Ethyl (3-methyl-4-oxo-5-piperidinothiazolidin-2-ylidene)acetate (BioDeep_00001884453)
代谢物信息卡片
化学式: C13H20N2O3S (284.119457)
中文名称: 依托唑啉
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCOC(=O)C=C1N(C(=O)C(S1)N2CCCCC2)C
InChI: InChI=1S/C13H20N2O3S/c1-3-18-11(16)9-10-14(2)12(17)13(19-10)15-7-5-4-6-8-15/h9,13H,3-8H2,1-2H3
描述信息
C - Cardiovascular system > C03 - Diuretics > C03C - High-ceiling diuretics
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D045283 - Natriuretic Agents
D045283 - Natriuretic Agents > D004232 - Diuretics
同义名列表
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Vijaya M Musini, Pouria Rezapour, James M Wright, Ken Bassett, Ciprian D Jauca. Blood pressure-lowering efficacy of loop diuretics for primary hypertension.
The Cochrane database of systematic reviews.
2015 May; ?(5):CD003825. doi:
10.1002/14651858.cd003825.pub4. [PMID: 26000442] - Kristin Holvik, Luai A Ahmed, Siri Forsmo, Clara G Gjesdal, Guri Grimnes, Sven Ove Samuelsen, Berit Schei, Rune Blomhoff, Grethe S Tell, Haakon E Meyer. Low serum levels of 25-hydroxyvitamin D predict hip fracture in the elderly: a NOREPOS study.
The Journal of clinical endocrinology and metabolism.
2013 Aug; 98(8):3341-50. doi:
10.1210/jc.2013-1468. [PMID: 23678033] - Vijaya M Musini, Pouria Rezapour, James M Wright, Ken Bassett, Ciprian D Jauca. Blood pressure lowering efficacy of loop diuretics for primary hypertension.
The Cochrane database of systematic reviews.
2012 Aug; ?(8):CD003825. doi:
10.1002/14651858.cd003825.pub3. [PMID: 22895937] - Vijaya M Musini, James M Wright, Ken Bassett, Ciprian D Jauca. Blood pressure lowering efficacy of loop diuretics for primary hypertension.
The Cochrane database of systematic reviews.
2009 Oct; ?(4):CD003825. doi:
10.1002/14651858.cd003825.pub2. [PMID: 19821314] - Jochen Beyer, Anabelle Bierl, Frank T Peters, Hans H Maurer. Screening procedure for detection of diuretics and uricosurics and/or their metabolites in human urine using gas chromatography-mass spectrometry after extractive methylation.
Therapeutic drug monitoring.
2005 Aug; 27(4):509-20. doi:
10.1097/01.ftd.0000160719.96445.91. [PMID: 16044110] - L Burdick, R Mangiarotti, C Pini, A Fasoli. [Effects of etozoline in patients with acute cardiac failure].
Minerva medica.
1991 Nov; 82(11):749-52. doi:
NULL. [PMID: 1766576] - R Nami, B Lucani, G Pavese, F Panza, D Moscato, M Martinelli, C Gennari. Acute antihypertensive, diuretic and metabolic effects of etozolin and chlorthalidone.
Panminerva medica.
1991 Jul; 33(3):157-63. doi:
NULL. [PMID: 1771100] - G Cellina, P Binaghi, M E De Carolis, A Limonta, G Lo Cicero, R Di Michele. [Arterial hypertension in perimenopausal women; tolerability of etozolin].
Minerva cardioangiologica.
1990 Jul; 38(7-8):341-4. doi:
NULL. [PMID: 2080024] - H Knauf, M Missmahl, J Schölmerich, W Gerok, E Mutschler. Altered kinetics of etozolin and its active metabolite ozolinone in hepatitis and hepatic cirrhosis with ascites.
Arzneimittel-Forschung.
1987 Dec; 37(12):1385-8. doi:
NULL. [PMID: 3449068] - M Vrzánová, J Osten, M Horácková. [Experience with etozolin, a new diuretic].
Vnitrni lekarstvi.
1986 Feb; 32(2):190-4. doi:
NULL. [PMID: 3962200] - H Knauf, R Liebig, P Schollmeyer, J Rosenthal, E U Kölle, E Mutschler. Pharmacodynamics and kinetics of etozolin/ozolinone in hypertensive patients with normal and impaired kidney function.
European journal of clinical pharmacology.
1984; 26(6):687-93. doi:
10.1007/bf00541926. [PMID: 6386484] - H Nau, R Steldinger, E Ivan. Placental transfer of etozolin and ozolinone during the first half of gestation in man.
European journal of clinical pharmacology.
1982; 23(3):253-60. doi:
10.1007/bf00547564. [PMID: 7173295] - C Liddiard, H Nau. Determination of etozolin and ozolinone in human plasma and tissues by reversed-phase high-performance liquid chromatography.
Journal of chromatography.
1981 Oct; 225(2):504-8. doi:
10.1016/s0378-4347(00)80304-7. [PMID: 7298786] - H Hengy, K O Vollmer, V Gladigau, E U Kölle. Assay of etozolin and its main metabolite, ozolinone, in plasma by high performance liquid chromatography.
Arzneimittel-Forschung.
1980; 30(10):1788-90. doi:
NULL. [PMID: 7192115] - H Knauf, G Hasenfuss, U Wais, P Schollmeyer, E Mutschler. Independent of etozolin elimination of kidney function. Single dose experiments in patients with renal insufficiency.
Arzneimittel-Forschung.
1980; 30(10):1791-3. doi:
NULL. [PMID: 7192116] - M Haslbeck, R Renner, W Kemmler, B Schneider, H Mehnert. [Effect on carbohydrate metabolism of a new saluretic, etozolin].
Fortschritte der Medizin.
1979 Oct; 97(40):1825-30. doi:
NULL. [PMID: 396216] - O HEINDENREICH, G FUELGRAFF, L BAUMEISTER, K SCHMIZ. [LOCALIZATION OF THE SITE OF ACTION OF THE DIURETIC ETOZOLIN IN THE MEPHRON OF THE DOG AND REPORT OF A MATHEMATICAL EVALUATION METHOD OF STOP-FLOW EXPERIMENTS].
Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie.
1964 Nov; 249(?):432-45. doi:
NULL. [PMID: 14340709]