Phosphatidylinositol-5-phosphate (BioDeep_00001884551)
代谢物信息卡片
Phosphatidylinositol-5-phosphate
化学式: C46H82O16P2 (952.5078)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCCC(=O)OCC(COP(=O)(O)OC1C(C(C(C(C1O)OP(=O)(O)O)O)O)O)OC(=O)CCCC=CCC=CCC=CCC=CCCCCC
InChI: InChI=1S/C46H82O16P2/c1-3-5-7-9-11-13-15-17-19-20-21-23-25-27-29-31-33-35-40(48)60-38(36-58-39(47)34-32-30-28-26-24-22-18-16-14-12-10-8-6-4-2)37-59-64(56,57)62-46-43(51)41(49)42(50)45(44(46)52)61-63(53,54)55/h11,13,17,19,21,23,27,29,38,41-46,49-52H,3-10,12,14-16,18,20,22,24-26,28,30-37H2,1-2H3,(H,56,57)(H2,53,54,55)/b13-11-,19-17-,23-21-,29-27-/t38-,41-,42?,43?,44?,45?,46-/m1/s1
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Xu Chen, Yuhong Zhang, Xiang Ren, Qi Su, Yan Liu, Xing Dang, Yuanyuan Qin, Xinyi Yang, Zhengcao Xing, Yajie Shen, Yaya Wang, Zhantao Bai, Edward T H Yeh, Hongmei Wu, Yitao Qi. The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels.
The Journal of biological chemistry.
2021 10; 297(4):101183. doi:
10.1016/j.jbc.2021.101183. [PMID: 34509475] - Ying Yang, Daniel J Klionsky. An AMPK-ULK1-PIKFYVE signaling axis for PtdIns5P-dependent autophagy regulation upon glucose starvation.
Autophagy.
2021 10; 17(10):2663-2664. doi:
10.1080/15548627.2021.1959240. [PMID: 34369843] - Lizbeth de la Cruz, Alexis Traynor-Kaplan, Oscar Vivas, Bertil Hille, Jill B Jensen. Plasma membrane processes are differentially regulated by type I phosphatidylinositol phosphate 5-kinases and RASSF4.
Journal of cell science.
2020 01; 133(2):. doi:
10.1242/jcs.233254. [PMID: 31831523] - Sonia Rodríguez-Fdez, Carmen Citterio, L Francisco Lorenzo-Martín, Jesús Baltanás-Copado, Clara Llorente-González, Senena Corbalán-García, Miguel Vicente-Manzanares, Xosé R Bustelo. Phosphatidylinositol Monophosphates Regulate Optimal Vav1 Signaling Output.
Cells.
2019 12; 8(12):. doi:
10.3390/cells8121649. [PMID: 31888228] - Avishek Ghosh, Sanjeev Sharma, Dhananjay Shinde, Visvanathan Ramya, Padinjat Raghu. A novel mass assay to measure phosphatidylinositol-5-phosphate from cells and tissues.
Bioscience reports.
2019 10; 39(10):. doi:
10.1042/bsr20192502. [PMID: 31652444] - Alessandro Poli, Antonio Enrico Zaurito, Shidqiyyah Abdul-Hamid, Roberta Fiume, Irene Faenza, Nullin Divecha. Phosphatidylinositol 5 Phosphate (PI5P): From Behind the Scenes to the Front (Nuclear) Stage.
International journal of molecular sciences.
2019 Apr; 20(9):. doi:
10.3390/ijms20092080. [PMID: 31035587] - Mark R Lundquist, Marcus D Goncalves, Ryan M Loughran, Elite Possik, Tarika Vijayaraghavan, Annan Yang, Chantal Pauli, Archna Ravi, Akanksha Verma, Zhiwei Yang, Jared L Johnson, Jenny C Y Wong, Yilun Ma, Katie Seo-Kyoung Hwang, David Weinkove, Nullin Divecha, John M Asara, Olivier Elemento, Mark A Rubin, Alec C Kimmelman, Arnim Pause, Lewis C Cantley, Brooke M Emerling. Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy.
Molecular cell.
2018 05; 70(3):531-544.e9. doi:
10.1016/j.molcel.2018.03.037. [PMID: 29727621] - Roya M Dayam, Chun X Sun, Christopher H Choy, Gemma Mancuso, Michael Glogauer, Roberto J Botelho. The Lipid Kinase PIKfyve Coordinates the Neutrophil Immune Response through the Activation of the Rac GTPase.
Journal of immunology (Baltimore, Md. : 1950).
2017 09; 199(6):2096-2105. doi:
10.4049/jimmunol.1601466. [PMID: 28779020] - Anna Chiara Nascimbeni, Patrice Codogno, Etienne Morel. Phosphatidylinositol-3-phosphate in the regulation of autophagy membrane dynamics.
The FEBS journal.
2017 05; 284(9):1267-1278. doi:
10.1111/febs.13987. [PMID: 27973739] - Johan-Owen De Craene, Dimitri L Bertazzi, Séverine Bär, Sylvie Friant. Phosphoinositides, Major Actors in Membrane Trafficking and Lipid Signaling Pathways.
International journal of molecular sciences.
2017 Mar; 18(3):. doi:
10.3390/ijms18030634. [PMID: 28294977] - Simon J Bulley, Alaa Droubi, Jonathan H Clarke, Karen E Anderson, Len R Stephens, Phillip T Hawkins, Robin F Irvine. In B cells, phosphatidylinositol 5-phosphate 4-kinase-α synthesizes PI(4,5)P2 to impact mTORC2 and Akt signaling.
Proceedings of the National Academy of Sciences of the United States of America.
2016 09; 113(38):10571-6. doi:
10.1073/pnas.1522478113. [PMID: 27601656] - Kailash Gulshan, Gregory Brubaker, Heather Conger, Shuhui Wang, Renliang Zhang, Stanley L Hazen, Jonathan D Smith. PI(4,5)P2 Is Translocated by ABCA1 to the Cell Surface Where It Mediates Apolipoprotein A1 Binding and Nascent HDL Assembly.
Circulation research.
2016 Sep; 119(7):827-38. doi:
10.1161/circresaha.116.308856. [PMID: 27514935] - Karen E Anderson, Veronique Juvin, Jonathan Clark, Len R Stephens, Phillip T Hawkins. Investigating the effect of arachidonate supplementation on the phosphoinositide content of MCF10a breast epithelial cells.
Advances in biological regulation.
2016 09; 62(?):18-24. doi:
10.1016/j.jbior.2015.11.002. [PMID: 26639089] - Abdellah Akil, Juan Peng, Mohyeddine Omrane, Claire Gondeau, Christophe Desterke, Mickaël Marin, Hélène Tronchère, Cyntia Taveneau, Sokhavuth Sar, Philippe Briolotti, Soumaya Benjelloun, Abdelaziz Benjouad, Patrick Maurel, Valérie Thiers, Stéphane Bressanelli, Didier Samuel, Christian Bréchot, Ama Gassama-Diagne. Septin 9 induces lipid droplets growth by a phosphatidylinositol-5-phosphate and microtubule-dependent mechanism hijacked by HCV.
Nature communications.
2016 07; 7(?):12203. doi:
10.1038/ncomms12203. [PMID: 27417143] - Eunha Kim, Jiyoon Beon, Seulgi Lee, Jina Park, Seyun Kim. IPMK: A versatile regulator of nuclear signaling events.
Advances in biological regulation.
2016 05; 61(?):25-32. doi:
10.1016/j.jbior.2015.11.005. [PMID: 26682649] - Maria-Luisa Giudici, Jonathan H Clarke, Robin F Irvine. Phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ), a lipid signalling enigma.
Advances in biological regulation.
2016 05; 61(?):47-50. doi:
10.1016/j.jbior.2015.11.007. [PMID: 26710750] - Kazutaka Sumita, Yu-Hua Lo, Koh Takeuchi, Miki Senda, Satoshi Kofuji, Yoshiki Ikeda, Jumpei Terakawa, Mika Sasaki, Hirofumi Yoshino, Nazanin Majd, Yuxiang Zheng, Emily Rose Kahoud, Takehiro Yokota, Brooke M Emerling, John M Asara, Tetsuo Ishida, Jason W Locasale, Takiko Daikoku, Dimitrios Anastasiou, Toshiya Senda, Atsuo T Sasaki. The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.
Molecular cell.
2016 Jan; 61(2):187-98. doi:
10.1016/j.molcel.2015.12.011. [PMID: 26774281] - Roberta Fiume, Yvette Stijf-Bultsma, Zahid H Shah, Willem Jan Keune, David R Jones, Julian Georg Jude, Nullin Divecha. PIP4K and the role of nuclear phosphoinositides in tumour suppression.
Biochimica et biophysica acta.
2015 Jun; 1851(6):898-910. doi:
10.1016/j.bbalip.2015.02.014. [PMID: 25728392] - Julian G Jude, Gary J Spencer, Xu Huang, Tim D D Somerville, David R Jones, Nullin Divecha, Tim C P Somervaille. A targeted knockdown screen of genes coding for phosphoinositide modulators identifies PIP4K2A as required for acute myeloid leukemia cell proliferation and survival.
Oncogene.
2015 Mar; 34(10):1253-1262. doi:
10.1038/onc.2014.77. [PMID: 24681948] - Yukika Wada, Hiroaki Kusano, Tomohiko Tsuge, Takashi Aoyama. Phosphatidylinositol phosphate 5-kinase genes respond to phosphate deficiency for root hair elongation in Arabidopsis thaliana.
The Plant journal : for cell and molecular biology.
2015 Feb; 81(3):426-37. doi:
10.1111/tpj.12741. [PMID: 25477067] - Angela Oppelt, Ellen M Haugsten, Tobias Zech, Håvard E Danielsen, Anita Sveen, Viola H Lobert, Rolf I Skotheim, Jørgen Wesche. PIKfyve, MTMR3 and their product PtdIns5P regulate cancer cell migration and invasion through activation of Rac1.
The Biochemical journal.
2014 Aug; 461(3):383-90. doi:
10.1042/bj20140132. [PMID: 24840251] - Kathy A Gelato, Maria Tauber, Michelle S Ong, Stefan Winter, Kyoko Hiragami-Hamada, Julia Sindlinger, Alexander Lemak, Yvette Bultsma, Scott Houliston, Dirk Schwarzer, Nullin Divecha, Cheryl H Arrowsmith, Wolfgang Fischle. Accessibility of different histone H3-binding domains of UHRF1 is allosterically regulated by phosphatidylinositol 5-phosphate.
Molecular cell.
2014 Jun; 54(6):905-919. doi:
10.1016/j.molcel.2014.04.004. [PMID: 24813945] - Julien Viaud, Frédéric Lagarrigue, Damien Ramel, Sophie Allart, Gaëtan Chicanne, Laurie Ceccato, Delphine Courilleau, Jean-Marie Xuereb, Olivier Pertz, Bernard Payrastre, Frédérique Gaits-Iacovoni. Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1.
Nature communications.
2014 Jun; 5(?):4080. doi:
10.1038/ncomms5080. [PMID: 24905281] - Julien Viaud, Frédéric Boal, Hélène Tronchère, Frédérique Gaits-Iacovoni, Bernard Payrastre. Phosphatidylinositol 5-phosphate: a nuclear stress lipid and a tuner of membranes and cytoskeleton dynamics.
BioEssays : news and reviews in molecular, cellular and developmental biology.
2014 Mar; 36(3):260-72. doi:
10.1002/bies.201300132. [PMID: 24375703] - Andrea Puhar, Hélène Tronchère, Bernard Payrastre, Guy Tran Van Nhieu, Philippe J Sansonetti. A Shigella effector dampens inflammation by regulating epithelial release of danger signal ATP through production of the lipid mediator PtdIns5P.
Immunity.
2013 Dec; 39(6):1121-31. doi:
10.1016/j.immuni.2013.11.013. [PMID: 24332032] - Takumi Kawasaki, Naoki Takemura, Daron M Standley, Shizuo Akira, Taro Kawai. The second messenger phosphatidylinositol-5-phosphate facilitates antiviral innate immune signaling.
Cell host & microbe.
2013 Aug; 14(2):148-58. doi:
10.1016/j.chom.2013.07.011. [PMID: 23954154] - David R Jones, Rebecca Foulger, Willem-Jan Keune, Yvette Bultsma, Nullin Divecha. PtdIns5P is an oxidative stress-induced second messenger that regulates PKB activation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2013 Apr; 27(4):1644-56. doi:
10.1096/fj.12-218842. [PMID: 23241309] - Mindy I Davis, Atsuo T Sasaki, Min Shen, Brooke M Emerling, Natasha Thorne, Sam Michael, Rajan Pragani, Matthew Boxer, Kazutaka Sumita, Koh Takeuchi, Douglas S Auld, Zhuyin Li, Lewis C Cantley, Anton Simeonov. A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation.
PloS one.
2013; 8(1):e54127. doi:
10.1371/journal.pone.0054127. [PMID: 23326584] - Teun Munnik. Analysis of D3-,4-,5-phosphorylated phosphoinositides using HPLC.
Methods in molecular biology (Clifton, N.J.).
2013; 1009(?):17-24. doi:
10.1007/978-1-62703-401-2_2. [PMID: 23681519] - Sergey N Zolov, Dave Bridges, Yanling Zhang, Wei-Wei Lee, Ellen Riehle, Rakesh Verma, Guy M Lenk, Kimber Converso-Baran, Thomas Weide, Roger L Albin, Alan R Saltiel, Miriam H Meisler, Mark W Russell, Lois S Weisman. In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.
Proceedings of the National Academy of Sciences of the United States of America.
2012 Oct; 109(43):17472-7. doi:
10.1073/pnas.1203106109. [PMID: 23047693] - Diego Sbrissa, Ognian C Ikonomov, Catherine Filios, Khortnal Delvecchio, Assia Shisheva. Functional dissociation between PIKfyve-synthesized PtdIns5P and PtdIns(3,5)P2 by means of the PIKfyve inhibitor YM201636.
American journal of physiology. Cell physiology.
2012 Aug; 303(4):C436-46. doi:
10.1152/ajpcell.00105.2012. [PMID: 22621786] - Yong Ding, Ivan Ndamukong, Yang Zhao, Yuannan Xia, Jean-Jack Riethoven, David R Jones, Nullin Divecha, Zoya Avramova. Divergent functions of the myotubularin (MTM) homologs AtMTM1 and AtMTM2 in Arabidopsis thaliana: evolution of the plant MTM family.
The Plant journal : for cell and molecular biology.
2012 Jun; 70(5):866-78. doi:
10.1111/j.1365-313x.2012.04936.x. [PMID: 22324391] - Assia Shisheva. PIKfyve and its Lipid products in health and in sickness.
Current topics in microbiology and immunology.
2012; 362(?):127-62. doi:
10.1007/978-94-007-5025-8_7. [PMID: 23086417] - Deborah L Grainger, Christodoulos Tavelis, Alexander J Ryan, Katherine A Hinchliffe. Involvement of phosphatidylinositol 5-phosphate in insulin-stimulated glucose uptake in the L6 myotube model of skeletal muscle.
Pflugers Archiv : European journal of physiology.
2011 Nov; 462(5):723-32. doi:
10.1007/s00424-011-1008-4. [PMID: 21847559] - Ognian C Ikonomov, Diego Sbrissa, Khortnal Delvecchio, Yufen Xie, Jian-Ping Jin, Daniel Rappolee, Assia Shisheva. The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- mice.
The Journal of biological chemistry.
2011 Apr; 286(15):13404-13. doi:
10.1074/jbc.m111.222364. [PMID: 21349843] - Ivan Ndamukong, David R Jones, Hanna Lapko, Nullin Divecha, Zoya Avramova. Phosphatidylinositol 5-phosphate links dehydration stress to the activity of ARABIDOPSIS TRITHORAX-LIKE factor ATX1.
PloS one.
2010 Oct; 5(10):e13396. doi:
10.1371/journal.pone.0013396. [PMID: 20967218] - Geoffrey Guittard, Eva Mortier, Hélène Tronchère, Guylène Firaguay, Audrey Gérard, Pascale Zimmermann, Bernard Payrastre, Jacques A Nunès. Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways.
FEBS letters.
2010 Jun; 584(11):2455-60. doi:
10.1016/j.febslet.2010.04.051. [PMID: 20417634] - Jonathan M Backer. New methods for capturing the mystery lipid, PtdIns5P.
The Biochemical journal.
2010 May; 428(3):e1-2. doi:
10.1042/bj20100688. [PMID: 20504279] - Deborah Sarkes, Lucia E Rameh. A novel HPLC-based approach makes possible the spatial characterization of cellular PtdIns5P and other phosphoinositides.
The Biochemical journal.
2010 May; 428(3):375-84. doi:
10.1042/bj20100129. [PMID: 20370717] - Damien Ramel, Frédéric Lagarrigue, Sophie Dupuis-Coronas, Gaëtan Chicanne, Nicholas Leslie, Frédérique Gaits-Iacovoni, Bernard Payrastre, Hélène Tronchère. PtdIns5P protects Akt from dephosphorylation through PP2A inhibition.
Biochemical and biophysical research communications.
2009 Sep; 387(1):127-31. doi:
10.1016/j.bbrc.2009.06.139. [PMID: 19576174] - Dennis J Bua, Olivier Binda. The return of the INGs, histone mark sensors and phospholipid signaling effectors.
Current drug targets.
2009 May; 10(5):418-31. doi:
10.2174/138945009788185112. [PMID: 19442114] - Geoffrey Guittard, Audrey Gérard, Sophie Dupuis-Coronas, Hélène Tronchère, Eva Mortier, Cédric Favre, Daniel Olive, Pascale Zimmermann, Bernard Payrastre, Jacques A Nunès. Cutting edge: Dok-1 and Dok-2 adaptor molecules are regulated by phosphatidylinositol 5-phosphate production in T cells.
Journal of immunology (Baltimore, Md. : 1950).
2009 Apr; 182(7):3974-8. doi:
10.4049/jimmunol.0804172. [PMID: 19299694] - Odile Lecompte, Olivier Poch, Jocelyn Laporte. PtdIns5P regulation through evolution: roles in membrane trafficking?.
Trends in biochemical sciences.
2008 Oct; 33(10):453-60. doi:
10.1016/j.tibs.2008.07.002. [PMID: 18774718] - S Coronas, F Lagarrigue, D Ramel, G Chicanne, G Delsol, B Payrastre, H Tronchère. Elevated levels of PtdIns5P in NPM-ALK transformed cells: implication of PIKfyve.
Biochemical and biophysical research communications.
2008 Jul; 372(2):351-5. doi:
10.1016/j.bbrc.2008.05.062. [PMID: 18501703] - Andrew Wilcox, Katherine A Hinchliffe. Regulation of extranuclear PtdIns5P production by phosphatidylinositol phosphate 4-kinase 2alpha.
FEBS letters.
2008 Apr; 582(9):1391-4. doi:
10.1016/j.febslet.2008.03.022. [PMID: 18364242] - Matthew W Bunce, Igor V Boronenkov, Richard A Anderson. Coordinated activation of the nuclear ubiquitin ligase Cul3-SPOP by the generation of phosphatidylinositol 5-phosphate.
The Journal of biological chemistry.
2008 Mar; 283(13):8678-86. doi:
10.1074/jbc.m710222200. [PMID: 18218622] - Wei Huang, Honglu Zhang, Foteini Davrazou, Tatiana G Kutateladze, Xiaobing Shi, Or Gozani, Glenn D Prestwich. Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling.
Journal of the American Chemical Society.
2007 May; 129(20):6498-506. doi:
10.1021/ja070195b. [PMID: 17469822] - David Mason, Gustavo V Mallo, Mauricio R Terebiznik, Bernard Payrastre, B Brett Finlay, John H Brumell, Lucia Rameh, Sergio Grinstein. Alteration of epithelial structure and function associated with PtdIns(4,5)P2 degradation by a bacterial phosphatase.
The Journal of general physiology.
2007 Apr; 129(4):267-83. doi:
10.1085/jgp.200609656. [PMID: 17389247] - Jonathan H Clarke, Jonathan P Richardson, Katherine A Hinchliffe, Robin F Irvine. Type II PtdInsP kinases: location, regulation and function.
Biochemical Society symposium.
2007; ?(74):149-59. doi:
10.1042/bss0740149. [PMID: 17233588] - Katherine A Hinchliffe, Robin F Irvine. Regulation of type II PIP kinase by PKD phosphorylation.
Cellular signalling.
2006 Nov; 18(11):1906-13. doi:
10.1016/j.cellsig.2006.02.005. [PMID: 16563698] - Raul Alvarez-Venegas, Monther Sadder, Andrej Hlavacka, Frantisek Baluska, Yuannan Xia, Guoqing Lu, Alexey Firsov, Gautam Sarath, Hideaki Moriyama, Joseph G Dubrovsky, Zoya Avramova. The Arabidopsis homolog of trithorax, ATX1, binds phosphatidylinositol 5-phosphate, and the two regulate a common set of target genes.
Proceedings of the National Academy of Sciences of the United States of America.
2006 Apr; 103(15):6049-54. doi:
10.1073/pnas.0600944103. [PMID: 16585509] - Caroline Pendaries, Hélène Tronchère, Laurence Arbibe, Joelle Mounier, Or Gozani, Lewis Cantley, Michael J Fry, Frédérique Gaits-Iacovoni, Philippe J Sansonetti, Bernard Payrastre. PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection.
The EMBO journal.
2006 Mar; 25(5):1024-34. doi:
10.1038/sj.emboj.7601001. [PMID: 16482216] - Hilary F Roberts, Jonathan H Clarke, Andrew J Letcher, Robin F Irvine, Katherine A Hinchliffe. Effects of lipid kinase expression and cellular stimuli on phosphatidylinositol 5-phosphate levels in mammalian cell lines.
FEBS letters.
2005 May; 579(13):2868-72. doi:
10.1016/j.febslet.2005.04.027. [PMID: 15876433] - Caroline Pendaries, Hélène Tronchère, Claire Racaud-Sultan, Frédérique Gaits-Iacovoni, Sophie Coronas, Stéphane Manenti, Marie-Pierre Gratacap, Monique Plantavid, Bernard Payrastre. Emerging roles of phosphatidylinositol monophosphates in cellular signaling and trafficking.
Advances in enzyme regulation.
2005; 45(?):201-14. doi:
10.1016/j.advenzreg.2005.02.006. [PMID: 16023705] - Katja A Lamia, Odile D Peroni, Young-Bum Kim, Lucia E Rameh, Barbara B Kahn, Lewis C Cantley. Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase beta-/- mice.
Molecular and cellular biology.
2004 Jun; 24(11):5080-7. doi:
10.1128/mcb.24.11.5080-5087.2004. [PMID: 15143198] - Valerie Carricaburu, Katja A Lamia, Elizabeth Lo, Laetitia Favereaux, Bernard Payrastre, Lewis C Cantley, Lucia E Rameh. The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation.
Proceedings of the National Academy of Sciences of the United States of America.
2003 Aug; 100(17):9867-72. doi:
10.1073/pnas.1734038100. [PMID: 12897244] - Or Gozani, Philip Karuman, David R Jones, Dmitri Ivanov, James Cha, Alexey A Lugovskoy, Cheryl L Baird, Hong Zhu, Seth J Field, Stephen L Lessnick, Jennifer Villasenor, Bharat Mehrotra, Jian Chen, Vikram R Rao, Joan S Brugge, Colin G Ferguson, Bernard Payrastre, David G Myszka, Lewis C Cantley, Gerhard Wagner, Nullin Divecha, Glenn D Prestwich, Junying Yuan. The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor.
Cell.
2003 Jul; 114(1):99-111. doi:
10.1016/s0092-8674(03)00480-x. [PMID: 12859901] - Ognian C Ikonomov, Diego Sbrissa, Kristopher Mlak, Makoto Kanzaki, Jeffrey Pessin, Assia Shisheva. Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity.
The Journal of biological chemistry.
2002 Mar; 277(11):9206-11. doi:
10.1074/jbc.m108750200. [PMID: 11714711] - Bjørn K Drøbak, Begoña Heras. Nuclear phosphoinositides could bring FYVE alive.
Trends in plant science.
2002 Mar; 7(3):132-8. doi:
10.1016/s1360-1385(01)02213-0. [PMID: 11906837] - H J Meijer, C P Berrie, C Iurisci, N Divecha, A Musgrave, T Munnik. Identification of a new polyphosphoinositide in plants, phosphatidylinositol 5-monophosphate (PtdIns5P), and its accumulation upon osmotic stress.
The Biochemical journal.
2001 Dec; 360(Pt 2):491-8. doi:
10.1042/0264-6021:3600491. [PMID: 11716778] - J B Morris, K A Hinchliffe, A Ciruela, A J Letcher, R F Irvine. Thrombin stimulation of platelets causes an increase in phosphatidylinositol 5-phosphate revealed by mass assay.
FEBS letters.
2000 Jun; 475(1):57-60. doi:
10.1016/s0014-5793(00)01625-2. [PMID: 10854858] - K A Hinchliffe, A Ciruela, R F Irvine. PIPkins1, their substrates and their products: new functions for old enzymes.
Biochimica et biophysica acta.
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