Polymyxin B Sulfate (BioDeep_00000018946)

   

human metabolite blood metabolite


代谢物信息卡片


N-[3-Amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-2,5,8,11,14,17,20-heptahydroxy-3-(1-hydroxyethyl)-12-(2-methylpropyl)-1,4,7,10,13,16,19-heptaazacyclotricosa-1,4,7,10,13,16,19-heptaen-21-yl]-C-hydroxycarbonimidoyl}propyl)-C-hydroxycarbonimidoyl]-2-hydroxypropyl}-C-hydroxycarbonimidoyl)propyl]-6-methyloctanimidate

化学式: C56H98N16O13 (1202.7498898)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC(C)CCCCC(=O)NC(CCN)C(=O)NC(C(C)O)C(=O)NC(CCN)C(=O)NC1CCNC(=O)C(NC(=O)C(CCN)NC(=O)C(CCN)NC(=O)C(CC(C)C)NC(=O)C(CC2=CC=CC=C2)NC(=O)C(CCN)NC1=O)C(C)O
InChI: InChI=1S/C56H98N16O13/c1-7-32(4)13-11-12-16-44(75)63-36(17-23-57)51(80)72-46(34(6)74)56(85)68-39(20-26-60)48(77)67-41-22-28-62-55(84)45(33(5)73)71-52(81)40(21-27-61)65-47(76)37(18-24-58)66-53(82)42(29-31(2)3)69-54(83)43(30-35-14-9-8-10-15-35)70-49(78)38(19-25-59)64-50(41)79/h8-10,14-15,31-34,36-43,45-46,73-74H,7,11-13,16-30,57-61H2,1-6H3,(H,62,84)(H,63,75)(H,64,79)(H,65,76)(H,66,82)(H,67,77)(H,68,85)(H,69,83)(H,70,78)(H,71,81)(H,72,80)/t32?,33-,34-,36+,37+,38-,39+,40+,41+,42+,43-,45+,46+/m1/s1

描述信息

Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D011113 - Polymyxins
D000890 - Anti-Infective Agents > D023181 - Antimicrobial Cationic Peptides

同义名列表

14 个代谢物同义名

N-[3-Amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-2,5,8,11,14,17,20-heptahydroxy-3-(1-hydroxyethyl)-12-(2-methylpropyl)-1,4,7,10,13,16,19-heptaazacyclotricosa-1,4,7,10,13,16,19-heptaen-21-yl]-C-hydroxycarbonimidoyl}propyl)-C-hydroxycarbonimidoyl]-2-hydroxypropyl}-C-hydroxycarbonimidoyl)propyl]-6-methyloctanimidate; N-[(2S)-4-amino-1-[[(2S,3R)-1-[[(2S)-4-amino-1-oxo-1-[[(3S,6S,9S,12S,15R,18R,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-[(1R)-1-hydroxyethyl]-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptazacyclotricos-21-yl]amino]butan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-1-oxobutan-2-yl]-6-methyloctanamide; N-[3-amino-1-({1-[(3-amino-1-{[6,9,18-tris(2-aminoethyl)-15-benzyl-3-(1-hydroxyethyl)-12-(2-methylpropyl)-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl]carbamoyl}propyl)carbamoyl]-2-hydroxypropyl}carbamoyl)propyl]-6-methyloctanamide; Polymyxin b sulphuric acid; Polymyxin b sulphate salt; Polymyxin b sulfuric acid; Polymyxin b sulfate salt; Sulfate, polymyxin b; Polymixin b sulphate; Polymyxin b sulphate; Polymyxin B sulfate; Polymixin b sulfate; Polymyxin b; Aerosporin



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Hui Li, Wenhui E, Dongying Zhao, Haiyang Liu, Jian Pei, Binghai Du, Kai Liu, Xueming Zhu, Chengqiang Wang. Response of Paenibacillus polymyxa SC2 to the stress of polymyxin B and a key ABC transporter YwjA involved. Applied microbiology and biotechnology. 2024 Dec; 108(1):17. doi: 10.1007/s00253-023-12916-3. [PMID: 38170316]
  • Marie Burt, Georgia Angelidou, Christopher Nils Mais, Christian Preußer, Timo Glatter, Thomas Heimerl, Rüdiger Groß, Javier Serrania, Gowtham Boosarpu, Elke Pogge von Strandmann, Janis A Müller, Gert Bange, Anke Becker, Mareike Lehmann, Danny Jonigk, Lavinia Neubert, Hinrich Freitag, Nicole Paczia, Bernd Schmeck, Anna Lena Jung. Lipid A in outer membrane vesicles shields bacteria from polymyxins. Journal of extracellular vesicles. 2024 May; 13(5):e12447. doi: 10.1002/jev2.12447. [PMID: 38766978]
  • Hui-Zhong Sun, Qing Li, Wei Shang, Bin Qiao, Qiu-Man Xu, Jing-Sheng Cheng. Combinatorial metabolic engineering of Bacillus subtilis for de novo production of polymyxin B. Metabolic engineering. 2024 May; 83(?):123-136. doi: 10.1016/j.ymben.2024.04.001. [PMID: 38582143]
  • Nina Královič-Kanjaková, Ali Asi Shirazi, Lukáš Hubčík, Mária Klacsová, Atoosa Keshavarzi, Juan Carlos Martínez, Sophie Combet, José Teixeira, Daniela Uhríková. Polymyxin B-Enriched Exogenous Lung Surfactant: Thermodynamics and Structure. Langmuir : the ACS journal of surfaces and colloids. 2024 Apr; 40(13):6847-6861. doi: 10.1021/acs.langmuir.3c03746. [PMID: 38501650]
  • Manon Janet-Maitre, Viviana Job, Maxime Bour, Mylène Robert-Genthon, Sabine Brugière, Pauline Triponney, David Cobessi, Yohann Couté, Katy Jeannot, Ina Attrée. Pseudomonas aeruginosa MipA-MipB envelope proteins act as new sensors of polymyxins. mBio. 2024 Mar; 15(3):e0221123. doi: 10.1128/mbio.02211-23. [PMID: 38345374]
  • G L Xia, X Xu, X B You, X Wang, D D Feng, S Lei, R L Jiang. Efficacy and nephrotoxicity of polymyxin B in elderly patients with carbapenem resistant bacterial infection. Annals of clinical microbiology and antimicrobials. 2023 Nov; 22(1):101. doi: 10.1186/s12941-023-00647-2. [PMID: 37968642]
  • Chunxia Hu, Jinyong Zhang, Ruiqin Cui, Shiyi Liu, Ying Huang, Huan Zeng, Shumin Cheng, Guibao Zhou, Jingli Li, Longqin Sun, Yan Zhao, Xiao Wang, Jianhua Liu, Quanming Zou, Wei Huang. The enhancement effect of small molecule Lyb24 reveals AzoR as a novel target of polymyxin B. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Nov; ?(?):115856. doi: 10.1016/j.biopha.2023.115856. [PMID: 37949698]
  • Melanie N Hurst, Connor J Beebout, Alexis Hollingsworth, Kirsten R Guckes, Alexandria Purcell, Tomas A Bermudez, Diamond Williams, Seth A Reasoner, M Stephen Trent, Maria Hadjifrangiskou. The QseB response regulator imparts tolerance to positively charged antibiotics by controlling metabolism and minor changes to LPS. mSphere. 2023 10; 8(5):e0005923. doi: 10.1128/msphere.00059-23. [PMID: 37676915]
  • Xiangfeng Lai, Seong Hoong Chow, Anton P Le Brun, Benjamin W Muir, Phillip J Bergen, Jacinta White, Heidi H Yu, Jiping Wang, Jill Danne, Jhih-Hang Jiang, Francesca L Short, Mei-Ling Han, Richard A Strugnell, Jiangning Song, Neil R Cameron, Anton Y Peleg, Jian Li, Hsin-Hui Shen. Polysaccharide-Targeting Lipid Nanoparticles to Kill Gram-Negative Bacteria. Small (Weinheim an der Bergstrasse, Germany). 2023 Oct; ?(?):e2305052. doi: 10.1002/smll.202305052. [PMID: 37798622]
  • Meiling Yu, Hongyu Li, Boying Wang, Zhenxiang Wu, Sheng Wu, Guojun Jiang, Huaxue Wang, Yingying Huang. Baicalein ameliorates polymyxin B-induced acute renal injury by inhibiting ferroptosis via regulation of SIRT1/p53 acetylation. Chemico-biological interactions. 2023 Sep; 382(?):110607. doi: 10.1016/j.cbi.2023.110607. [PMID: 37354967]
  • Jing Lu, Meiling Han, Heidi H Yu, Phillip J Bergen, Yiyun Liu, Jinxin Zhao, Hasini Wickremasinghe, Xukai Jiang, Yang Hu, Haiyan Du, Yan Zhu, Tony Velkov. Lipid A Modification and Metabolic Adaptation in Polymyxin-Resistant, New Delhi Metallo-β-Lactamase-Producing Klebsiella pneumoniae. Microbiology spectrum. 2023 Jul; ?(?):e0085223. doi: 10.1128/spectrum.00852-23. [PMID: 37432123]
  • Hongyu Li, Boying Wang, Sheng Wu, Shuying Dong, Guojun Jiang, Yingying Huang, Xuhui Tong, Meiling Yu. Ferroptosis is involved in polymyxin B-induced acute kidney injury via activation of p53. Chemico-biological interactions. 2023 Jun; 378(?):110479. doi: 10.1016/j.cbi.2023.110479. [PMID: 37088170]
  • Alexandria B Purcell, Brent W Simpson, M Stephen Trent. Impact of the cAMP-cAMP Receptor Protein Regulatory Complex on Lipopolysaccharide Modifications and Polymyxin B Resistance in Escherichia coli. Journal of bacteriology. 2023 Apr; ?(?):e0006723. doi: 10.1128/jb.00067-23. [PMID: 37070977]
  • Bradley Whitehead, Fabio Antennuci, Anders T Boysen, Peter Nejsum. Polymyxin B inhibits pro-inflammatory effects of E. coli outer membrane vesicles whilst increasing immune cell uptake and clearance. The Journal of antibiotics. 2023 Apr; ?(?):. doi: 10.1038/s41429-023-00615-0. [PMID: 37016014]
  • Patrick O Hanafin, Nusaibah Abdul Rahim, Rajnikant Sharma, Colin G Cess, Stacey D Finley, Phillip J Bergen, Tony Velkov, Jian Li, Gauri G Rao. Proof-of-concept for incorporating mechanistic insights from multi-omics analyses of polymyxin B in combination with chloramphenicol against Klebsiella pneumoniae. CPT: pharmacometrics & systems pharmacology. 2023 03; 12(3):387-400. doi: 10.1002/psp4.12923. [PMID: 36661181]
  • Lewis MacDonald, Sean Keenan, Flaviana Di Lorenzo, Nana E Adade, Dervla T D Kenna, Beverley C Millar, John E Moore, José Ramos Vivas, Antonio Molinaro, Miguel A Valvano. Polymyxin Resistance and Heteroresistance Are Common in Clinical Isolates of Achromobacter Species and Correlate with Modifications of the Lipid A Moiety of Lipopolysaccharide. Microbiology spectrum. 2023 Feb; 11(1):e0372922. doi: 10.1128/spectrum.03729-22. [PMID: 36519943]
  • Mohd Hafidz Mahamad Maifiah, Yan Zhu, Brian T Tsuji, Darren J Creek, Tony Velkov, Jian Li. Integrated metabolomic and transcriptomic analyses of the synergistic effect of polymyxin-rifampicin combination against Pseudomonas aeruginosa. Journal of biomedical science. 2022 Oct; 29(1):89. doi: 10.1186/s12929-022-00874-3. [PMID: 36310165]
  • Diship Srivastava, Niladri Patra. Self-Uptake Mechanism of Polymyxin-Based Lipopeptide against Gram-Negative Bacterial Membrane: Role of the First Adsorbed Lipopeptide. The journal of physical chemistry. B. 2022 10; 126(41):8222-8232. doi: 10.1021/acs.jpcb.2c03827. [PMID: 36126341]
  • Lei Fu, Xiangyuan Li, Shan Zhang, Yi Dong, Weihai Fang, Lianghui Gao. Polymyxins induce lipid scrambling and disrupt the homeostasis of Gram-negative bacteria membrane. Biophysical journal. 2022 09; 121(18):3486-3498. doi: 10.1016/j.bpj.2022.08.007. [PMID: 35964158]
  • Ting Huang, Mao Zeng, Huiyao Fu, Kelei Zhao, Tao Song, Yidong Guo, Jingyu Zhou, Longfei Zhai, Chaolan Liu, Balakrishnan Prithiviraj, Xinrong Wang, Yiwen Chu. A novel antibiotic combination of linezolid and polymyxin B octapeptide PBOP against clinical Pseudomonas aeruginosa strains. Annals of clinical microbiology and antimicrobials. 2022 Aug; 21(1):38. doi: 10.1186/s12941-022-00531-5. [PMID: 36038932]
  • Christopher Mullally, Keith A Stubbs, Van C Thai, Anandhi Anandan, Stephanie Bartley, Martin J Scanlon, Gary A Jarvis, Constance M John, Katherine Y L Lim, Courtney M Sullivan, Mitali Sarkar-Tyson, Alice Vrielink, Charlene M Kahler. Novel small molecules that increase the susceptibility of Neisseria gonorrhoeae to cationic antimicrobial peptides by inhibiting lipid A phosphoethanolamine transferase. The Journal of antimicrobial chemotherapy. 2022 08; 77(9):2441-2447. doi: 10.1093/jac/dkac204. [PMID: 35770844]
  • Xuemei Luo, Yusheng Zhang, Pei Liang, Huaijun Zhu, Meijuan Li, Xuansheng Ding, Jinping Zhang. Population pharmacokinetics of polymyxin B and dosage strategy in critically ill patients with/without continuous renal replacement therapy. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2022 Aug; 175(?):106214. doi: 10.1016/j.ejps.2022.106214. [PMID: 35609779]
  • Emanuela Locci, Jiajun Liu, Gwendolyn M Pais, Alberto Chighine, Dariusc Andrea Kahnamoei, Theodoros Xanthos, Athanasios Chalkias, Andrew Lee, Alan R Hauser, Jack Chang, Nathaniel J Rhodes, Ernesto d'Aloja, Marc H Scheetz. Urinary Metabolomics From a Dose-Fractionated Polymyxin B Rat Model of Acute Kidney Injury. International journal of antimicrobial agents. 2022 Jul; 60(1):106593. doi: 10.1016/j.ijantimicag.2022.106593. [PMID: 35460851]
  • Kazumasa Ohashi, Ryo Ito, Ryo Koda, Noriaki Iino, Toshinori Takada. Serum cytokine changes induced by direct hemoperfusion with polymyxin B-immobilized fiber in patients with acute respiratory failure. Respiratory investigation. 2022 Jul; 60(4):585-594. doi: 10.1016/j.resinv.2022.04.003. [PMID: 35525835]
  • Guanhao Zheng, Jiaqi Cai, Shenghui Zhou, Ning Du, Hao Bai, Juan He, Xiaolan Bian. Risk of polymyxin B-induced acute kidney injury with a non adjusted dose versus adjusted dose based on renal function. Personalized medicine. 2022 Jul; 19(4):307-314. doi: 10.2217/pme-2021-0003. [PMID: 35762314]
  • Taylor Abbey, Alesia Vialichka, Michele Jurkovic, Mark Biagi, Eric Wenzler. Activity of Omadacycline Alone and in Combination against Carbapenem-Nonsusceptible Acinetobacter baumannii with Varying Minocycline Susceptibility. Microbiology spectrum. 2022 06; 10(3):e0054222. doi: 10.1128/spectrum.00542-22. [PMID: 35647655]
  • Taotao Lu, Xinyu Zheng, Fei Mao, Qiao Cao, Qin Cao, Jin Zhu, Xiaokang Li, Lefu Lan, Baoli Li, Jian Li. Novel niclosamide-derived adjuvants elevating the efficacy of polymyxin B against MDR Pseudomonas aeruginosa DK2. European journal of medicinal chemistry. 2022 Jun; 236(?):114318. doi: 10.1016/j.ejmech.2022.114318. [PMID: 35398731]
  • Daisuke Katagiri, Shinyu Izumi, Hideki Takano. When should polymyxin B-immobilized polystyrene column be introduced to improve COVID-19 prognosis?. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2022 06; 26(3):550-551. doi: 10.1111/1744-9987.13825. [PMID: 35247232]
  • Mingyeong Kang, Wonjae Kim, Jaebok Lee, Hye Su Jung, Che Ok Jeon, Woojun Park. 6-Bromo-2-naphthol from Silene armeria extract sensitizes Acinetobacter baumannii strains to polymyxin. Scientific reports. 2022 05; 12(1):8546. doi: 10.1038/s41598-022-11995-y. [PMID: 35595766]
  • Claudio Ronco, Rinaldo Bellomo. Hemoperfusion: technical aspects and state of the art. Critical care (London, England). 2022 05; 26(1):135. doi: 10.1186/s13054-022-04009-w. [PMID: 35549999]
  • Qinghua Ye, Qianlin Wang, Ziying Chen, Wenqian Chen, Qingyuan Zhan, Chen Wang. Effectiveness, nephrotoxicity, and therapeutic drug monitoring of polymyxin B in nosocomial pneumonia among critically ill patients. The clinical respiratory journal. 2022 May; 16(5):402-412. doi: 10.1111/crj.13493. [PMID: 35586931]
  • Yury A Surovoy, Maksim A Burkin, Inna A Galvidis, Pavel O Bochkov, Armen V Oganesyan, Sergei V Tsarenko. Comparative polymyxin B pharmacokinetics in patients receiving extracorporeal membrane oxygenation. The Journal of antimicrobial chemotherapy. 2022 04; 77(5):1379-1384. doi: 10.1093/jac/dkac021. [PMID: 35134959]
  • M Mohammed Atiyah, H Shnawa Jasim, H Mohammed Atiyah. Phytochemical Screening and Antibacterial Activities of Aqueous and Alcoholic Extracts of Averrhoa bilimbi Leaf against Bacteria Isolated from Oral Cavity. Archives of Razi Institute. 2022 Apr; 77(2):923-928. doi: 10.22092/ari.2022.357207.1996. [PMID: 36284968]
  • Kang Chang, Haibo Wang, Jianping Zhao, Xianghong Yang, Bo Wu, Wenkui Sun, Man Huang, Zhenshun Cheng, Hong Chen, Yuanlin Song, Ping Chen, Xiangqi Chen, Xin Gan, Wanli Ma, Lihua Xing, Yimin Wang, Bin Cao. Risk factors for polymyxin B-associated acute kidney injury. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2022 Apr; 117(?):37-44. doi: 10.1016/j.ijid.2022.01.055. [PMID: 35108608]
  • Mousumi Ray, Ashwini Manjunath, Prakash M Halami. Prevalence of polymyxin resistance through the food chain, the global crisis. The Journal of antibiotics. 2022 04; 75(4):185-198. doi: 10.1038/s41429-022-00502-0. [PMID: 35079146]
  • Xiaolan Huang, Xiaofen Liu, Yu Wang, Jing Zhang. Determination of polymyxin B in dried blood spots using LC-MS/MS for therapeutic drug monitoring. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2022 Mar; 1192(?):123131. doi: 10.1016/j.jchromb.2022.123131. [PMID: 35149368]
  • Lu Han, Fang-Min Xu, Xiao-Shan Zhang, Chun-Hong Zhang, Ying Dai, Zi-Ye Zhou, Ye-Xuan Wang, Fan Chen, Da-Wei Shi, Guan-Yang Lin, Xu-Ben Yu. Trough polymyxin B plasma concentration is an independent risk factor for its nephrotoxicity. British journal of clinical pharmacology. 2022 03; 88(3):1202-1210. doi: 10.1111/bcp.15061. [PMID: 34449094]
  • Yuliang Sun, Zhixiong Deng, Xukai Jiang, Bing Yuan, Kai Yang. Interactions between polymyxin B and various bacterial membrane mimics: A molecular dynamics study. Colloids and surfaces. B, Biointerfaces. 2022 Mar; 211(?):112288. doi: 10.1016/j.colsurfb.2021.112288. [PMID: 34942463]
  • Tamer Z Attia, Mahmoud A Abdelmajed, Mahmoud A Omar, Khalid M Badr El-Din. Selective Spectrofluorimetric Protocol for Determination of Commonly Used Gram-negative Bactericidal Drug in Combined Pharmaceutical Dosage Forms and Human Plasma. Journal of fluorescence. 2022 Mar; 32(2):603-612. doi: 10.1007/s10895-021-02862-6. [PMID: 35013853]
  • Jun Li, Mengli Tang, Fengjun Xia, Changhang Min, Yongmei Hu, Haichen Wang, Mingxiang Zou. Emergence of polymyxin B-heteroresistant hypervirulent Klebsiella pneumoniae from an individual in the community with asymptomatic bacteriuria. BMC microbiology. 2022 02; 22(1):47. doi: 10.1186/s12866-022-02462-9. [PMID: 35130831]
  • Xiangfeng Lai, Mei-Ling Han, Yue Ding, Seong Hoong Chow, Anton P Le Brun, Chun-Ming Wu, Phillip J Bergen, Jhih-Hang Jiang, Hsien-Yi Hsu, Benjamin W Muir, Jacinta White, Jiangning Song, Jian Li, Hsin-Hui Shen. A polytherapy based approach to combat antimicrobial resistance using cubosomes. Nature communications. 2022 01; 13(1):343. doi: 10.1038/s41467-022-28012-5. [PMID: 35039508]
  • Tomohiro Kagi, Rio Naganuma, Aya Inoue, Takuya Noguchi, Shuhei Hamano, Yuto Sekiguchi, Gi-Wook Hwang, Yusuke Hirata, Atsushi Matsuzawa. The polypeptide antibiotic polymyxin B acts as a pro-inflammatory irritant by preferentially targeting macrophages. The Journal of antibiotics. 2022 01; 75(1):29-39. doi: 10.1038/s41429-021-00490-7. [PMID: 34824374]
  • Sadudee Peerapornratana, Phatadon Sirivongrangson, Somkanya Tungsanga, Kanitha Tiankanon, Win Kulvichit, Opass Putcharoen, John A Kellum, Nattachai Srisawat. Endotoxin Adsorbent Therapy in Severe COVID-19 Pneumonia. Blood purification. 2022; 51(1):47-54. doi: 10.1159/000515628. [PMID: 33857940]
  • Alice Goode, Vivien Yeh, Boyan B Bonev. Interactions of polymyxin B with lipopolysaccharide-containing membranes. Faraday discussions. 2021 12; 232(0):317-329. doi: 10.1039/d1fd00036e. [PMID: 34550139]
  • Patrick O Hanafin, Roger L Nation, Marc H Scheetz, Alexandre P Zavascki, Ana M Sandri, Andrea L Kwa, Benjamin P Z Cherng, Christine J Kubin, Michael T Yin, Jiping Wang, Jian Li, Keith S Kaye, Gauri G Rao. Assessing the predictive performance of population pharmacokinetic models for intravenous polymyxin B in critically ill patients. CPT: pharmacometrics & systems pharmacology. 2021 12; 10(12):1525-1537. doi: 10.1002/psp4.12720. [PMID: 34811968]
  • Anna Olsson, Marcus Hong, Hissa Al-Farsi, Christian G Giske, Pernilla Lagerbäck, Thomas Tängdén. Interactions of Polymyxin B in Combination with Aztreonam, Minocycline, Meropenem, and Rifampin against Escherichia coli Producing NDM and OXA-48-Group Carbapenemases. Antimicrobial agents and chemotherapy. 2021 11; 65(12):e0106521. doi: 10.1128/aac.01065-21. [PMID: 34516251]
  • Cassandra E Nelson, Weiliang Huang, Emily M Zygiel, Elizabeth M Nolan, Maureen A Kane, Amanda G Oglesby. The Human Innate Immune Protein Calprotectin Elicits a Multimetal Starvation Response in Pseudomonas aeruginosa. Microbiology spectrum. 2021 10; 9(2):e0051921. doi: 10.1128/spectrum.00519-21. [PMID: 34549997]
  • Zhen Wang, Jiawei Wang, Jie Cheng, Xiaowen Yang, Hai Jiang, Qingmin Wu. Genome-Wide Analysis of the Response of Brucella melitensis NI to Polymyxin B. Current pharmaceutical biotechnology. 2021 Oct; 22(14):1891-1899. doi: 10.2174/1389201021666201218125148. [PMID: 33342409]
  • Jibao Zhu, Chengfei Hu, Zizhen Zeng, Xiaoyu Deng, Lingbing Zeng, Saisai Xie, Yuanying Fang, Yi Jin, Valérie Alezra, Yang Wan. Polymyxin B-inspired non-hemolytic tyrocidine A analogues with significantly enhanced activity against gram-negative bacteria: How cationicity impacts cell specificity and antibacterial mechanism. European journal of medicinal chemistry. 2021 Oct; 221(?):113488. doi: 10.1016/j.ejmech.2021.113488. [PMID: 33991963]
  • G L Xia, R L Jiang. Efficacy and safety of polymyxin B in carbapenem-resistant gram-negative organisms infections. BMC infectious diseases. 2021 Oct; 21(1):1034. doi: 10.1186/s12879-021-06719-y. [PMID: 34607561]
  • Yanli Shi, Yong He, Lvxia Zhang, Lin Wang, Zhifeng Fu. Dual-site recognition of Pseudomonas aeruginosa using polymyxin B and bacteriophage tail fiber protein. Analytica chimica acta. 2021 Oct; 1180(?):338855. doi: 10.1016/j.aca.2021.338855. [PMID: 34538321]
  • Haruhiko Ogawa, Yasushi Kakuchi, Hidesaku Asakura. Possibility of PMX-DHP therapy as a principal strategy against cytokine storm in COVID-19: Insights from reconstructed coagulation data. Journal of clinical apheresis. 2021 Oct; 36(5):785-786. doi: 10.1002/jca.21925. [PMID: 34252978]
  • Jong Min Lee, Seung Don Baek, Tae Hyun Kim, Hwa Ran Jeon, Jin Hee Han, Jai Won Chang. Uncertain Clinical Effect of Polymyxin B Hemoperfusion in Patients with Septic Acute Kidney Injury Requiring Continuous Renal Replacement Therapy. Shock (Augusta, Ga.). 2021 10; 56(4):551-556. doi: 10.1097/shk.0000000000001752. [PMID: 33606479]
  • Ryan L Crass, Tamara Al Naimi, Bo Wen, Ernane Souza, Susan Murray, Manjunath P Pai, Shijing Jia. Pharmacokinetics of Polymyxin B in Hospitalized Adults with Cystic Fibrosis. Antimicrobial agents and chemotherapy. 2021 09; 65(10):e0079221. doi: 10.1128/aac.00792-21. [PMID: 34252297]
  • Maksim A Burkin, Inna A Galvidis, Yuri A Surovoy, Ivan V Plyushchenko, Igor A Rodin, Sergei V Tsarenko. Development of ELISA formats for polymyxin B monitoring in serum of critically ill patients. Journal of pharmaceutical and biomedical analysis. 2021 Sep; 204(?):114275. doi: 10.1016/j.jpba.2021.114275. [PMID: 34311285]
  • Maizbha U Ahmed, Mohammad A K Azad, Mengyao Li, Darren J Creek, Meiling Han, Fanfan Zhou, Kim Chan, Qi Tony Zhou, Tony Velkov, Jian Li. Polymyxin-Induced Metabolic Perturbations in Human Lung Epithelial Cells. Antimicrobial agents and chemotherapy. 2021 08; 65(9):e0083521. doi: 10.1128/aac.00835-21. [PMID: 34228550]
  • Sean N Avedissian, Marc H Scheetz. Does renal function matter for polymyxin B?. British journal of clinical pharmacology. 2021 07; 87(7):2629-2632. doi: 10.1111/bcp.14675. [PMID: 33325056]
  • Jaeeun Park, Misung Kim, Bora Shin, Mingyeong Kang, Jihye Yang, Tae Kwon Lee, Woojun Park. A novel decoy strategy for polymyxin resistance in Acinetobacter baumannii. eLife. 2021 06; 10(?):. doi: 10.7554/elife.66988. [PMID: 34180396]
  • Zhentao Li, Xin Yan, Keke Wu, Yanpeng Jiao, Changren Zhou, Jingxin Yang. Surface Modification of Reduced Graphene Oxide Beads: Integrating Efficient Endotoxin Adsorption and Improved Blood Compatibility. ACS applied bio materials. 2021 06; 4(6):4896-4906. doi: 10.1021/acsabm.0c01666. [PMID: 35007038]
  • Chui-Yoke Chin, Jinshi Zhao, Anna C Llewellyn, Igor Golovliov, Anders Sjöstedt, Pei Zhou, David S Weiss. Francisella FlmX broadly affects lipopolysaccharide modification and virulence. Cell reports. 2021 06; 35(11):109247. doi: 10.1016/j.celrep.2021.109247. [PMID: 34133919]
  • Silvia De Rosa, Salvatore Lucio Cutuli, Ricard Ferrer, Massimo Antonelli, Claudio Ronco. Polymyxin B hemoperfusion in coronavirus disease 2019 patients with endotoxic shock: Case series from EUPHAS2 registry. Artificial organs. 2021 Jun; 45(6):E187-E194. doi: 10.1111/aor.13900. [PMID: 33377184]
  • Daisuke Katagiri, Masahiro Ishikane, Yusuke Asai, Shinyu Izumi, Jin Takasaki, Hiyori Katsuoka, Isao Kondo, Satoshi Ide, Keiji Nakamura, Takato Nakamoto, Hidetoshi Nomoto, Yutaro Akiyama, Yusuke Miyazato, Tetsuya Suzuki, Noriko Kinoshita, Tatsunori Ogawa, Tomiteru Togano, Manabu Suzuki, Masao Hashimoto, Keita Sakamoto, Yusaku Kusaba, Takashi Katsuno, Takashi Fukaya, Masayuki Hojo, Masaya Sugiyama, Masashi Mizokami, Tatsuya Okamoto, Akio Kimura, Eisei Noiri, Norio Ohmagari, Fumihiko Hinoshita, Haruhito Sugiyama. Direct hemoperfusion using a polymyxin B-immobilized polystyrene column for COVID-19. Journal of clinical apheresis. 2021 Jun; 36(3):313-321. doi: 10.1002/jca.21861. [PMID: 33325084]
  • Nayara Helisandra Fedrigo, Danielle Rosani Shinohara, Josmar Mazucheli, Sheila Alexandra Belini Nishiyama, Floristher Elaine Carrara-Marroni, Frederico Severino Martins, Peijuan Zhu, Mingming Yu, Sherwin Kenneth B Sy, Maria Cristina Bronharo Tognim. Pharmacodynamic evaluation of suppression of in vitro resistance in Acinetobacter baumannii strains using polymyxin B-based combination therapy. Scientific reports. 2021 05; 11(1):11339. doi: 10.1038/s41598-021-90709-2. [PMID: 34059725]
  • Cong Bang Truong, Spencer H Durham, Jingjing Qian. Comparisons of adverse event reporting for colistin versus polymyxin B using the US Food and Drug Administration Adverse Event Reporting System (FAERS). Expert opinion on drug safety. 2021 May; 20(5):603-609. doi: 10.1080/14740338.2021.1890024. [PMID: 33573405]
  • Xu-Ben Yu, Zheng Jiao, Chun-Hong Zhang, Ying Dai, Zi-Ye Zhou, Lu Han, Xin Wen, Chang-Cheng Sheng, Guan-Yang Lin, Jing-Ye Pan. Population pharmacokinetic and optimization of polymyxin B dosing in adult patients with various renal functions. British journal of clinical pharmacology. 2021 04; 87(4):1869-1877. doi: 10.1111/bcp.14576. [PMID: 33002196]
  • Lili Zhou, Caiting Li, Qinyong Weng, Jinting Wu, Haoteng Luo, Zhiqiang Xue, Ying Xiao, Cunrong Chen. [Clinical study on intravenous combined with aerosol inhalation of polymyxin B for the treatment of pneumonia caused by multidrug-resistant Gram-negative bacteria]. Zhonghua wei zhong bing ji jiu yi xue. 2021 Apr; 33(4):416-420. doi: 10.3760/cma.j.cn121430-20201215-00753. [PMID: 34053483]
  • Bruno C Borro, Marie S Toussaint, Saskia Bucciarelli, Martin Malmsten. Effects of charge contrast and composition on microgel formation and interactions with bacteria-mimicking liposomes. Biochimica et biophysica acta. General subjects. 2021 04; 1865(4):129485. doi: 10.1016/j.bbagen.2019.129485. [PMID: 31734459]
  • Hisataka Shoji, Steven M Opal. Therapeutic Rationale for Endotoxin Removal with Polymyxin B Immobilized Fiber Column (PMX) for Septic Shock. International journal of molecular sciences. 2021 Feb; 22(4):. doi: 10.3390/ijms22042228. [PMID: 33672437]
  • Sveva Auletta, Filippo Galli, Michela Varani, Giuseppe Campagna, Martina Conserva, Daniela Martinelli, Iolanda Santino, Alberto Signore. In Vitro and In Vivo Evaluation of 99mTc-Polymyxin B for Specific Targeting of Gram-Bacteria. Biomolecules. 2021 02; 11(2):. doi: 10.3390/biom11020232. [PMID: 33562877]
  • Takao Kobayashi, Sota Iwatani, Akihiro Hirata, Miwa Yamamoto, Seiji Yoshimoto. Rapid changes in serum IL-6 levels in preterm newborns with Gram-negative early-onset sepsis. Cytokine. 2021 02; 138(?):155371. doi: 10.1016/j.cyto.2020.155371. [PMID: 33243627]
  • Peile Wang, Qiwen Zhang, Zhenfeng Zhu, Hui Pei, Min Feng, Tongwen Sun, Jing Yang, Xiaojian Zhang. Comparing the Population Pharmacokinetics of and Acute Kidney Injury Due to Polymyxin B in Chinese Patients with or without Renal Insufficiency. Antimicrobial agents and chemotherapy. 2021 01; 65(2):. doi: 10.1128/aac.01900-20. [PMID: 33168613]
  • Wenqian Chen, Huifang Liu, Qianlin Wang, Xiaoxing Wang, Xudong Kong, Xiaoxue Wang, Xianglin Zhang, Qingyuan Zhan, Pengmei Li. Estimation of the area under concentration-time curve of polymyxin B based on limited sampling concentrations in Chinese patients with severe pneumonia. European journal of clinical pharmacology. 2021 Jan; 77(1):95-105. doi: 10.1007/s00228-020-02986-x. [PMID: 32875388]
  • Wenrui Sun, Binchuan Hu, Xiaoshan Zhang, Yuzhen Wang, Zheng Xiang, Guanyang Lin. Effect of Different Dosage Frequency of Polymyxin B on Rat Nephrotoxicity. Drug design, development and therapy. 2021; 15(?):611-616. doi: 10.2147/dddt.s287332. [PMID: 33623370]
  • Toshiaki Utsunomiya, Yuka Mimura-Kimura, Takeshi Yamamoto, Keisuke Aoe, Keiji Oishi, Haruhito Kamei, Kazuto Matsunaga, Masafumi Yano, Yusuke Mimura. Cytokine Adsorption to Polymyxin B-Immobilized Fiber: An in vitro Study. Blood purification. 2021; 50(2):230-237. doi: 10.1159/000510290. [PMID: 32894831]
  • Amanda Castillo-Zeledón, Nazareth Ruiz-Villalobos, Pamela Altamirano-Silva, Carlos Chacón-Díaz, Elías Barquero-Calvo, Esteban Chaves-Olarte, Caterina Guzmán-Verri. A Sinorhizobium meliloti and Agrobacterium tumefaciens ExoR ortholog is not crucial for Brucella abortus virulence. PloS one. 2021; 16(8):e0254568. doi: 10.1371/journal.pone.0254568. [PMID: 34388167]
  • Xuben Yu, Jingye Pan, Ziye Zhou, Xin Wen, Ying Dai, Guanyang Lin, Zheng Jiao, Chunhong Zhang. TDM-guided medication of polymyxin B in a patient with CRKP-induced bloodstream infection: a case report. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2021 Jan; 40(1):201-204. doi: 10.1007/s10096-020-03945-1. [PMID: 32661810]
  • Naohide Kurita, Kazuo Yamashiro, Takuma Kuroki, Ryota Tanaka, Takao Urabe, Yuji Ueno, Nobukazu Miyamoto, Masashi Takanashi, Hideki Shimura, Toshiki Inaba, Yuichiro Yamashiro, Koji Nomoto, Satoshi Matsumoto, Takuya Takahashi, Hirokazu Tsuji, Takashi Asahara, Nobutaka Hattori. Metabolic endotoxemia promotes neuroinflammation after focal cerebral ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2020 12; 40(12):2505-2520. doi: 10.1177/0271678x19899577. [PMID: 31910709]
  • Tomoki Imaoka, Jade Yang, Lu Wang, Matthew G McDonald, Zahra Afsharinejad, Theo K Bammler, Kirk Van Ness, Catherine K Yeung, Allan E Rettie, Jonathan Himmelfarb, Edward J Kelly. Microphysiological system modeling of ochratoxin A-associated nephrotoxicity. Toxicology. 2020 11; 444(?):152582. doi: 10.1016/j.tox.2020.152582. [PMID: 32905824]
  • Irene Hortelano, Yolanda Moreno, Fidson Juarismi Vesga, María Antonia Ferrús. Evaluation of different culture media for detection and quantification of H. pylori in environmental and clinical samples. International microbiology : the official journal of the Spanish Society for Microbiology. 2020 Nov; 23(4):481-487. doi: 10.1007/s10123-020-00135-z. [PMID: 32607781]
  • Ming Ni, Xiangdong Meng, Limin Wang, Yanan Zhao, Min Yu, Sheng Shi. Polymyxin B-induced rhabdomyolysis: A case report. Medicine. 2020 Oct; 99(43):e22924. doi: 10.1097/md.0000000000022924. [PMID: 33120846]
  • Mennatallah A Gowayed, Samar El Achy, Maher A Kamel, Rasha A El-Tahan. Polymyxin B prevents the development of adjuvant arthritis via modulation of TLR/Cox-2 signaling pathway. Life sciences. 2020 Oct; 259(?):118250. doi: 10.1016/j.lfs.2020.118250. [PMID: 32791152]
  • Peile Wang, Qiwen Zhang, Zifei Qin, Han Xing, Min Xu, Hui Pei, Jing Yang, Xiaojian Zhang. A Simple and Robust Liquid Chromatography With Tandem Mass Spectrometry Analytical Method for Therapeutic Drug Monitoring of Plasma and Cerebrospinal Fluid Polymyxin B1 and B2. Therapeutic drug monitoring. 2020 10; 42(5):716-723. doi: 10.1097/ftd.0000000000000754. [PMID: 32941397]
  • Yusaku Kusaba, Shinyu Izumi, Jin Takasaki, Manabu Suzuki, Daisuke Katagiri, Takashi Katsuno, Shuichiro Matsumoto, Keita Sakamoto, Masao Hashimoto, Norio Ohmagari, Harutaka Katano, Tadaki Suzuki, Masayuki Hojo, Haruhito Sugiyama. Successful Recovery from COVID-19-associated Acute Respiratory Failure with Polymyxin B-immobilized Fiber Column-direct Hemoperfusion. Internal medicine (Tokyo, Japan). 2020 Oct; 59(19):2405-2408. doi: 10.2169/internalmedicine.5413-20. [PMID: 32863364]
  • Xingqiao Peng, Xingyue Yan, Li Zhu, Yiran Gu, Zhenglong Sun, Xiaobei Zhan. Preparation of polymyxin B-loaded gellan-polylysine polyion complex fibers with high affinity to endotoxin. International journal of biological macromolecules. 2020 Oct; 160(?):703-710. doi: 10.1016/j.ijbiomac.2020.05.263. [PMID: 32497663]
  • Jianguo Li, Roger Beuerman, Chandra S Verma. Mechanism of polyamine induced colistin resistance through electrostatic networks on bacterial outer membranes. Biochimica et biophysica acta. Biomembranes. 2020 09; 1862(9):183297. doi: 10.1016/j.bbamem.2020.183297. [PMID: 32339485]
  • Yawei Zhang, Chunjiang Zhao, Qi Wang, Xiaojuan Wang, Hongbin Chen, Henan Li, Feifei Zhang, Hui Wang. Evaluation of the in vitro activity of new polymyxin B analogue SPR206 against clinical MDR, colistin-resistant and tigecycline-resistant Gram-negative bacilli. The Journal of antimicrobial chemotherapy. 2020 09; 75(9):2609-2615. doi: 10.1093/jac/dkaa217. [PMID: 32591806]
  • Akira Yamagata, Machiko Arita, Ayaka Tanaka, Fumiaki Tokioka, Tomohiro Yoshida, Keisuke Nishimura, Tadashi Ishida. Therapeutic plasma exchange for clinically amyopathic dermatomyositis (CADM) associated with rapidly progressive interstitial pneumonia. Journal of clinical apheresis. 2020 Sep; 35(5):435-443. doi: 10.1002/jca.21824. [PMID: 32810902]
  • Ying Ran, Hirokazu Fukui, Xin Xu, Xuan Wang, Nobuhiko Ebisutani, Yoshiki Tanaka, Ayako Maeda, Yutaka Makizaki, Hiroshi Ohno, Takashi Kondo, Tomoaki Kono, Katsuyuki Tozawa, Toshihiko Tomita, Tadayuki Oshima, Hiroto Miwa. Alteration of Colonic Mucosal Permeability during Antibiotic-Induced Dysbiosis. International journal of molecular sciences. 2020 Aug; 21(17):. doi: 10.3390/ijms21176108. [PMID: 32854266]
  • Nusaibah Abdul Rahim, Soon-Ee Cheah, Matthew D Johnson, Yan Zhu, Heidi H Yu, Hanna E Sidjabat, Mark S Butler, Matthew A Cooper, Jing Fu, David L Paterson, Roger L Nation, John D Boyce, Phillip J Bergen, Tony Velkov, Jian Li. Transcriptomic responses of a New Delhi metallo-β-lactamase-producing Klebsiella pneumoniae isolate to the combination of polymyxin B and chloramphenicol. International journal of antimicrobial agents. 2020 Aug; 56(2):106061. doi: 10.1016/j.ijantimicag.2020.106061. [PMID: 32574791]
  • Christian Nehls, Arne Böhling, Rainer Podschun, Sabine Schubert, Joachim Grötzinger, Andra Schromm, Henning Fedders, Matthias Leippe, Jürgen Harder, Yani Kaconis, Sabine Gronow, Thomas Gutsmann. Influence of disulfide bonds in human beta defensin-3 on its strain specific activity against Gram-negative bacteria. Biochimica et biophysica acta. Biomembranes. 2020 08; 1862(8):183273. doi: 10.1016/j.bbamem.2020.183273. [PMID: 32171739]
  • Dawood Al-Ajmi, Shafeeq Rahman, Sharmila Banu. Occurrence, virulence genes, and antimicrobial profiles of Escherichia coli O157 isolated from ruminants slaughtered in Al Ain, United Arab Emirates. BMC microbiology. 2020 07; 20(1):210. doi: 10.1186/s12866-020-01899-0. [PMID: 32677884]
  • Martina Paldrychová, Eva Vaňková, Petra Kašparová, Eliška Sembolová, Olga Maťátková, Jan Masák, Vladimír Scholtz, Jaroslav Julák. Use of non-thermal plasma pre-treatment to enhance antibiotic action against mature Pseudomonas aeruginosa biofilms. World journal of microbiology & biotechnology. 2020 Jul; 36(8):108. doi: 10.1007/s11274-020-02891-6. [PMID: 32656596]
  • Choongdeok Lee, Meong Il Kim, Jaewan Park, Junghun Kim, Hansol Oh, Yoeseph Cho, Junghyun Son, Bo-Young Jeon, Hakhyun Ka, Minsun Hong. Crystal structure of the Pseudomonas aeruginosa PA0423 protein and its functional implication in antibiotic sequestration. Biochemical and biophysical research communications. 2020 07; 528(1):85-91. doi: 10.1016/j.bbrc.2020.05.023. [PMID: 32451086]
  • A-Long Cui, Xin-Xin Hu, Yang Chen, Jie Jin, Hong Yi, Xiu-Kun Wang, Qi-Yang He, Xue-Fu You, Zhuo-Rong Li. Design, Synthesis, and Bioactivity of Cyclic Lipopeptide Antibiotics with Varied Polarity, Hydrophobicity, and Positive Charge Distribution. ACS infectious diseases. 2020 07; 6(7):1796-1806. doi: 10.1021/acsinfecdis.0c00056. [PMID: 32330004]
  • Takayoshi Gocho, Hisatake Mori, Md Monirul Islam, Yuki Maruchi, Nobuyoshi Takenaka, Atsutoshi Tomino, Masanobu Tsuda, Hideki Kano, Naoshi Takeyama. Removal of Circulating Neutrophil Extracellular Trap Components With an Immobilized Polymyxin B Filter: A Preliminary Study. Shock (Augusta, Ga.). 2020 07; 54(1):44-49. doi: 10.1097/shk.0000000000001476. [PMID: 31764624]
  • Maytham Hussein, Elena K Schneider-Futschik, Olivia K A Paulin, Rafah Allobawi, Simon Crawford, Qi Tony Zhou, Adil Hanif, Mark Baker, Yan Zhu, Jian Li, Tony Velkov. Effective Strategy Targeting Polymyxin-Resistant Gram-Negative Pathogens: Polymyxin B in Combination with the Selective Serotonin Reuptake Inhibitor Sertraline. ACS infectious diseases. 2020 06; 6(6):1436-1450. doi: 10.1021/acsinfecdis.0c00108. [PMID: 32427476]
  • Xiaofen Liu, Zhenwei Yu, Yu Wang, Hailan Wu, Xingchen Bian, Xin Li, Yaxin Fan, Beining Guo, Jing Zhang. Therapeutic drug monitoring of polymyxin B by LC-MS/MS in plasma and urine. Bioanalysis. 2020 Jun; 12(12):845-855. doi: 10.4155/bio-2020-0051. [PMID: 32558589]
  • Vincent Peyko, Henry Cohen. A Comparison of Adjusted Versus Unadjusted Doses of Polymyxin B Based on Renal Function and Incidence of Acute Kidney Injury. Journal of pharmacy practice. 2020 Jun; 33(3):255-261. doi: 10.1177/0897190018798881. [PMID: 30189762]
  • Bejoy P Maniara, Lauren E Healy, Thien-Ly Doan. Risk of Nephrotoxicity Associated With Nonrenally Adjusted Intravenous Polymyxin B Compared to Traditional Dosing. Journal of pharmacy practice. 2020 Jun; 33(3):287-292. doi: 10.1177/0897190018799261. [PMID: 30253682]