N,N-dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)indoline-5-sulfonamide (BioDeep_00001884874)

   


代谢物信息卡片


N,N-dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylene)indoline-5-sulfonamide

化学式: C19H21N3O3S (371.13035560000003)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(C)S(=O)(=O)C1=CC2=C(C=C1)NC(=O)C2=CC3=CC4=C(N3)CCCC4
InChI: InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)



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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ting Yu, Enze Zheng, Yanping Li, Yuqi Li, Jun Xia, Qiuying Ding, Zhengping Hou, Xiong Z Ruan, Lei Zhao, Yaxi Chen. Src-mediated Tyr353 phosphorylation of IP3R1 promotes its stability and causes apoptosis in palmitic acid-treated hepatocytes. Experimental cell research. 2021 02; 399(2):112438. doi: 10.1016/j.yexcr.2020.112438. [PMID: 33358861]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Tuyen N M Hua, Min-Kyu Kim, Vu T A Vo, Jong-Whan Choi, Jang Hyun Choi, Hyun-Won Kim, Seung-Kuy Cha, Kyu-Sang Park, Yangsik Jeong. Inhibition of oncogenic Src induces FABP4-mediated lipolysis via PPARγ activation exerting cancer growth suppression. EBioMedicine. 2019 Mar; 41(?):134-145. doi: 10.1016/j.ebiom.2019.02.015. [PMID: 30755372]
  • Oscar Lindblad, Julhash U Kazi, Lars Rönnstrand, Jianmin Sun. PI3 kinase is indispensable for oncogenic transformation by the V560D mutant of c-Kit in a kinase-independent manner. Cellular and molecular life sciences : CMLS. 2015 Nov; 72(22):4399-407. doi: 10.1007/s00018-015-1944-9. [PMID: 26040420]
  • Mathangi Ramesh, Navasona Krishnan, Senthil K Muthuswamy, Nicholas K Tonks. A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells. The Journal of biological chemistry. 2015 Apr; 290(15):9646-59. doi: 10.1074/jbc.m114.627968. [PMID: 25681440]
  • Atsushi Mukai, Naohiro Hashimoto. Regulation of pre-fusion events: recruitment of M-cadherin to microrafts organized at fusion-competent sites of myogenic cells. BMC cell biology. 2013 Aug; 14(?):37. doi: 10.1186/1471-2121-14-37. [PMID: 23978243]
  • Yo-Chuen Lin, Pei-Hsun Tsai, Chun-Yu Lin, Chia-Hsiung Cheng, Tsung-Han Lin, Kevin P H Lee, Kai-Yun Huang, Shih-Hsun Chen, Jiuan-Jiuan Hwang, Chithan C Kandaswami, Ming-Ting Lee. Impact of flavonoids on matrix metalloproteinase secretion and invadopodia formation in highly invasive A431-III cancer cells. PloS one. 2013; 8(8):e71903. doi: 10.1371/journal.pone.0071903. [PMID: 23991004]
  • Ying Han, Ning Yuan, Shu-Juan Zhang, Juan Gao, Zhen Shi, Ye-Bo Zhou, Xing-Ya Gao, Guo-Qing Zhu. c-Src in paraventricular nucleus modulates sympathetic activity and cardiac sympathetic afferent reflex in renovascular hypertensive rats. Pflugers Archiv : European journal of physiology. 2011 Apr; 461(4):437-46. doi: 10.1007/s00424-011-0932-7. [PMID: 21340460]
  • Eijiro Yamada, Jeffrey E Pessin, Irwin J Kurland, Gary J Schwartz, Claire C Bastie. Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1. Cell metabolism. 2010 Feb; 11(2):113-24. doi: 10.1016/j.cmet.2009.12.010. [PMID: 20142099]
  • Sabiha N Zaman, Mary E Resek, Stephen M Robbins. Dual acylation and lipid raft association of Src-family protein tyrosine kinases are required for SDF-1/CXCL12-mediated chemotaxis in the Jurkat human T cell lymphoma cell line. Journal of leukocyte biology. 2008 Oct; 84(4):1082-91. doi: 10.1189/jlb.1007698. [PMID: 18632989]
  • Xuan Li, Valerie G Brunton, Helen R Burgar, Lee M Wheldon, John K Heath. FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity. Journal of cell science. 2004 Dec; 117(Pt 25):6007-17. doi: 10.1242/jcs.01519. [PMID: 15564375]