8S,9R-EpETrE (BioDeep_00001883700)
代谢物信息卡片
8S,9R-EpETrE
化学式: C20H32O3 (320.23513219999995)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCC/C=C\C/C=C\C[C@@H]1[C@H](C/C=C\CCCC(=O)O)O1
InChI: InChI=1S/C20H32O3/c1-2-3-4-5-6-7-8-9-12-15-18-19(23-18)16-13-10-11-14-17-20(21)22/h6-7,9-10,12-13,18-19H,2-5,8,11,14-17H2,1H3,(H,21,22)/b7-6-,12-9-,13-10-/t18-,19+/m1/s1
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- John D Imig, Wojciech K Jankiewicz, Abdul H Khan. Epoxy Fatty Acids: From Salt Regulation to Kidney and Cardiovascular Therapeutics: 2019 Lewis K. Dahl Memorial Lecture.
Hypertension (Dallas, Tex. : 1979).
2020 07; 76(1):3-15. doi:
10.1161/hypertensionaha.120.13898. [PMID: 32475311] - Anne Marowsky, Imke Meyer, Kira Erismann-Ebner, Giovanni Pellegrini, Nandkishor Mule, Michael Arand. Beyond detoxification: a role for mouse mEH in the hepatic metabolism of endogenous lipids.
Archives of toxicology.
2017 Nov; 91(11):3571-3585. doi:
10.1007/s00204-017-2060-4. [PMID: 28975360] - Theresa Aliwarga, Brianne S Raccor, Rozenn N Lemaitre, Nona Sotoodehnia, Sina A Gharib, Libin Xu, Rheem A Totah. Enzymatic and free radical formation of cis- and trans- epoxyeicosatrienoic acids in vitro and in vivo.
Free radical biology & medicine.
2017 11; 112(?):131-140. doi:
10.1016/j.freeradbiomed.2017.07.015. [PMID: 28734877] - Quan-Fei Zhu, Yan-Hong Hao, Ming-Zhou Liu, Jiang Yue, Jian Ni, Bi-Feng Yuan, Yu-Qi Feng. Analysis of cytochrome P450 metabolites of arachidonic acid by stable isotope probe labeling coupled with ultra high-performance liquid chromatography/mass spectrometry.
Journal of chromatography. A.
2015 Sep; 1410(?):154-63. doi:
10.1016/j.chroma.2015.07.100. [PMID: 26253834] - Yanxiang Gao, Juan Feng, Kongyang Ma, Zhou Zhou, Yi Zhu, Qingbo Xu, Xian Wang. 8,9-Epoxyeicosatrienoic acid inhibits antibody production of B lymphocytes in mice.
PloS one.
2012; 7(7):e40258. doi:
10.1371/journal.pone.0040258. [PMID: 22802958] - Tengis S Pavlov, Daria V Ilatovskaya, Vladislav Levchenko, David L Mattson, Richard J Roman, Alexander Staruschenko. Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC).
American journal of physiology. Renal physiology.
2011 Sep; 301(3):F672-81. doi:
10.1152/ajprenal.00597.2010. [PMID: 21697242] - Houli Jiang, John Quilley, Anabel B Doumad, Angela G Zhu, John R Falck, Bruce D Hammock, Charles T Stier, Mairead A Carroll. Increases in plasma trans-EETs and blood pressure reduction in spontaneously hypertensive rats.
American journal of physiology. Heart and circulatory physiology.
2011 Jun; 300(6):H1990-6. doi:
10.1152/ajpheart.01267.2010. [PMID: 21398593] - Jun Ma, Lei Zhang, Shanshan Li, Shulin Liu, Cui Ma, Weiyang Li, J R Falck, Vijay L Manthati, D Sudarshan Reddy, Meetha Medhora, Elizabeth R Jacobs, Daling Zhu. 8,9-Epoxyeicosatrienoic acid analog protects pulmonary artery smooth muscle cells from apoptosis via ROCK pathway.
Experimental cell research.
2010 Aug; 316(14):2340-53. doi:
10.1016/j.yexcr.2010.05.013. [PMID: 20493836] - Mukut Sharma, Ellen T McCarthy, D Sudarshan Reddy, Paresh K Patel, Virginia J Savin, Meetha Medhora, John R Falck. 8,9-Epoxyeicosatrienoic acid protects the glomerular filtration barrier.
Prostaglandins & other lipid mediators.
2009 Jun; 89(1-2):43-51. doi:
10.1016/j.prostaglandins.2009.04.004. [PMID: 19480064] - Ambra Pozzi, Ines Macias-Perez, Tristin Abair, Shouzuo Wei, Yan Su, Roy Zent, John R Falck, Jorge H Capdevila. Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipids.
The Journal of biological chemistry.
2005 Jul; 280(29):27138-46. doi:
10.1074/jbc.m501730200. [PMID: 15917237] - Kathryn M Gauthier, Christina Deeter, U Murali Krishna, Y Krishna Reddy, Muralidhar Bondlela, J R Falck, William B Campbell. 14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries.
Circulation research.
2002 May; 90(9):1028-36. doi:
10.1161/01.res.0000018162.87285.f8. [PMID: 12016270] - J D Imig, X Zhao, J R Falck, S Wei, J H Capdevila. Enhanced renal microvascular reactivity to angiotensin II in hypertension is ameliorated by the sulfonimide analog of 11,12-epoxyeicosatrienoic acid.
Journal of hypertension.
2001 May; 19(5):983-92. doi:
10.1097/00004872-200105000-00020. [PMID: 11393683] - Z Yu, F Xu, L M Huse, C Morisseau, A J Draper, J W Newman, C Parker, L Graham, M M Engler, B D Hammock, D C Zeldin, D L Kroetz. Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids.
Circulation research.
2000 Nov; 87(11):992-8. doi:
10.1161/01.res.87.11.992. [PMID: 11090543] - C L Oltman, N L Weintraub, M VanRollins, K C Dellsperger. Epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids are potent vasodilators in the canine coronary microcirculation.
Circulation research.
1998 Nov; 83(9):932-9. doi:
10.1161/01.res.83.9.932. [PMID: 9797342] - M VanRollins, P M Kochanek, R W Evans, J K Schiding, E M Nemoto. Optimization of epoxyeicosatrienoic acid syntheses to test their effects on cerebral blood flow in vivo.
Biochimica et biophysica acta.
1995 Jun; 1256(3):263-74. doi:
10.1016/0005-2760(95)00029-c. [PMID: 7786887] - B A Escalante, R Staudinger, M Schwartzman, N Abraham. Amiloride-sensitive ion transport inhibition by epoxyeicosatrienoic acids in renal epithelial cells.
Advances in prostaglandin, thromboxane, and leukotriene research.
1995; 23(?):207-9. doi:
NULL. [PMID: 7732836] - A Karara, S Wei, D Spady, L Swift, J H Capdevila, J R Falck. Arachidonic acid epoxygenase: structural characterization and quantification of epoxyeicosatrienoates in plasma.
Biochemical and biophysical research communications.
1992 Feb; 182(3):1320-5. doi:
10.1016/0006-291x(92)91877-s. [PMID: 1540175] - M A Carroll, M P Garcia, J R Falck, J C McGiff. Cyclooxygenase dependency of the renovascular actions of cytochrome P450-derived arachidonate metabolites.
The Journal of pharmacology and experimental therapeutics.
1992 Jan; 260(1):104-9. doi:
. [PMID: 1731035] - M L Heizer, J S McKinney, E F Ellis. 14,15-Epoxyeicosatrienoic acid inhibits platelet aggregation in mouse cerebral arterioles.
Stroke.
1991 Nov; 22(11):1389-93. doi:
10.1161/01.str.22.11.1389. [PMID: 1750047] - T Katoh, K Takahashi, J Capdevila, A Karara, J R Falck, H R Jacobson, K F Badr. Glomerular stereospecific synthesis and hemodynamic actions of 8,9-epoxyeicosatrienoic acid in rat kidney.
The American journal of physiology.
1991 Oct; 261(4 Pt 2):F578-86. doi:
10.1152/ajprenal.1991.261.4.f578. [PMID: 1928373] - F Catella, J Lawson, G Braden, D J Fitzgerald, E Shipp, G A FitzGerald. Biosynthesis of P450 products of arachidonic acid in humans: increased formation in cardiovascular disease.
Advances in prostaglandin, thromboxane, and leukotriene research.
1991; 21A(?):193-6. doi:
NULL. [PMID: 1705382] - F Catella, J A Lawson, D J Fitzgerald, G A FitzGerald. Endogenous biosynthesis of arachidonic acid epoxides in humans: increased formation in pregnancy-induced hypertension.
Proceedings of the National Academy of Sciences of the United States of America.
1990 Aug; 87(15):5893-7. doi:
10.1073/pnas.87.15.5893. [PMID: 2198572] - A Karara, E Dishman, H Jacobson, J R Falck, J H Capdevila. Arachidonic acid epoxygenase. Stereochemical analysis of the endogenous epoxyeicosatrienoic acids of human kidney cortex.
FEBS letters.
1990 Jul; 268(1):227-30. doi:
10.1016/0014-5793(90)81014-f. [PMID: 2384159] - G A Ulsaker, G Teien. Gas chromatographic-mass spectrometric identification of four triene monoepoxides of arachidonic acid in human plasma.
The Analyst.
1990 Mar; 115(3):259-62. doi:
10.1039/an9901500259. [PMID: 2327589]