3,7,11-Trimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate (BioDeep_00001883801)

   


Metabolite Card


3,7,11-Trimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate

  Formula: C15H28O7P2 (382.131)
Chinese Names:
  Spectrum Hits: Top Source () %

Molecular Structure

SMILES: CC(=CCCC(=CCCC(=CCOP(=O)(O)OP(=O)(O)O)C)C)C
InChI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)


Description

Synonyms

1 synonym names

3,7,11-Trimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate



Cross Reference

2 cross reference id

Classification Terms

Related Pathways

Reactome(3)

BioCyc()

PlantCyc()

Biological Process

related biological process reactions.

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

10 organism taxonomy source information

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

Sub-cellular location Genes


Literature Reference

  • Kuo-Hsun Teng, Po-Huang Liang. Undecaprenyl diphosphate synthase, a cis-prenyltransferase synthesizing lipid carrier for bacterial cell wall biosynthesis. Molecular membrane biology. 2012 Nov; 29(7):267-73. doi: 10.3109/09687688.2012.674162. [PMID: 22471620]
  • Mohamed Attia, Soo-Un Kim, Dae-Kyun Ro. Molecular cloning and characterization of (+)-epi-α-bisabolol synthase, catalyzing the first step in the biosynthesis of the natural sweetener, hernandulcin, in Lippia dulcis. Archives of biochemistry and biophysics. 2012 Nov; 527(1):37-44. doi: 10.1016/j.abb.2012.07.010. [PMID: 22867794]
  • Zhubo Dai, Yi Liu, Luqi Huang, Xueli Zhang. Production of miltiradiene by metabolically engineered Saccharomyces cerevisiae. Biotechnology and bioengineering. 2012 Nov; 109(11):2845-53. doi: 10.1002/bit.24547. [PMID: 22566191]
  • Nobuaki Suzuki, Hirotaka Uefuji, Takashi Nishikawa, Yukio Mukai, Atsushi Yamashita, Masahira Hattori, Naotake Ogasawara, Takeshi Bamba, Ei-ichiro Fukusaki, Akio Kobayashi, Yoshiyuki Ogata, Nozomu Sakurai, Hideyuki Suzuki, Daisuke Shibata, Yoshihisa Nakazawa. Construction and analysis of EST libraries of the trans-polyisoprene producing plant, Eucommia ulmoides Oliver. Planta. 2012 Nov; 236(5):1405-17. doi: 10.1007/s00425-012-1679-x. [PMID: 22729820]
  • Oscar Cascón, Sabrina Touchet, David J Miller, Veronica Gonzalez, Juan A Faraldos, Rudolf K Allemann. Chemoenzymatic preparation of germacrene analogues. Chemical communications (Cambridge, England). 2012 Oct; 48(78):9702-4. doi: 10.1039/c2cc35542f. [PMID: 22914774]
  • Kota Kera, Seiji Takahashi, Tsuyoshi Sutoh, Tanetoshi Koyama, Toru Nakayama. Identification and characterization of a cis,trans-mixed heptaprenyl diphosphate synthase from Arabidopsis thaliana. The FEBS journal. 2012 Oct; 279(20):3813-27. doi: 10.1111/j.1742-4658.2012.08742.x. [PMID: 22883514]
  • Eliana Gonzales-Vigil, David E Hufnagel, Jeongwoon Kim, Robert L Last, Cornelius S Barry. Evolution of TPS20-related terpene synthases influences chemical diversity in the glandular trichomes of the wild tomato relative Solanum habrochaites. The Plant journal : for cell and molecular biology. 2012 Sep; 71(6):921-35. doi: 10.1111/j.1365-313x.2012.05040.x. [PMID: 22563774]
  • Ling Li, Wei Zhang, Shaowu Cheng, Dongfeng Cao, Marc Parent. Isoprenoids and related pharmacological interventions: potential application in Alzheimer's disease. Molecular neurobiology. 2012 Aug; 46(1):64-77. doi: 10.1007/s12035-012-8253-1. [PMID: 22418893]
  • Barbara Menin, Cinzia Comino, Ezio Portis, Andrea Moglia, Katarina Cankar, Harro J Bouwmeester, Sergio Lanteri, Jules Beekwilder. Genetic mapping and characterization of the globe artichoke (+)-germacrene A synthase gene, encoding the first dedicated enzyme for biosynthesis of the bitter sesquiterpene lactone cynaropicrin. Plant science : an international journal of experimental plant biology. 2012 Jul; 190(?):1-8. doi: 10.1016/j.plantsci.2012.03.006. [PMID: 22608514]
  • Rama Raju Baadhe, Naveen Kumar Mekala, Satwik Reddy Palagiri, Sreenivasa Rao Parcha. Development of petri net-based dynamic model for improved production of farnesyl pyrophosphate by integrating mevalonate and methylerythritol phosphate pathways in yeast. Applied biochemistry and biotechnology. 2012 Jul; 167(5):1172-82. doi: 10.1007/s12010-012-9583-1. [PMID: 22350871]
  • Selvaraju Kanagarajan, Saraladevi Muthusamy, Anna Gliszczyńska, Anneli Lundgren, Peter E Brodelius. Functional expression and characterization of sesquiterpene synthases from Artemisia annua L. using transient expression system in Nicotiana benthamiana. Plant cell reports. 2012 Jul; 31(7):1309-19. doi: 10.1007/s00299-012-1250-z. [PMID: 22565787]
  • Jingjing Li, Jixin Jiang, Hao Yin, Lifeng Wang, Ruijuan Tian, Haijie Li, Zengyong Wang, Dong Li, Yuebing Wang, Yu Gui, Michael P Walsh, Xi-Long Zheng. Atorvastatin inhibits myocardin expression in vascular smooth muscle cells. Hypertension (Dallas, Tex. : 1979). 2012 Jul; 60(1):145-53. doi: 10.1161/hypertensionaha.112.195644. [PMID: 22615115]
  • Wajid Waheed Bhat, Surrinder K Lattoo, Sumeer Razdan, Niha Dhar, Satiander Rana, Rekha S Dhar, Shabnam Khan, Ram A Vishwakarma. Molecular cloning, bacterial expression and promoter analysis of squalene synthase from Withania somnifera (L.) Dunal. Gene. 2012 May; 499(1):25-36. doi: 10.1016/j.gene.2012.03.004. [PMID: 22425978]
  • Megumi Fujita, Makiko Tohi, Kyoko Sawada, Yasuhiro Yamamoto, Tsutomu Nakamura, Tatsurou Yagami, Motohiro Yamamori, Noboru Okamura. Involvement of the mevalonate pathway in the antiproliferative effect of zoledronate on ACHN renal cell carcinoma cells. Oncology reports. 2012 May; 27(5):1371-6. doi: 10.3892/or.2012.1683. [PMID: 22322451]
  • Danilo Aros, Veronica Gonzalez, Rudolf K Allemann, Carsten T Müller, Carlo Rosati, Hilary J Rogers. Volatile emissions of scented Alstroemeria genotypes are dominated by terpenes, and a myrcene synthase gene is highly expressed in scented Alstroemeria flowers. Journal of experimental botany. 2012 Apr; 63(7):2739-52. doi: 10.1093/jxb/err456. [PMID: 22268153]
  • Komar Ruslan, Anggrahaeni Dewi Selfitri, Shella A Bulan, Yaya Rukayadi, Elfahmi. Effect of Agrobacterium rhizogenes and elicitation on the asiaticoside production in cell cultures of Centella asiatica. Pharmacognosy magazine. 2012 Apr; 8(30):111-5. doi: 10.4103/0973-1296.96552. [PMID: 22701283]
  • Yimian Ma, Lichai Yuan, Bin Wu, Xian'en Li, Shilin Chen, Shanfa Lu. Genome-wide identification and characterization of novel genes involved in terpenoid biosynthesis in Salvia miltiorrhiza. Journal of experimental botany. 2012 Apr; 63(7):2809-23. doi: 10.1093/jxb/err466. [PMID: 22291132]
  • Raimund Nagel, Jonathan Gershenzon, Axel Schmidt. Nonradioactive assay for detecting isoprenyl diphosphate synthase activity in crude plant extracts using liquid chromatography coupled with tandem mass spectrometry. Analytical biochemistry. 2012 Mar; 422(1):33-8. doi: 10.1016/j.ab.2011.12.037. [PMID: 22266300]
  • Sol A Green, Xiuyin Chen, Niels J Nieuwenhuizen, Adam J Matich, Mindy Y Wang, Barry J Bunn, Yar-Khing Yauk, Ross G Atkinson. Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). Journal of experimental botany. 2012 Mar; 63(5):1951-67. doi: 10.1093/jxb/err393. [PMID: 22162874]
  • Franziska Exnowitz, Bernd Meyer, Thomas Hackl. NMR for direct determination of K(m) and V(max) of enzyme reactions based on the Lambert W function-analysis of progress curves. Biochimica et biophysica acta. 2012 Mar; 1824(3):443-9. doi: 10.1016/j.bbapap.2011.10.011. [PMID: 22079737]
  • Xiaoying Cao, Ting Yin, Qian Miao, Changgen Li, Xiuyun Ju, Yong Sun, Jihong Jiang. Molecular characterization and expression analysis of a gene encoding for farnesyl diphosphate synthase from Euphorbia pekinensis Rupr. Molecular biology reports. 2012 Feb; 39(2):1487-92. doi: 10.1007/s11033-011-0886-z. [PMID: 21614522]
  • Bin Wu, Ying Li, Haixia Yan, Yimian Ma, Hongmei Luo, Lichai Yuan, Shilin Chen, Shanfa Lu. Comprehensive transcriptome analysis reveals novel genes involved in cardiac glycoside biosynthesis and mlncRNAs associated with secondary metabolism and stress response in Digitalis purpurea. BMC genomics. 2012 Jan; 13(?):15. doi: 10.1186/1471-2164-13-15. [PMID: 22233149]
  • Tahira Fatima, Crystal L Snyder, William R Schroeder, Dustin Cram, Raju Datla, David Wishart, Randall J Weselake, Priti Krishna. Fatty acid composition of developing sea buckthorn (Hippophae rhamnoides L.) berry and the transcriptome of the mature seed. PloS one. 2012; 7(4):e34099. doi: 10.1371/journal.pone.0034099. [PMID: 22558083]
  • Catarina M Quinzii, Saba Tadesse, Ali Naini, Michio Hirano. Effects of inhibiting CoQ10 biosynthesis with 4-nitrobenzoate in human fibroblasts. PloS one. 2012; 7(2):e30606. doi: 10.1371/journal.pone.0030606. [PMID: 22359546]
  • Munechika Enjoji, Motoyuki Kohjima, Kazuhiro Kotoh, Makoto Nakamuta. Metabolic disorders and steatosis in patients with chronic hepatitis C: metabolic strategies for antiviral treatments. International journal of hepatology. 2012; 2012(?):264017. doi: 10.1155/2012/264017. [PMID: 22701799]
  • Md Sarfaraj Hussain, Sheeba Fareed, Saba Ansari, Md Akhlaquer Rahman, Iffat Zareen Ahmad, Mohd Saeed. Current approaches toward production of secondary plant metabolites. Journal of pharmacy & bioallied sciences. 2012 Jan; 4(1):10-20. doi: 10.4103/0975-7406.92725. [PMID: 22368394]
  • Adelene Ai Lian Song, Janna O Abdullah, Mohd Puad Abdullah, Norazizah Shafee, Raha A Rahim. Functional expression of an orchid fragrance gene in Lactococcus lactis. International journal of molecular sciences. 2012; 13(2):1582-1597. doi: 10.3390/ijms13021582. [PMID: 22408409]
  • Lakshmi P Manavalan, Xi Chen, Joseph Clarke, John Salmeron, Henry T Nguyen. RNAi-mediated disruption of squalene synthase improves drought tolerance and yield in rice. Journal of experimental botany. 2012 Jan; 63(1):163-75. doi: 10.1093/jxb/err258. [PMID: 21926092]
  • Tomoko Toyama, Michiru Tahara, Kisaburo Nagamune, Kenji Arimitsu, Yoshio Hamashima, Nirianne M Q Palacpac, Hiroshi Kawaide, Toshihiro Horii, Kazuyuki Tanabe. Gibberellin biosynthetic inhibitors make human malaria parasite Plasmodium falciparum cells swell and rupture to death. PloS one. 2012; 7(3):e32246. doi: 10.1371/journal.pone.0032246. [PMID: 22412858]
  • Gudrun Nürenberg, Dietrich A Volmer. The analytical determination of isoprenoid intermediates from the mevalonate pathway. Analytical and bioanalytical chemistry. 2012 Jan; 402(2):671-85. doi: 10.1007/s00216-011-5262-2. [PMID: 21789486]
  • Takeru Yokoi, Keisuke Isobe, Tohru Yoshimura, Hisashi Hemmi. Archaeal phospholipid biosynthetic pathway reconstructed in Escherichia coli. Archaea (Vancouver, B.C.). 2012; 2012(?):438931. doi: 10.1155/2012/438931. [PMID: 22645416]
  • Tapan Kumar Mohanta, Andrea Occhipinti, Simon Atsbaha Zebelo, Maria Foti, Judith Fliegmann, Simone Bossi, Massimo E Maffei, Cinzia M Bertea. Ginkgo biloba responds to herbivory by activating early signaling and direct defenses. PloS one. 2012; 7(3):e32822. doi: 10.1371/journal.pone.0032822. [PMID: 22448229]
  • LingLin Wan, Juan Han, Min Sang, AiFen Li, Hong Wu, ShunJi Yin, ChengWu Zhang. De novo transcriptomic analysis of an oleaginous microalga: pathway description and gene discovery for production of next-generation biofuels. PloS one. 2012; 7(4):e35142. doi: 10.1371/journal.pone.0035142. [PMID: 22536352]
  • Hongmei Luo, Chao Sun, Yongzhen Sun, Qiong Wu, Ying Li, Jingyuan Song, Yunyun Niu, Xianglin Cheng, Hongxi Xu, Chuyuan Li, Juyan Liu, André Steinmetz, Shilin Chen. Analysis of the transcriptome of Panax notoginseng root uncovers putative triterpene saponin-biosynthetic genes and genetic markers. BMC genomics. 2011 Dec; 12 Suppl 5(?):S5. doi: 10.1186/1471-2164-12-s5-s5. [PMID: 22369100]
  • Roberto A Barrero, Brett Chapman, Yanfang Yang, Paula Moolhuijzen, Gabriel Keeble-Gagnère, Nan Zhang, Qi Tang, Matthew I Bellgard, Deyou Qiu. De novo assembly of Euphorbia fischeriana root transcriptome identifies prostratin pathway related genes. BMC genomics. 2011 Dec; 12(?):600. doi: 10.1186/1471-2164-12-600. [PMID: 22151917]
  • Ryan P McAndrew, Pamela P Peralta-Yahya, Andy DeGiovanni, Jose H Pereira, Masood Z Hadi, Jay D Keasling, Paul D Adams. Structure of a three-domain sesquiterpene synthase: a prospective target for advanced biofuels production. Structure (London, England : 1993). 2011 Dec; 19(12):1876-84. doi: 10.1016/j.str.2011.09.013. [PMID: 22153510]
  • Marc Clastre, Nicolas Papon, Vincent Courdavault, Nathalie Giglioli-Guivarc'h, Benoit St-Pierre, Andrew J Simkin. Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis. Plant signaling & behavior. 2011 Dec; 6(12):2044-6. doi: 10.4161/psb.6.12.18173. [PMID: 22080790]
  • Axel Schmidt, Raimund Nagel, Trygve Krekling, Erik Christiansen, Jonathan Gershenzon, Paal Krokene. Induction of isoprenyl diphosphate synthases, plant hormones and defense signalling genes correlates with traumatic resin duct formation in Norway spruce (Picea abies). Plant molecular biology. 2011 Dec; 77(6):577-90. doi: 10.1007/s11103-011-9832-7. [PMID: 22002747]
  • Nelson L Brock, Bettina Tudzynski, Jeroen S Dickschat. Biosynthesis of sesqui- and diterpenes by the gibberellin producer Fusarium fujikuroi. Chembiochem : a European journal of chemical biology. 2011 Nov; 12(17):2667-76. doi: 10.1002/cbic.201100516. [PMID: 21990128]
  • Brian M Wasko, Jacqueline P Smits, Larry W Shull, David F Wiemer, Raymond J Hohl. A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro. Journal of lipid research. 2011 Nov; 52(11):1957-64. doi: 10.1194/jlr.m016089. [PMID: 21903868]
  • Petra M Bleeker, Eleni A Spyropoulou, Paul J Diergaarde, Hanne Volpin, Michiel T J De Both, Philipp Zerbe, Joerg Bohlmann, Vasiliki Falara, Yuki Matsuba, Eran Pichersky, Michel A Haring, Robert C Schuurink. RNA-seq discovery, functional characterization, and comparison of sesquiterpene synthases from Solanum lycopersicum and Solanum habrochaites trichomes. Plant molecular biology. 2011 Nov; 77(4-5):323-36. doi: 10.1007/s11103-011-9813-x. [PMID: 21818683]
  • Sarah A Holstein, Craig H Kuder, Huaxiang Tong, Raymond J Hohl. Pleiotropic effects of a schweinfurthin on isoprenoid homeostasis. Lipids. 2011 Oct; 46(10):907-21. doi: 10.1007/s11745-011-3572-y. [PMID: 21633866]
  • Vasiliki Falara, Tariq A Akhtar, Thuong T H Nguyen, Eleni A Spyropoulou, Petra M Bleeker, Ines Schauvinhold, Yuki Matsuba, Megan E Bonini, Anthony L Schilmiller, Robert L Last, Robert C Schuurink, Eran Pichersky. The tomato terpene synthase gene family. Plant physiology. 2011 Oct; 157(2):770-89. doi: 10.1104/pp.111.179648. [PMID: 21813655]
  • Charles G Nasmith, Sean Walkowiak, Li Wang, Winnie W Y Leung, Yunchen Gong, Anne Johnston, Linda J Harris, David S Guttman, Rajagopal Subramaniam. Tri6 is a global transcription regulator in the phytopathogen Fusarium graminearum. PLoS pathogens. 2011 Sep; 7(9):e1002266. doi: 10.1371/journal.ppat.1002266. [PMID: 21980289]
  • Moran Farhi, Elena Marhevka, Tania Masci, Evgeniya Marcos, Yoram Eyal, Mariana Ovadis, Hagai Abeliovich, Alexander Vainstein. Harnessing yeast subcellular compartments for the production of plant terpenoids. Metabolic engineering. 2011 Sep; 13(5):474-81. doi: 10.1016/j.ymben.2011.05.001. [PMID: 21601648]
  • John H Beattie, Fergus Nicol, Margaret-Jane Gordon, Martin D Reid, Louise Cantlay, Graham W Horgan, In-Sook Kwun, Ji-Yun Ahn, Tae-Youl Ha. Ginger phytochemicals mitigate the obesogenic effects of a high-fat diet in mice: a proteomic and biomarker network analysis. Molecular nutrition & food research. 2011 Sep; 55 Suppl 2(?):S203-13. doi: 10.1002/mnfr.201100193. [PMID: 21954187]
  • Soon-Sen Leow, Shamala Devi Sekaran, Kalyana Sundram, YewAi Tan, Ravigadevi Sambanthamurthi. Differential transcriptomic profiles effected by oil palm phenolics indicate novel health outcomes. BMC genomics. 2011 Aug; 12(?):432. doi: 10.1186/1471-2164-12-432. [PMID: 21864415]
  • Tsuyoshi Goto, Hiroyuki Nagai, Kahori Egawa, Young-Il Kim, Sota Kato, Aki Taimatsu, Tomoya Sakamoto, Shogo Ebisu, Takahiro Hohsaka, Hiroh Miyagawa, Shigeru Murakami, Nobuyuki Takahashi, Teruo Kawada. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. The Biochemical journal. 2011 Aug; 438(1):111-9. doi: 10.1042/bj20101939. [PMID: 21605082]
  • Ruiyi Yang, Xueqin Yang, Liling Feng, Qingping Zeng. [Isolation and characterization of promoter of ADS from Artemisia annua]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Aug; 36(15):2052-5. doi: 10.4268/cjcmm20111509. [PMID: 22066438]
  • Wei Wen, Rongmin Yu. Artemisinin biosynthesis and its regulatory enzymes: Progress and perspective. Pharmacognosy reviews. 2011 Jul; 5(10):189-94. doi: 10.4103/0973-7847.91118. [PMID: 22279377]
  • Laura M Vaughn, Patrick H Masson. A QTL Study for Regions Contributing to Arabidopsis thaliana Root Skewing on Tilted Surfaces. G3 (Bethesda, Md.). 2011 Jul; 1(2):105-15. doi: 10.1534/g3.111.000331. [PMID: 22384323]
  • Pilar Martinez-Moya, Steven Alexander Watt, Karsten Niehaus, Jennifer Alcaíno, Marcelo Baeza, Víctor Cifuentes. Proteomic analysis of the carotenogenic yeast Xanthophyllomyces dendrorhous. BMC microbiology. 2011 Jun; 11(?):131. doi: 10.1186/1471-2180-11-131. [PMID: 21669001]
  • Jianxin Yang, Margit L MacDougall, Michael T McDowell, Li Xi, Ru Wei, William J Zavadoski, Mark P Molloy, John D Baker, Max Kuhn, Over Cabrera, Judith L Treadway. Polyomic profiling reveals significant hepatic metabolic alterations in glucagon-receptor (GCGR) knockout mice: implications on anti-glucagon therapies for diabetes. BMC genomics. 2011 Jun; 12(?):281. doi: 10.1186/1471-2164-12-281. [PMID: 21631939]
  • Megan M Weivoda, Raymond J Hohl. The effects of direct inhibition of geranylgeranyl pyrophosphate synthase on osteoblast differentiation. Journal of cellular biochemistry. 2011 Jun; 112(6):1506-13. doi: 10.1002/jcb.23087. [PMID: 21503955]
  • Mustafa Köksal, Huayou Hu, Robert M Coates, Reuben J Peters, David W Christianson. Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase. Nature chemical biology. 2011 May; 7(7):431-3. doi: 10.1038/nchembio.578. [PMID: 21602811]
  • Kenneth D Harrison, Eon Joo Park, Ningguo Gao, Andrew Kuo, Jeffrey S Rush, Charles J Waechter, Mark A Lehrman, William C Sessa. Nogo-B receptor is necessary for cellular dolichol biosynthesis and protein N-glycosylation. The EMBO journal. 2011 May; 30(12):2490-500. doi: 10.1038/emboj.2011.147. [PMID: 21572394]
  • Sangsu Bang, Sungjae Yoo, Tae-Jin Yang, Hawon Cho, Sun Wook Hwang. Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels. Pain. 2011 May; 152(5):1156-1164. doi: 10.1016/j.pain.2011.01.044. [PMID: 21353389]
  • Marisa Wong Medina, Feng Gao, Devesh Naidoo, Lawrence L Rudel, Ryan E Temel, Allison L McDaniel, Stephanie M Marshall, Ronald M Krauss. Coordinately regulated alternative splicing of genes involved in cholesterol biosynthesis and uptake. PloS one. 2011 Apr; 6(4):e19420. doi: 10.1371/journal.pone.0019420. [PMID: 21559365]
  • Shouji Shimoyama. Statins are logical candidates for overcoming limitations of targeting therapies on malignancy: their potential application to gastrointestinal cancers. Cancer chemotherapy and pharmacology. 2011 Apr; 67(4):729-39. doi: 10.1007/s00280-011-1583-2. [PMID: 21327931]
  • Youssef Ismail, Susan McCormick, Mohamed Hijri. A fungal symbiont of plant-roots modulates mycotoxin gene expression in the pathogen Fusarium sambucinum. PloS one. 2011 Mar; 6(3):e17990. doi: 10.1371/journal.pone.0017990. [PMID: 21455305]
  • Linda Olofsson, Alexander Engström, Anneli Lundgren, Peter E Brodelius. Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L. BMC plant biology. 2011 Mar; 11(?):45. doi: 10.1186/1471-2229-11-45. [PMID: 21388533]
  • Christopher I Keeling, Sabrina Weisshaar, Steven G Ralph, Sharon Jancsik, Britta Hamberger, Harpreet K Dullat, Jörg Bohlmann. Transcriptome mining, functional characterization, and phylogeny of a large terpene synthase gene family in spruce (Picea spp.). BMC plant biology. 2011 Mar; 11(?):43. doi: 10.1186/1471-2229-11-43. [PMID: 21385377]
  • Matjaž Simončič, Tadeja Režen, Peter Juvan, Damjana Rozman, Gregor Fazarinc, Catherine Fievet, Bart Staels, Simon Horvat. Obesity resistant mechanisms in the Lean polygenic mouse model as indicated by liver transcriptome and expression of selected genes in skeletal muscle. BMC genomics. 2011 Feb; 12(?):96. doi: 10.1186/1471-2164-12-96. [PMID: 21291556]
  • Codruta Ignea, Ivana Cvetkovic, Sofia Loupassaki, Panagiotis Kefalas, Christopher B Johnson, Sotirios C Kampranis, Antonios M Makris. Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids. Microbial cell factories. 2011 Jan; 10(?):4. doi: 10.1186/1475-2859-10-4. [PMID: 21276210]
  • Kelly Ishida, Juliany Cola Fernandes Rodrigues, Simon Cammerer, Julio A Urbina, Ian Gilbert, Wanderley de Souza, Sonia Rozental. Synthetic arylquinuclidine derivatives exhibit antifungal activity against Candida albicans, Candida tropicalis and Candida parapsilopsis. Annals of clinical microbiology and antimicrobials. 2011 Jan; 10(?):3. doi: 10.1186/1476-0711-10-3. [PMID: 21255433]
  • Melanie Hamalukic, Johannes Huelsenbeck, Arno Schad, Stefan Wirtz, Bernd Kaina, Gerhard Fritz. Rac1-regulated endothelial radiation response stimulates extravasation and metastasis that can be blocked by HMG-CoA reductase inhibitors. PloS one. 2011; 6(10):e26413. doi: 10.1371/journal.pone.0026413. [PMID: 22039482]
  • Mohana Roy, Hsing-Jien Kung, Paramita M Ghosh. Statins and prostate cancer: role of cholesterol inhibition vs. prevention of small GTP-binding proteins. American journal of cancer research. 2011; 1(4):542-61. doi: . [PMID: 21984972]
  • Marcello Arca, Giovanni Pigna. Treating statin-intolerant patients. Diabetes, metabolic syndrome and obesity : targets and therapy. 2011; 4(?):155-66. doi: 10.2147/dmso.s11244. [PMID: 21779147]
  • Tae-Dong Kim, Jung-Yeon Han, Gyung Hye Huh, Yong-Eui Choi. Expression and functional characterization of three squalene synthase genes associated with saponin biosynthesis in Panax ginseng. Plant & cell physiology. 2011 Jan; 52(1):125-37. doi: 10.1093/pcp/pcq179. [PMID: 21134898]
  • Vicenta Martínez-Sales, Virtudes Vila, Marcos Ferrando, Edelmiro Reganon. Atorvastatin neutralises the thrombin-induced tissue factor expresion in endothelial cells via geranylgeranyl pyrophosphate. Cytotechnology. 2011 Jan; 63(1):1-5. doi: 10.1007/s10616-010-9319-4. [PMID: 21052830]
  • Qing Liu, Mohammad Majdi, Katarina Cankar, Miriam Goedbloed, Tatsiana Charnikhova, Francel W A Verstappen, Ric C H de Vos, Jules Beekwilder, Sander van der Krol, Harro J Bouwmeester. Reconstitution of the costunolide biosynthetic pathway in yeast and Nicotiana benthamiana. PloS one. 2011; 6(8):e23255. doi: 10.1371/journal.pone.0023255. [PMID: 21858047]
  • Sébastien Verne, Barry Jaquish, Rick White, Carol Ritland, Kermit Ritland. Global transcriptome analysis of constitutive resistance to the white pine weevil in spruce. Genome biology and evolution. 2011; 3(?):851-67. doi: 10.1093/gbe/evr069. [PMID: 21852250]
  • M Mudagal, J Patel, Nc Nagalakshmi, M Asif Ansari. Renoprotective effects of combining ACE inhibitors and statins in experimental diabetic rats. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2011; 19(5):322-5. doi: NULL. [PMID: 22615676]
  • Neil A Brown, Chris Bass, Thomas K Baldwin, Huaigu Chen, Fabien Massot, Pierre W C Carion, Martin Urban, Allison M L van de Meene, Kim E Hammond-Kosack. Characterisation of the Fusarium graminearum-Wheat Floral Interaction. Journal of pathogens. 2011; 2011(?):626345. doi: 10.4061/2011/626345. [PMID: 22567335]
  • Satoru Sawai, Kazuki Saito. Triterpenoid biosynthesis and engineering in plants. Frontiers in plant science. 2011; 2(?):25. doi: 10.3389/fpls.2011.00025. [PMID: 22639586]
  • Fernando Alvarez-Vasquez, Howard Riezman, Yusuf A Hannun, Eberhard O Voit. Mathematical modeling and validation of the ergosterol pathway in Saccharomyces cerevisiae. PloS one. 2011; 6(12):e28344. doi: 10.1371/journal.pone.0028344. [PMID: 22194828]
  • Stéphane Jouneau, Mélanie Bonizec, Chantal Belleguic, Benoit Desrues, Graziella Brinchault, Jeanne Galaine, Jean-Pierre Gangneux, Corinne Martin-Chouly. Anti-inflammatory effect of fluvastatin on IL-8 production induced by Pseudomonas aeruginosa and Aspergillus fumigatus antigens in cystic fibrosis. PloS one. 2011; 6(8):e22655. doi: 10.1371/journal.pone.0022655. [PMID: 21826199]
  • Jo V Rushworth, Nigel M Hooper. Lipid Rafts: Linking Alzheimer's Amyloid-β Production, Aggregation, and Toxicity at Neuronal Membranes. International journal of Alzheimer's disease. 2010 Dec; 2011(?):603052. doi: 10.4061/2011/603052. [PMID: 21234417]
  • Richard Kones. Rosuvastatin, inflammation, C-reactive protein, JUPITER, and primary prevention of cardiovascular disease--a perspective. Drug design, development and therapy. 2010 Dec; 4(?):383-413. doi: 10.2147/dddt.s10812. [PMID: 21267417]
  • Teun W J M van Herpen, Katarina Cankar, Marilise Nogueira, Dirk Bosch, Harro J Bouwmeester, Jules Beekwilder. Nicotiana benthamiana as a production platform for artemisinin precursors. PloS one. 2010 Dec; 5(12):e14222. doi: 10.1371/journal.pone.0014222. [PMID: 21151979]
  • Wayne Chadwick, Randall Brenneman, Bronwen Martin, Stuart Maudsley. Complex and multidimensional lipid raft alterations in a murine model of Alzheimer's disease. International journal of Alzheimer's disease. 2010 Dec; 2010(?):604792. doi: 10.4061/2010/604792. [PMID: 21151659]
  • Grit Kunert, Carolina Reinhold, Jonathan Gershenzon. Constitutive emission of the aphid alarm pheromone, (E)-β-farnesene, from plants does not serve as a direct defense against aphids. BMC ecology. 2010 Nov; 10(?):23. doi: 10.1186/1472-6785-10-23. [PMID: 21092302]
  • Jia-Xing Yue, Jinpeng Li, Dan Wang, Hitoshi Araki, Dacheng Tian, Sihai Yang. Genome-wide investigation reveals high evolutionary rates in annual model plants. BMC plant biology. 2010 Nov; 10(?):242. doi: 10.1186/1471-2229-10-242. [PMID: 21062446]
  • Jayaram Bhandari, A Heather Fitzpatrick, Dring N Crowell. Identification of a novel abscisic acid-regulated farnesol dehydrogenase from Arabidopsis. Plant physiology. 2010 Nov; 154(3):1116-27. doi: 10.1104/pp.110.157784. [PMID: 20807998]
  • Diane M Martin, Sébastien Aubourg, Marina B Schouwey, Laurent Daviet, Michel Schalk, Omid Toub, Steven T Lund, Jörg Bohlmann. Functional annotation, genome organization and phylogeny of the grapevine (Vitis vinifera) terpene synthase gene family based on genome assembly, FLcDNA cloning, and enzyme assays. BMC plant biology. 2010 Oct; 10(?):226. doi: 10.1186/1471-2229-10-226. [PMID: 20964856]
  • Sung Ha Lee, Siham Raboune, J Michael Walker, Heather B Bradshaw. Distribution of endogenous farnesyl pyrophosphate and four species of lysophosphatidic acid in rodent brain. International journal of molecular sciences. 2010 Oct; 11(10):3965-76. doi: 10.3390/ijms11103965. [PMID: 21152313]
  • Patrick R Arsenault, Daniel Vail, Kristin K Wobbe, Karen Erickson, Pamela J Weathers. Reproductive development modulates gene expression and metabolite levels with possible feedback inhibition of artemisinin in Artemisia annua. Plant physiology. 2010 Oct; 154(2):958-68. doi: 10.1104/pp.110.162552. [PMID: 20724645]
  • Rui-Long Wang, Christian Staehelin, Shao-Lin Peng, Wen-Tian Wang, Xi-Mei Xie, Hui-Ning Lu. Responses of Mikania micrantha, an invasive weed to elevated CO₂: induction of β-caryophyllene synthase, changes in emission capability and allelopathic potential of β-caryophyllene. Journal of chemical ecology. 2010 Oct; 36(10):1076-82. doi: 10.1007/s10886-010-9843-x. [PMID: 20821346]
  • Gero P Hooff, Nina Patel, W Gibson Wood, Walter E Müller, Gunter P Eckert, Dietrich A Volmer. A rapid and sensitive assay for determining human brain levels of farnesyl-(FPP) and geranylgeranylpyrophosphate (GGPP) and transferase activities using UHPLC-MS/MS. Analytical and bioanalytical chemistry. 2010 Oct; 398(4):1801-8. doi: 10.1007/s00216-010-4088-7. [PMID: 20730526]
  • Ping Lan, Wenfeng Li, Huizhong Wang, Wujun Ma. Characterization, sub-cellular localization and expression profiling of the isoprenylcysteine methylesterase gene family in Arabidopsis thaliana. BMC plant biology. 2010 Sep; 10(?):212. doi: 10.1186/1471-2229-10-212. [PMID: 20868530]
  • Hongmei Luo, Ying Li, Chao Sun, Qiong Wu, Jingyuan Song, Yongzhen Sun, André Steinmetz, Shilin Chen. Comparison of 454-ESTs from Huperzia serrata and Phlegmariurus carinatus reveals putative genes involved in lycopodium alkaloid biosynthesis and developmental regulation. BMC plant biology. 2010 Sep; 10(?):209. doi: 10.1186/1471-2229-10-209. [PMID: 20854695]
  • Vasiliki Falara, Eran Pichersky, Angelos K Kanellis. A copal-8-ol diphosphate synthase from the angiosperm Cistus creticus subsp. creticus is a putative key enzyme for the formation of pharmacologically active, oxygen-containing labdane-type diterpenes. Plant physiology. 2010 Sep; 154(1):301-10. doi: 10.1104/pp.110.159566. [PMID: 20595348]
  • Gabor Tigyi. Aiming drug discovery at lysophosphatidic acid targets. British journal of pharmacology. 2010 Sep; 161(2):241-70. doi: 10.1111/j.1476-5381.2010.00815.x. [PMID: 20735414]
  • Gavin M George, Margaretha J van der Merwe, Adriano Nunes-Nesi, Rolene Bauer, Alisdair R Fernie, Jens Kossmann, James R Lloyd. Virus-induced gene silencing of plastidial soluble inorganic pyrophosphatase impairs essential leaf anabolic pathways and reduces drought stress tolerance in Nicotiana benthamiana. Plant physiology. 2010 Sep; 154(1):55-66. doi: 10.1104/pp.110.157776. [PMID: 20605913]
  • Gustavo G L Costa, Kiara C Cardoso, Luís E V Del Bem, Aline C Lima, Muciana A S Cunha, Luciana de Campos-Leite, Renato Vicentini, Fábio Papes, Raquel C Moreira, José A Yunes, Francisco A P Campos, Márcio J Da Silva. Transcriptome analysis of the oil-rich seed of the bioenergy crop Jatropha curcas L. BMC genomics. 2010 Aug; 11(?):462. doi: 10.1186/1471-2164-11-462. [PMID: 20691070]
  • Mitsuko Kishi-Kaboshi, Kazunori Okada, Leona Kurimoto, Shinya Murakami, Toshiaki Umezawa, Naoto Shibuya, Hisakazu Yamane, Akio Miyao, Hiroshi Takatsuji, Akira Takahashi, Hirohiko Hirochika. A rice fungal MAMP-responsive MAPK cascade regulates metabolic flow to antimicrobial metabolite synthesis. The Plant journal : for cell and molecular biology. 2010 Aug; 63(4):599-612. doi: 10.1111/j.1365-313x.2010.04264.x. [PMID: 20525005]
  • Julia M Fres, Stefan Müller, Gerrit J K Praefcke. Purification of the CaaX-modified, dynamin-related large GTPase hGBP1 by coexpression with farnesyltransferase. Journal of lipid research. 2010 Aug; 51(8):2454-9. doi: 10.1194/jlr.d005397. [PMID: 20348589]
  • Amanda Padovan, Andras Keszei, Tobias G Köllner, Jörg Degenhardt, William J Foley. The molecular basis of host plant selection in Melaleuca quinquenervia by a successful biological control agent. Phytochemistry. 2010 Aug; 71(11-12):1237-44. doi: 10.1016/j.phytochem.2010.05.013. [PMID: 20554297]
  • Michael Pazianas, Cyrus Cooper, F Hal Ebetino, R Graham G Russell. Long-term treatment with bisphosphonates and their safety in postmenopausal osteoporosis. Therapeutics and clinical risk management. 2010 Jul; 6(?):325-43. doi: 10.2147/tcrm.s8054. [PMID: 20668715]