5,7-Dihydroxyisoflavone (BioDeep_00000018888)

   

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


5,7-Dihydroxy-3-phenyl-4H-1-benzopyran-4-one, 9ci

化学式: C15H10O4 (254.057906)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 25%

分子结构信息

SMILES: c1(cc(c2c(c1)occ(c2=O)c1ccccc1)O)O
InChI: InChI=1S/C15H10O4/c16-10-6-12(17)14-13(7-10)19-8-11(15(14)18)9-4-2-1-3-5-9/h1-8,16-17H

描述信息

5,7-Dihydroxyisoflavone is found in nuts. 5,7-Dihydroxyisoflavone is isolated from hydrolysed flour of Arachis hypogaea (peanut) Mefenamic acid, an anthranilic acid derivative, is a member of the fenamate group of nonsteroidal anti-inflammatory drugs (NSAIDs). It exhibits anti-inflammatory, analgesic, and antipyretic activities. Similar to other NSAIDs, mefenamic acid inhibits prostaglandin synthetase
D018501 - Antirheumatic Agents > D000894 - Anti-Inflammatory Agents, Non-Steroidal > D016861 - Cyclooxygenase Inhibitors
Isolated from hydrolysed flour of Arachis hypogaea (peanut). 5,7-Dihydroxyisoflavone is found in peanut and nuts.
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000893 - Anti-Inflammatory Agents
D004791 - Enzyme Inhibitors

同义名列表

87 个代谢物同义名

5,7-Dihydroxy-3-phenyl-4H-1-benzopyran-4-one, 9ci; 2,3-Dimethyl-2-diphenylaminecarboxylic acid; 2-((2,3-Dimethylphenyl)amino)-benzoic acid; 2-[(2,3-Dimethylphenyl)amino]-benzoic acid; 2-((2,3-Dimethylphenyl)amino)benzoic acid; 2-[(2,3-dimethylphenyl)amino]benzoic acid; 2-(2,3-Dimethylphenyl)amino-benzoic acid; N-(2, 3-Dimethylphenyl)anthranilic acid; 5,7-dihydroxy-3-phenyl-4H-chromen-4-one; Warner-lambert brand OF mefenamic acid; N-(2,3-Dimethylphenyl)anthranilic acid; Warner lambert brand OF mefenamic acid; First horizon brand OF mefenamic acid; Pharmascience brand OF mefenamic acid; 5,7-dihydroxy-3-phenylchromen-4-one; Farmasierra brand OF mefenamic acid; 2-(2,3-dimethylanilino)Benzoic acid; Parke davis brand OF mefenamic acid; N-(2,3-Xylyl)-2-aminobenzoic acid; Ashbourne brand OF mefenamic acid; Chemidex brand OF mefenamic acid; Nu pharm brand OF mefenamic acid; Pinewood brand OF mefenamic acid; Nu-pharm brand OF mefenamic acid; Antigen brand OF mefenamic acid; Clonmel brand OF mefenamic acid; Pfizer brand OF mefenamic acid; Apotex brand OF mefenamic acid; N-(2,3-Xylyl)-anthranilic acid; N-(2,3-Xylyl)anthranilic acid; Mefenamic acid (JP15/usp/inn); Rowa brand OF mefenamic acid; Elan brand OF mefenamic acid; N-2,3-Xylyl-anthranilic acid; APS brand OF mefenamic acid; N-2,3-Xylylanthranilic acid; 5,7-Dihydroxyisoflavone; Acidum mefenamicum; PMS-Mefenamic acid; PMS Mefenamic acid; Mephenaminic acid; Acid, mefenaminic; Acido mefenamico; Mefenaminic acid; Acid, mefenamic; Mephenamic acid; Methenamic acid; Bafhameritin-m; Forte, ponstan; mefenamic acid; Ac. mefenamico; Apo-mefenamic; Bafameritin-m; Tamany bonsan; Ponstan forte; Apo mefenamic; ApoMefenamic; Nu-mefenamic; Nu mefenamic; NuMefenamic; Pinalgesic; Mefenamate; Contraflam; Mycasaal; Ponalgic; Parkemed; Mefedolo; Vialidon; Namphen; Mefacit; Ponstan; Bonabol; Fenamin; Lysalgo; Ponstel; Ponstyl; Ponalar; Tanston; Ponstil; Coslan; Dysman; Ponsyl; Ponmel; Pontal; Rolan; Mefac; Mefic



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jose Guzman-Esquivel, Hector R Galvan-Salazar, Hannah P Guzman-Solorzano, Andrea C Cuevas-Velazquez, Jose A Guzman-Solorzano, Karen A Mokay-Ramirez, Brenda A Paz-Michel, Efren Murillo-Zamora, Josuel Delgado-Enciso, Valery Melnikov, Osiris G Delgado-Enciso, Iram P Rodriguez-Sanchez, Margarita L Martinez-Fierro, Fabian Rojas-Larios, Mireya Walle-Guillen, Citlaly B Cardenas-Aguilar, Oscar Beas-Guzman, Daniel Chaviano-Conesa, Hossana S Garcia-Garcia, Ivan Delgado-Enciso. Efficacy of the use of mefenamic acid combined with standard medical care vs. standard medical care alone for the treatment of COVID‑19: A randomized double‑blind placebo‑controlled trial. International journal of molecular medicine. 2022 Mar; 49(3):. doi: 10.3892/ijmm.2022.5084. [PMID: 35029292]
  • Dounia Sid, Milad Baitiche, Zineb Elbahri, Ferhat Djerboua, Mokhtar Boutahala, Zouhair Bouaziz, Marc Le Borgne. Solubility enhancement of mefenamic acid by inclusion complex with β-cyclodextrin: in silico modelling, formulation, characterisation, and in vitro studies. Journal of enzyme inhibition and medicinal chemistry. 2021 Dec; 36(1):605-617. doi: 10.1080/14756366.2020.1869225. [PMID: 33557644]
  • Yan Rong, Tony K L Kiang. Characterization of human sulfotransferases catalyzing the formation of p-cresol sulfate and identification of mefenamic acid as a potent metabolism inhibitor and potential therapeutic agent for detoxification. Toxicology and applied pharmacology. 2021 08; 425(?):115553. doi: 10.1016/j.taap.2021.115553. [PMID: 33915121]
  • Rami Ayoub, Qais Jarrar, Dalia Ali, Said Moshawih, Yazun Jarrar, Muhammad Hakim, Zainul Zakaria. Synthesis of Novel Esters of Mefenamic Acid with Pronounced Anti-nociceptive Effects and a Proposed Activity on GABA, Opioid and Glutamate Receptors. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2021 Aug; 163(?):105865. doi: 10.1016/j.ejps.2021.105865. [PMID: 33979659]
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  • Yazun Jarrar, Qais Jarrar, Mohammad Abu-Shalhoob, Abdulqader Abed, Esra'a Sha'ban. Relative Expression of Mouse Udp-glucuronosyl Transferase 2b1 Gene in the Livers, Kidneys, and Hearts: The Influence of Nonsteroidal Anti-inflammatory Drug Treatment. Current drug metabolism. 2019; 20(11):918-923. doi: 10.2174/1389200220666191115103310. [PMID: 31733637]
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  • Hamid Asiabi, Yadollah Yamini, Maryam Shamsayei. Development of electrochemically controlled packed-in-tube solid phase microextraction method for sensitive analysis of acidic drugs in biological samples. Talanta. 2018 Aug; 185(?):80-88. doi: 10.1016/j.talanta.2018.03.058. [PMID: 29759253]
  • Esra Dilek, Sema Caglar, Kübra Erdogan, Bülent Caglar, Onur Sahin. Synthesis and characterization of four novel palladium(II) and platinum(II) complexes with 1-(2-aminoethyl)pyrrolidine, diclofenac and mefenamic acid: In vitro effect of these complexes on human serum paraoxanase1 activity. Journal of biochemical and molecular toxicology. 2018 Apr; 32(4):e22043. doi: 10.1002/jbt.22043. [PMID: 29512227]
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  • Siok Yean Tan, Mei Mei Wong, Angela Lu Wun Tiew, Yai Wen Choo, Suat Hun Lim, Ing Hong Ooi, Pilar Modamio, Cecilia Fernández, Eduardo L Mariño, Ignacio Segarra. Sunitinib DDI with paracetamol, diclofenac, mefenamic acid and ibuprofen shows sex-divergent effects on the tissue uptake and distribution pattern of sunitinib in mice. Cancer chemotherapy and pharmacology. 2016 10; 78(4):709-18. doi: 10.1007/s00280-016-3120-9. [PMID: 27495788]
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