U50488 (BioDeep_00001883409)
Main id: BioDeep_00000008878
代谢物信息卡片
trans-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzeneacetamide
化学式: C19H26Cl2N2O (368.1422086)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN(C1CCCCC1N2CCCC2)C(=O)CC3=CC(=C(C=C3)Cl)Cl
InChI: InChI=1S/C19H26Cl2N2O/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23/h8-9,12,17-18H,2-7,10-11,13H2,1H3/t17-,18-/m1/s1
描述信息
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:73358
- KEGG: C11796
- PubChem: 3036289
- ChEMBL: CHEMBL441765
- MeSH: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer
- CAS: 67198-13-4
- PubChem: 13960
- NIKKAJI: J253.797D
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qin Zheng, Qi Wu, Hong Yang, Qiuhong Chen, Xiaohui Li, Jingyi Guo. A κ-OR Agonist Protects the Endothelial Function Impaired by Hyperuricemia Through Regulating the Akt/eNOS Signal Pathway.
Probiotics and antimicrobial proteins.
2022 08; 14(4):751-759. doi:
10.1007/s12602-022-09945-1. [PMID: 35536506] - Kanako Miyano, Yuki Yoshida, Shigeto Hirayama, Hideki Takahashi, Haruka Ono, Yoshiyuki Meguro, Sei Manabe, Akane Komatsu, Miki Nonaka, Takaaki Mizuguchi, Hideaki Fujii, Yoshikazu Higami, Minoru Narita, Yasuhito Uezono. Oxytocin Is a Positive Allosteric Modulator of κ-Opioid Receptors but Not δ-Opioid Receptors in the G Protein Signaling Pathway.
Cells.
2021 10; 10(10):. doi:
10.3390/cells10102651. [PMID: 34685631] - Edin Muratspahić, Nataša Tomašević, Shahrooz Nasrollahi-Shirazi, Jasmin Gattringer, Fabiola Susanna Emser, Michael Freissmuth, Christian W Gruber. Plant-Derived Cyclotides Modulate κ-Opioid Receptor Signaling.
Journal of natural products.
2021 08; 84(8):2238-2248. doi:
10.1021/acs.jnatprod.1c00301. [PMID: 34308635] - Laura L Erwin, Mark R Nilges, Ian B Denys, Jane C Sutphen, Ashton J Friend, Daniel R Kapusta, Peter J Winsauer. Interactive effects of (±)-trans-U50488 and its stereoisomers with cannabinoids.
Pharmacology, biochemistry, and behavior.
2021 08; 207(?):173218. doi:
10.1016/j.pbb.2021.173218. [PMID: 34118232] - Tengfei Wu, Hui Yao, Binghua Zhang, Shenglai Zhou, Ping Hou, Keyan Chen. κ Opioid Receptor Agonist Inhibits Myocardial Injury in Heart Failure Rats through Activating Nrf2/HO-1 Pathway and Regulating Ca2+-SERCA2a.
Oxidative medicine and cellular longevity.
2021; 2021(?):7328437. doi:
10.1155/2021/7328437. [PMID: 34373768] - Amelia Dunn, Kyle Windisch, Ariel Ben-Ezra, Phillip Pikus, Michelle Morochnik, Jose Erazo, Brian Reed, Mary Jeanne Kreek. Modulation of cocaine-related behaviors by low doses of the potent KOR agonist nalfurafine in male C57BL6 mice.
Psychopharmacology.
2020 Aug; 237(8):2405-2418. doi:
10.1007/s00213-020-05543-7. [PMID: 32435819] - Samuel Obeng, Shyam H Kamble, Morgan E Reeves, Luis F Restrepo, Avi Patel, Mira Behnke, Nelson J-Y Chear, Surash Ramanathan, Abhisheak Sharma, Francisco León, Takato Hiranita, Bonnie A Avery, Lance R McMahon, Christopher R McCurdy. Investigation of the Adrenergic and Opioid Binding Affinities, Metabolic Stability, Plasma Protein Binding Properties, and Functional Effects of Selected Indole-Based Kratom Alkaloids.
Journal of medicinal chemistry.
2020 01; 63(1):433-439. doi:
10.1021/acs.jmedchem.9b01465. [PMID: 31834797] - Xin Tian, Yaguang Zhou, Yuanbo Wang, Shumiao Zhang, Jiahao Feng, Xu Wang, Haitao Guo, Rong Fan, Na Feng, Min Jia, Xiaoming Gu, Juan Li, Lu Yang, Yueming Wang, Jun Li, Guoxu Zheng, Feng Fu, Jianming Pei. Mitochondrial Dysfunction and Apoptosis Are Attenuated on κ-Opioid Receptor Activation Through AMPK/GSK-3β Pathway After Myocardial Ischemia and Reperfusion.
Journal of cardiovascular pharmacology.
2019 02; 73(2):70-81. doi:
10.1097/fjc.0000000000000635. [PMID: 30422891] - Shumiao Zhang, Yaguang Zhou, Lei Zhao, Xin Tian, Min Jia, Xiaoming Gu, Na Feng, Rui An, Lu Yang, Guoxu Zheng, Juan Li, Haitao Guo, Rong Fan, Jianming Pei. κ-opioid receptor activation protects against myocardial ischemia-reperfusion injury via AMPK/Akt/eNOS signaling activation.
European journal of pharmacology.
2018 Aug; 833(?):100-108. doi:
10.1016/j.ejphar.2018.05.043. [PMID: 29856969] - Yaguang Zhou, Xin Tian, Xueying Wang, Yuanbo Wang, Rong Fan, Yuemin Wang, Na Feng, Shumiao Zhang, Haitao Guo, Xiaoming Gu, Min Jia, Wen Yin, Zuoxu Hou, Juan Li, Jianming Pei. Quaternary ammonium salt of U50,488H elicits protective effects against hypoxic pulmonary hypertension.
European journal of pharmacology.
2018 Aug; 832(?):129-137. doi:
10.1016/j.ejphar.2018.05.025. [PMID: 29782857] - Admire Munanairi, Xian-Yu Liu, Devin M Barry, Qianyi Yang, Jun-Bin Yin, Hua Jin, Hui Li, Qing-Tao Meng, Jia-Hang Peng, Zhen-Yu Wu, Jun Yin, Xuan-Yi Zhou, Li Wan, Ping Mo, Seungil Kim, Fu-Quan Huo, Joseph Jeffry, Yun-Qing Li, Rita Bardoni, Michael R Bruchas, Zhou-Feng Chen. Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice.
Cell reports.
2018 Apr; 23(3):866-877. doi:
10.1016/j.celrep.2018.03.087. [PMID: 29669290] - Li-Jie Liu, Jian-Jun Yu, Xiao-Lin Xu. Kappa-opioid receptor agonist U50448H protects against renal ischemia-reperfusion injury in rats via activating the PI3K/Akt signaling pathway.
Acta pharmacologica Sinica.
2018 Jan; 39(1):97-106. doi:
10.1038/aps.2017.51. [PMID: 28770825] - José Luis Vázquez López, Lorenz Schild, Thomas Günther, Stefan Schulz, Hartmud Neurath, Axel Becker. The effects of kratom on restraint-stress-induced analgesia and its mechanisms of action.
Journal of ethnopharmacology.
2017 Jun; 205(?):178-185. doi:
10.1016/j.jep.2017.05.008. [PMID: 28501425] - M Morgan, A Heffernan, F Benhabib, S Wagner, A K Hewavitharana, P N Shaw, P J Cabot. The efficacy of Dynorphin fragments at the κ, μ and δ opioid receptor in transfected HEK cells and in an animal model of unilateral peripheral inflammation.
Peptides.
2017 03; 89(?):9-16. doi:
10.1016/j.peptides.2016.12.019. [PMID: 28049031] - Luke R Odell, Mohammed K Abdel-Hamid, Timothy A Hill, Ngoc Chau, Kelly A Young, Fiona M Deane, Jennette A Sakoff, Sofia Andersson, James A Daniel, Phillip J Robinson, Adam McCluskey. Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain.
Journal of medicinal chemistry.
2017 01; 60(1):349-361. doi:
10.1021/acs.jmedchem.6b01422. [PMID: 27997171] - S Michael Owens, Gerald T Pollard, James L Howard, Timothy R Fennell, Rodney W Snyder, F Ivy Carroll. Pharmacodynamic Relationships between Duration of Action of JDTic-like Kappa-Opioid Receptor Antagonists and Their Brain and Plasma Pharmacokinetics in Rats.
ACS chemical neuroscience.
2016 12; 7(12):1737-1745. doi:
10.1021/acschemneuro.6b00249. [PMID: 27700049] - Juan Li, Xiaojie Liang, Yaguang Zhou, Shumiao Zhang, Fan Yang, Haitao Guo, Rong Fan, Na Feng, Min Jia, Yueming Wang, Mingchao Liu, Jianming Pei. Role of dynorphin in hypoxic pulmonary hypertension.
European journal of pharmacology.
2016 Nov; 791(?):78-84. doi:
10.1016/j.ejphar.2016.08.019. [PMID: 27568355] - Géza Berecki, Leonid Motin, David J Adams. Mechanism of direct Cav2.2 channel block by the κ-opioid receptor agonist U50488H.
Neuropharmacology.
2016 10; 109(?):49-58. doi:
10.1016/j.neuropharm.2016.05.019. [PMID: 27245500] - Girish R Chopda, Viraj Parge, Ganesh A Thakur, S John Gatley, Alexandros Makriyannis, Carol A Paronis. Tolerance to the Diuretic Effects of Cannabinoids and Cross-Tolerance to a κ-Opioid Agonist in THC-Treated Mice.
The Journal of pharmacology and experimental therapeutics.
2016 08; 358(2):334-41. doi:
10.1124/jpet.116.232132. [PMID: 27231154] - Andrew C Kruegel, Madalee M Gassaway, Abhijeet Kapoor, András Váradi, Susruta Majumdar, Marta Filizola, Jonathan A Javitch, Dalibor Sames. Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators.
Journal of the American Chemical Society.
2016 06; 138(21):6754-64. doi:
10.1021/jacs.6b00360. [PMID: 27192616] - Fei Tian, Xu-Yang Zheng, Juan Li, Shu-Miao Zhang, Na Feng, Hai-Tao Guo, Min Jia, Yue-Min Wang, Rong Fan, Jian-Ming Pei. κ-Opioid Receptor Stimulation Improves Endothelial Function via Akt-stimulated NO Production in Hyperlipidemic Rats.
Scientific reports.
2016 05; 6(?):26807. doi:
10.1038/srep26807. [PMID: 27226238] - Nicole A Crowley, Daniel W Bloodgood, J Andrew Hardaway, Alexis M Kendra, Jordan G McCall, Ream Al-Hasani, Nora M McCall, Waylin Yu, Zachary L Schools, Michael J Krashes, Bradford B Lowell, Jennifer L Whistler, Michael R Bruchas, Thomas L Kash. Dynorphin Controls the Gain of an Amygdalar Anxiety Circuit.
Cell reports.
2016 Mar; 14(12):2774-83. doi:
10.1016/j.celrep.2016.02.069. [PMID: 26997280] - Xuan Zhou, Dongjuan Wang, Yuyang Zhang, Jinxia Zhang, Dingcheng Xiang, Haichang Wang. Activation of κ-opioid receptor by U50,488H improves vascular dysfunction in streptozotocin-induced diabetic rats.
BMC endocrine disorders.
2015 Feb; 15(?):7. doi:
10.1186/s12902-015-0004-7. [PMID: 25887435] - Yulong Shang, Fan Guo, Juan Li, Rong Fan, Xinliang Ma, Yuemin Wang, Na Feng, Yue Yin, Min Jia, Shumiao Zhang, Jingjun Zhou, Hongbing Wang, Jianming Pei. Activation of κ-opioid receptor exerts the glucose-homeostatic effect in streptozotocin-induced diabetic mice.
Journal of cellular biochemistry.
2015 Feb; 116(2):252-9. doi:
10.1002/jcb.24962. [PMID: 25186835] - Qianmei Wang, Yang Sun, Juan Li, Wenjuan Xing, Shumiao Zhang, Xiaoming Gu, Na Feng, Lei Zhao, Rong Fan, Yuemin Wang, Wen Yin, Jianming Pei. Quaternary ammonium salt of U50488H, a new κ-opioid receptor agonist, protects rat heart against ischemia/reperfusion injury.
European journal of pharmacology.
2014 Aug; 737(?):177-84. doi:
10.1016/j.ejphar.2014.05.006. [PMID: 24855042] - Shayla E Russell, Anna B Rachlin, Karen L Smith, John Muschamp, Loren Berry, Zhiyang Zhao, Elena H Chartoff. Sex differences in sensitivity to the depressive-like effects of the kappa opioid receptor agonist U-50488 in rats.
Biological psychiatry.
2014 Aug; 76(3):213-22. doi:
10.1016/j.biopsych.2013.07.042. [PMID: 24090794] - JiaJi Lin, HaiYan Wang, Juan Li, QianMei Wang, ShuMiao Zhang, Na Feng, Rong Fan, JianMing Pei. κ-Opioid receptor stimulation modulates TLR4/NF-κB signaling in the rat heart subjected to ischemia-reperfusion.
Cytokine.
2013 Mar; 61(3):842-8. doi:
10.1016/j.cyto.2013.01.002. [PMID: 23402995] - Tânia C Chicre-Alcântara, Karla E Torres-Chávez, Luana Fischer, Juliana T Clemente-Napimoga, Vilma Melo, Carlos Amílcar Parada, Claudia Herrera Tambeli. Local kappa opioid receptor activation decreases temporomandibular joint inflammation.
Inflammation.
2012 Feb; 35(1):371-6. doi:
10.1007/s10753-011-9329-1. [PMID: 21484425] - Xiaodong Wu, Bo Zhang, Rong Fan, Lei Zhao, Yuemin Wang, Shumiao Zhang, Alan David Kaye, Luyu Huang, Jianming Pei. U50,488H inhibits neutrophil accumulation and TNF-α induction induced by ischemia-reperfusion in rat heart.
Cytokine.
2011 Nov; 56(2):503-7. doi:
10.1016/j.cyto.2011.07.015. [PMID: 21843951] - B A S Reyes, Charles Chavkin, E J Van Bockstaele. Agonist-induced internalization of κ-opioid receptors in noradrenergic neurons of the rat locus coeruleus.
Journal of chemical neuroanatomy.
2010 Dec; 40(4):301-9. doi:
10.1016/j.jchemneu.2010.09.003. [PMID: 20884346] - Amardeep Jaiswal, Santosh Kumar, Sandeep Seth, Amit Kumar Dinda, Subir Kumar Maulik. Effect of U50,488H, a κ-opioid receptor agonist on myocardial α-and β-myosin heavy chain expression and oxidative stress associated with isoproterenol-induced cardiac hypertrophy in rat.
Molecular and cellular biochemistry.
2010 Dec; 345(1-2):231-40. doi:
10.1007/s11010-010-0577-4. [PMID: 20730476] - Aashish S Morani, Bronwyn Kivell, Thomas E Prisinzano, Susan Schenk. Effect of kappa-opioid receptor agonists U69593, U50488H, spiradoline and salvinorin A on cocaine-induced drug-seeking in rats.
Pharmacology, biochemistry, and behavior.
2009 Dec; 94(2):244-9. doi:
10.1016/j.pbb.2009.09.002. [PMID: 19747933] - Yulin Wang, Wei Xu, Peng Huang, Charles Chavkin, Elisabeth J Van Bockstaele, Lee-Yuan Liu-Chen. Effects of acute agonist treatment on subcellular distribution of kappa opioid receptor in rat spinal cord.
Journal of neuroscience research.
2009 May; 87(7):1695-702. doi:
10.1002/jnr.21971. [PMID: 19130621] - Fan Rong, Zhang Peng, Ming-Xiang Ye, Quan-Yu Zhang, Yin Zhao, Shu-Miao Zhang, Hai-Tao Guo, Bi Hui, Yue-Min Wang, Cheng Liang, Chun-Hu Gu, Chen Tao, Qin Cui, Shi-Qiang Yu, Ding-Hua Yi, Jian-Ming Pei. Myocardial apoptosis and infarction after ischemia/reperfusion are attenuated by kappa-opioid receptor agonist.
Archives of medical research.
2009 May; 40(4):227-34. doi:
10.1016/j.arcmed.2009.04.009. [PMID: 19608010] - Lisa E Baker, John J Panos, Bryan A Killinger, Mary M Peet, Lisa M Bell, Larissa A Haliw, Sheryl L Walker. Comparison of the discriminative stimulus effects of salvinorin A and its derivatives to U69,593 and U50,488 in rats.
Psychopharmacology.
2009 Apr; 203(2):203-11. doi:
10.1007/s00213-008-1458-3. [PMID: 19153716] - Craig Bolte, Gilbert Newman, Jo El J Schultz. Hypertensive state, independent of hypertrophy, exhibits an attenuated decrease in systolic function on cardiac kappa-opioid receptor stimulation.
American journal of physiology. Heart and circulatory physiology.
2009 Apr; 296(4):H967-75. doi:
10.1152/ajpheart.00909.2008. [PMID: 19181965] - Walter Wittmann, Eduard Schunk, Iris Rosskothen, Stefano Gaburro, Nicolas Singewald, Herbert Herzog, Christoph Schwarzer. Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2009 Feb; 34(3):775-85. doi:
10.1038/npp.2008.142. [PMID: 18800067] - Magdalena Chadzinska, Trudi Hermsen, Huub F J Savelkoul, B M Lidy Verburg-van Kemenade. Cloning of opioid receptors in common carp (Cyprinus carpio L.) and their involvement in regulation of stress and immune response.
Brain, behavior, and immunity.
2009 Feb; 23(2):257-66. doi:
10.1016/j.bbi.2008.10.003. [PMID: 18977430] - Marc L Weber, Mariya Farooqui, Julia Nguyen, Michael Ansonoff, John E Pintar, Robert P Hebbel, Kalpna Gupta. Morphine induces mesangial cell proliferation and glomerulopathy via kappa-opioid receptors.
American journal of physiology. Renal physiology.
2008 Jun; 294(6):F1388-97. doi:
10.1152/ajprenal.00389.2007. [PMID: 18385270] - John E Pascoe, Keith L Williams, Partha Mukhopadhyay, Kenner C Rice, James H Woods, Mei-Chuan Ko. Effects of mu, kappa, and delta opioid receptor agonists on the function of hypothalamic-pituitary-adrenal axis in monkeys.
Psychoneuroendocrinology.
2008 May; 33(4):478-86. doi:
10.1016/j.psyneuen.2008.01.006. [PMID: 18325678] - R Capasso, F Borrelli, J Zjawiony, L Kutrzeba, G Aviello, G Sarnelli, F Capasso, A A Izzo. The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation-induced hypermotility in mice.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.
2008 Feb; 20(2):142-8. doi:
10.1111/j.1365-2982.2007.00994.x. [PMID: 17931335] - Hai-Tao Guo, Rong-Huai Zhang, Lu-Yu Huang, Juan Li, Ya-Li Liu, Hui Bi, Quan Yu Zhang, Yue-Min Wang, Xin Sun, Xin-Liang Ma, Liang Cheng, Jing-Cheng Liu, Shi-Qiang Yu, Ding-Hua Yi, Jian-Ming Pei. Mechanisms involved in the hypotensive effect of a kappa-opioid receptor agonist in hypertensive rats.
Archives of medical research.
2007 Oct; 38(7):723-9. doi:
10.1016/j.arcmed.2007.04.009. [PMID: 17845890] - Liang Cheng, Sai Ma, Long-Xiao Wei, Hai-Tao Guo, Lu-Yu Huang, Hui Bi, Rong Fan, Juan Li, Ya-Li Liu, Yue-Min Wang, Xin Sun, Quan-Yu Zhang, Shi-Qiang Yu, Ding-Hua Yi, Xin-Liang Ma, Jian-Ming Pei. Cardioprotective and antiarrhythmic effect of U50,488H in ischemia/reperfusion rat heart.
Heart and vessels.
2007 Sep; 22(5):335-44. doi:
10.1007/s00380-007-0983-z. [PMID: 17879026] - Wei Qi, K Kumar Ebenezar, Mohamed A Samhan, Francine G Smith. Renal responses to the kappa-opioid-receptor agonist U-50488H in conscious lambs.
American journal of physiology. Regulatory, integrative and comparative physiology.
2007 Jul; 293(1):R162-8. doi:
10.1152/ajpregu.00863.2006. [PMID: 17409260] - David Y W Lee, Minsheng He, Lee-Yuan Liu-Chen, Yulin Wang, Jian-Guo Li, Wei Xu, Zhongze Ma, William A Carlezon, Bruce Cohen. Synthesis and in vitro pharmacological studies of new C(4)-modified salvinorin A analogues.
Bioorganic & medicinal chemistry letters.
2006 Nov; 16(21):5498-502. doi:
10.1016/j.bmcl.2006.08.051. [PMID: 16945525] - Wei Qi, Francine G Smith. Modulation of systemic and renal haemodynamics by kappa-opioids in conscious lambs.
Experimental physiology.
2006 Sep; 91(5):877-85. doi:
10.1113/expphysiol.2006.033456. [PMID: 16728455] - Wei Xu, Su-In Yoon, Peng Huang, Yulin Wang, Chongguang Chen, Parkson Lee-Gau Chong, Lee-Yuan Liu-Chen. Localization of the kappa opioid receptor in lipid rafts.
The Journal of pharmacology and experimental therapeutics.
2006 Jun; 317(3):1295-306. doi:
10.1124/jpet.105.099507. [PMID: 16505160] - Jay P McLaughlin, Benjamin B Land, Shuang Li, John E Pintar, Charles Chavkin. Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2006 Apr; 31(4):787-94. doi:
10.1038/sj.npp.1300860. [PMID: 16123754] - Chongguang Chen, Jian-Guo Li, Yong Chen, Peng Huang, Yulin Wang, Lee-Yuan Liu-Chen. GEC1 interacts with the kappa opioid receptor and enhances expression of the receptor.
The Journal of biological chemistry.
2006 Mar; 281(12):7983-93. doi:
10.1074/jbc.m509805200. [PMID: 16431922] - Eva Maria Marco, Ricardo Llorente, Laura Pérez-Alvarez, Enrique Moreno, Carmen Guaza, Maria Paz Viveros. The kappa-opioid receptor is involved in the stimulating effect of nicotine on adrenocortical activity but not in nicotine induced anxiety.
Behavioural brain research.
2005 Sep; 163(2):212-8. doi:
10.1016/j.bbr.2005.05.005. [PMID: 15979169] - Eddy H T Wu, Yung H Wong. Activation of delta-, kappa-, and mu-opioid receptors induces phosphorylation of tuberin in transfected HEK 293 cells and native cells.
Biochemical and biophysical research communications.
2005 Sep; 334(3):838-44. doi:
10.1016/j.bbrc.2005.06.184. [PMID: 16053916] - Asunción Romero, Eulalia Planas, Raquel Poveda, Silvia Sánchez, Olga Pol, Margarita M Puig. Anti-exudative effects of opioid receptor agonists in a rat model of carrageenan-induced acute inflammation of the paw.
European journal of pharmacology.
2005 Mar; 511(2-3):207-17. doi:
10.1016/j.ejphar.2005.02.004. [PMID: 15792790] - Shiou-Lan Chen, Eagle Yi-Kung Huang, Lok-Hi Chow, Pao-Luh Tao. Dextromethorphan differentially affects opioid antinociception in rats.
British journal of pharmacology.
2005 Feb; 144(3):400-4. doi:
10.1038/sj.bjp.0706086. [PMID: 15655510] - Helmut B Gottlieb, Kurt J Varner, Velga A Kenigs, Antonio M Cabral, Daniel R Kapusta. Differential cardiovascular and renal responses produced by microinjection of the {kappa}-opioid U-50488H [(trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]-benzene-acetamide) methane sulfonate] into subregions of the paraventricular nucleus.
The Journal of pharmacology and experimental therapeutics.
2005 Feb; 312(2):678-85. doi:
10.1124/jpet.104.076828. [PMID: 15381735] - L Chen, D M Togasaki, J W Langston, D A Di Monte, M Quik. Enhanced striatal opioid receptor-mediated G-protein activation in L-DOPA-treated dyskinetic monkeys.
Neuroscience.
2005; 132(2):409-20. doi:
10.1016/j.neuroscience.2004.10.026. [PMID: 15802193] - Juliana T Clemente, Carlos A Parada, Maria C Arruda Veiga, Robert W Gear, Cláudia H Tambeli. Sexual dimorphism in the antinociception mediated by kappa opioid receptors in the rat temporomandibular joint.
Neuroscience letters.
2004 Dec; 372(3):250-5. doi:
10.1016/j.neulet.2004.09.048. [PMID: 15542250] - Guijun Wang, Hongxin Wang, Yanling Yang, Tak Ming Wong. Kappa-opioid receptor stimulation inhibits growth of neonatal rat ventricular myocytes.
European journal of pharmacology.
2004 Sep; 498(1-3):53-8. doi:
10.1016/j.ejphar.2004.07.082. [PMID: 15363975] - Magdalena Chadzinska, Barbara Plytycz. Differential migratory properties of mouse, fish, and frog leukocytes treated with agonists of opioid receptors.
Developmental and comparative immunology.
2004 Jul; 28(9):949-58. doi:
10.1016/j.dci.2004.02.003. [PMID: 15183035] - Peng Huang, Deborah Steplock, Edward J Weinman, Randy A Hall, Zhe Ding, Jianguo Li, Yulin Wang, Lee-Yuan Liu-Chen. kappa Opioid receptor interacts with Na(+)/H(+)-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na(+)/H(+) exchange independent of G(i)/G(o) proteins.
The Journal of biological chemistry.
2004 Jun; 279(24):25002-9. doi:
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