Lewis y Tetrasaccharide (BioDeep_00001883976)
代谢物信息卡片
Lewis y Tetrasaccharide
化学式: C26H45NO19 (675.258566)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C(C(C(C(O1)OC2C(C(OC(C2OC3C(C(C(C(O3)CO)O)O)OC4C(C(C(C(O4)C)O)O)O)CO)O)NC(=O)C)O)O)O
InChI: InChI=1S/C26H45NO19/c1-6-12(31)15(34)18(37)24(40-6)45-21-11(27-8(3)30)23(39)42-10(5-29)20(21)44-26-22(17(36)14(33)9(4-28)43-26)46-25-19(38)16(35)13(32)7(2)41-25/h6-7,9-26,28-29,31-39H,4-5H2,1-3H3,(H,27,30)/t6-,7-,9+,10+,11+,12+,13+,14-,15+,16+,17-,18-,19-,20+,21+,22+,23+,24-,25-,26-/m0/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Dorian A Stolk, Aram de Haas, Jana Vree, Sanne Duinkerken, Joyce Lübbers, Rieneke van de Ven, Martino Ambrosini, Hakan Kalay, Sven Bruijns, Hans J van der Vliet, Tanja D de Gruijl, Yvette van Kooyk. Lipo-Based Vaccines as an Approach to Target Dendritic Cells for Induction of T- and iNKT Cell Responses.
Frontiers in immunology.
2020; 11(?):990. doi:
10.3389/fimmu.2020.00990. [PMID: 32536918] - Eirikur Saeland, Ana I Belo, Sandra Mongera, Irma van Die, Gerrit A Meijer, Yvette van Kooyk. Differential glycosylation of MUC1 and CEACAM5 between normal mucosa and tumour tissue of colon cancer patients.
International journal of cancer.
2012 Jul; 131(1):117-28. doi:
10.1002/ijc.26354. [PMID: 21823122] - Jonas Van Hove, Elke Fouquaert, David F Smith, Paul Proost, Els J M Van Damme. Lectin activity of the nucleocytoplasmic EUL protein from Arabidopsis thaliana.
Biochemical and biophysical research communications.
2011 Oct; 414(1):101-5. doi:
10.1016/j.bbrc.2011.09.031. [PMID: 21945438] - Fan Zhang, Juanjuan Liu, Bei Lin, Qing Liu, Yue Zhao, Liancheng Zhu, Yingying Hao, Shulan Zhang, Masao Iwamori. Increase in docetaxel-resistance of ovarian carcinoma-derived RMG-1 cells with enhanced expression of Lewis Y antigen.
International journal of molecular sciences.
2011; 12(11):7323-34. doi:
10.3390/ijms12117323. [PMID: 22174601] - Limei Yan, Bei Lin, Lili Gao, Song Gao, Chuan Liu, Changzhi Wang, Yifei Wang, Shulan Zhang, Masao Iwamori. Lewis (y) antigen overexpression increases the expression of MMP-2 and MMP-9 and invasion of human ovarian cancer cells.
International journal of molecular sciences.
2010 Nov; 11(11):4441-52. doi:
10.3390/ijms11114441. [PMID: 21151448] - Christopher M Stead, Jinshi Zhao, Christian R H Raetz, M Stephen Trent. Removal of the outer Kdo from Helicobacter pylori lipopolysaccharide and its impact on the bacterial surface.
Molecular microbiology.
2010 Nov; 78(4):837-52. doi:
10.1111/j.1365-2958.2010.07304.x. [PMID: 20659292] - S Peinert, H M Prince, P M Guru, M H Kershaw, M J Smyth, J A Trapani, P Gambell, S Harrison, A M Scott, F E Smyth, P K Darcy, K Tainton, P Neeson, D S Ritchie, D Hönemann. Gene-modified T cells as immunotherapy for multiple myeloma and acute myeloid leukemia expressing the Lewis Y antigen.
Gene therapy.
2010 May; 17(5):678-86. doi:
10.1038/gt.2010.21. [PMID: 20200563] - Ellen Hildebrandt, David J McGee. Helicobacter pylori lipopolysaccharide modification, Lewis antigen expression, and gastric colonization are cholesterol-dependent.
BMC microbiology.
2009 Dec; 9(?):258. doi:
10.1186/1471-2180-9-258. [PMID: 20003432] - Bei Lin, Ying-Ying Hao, Dong-Dong Wang, Lian-Cheng Zhu, Shu-Lan Zhang, Makiko Saito, Masao Iwamori. [Transfection of alpha1, 2-fucosyltransferase gene increases the antigenic expression of Lewis y in ovarian cancer cell line RMG-I].
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae.
2008 Jun; 30(3):284-9. doi:
. [PMID: 18686606] - Shih-Chang Hsu, Tsung-Hsien Tsai, Hirokazu Kawasaki, Chien-Ho Chen, Beverly Plunkett, Reiko T Lee, Yuan C Lee, Shau-Ku Huang. Antigen coupled with Lewis-x trisaccharides elicits potent immune responses in mice.
The Journal of allergy and clinical immunology.
2007 Jun; 119(6):1522-8. doi:
10.1016/j.jaci.2007.01.034. [PMID: 17353042] - Yutaro Azuma, Yoshikazu Kurusu, Hirotaka Sato, Koji Higai, Kojiro Matsumoto. Increased expression of Lewis X and Y antigens on the cell surface and FUT 4 mRNA during granzyme B-induced Jurkat cell apoptosis.
Biological & pharmaceutical bulletin.
2007 Apr; 30(4):655-60. doi:
10.1248/bpb.30.655. [PMID: 17409497] - Robert Brodzik, Magdalena Glogowska, Katarzyna Bandurska, Monika Okulicz, Deepali Deka, Kisung Ko, Joke van der Linden, Jeanette H W Leusen, Natalia Pogrebnyak, Maxim Golovkin, Zenon Steplewski, Hilary Koprowski. Plant-derived anti-Lewis Y mAb exhibits biological activities for efficient immunotherapy against human cancer cells.
Proceedings of the National Academy of Sciences of the United States of America.
2006 Jun; 103(23):8804-9. doi:
10.1073/pnas.0603043103. [PMID: 16720700] - V E Piskarev, M D Lutsik-Kordovskiĭ, E L Piskareva, I A Iamskov. [Oligosaccharide specificity of the fucolectin from the bark of laburnum Laburnum anagyroides].
Prikladnaia biokhimiia i mikrobiologiia.
2003 Sep; 39(5):581-7. doi:
". [PMID: 14593874] - Anthony P Moran, Yuriy A Knirel, Sof'ya N Senchenkova, Goran Widmalm, Sean O Hynes, Per-Erik Jansson. Phenotypic variation in molecular mimicry between Helicobacter pylori lipopolysaccharides and human gastric epithelial cell surface glycoforms. Acid-induced phase variation in Lewis(x) and Lewis(y) expression by H. Pylori lipopolysaccharides.
The Journal of biological chemistry.
2002 Feb; 277(8):5785-95. doi:
10.1074/jbc.m108574200. [PMID: 11741906] - H C Ng, H E Khoo. Cancer-homing toxins.
Current pharmaceutical design.
2002; 8(22):1973-85. doi:
10.2174/1381612023393477. [PMID: 12171523] - M A Monteiro, B J Appelmelk, D A Rasko, A P Moran, S O Hynes, L L MacLean, K H Chan, F S Michael, S M Logan, J O'Rourke, A Lee, D E Taylor, M B Perry. Lipopolysaccharide structures of Helicobacter pylori genomic strains 26695 and J99, mouse model H. pylori Sydney strain, H. pylori P466 carrying sialyl Lewis X, and H. pylori UA915 expressing Lewis B classification of H. pylori lipopolysaccharides into glycotype families.
European journal of biochemistry.
2000 Jan; 267(2):305-20. doi:
10.1046/j.1432-1327.2000.01007.x. [PMID: 10632700] - K Kamiya, T Arisawa, H Goto, K Shibayama, T Horii, T Hayakawa, M Ohta. Are autoantibodies against Lewis antigens involved in the pathogenesis of Helicobacter pylori-induced peptic ulcers?.
Microbiology and immunology.
1999; 43(5):403-8. doi:
10.1111/j.1348-0421.1999.tb02423.x. [PMID: 10449246] - B J Appelmelk, B Shiberu, C Trinks, N Tapsi, P Y Zheng, T Verboom, J Maaskant, C H Hokke, W E Schiphorst, D Blanchard, I M Simoons-Smit, D H van den Eijnden, C M Vandenbroucke-Grauls. Phase variation in Helicobacter pylori lipopolysaccharide.
Infection and immunity.
1998 Jan; 66(1):70-6. doi:
10.1128/iai.66.1.70-76.1998. [PMID: 9423841] - R Mollicone, A Cailleau, A Imberty, P Gane, S Perez, R Oriol. Recognition of the blood group H type 2 trisaccharide epitope by 28 monoclonal antibodies and three lectins.
Glycoconjugate journal.
1996 Apr; 13(2):263-71. doi:
10.1007/bf00731501. [PMID: 8737251] - F A Neethling, E Koren, Y Ye, S V Richards, M Kujundzic, R Oriol, D K Cooper. Protection of pig kidney (PK15) cells from the cytotoxic effect of anti-pig antibodies by alpha-galactosyl oligosaccharides.
Transplantation.
1994 Mar; 57(6):959-63. doi:
10.1097/00007890-199403270-00032. [PMID: 8154046]