 16880595]
  • Yasuhiko Shimada, Akihiro Yamakawa, Tatsuya Morita, Kimio Sugiyama. Effects of dietary eritadenine on the liver microsomal Delta6-desaturase activity and its mRNA in rats. Bioscience, biotechnology, and biochemistry. 2003 Jun; 67(6):1258-66. doi: 10.1271/bbb.67.1258. [PMID: 12843651]
  • Yasuhiko Shimada, Tatsuya Morita, Kimio Sugiyama. Eritadenine-induced alterations of plasma lipoprotein lipid concentrations and phosphatidylcholine molecular species profile in rats fed cholesterol-free and cholesterol-enriched diets. Bioscience, biotechnology, and biochemistry. 2003 May; 67(5):996-1006. doi: 10.1271/bbb.67.996. [PMID: 12834276]
  • Yasuhiko Shimada, Tatsuya Morita, Kimio Sugiyama. Dietary eritadenine and ethanolamine depress fatty acid desaturase activities by increasing liver microsomal phosphatidylethanolamine in rats. The Journal of nutrition. 2003 Mar; 133(3):758-65. doi: 10.1093/jn/133.3.758. [PMID: 12612149]
  • Yasuhiko Shimada, Tatsuya Morita, Kimio Sugiyama. Effects of dietary eritadenine on delta6-desaturase activity and fatty acid profiles of several lipids in rats fed different fats. Bioscience, biotechnology, and biochemistry. 2002 Jul; 66(7):1605-9. doi: 10.1271/bbb.66.1605. [PMID: 12224653]
  • K Sugiyama, A Kumazawa, H Zhou, S Saeki. Dietary methionine level affects linoleic acid metabolism through phosphatidylethanolamine N-methylation in rats. Lipids. 1998 Mar; 33(3):235-42. doi: 10.1007/s11745-998-0201-2. [PMID: 9560797]
  • K Sugiyama, A Yamakawa, S Saeki. Correlation of suppressed linoleic acid metabolism with the hypocholesterolemic action of eritadenine in rats. Lipids. 1997 Aug; 32(8):859-66. doi: 10.1007/s11745-997-0110-4. [PMID: 9270978]
  • K Sugiyama, A Yamakawa, H Kawagishi, S Saeki. Dietary eritadenine modifies plasma phosphatidylcholine molecular species profile in rats fed different types of fat. The Journal of nutrition. 1997 Apr; 127(4):593-9. doi: 10.1093/jn/127.4.593. [PMID: 9109610]
  • K Sugiyama, A Yamakawa. Dietary eritadenine-induced alteration of molecular species composition of phospholipids in rats. Lipids. 1996 Apr; 31(4):399-404. doi: 10.1007/bf02522926. [PMID: 8743052]
  • K Sugiyama, T Akachi, A Yamakawa. Hypocholesterolemic action of eritadenine is mediated by a modification of hepatic phospholipid metabolism in rats. The Journal of nutrition. 1995 Aug; 125(8):2134-44. doi: 10.1093/jn/125.8.2134. [PMID: 7643248]
  • A Svardal, H Refsum, P M Ueland. Determination of in vivo protein binding of homocysteine and its relation to free homocysteine in the liver and other tissues of the rat. The Journal of biological chemistry. 1986 Mar; 261(7):3156-63. doi: 10.1016/s0021-9258(17)35762-9. [PMID: 3949766]