2,6-Dimethyl-4-(2-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester (BioDeep_00001882627)
代谢物信息卡片
2,6-Dimethyl-4-(2-nitrophenyl)-3,4-dihydropyridine-3,5-dicarboxylic acid dimethyl ester
化学式: C17H18N2O6 (346.1164808)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=NC(=C(C(C1C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC)C
InChI: InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,13,15H,1-4H3
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Daxesh P Patel, Primal Sharma, Mallika Sanyal, Puran Singhal, Pranav S Shrivastav. Highly sensitive and rapid ultra-performance liquid chromatography-tandem mass spectrometry method for the determination of nifedipine in human plasma and its application to a bioequivalence study.
Biomedical chromatography : BMC.
2012 Dec; 26(12):1509-18. doi:
10.1002/bmc.2725. [PMID: 22383257] - Chibing Dai, Na Liu, Wenmei Chen, Wei Qian, Xiaohua Hou. Simo decoction promotes contraction of antral circular smooth muscle mainly via muscarinic M3 receptor.
Journal of ethnopharmacology.
2012 Nov; 144(2):270-6. doi:
10.1016/j.jep.2012.09.008. [PMID: 23022322] - Satyakumar Vidyashankar, L M Sharath Kumar, Vandana Barooah, R Sandeep Varma, Krishna S Nandakumar, Pralhad Sadashiv Patki. Liv.52 up-regulates cellular antioxidants and increase glucose uptake to circumvent oleic acid induced hepatic steatosis in HepG2 cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2012 Oct; 19(13):1156-65. doi:
10.1016/j.phymed.2012.08.005. [PMID: 22940028] - Tasuku Nagasawa, Takefumi Mori, Yusuke Ohsaki, Yoshimi Yoneki, Qi Guo, Emiko Sato, Ikuko Oba, Sadayoshi Ito. Albuminuria indicates the pressure-associated injury of juxtamedullary nephrons and cerebral strain vessels in spontaneously hypertensive stroke-prone rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2012 Oct; 35(10):1024-31. doi:
10.1038/hr.2012.112. [PMID: 22914555] - Matthew A Kreitzer, Jason Jacoby, Ethan Naylor, Adam Baker, Trent Grable, Emma Tran, Sophie Erwin Booth, Haohua Qian, Robert Paul Malchow. Distinctive patterns of alterations in proton efflux from goldfish retinal horizontal cells monitored with self-referencing H⁺-selective electrodes.
The European journal of neuroscience.
2012 Oct; 36(8):3040-50. doi:
10.1111/j.1460-9568.2012.08226.x. [PMID: 22809323] - Mosun A Ayan-Oshodi, Brian A Willis, William F Annes, Stephen L Lowe, Stuart Friedrich, Amparo de la Peña, Wei Zhang, Thomas Brown, Stephen D Wise, Stephen D Hall. The effects on metabolic clearance when administering a potent CYP3A autoinducer with the prototypic CYP3A inhibitor, ketoconazole.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Oct; 40(10):1945-52. doi:
10.1124/dmd.112.046060. [PMID: 22789530] - G J Bakker, Y C L Haan, L J Maillette de Buy Wenniger, U Beuers. Sarcoidosis of the liver: to treat or not to treat?.
The Netherlands journal of medicine.
2012 Oct; 70(8):349-56. doi:
NULL. [PMID: 23065982] - He-Hsiung Cheng, Yi-Chau Lu, Ti Lu, Jin-Shiung Cheng, Guang-Yuan Mar, Yi-Chien Fang, Kuo-Liang Chai, Chung-Ren Jan. Effect of methoxychlor on Ca(2+) movement and viability in MDCK renal tubular cells.
Basic & clinical pharmacology & toxicology.
2012 Oct; 111(4):224-31. doi:
10.1111/j.1742-7843.2012.00887.x. [PMID: 22458924] - A Ziegelhöffer, J Mujkošová, M Ferko, N Vrbjar, T Ravingerová, O Uličná, I Waczulíková, B Ziegelhöffer. Dual influence of spontaneous hypertension on membrane properties and ATP production in heart and kidney mitochondria in rat: effect of captopril and nifedipine, adaptation and dysadaptation.
Canadian journal of physiology and pharmacology.
2012 Sep; 90(9):1311-23. doi:
10.1139/y2012-107. [PMID: 22913569] - Louise Marks, Samantha Borland, Karen Philp, Lorna Ewart, Pierre Lainée, Matthew Skinner, Sarah Kirk, Jean-Pierre Valentin. The role of the anaesthetised guinea-pig in the preclinical cardiac safety evaluation of drug candidate compounds.
Toxicology and applied pharmacology.
2012 Sep; 263(2):171-83. doi:
10.1016/j.taap.2012.06.007. [PMID: 22714037] - Ching-Chung Tsai, Shih-Che Huang, Jong-Kang Liu, Hsiu-Chuan Wang, Tong-Rong Tsai, Ping-Ju Tsai, Ching-Wen Liu, Li-Ching Chang. Salvia miltiorrhiza causes tonic contraction in rat ileum through Ca²⁺-calmodulin pathway.
Journal of ethnopharmacology.
2012 Aug; 142(3):694-9. doi:
10.1016/j.jep.2012.05.041. [PMID: 22683910] - Siyavash Joukar, Mohammad Sheibani, Farzin Joukar. Cardiovascular effect of nifedipine in morphine dependent rats: hemodynamic, histopathological, and biochemical evidence.
Croatian medical journal.
2012 Aug; 53(4):343-9. doi:
10.3325/cmj.2012.53.343. [PMID: 22911527] - Shabana Channa, Ahsana Dar. Calcium antagonistic activity of Bacopa monniera in guinea-pig trachea.
Indian journal of pharmacology.
2012 Jul; 44(4):516-8. doi:
10.4103/0253-7613.99336. [PMID: 23087517] - Yoshihiro Uesawa, Takahiro Takeuchi, Kiminori Mohri. Integrated analysis on the physicochemical properties of dihydropyridine calcium channel blockers in grapefruit juice interactions.
Current pharmaceutical biotechnology.
2012 Jul; 13(9):1705-17. doi:
10.2174/138920112800958878. [PMID: 22039822] - Corey B Toal, Peter A Meredith, Henry L Elliott. Long-acting dihydropyridine calcium-channel blockers and sympathetic nervous system activity in hypertension: a literature review comparing amlodipine and nifedipine GITS.
Blood pressure.
2012 Jul; 21 Suppl 1(?):3-10. doi:
10.3109/08037051.2012.690615. [PMID: 22762301] - Chaitali Banerjee, Ramansu Goswami, Gaurav Verma, Malabika Datta, Shibnath Mazumder. Aeromonas hydrophila induced head kidney macrophage apoptosis in Clarias batrachus involves the activation of calpain and is caspase-3 mediated.
Developmental and comparative immunology.
2012 Jul; 37(3-4):323-33. doi:
10.1016/j.dci.2012.02.005. [PMID: 22366184] - Margot Schulz, Adriano Marocco, Vincenzo Tabaglio. BOA detoxification of four summer weeds during germination and seedling growth.
Journal of chemical ecology.
2012 Jul; 38(7):933-46. doi:
10.1007/s10886-012-0136-4. [PMID: 22614450] - Shizuka Aritomi, Tomoyuki Konda, Michihiro Yoshimura. L/N-type calcium channel blocker suppresses reflex aldosterone production induced by antihypertensive action.
Heart and vessels.
2012 Jul; 27(4):419-23. doi:
10.1007/s00380-011-0191-8. [PMID: 21989861] - Sirinart Kumfu, Siriporn Chattipakorn, Kroekkiat Chinda, Suthat Fucharoen, Nipon Chattipakorn. T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice.
European journal of haematology.
2012 Jun; 88(6):535-48. doi:
10.1111/j.1600-0609.2012.01779.x. [PMID: 22404220] - Feng Qiu, Xiao-Long Hou, Kyoko Takahashi, Li-Xia Chen, Junichi Azuma, Ning Kang. Andrographolide inhibits the expression and metabolic activity of cytochrome P450 3A4 in the modified Caco-2 cells.
Journal of ethnopharmacology.
2012 Jun; 141(2):709-13. doi:
10.1016/j.jep.2011.09.002. [PMID: 21925256] - Christian Sonne, Jan O Bustnes, Dorte Herzke, Veerle L B Jaspers, Adrian Covaci, Igor Eulaers, Duncan J Halley, Truls Moum, Manuel Ballesteros, Marcel Eens, Rolf A Ims, Sveinn A Hanssen, Kjell E Erikstad, Trond V Johnsen, Frank F Rigét, Asger L Jensen, Mads Kjelgaard-Hansen. Blood plasma clinical-chemical parameters as biomarker endpoints for organohalogen contaminant exposure in Norwegian raptor nestlings.
Ecotoxicology and environmental safety.
2012 Jun; 80(?):76-83. doi:
10.1016/j.ecoenv.2012.02.012. [PMID: 22445502] - Chinnadurai Veeramani, Khalid S Al-Numair, Govindasamy Chandramohan, Mohammed A Alsaif, Kodukkur Viswanathan Pugalendi. Antihyperlipidemic effect of Melothria maderaspatana leaf extracts on DOCA-salt induced hypertensive rats.
Asian Pacific journal of tropical medicine.
2012 Jun; 5(6):434-9. doi:
10.1016/s1995-7645(12)60074-1. [PMID: 22575974] - Hana Cernecka, Lucia Veizerova, Lucia Mensikova, Jan Svetlik, Peter Krenek. Selective inhibitory action of Biginelli-type dihydropyrimidines on depolarization-induced arterial smooth muscle contraction.
The Journal of pharmacy and pharmacology.
2012 May; 64(5):735-41. doi:
10.1111/j.2042-7158.2012.01466.x. [PMID: 22471370] - Monica D Poteat, Mauricio Díaz-Jaramillo, David B Buchwalter. Divalent metal (Ca, Cd, Mn, Zn) uptake and interactions in the aquatic insect Hydropsyche sparna.
The Journal of experimental biology.
2012 May; 215(Pt 9):1575-83. doi:
10.1242/jeb.063412. [PMID: 22496295] - G Zadoyan, D Rokitta, S Klement, A Dienel, R Hoerr, T Gramatté, U Fuhr. Effect of Ginkgo biloba special extract EGb 761® on human cytochrome P450 activity: a cocktail interaction study in healthy volunteers.
European journal of clinical pharmacology.
2012 May; 68(5):553-60. doi:
10.1007/s00228-011-1174-5. [PMID: 22189672] - Robert Radford, Craig Slattery, Paul Jennings, Oliver Blacque, Oliver Blaque, Walter Pfaller, Hans Gmuender, Joost Van Delft, Michael P Ryan, Tara McMorrow. Carcinogens induce loss of the primary cilium in human renal proximal tubular epithelial cells independently of effects on the cell cycle.
American journal of physiology. Renal physiology.
2012 Apr; 302(8):F905-16. doi:
10.1152/ajprenal.00427.2011. [PMID: 22262483] - Guo-lin Zhang, Feng Yu, De-zai Dai, Yu-si Cheng, Can Zhang, Yin Dai. CPU86017-RS attenuate hypoxia-induced testicular dysfunction in mice by normalizing androgen biosynthesis genes and pro-inflammatory cytokines.
Acta pharmacologica Sinica.
2012 Apr; 33(4):470-8. doi:
10.1038/aps.2011.175. [PMID: 22426698] - Kenji Oki, Maria W Plonczynski, Milay Luis Lam, Elise P Gomez-Sanchez, Celso E Gomez-Sanchez. Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis.
Endocrinology.
2012 Apr; 153(4):1774-82. doi:
10.1210/en.2011-1733. [PMID: 22315453] - Abraham J Wilhelm, Peer de Graaf, Agnes I Veldkamp, Jeroen J W M Janssen, Peter C Huijgens, Eleonora L Swart. Population pharmacokinetics of ciclosporin in haematopoietic allogeneic stem cell transplantation with emphasis on limited sampling strategy.
British journal of clinical pharmacology.
2012 Apr; 73(4):553-63. doi:
10.1111/j.1365-2125.2011.04116.x. [PMID: 21988410] - Robert Zorec, Alfonso Araque, Giorgio Carmignoto, Philip G Haydon, Alexei Verkhratsky, Vladimir Parpura. Astroglial excitability and gliotransmission: an appraisal of Ca2+ as a signalling route.
ASN neuro.
2012 Mar; 4(2):. doi:
10.1042/an20110061. [PMID: 22313347] - Nina Gårevik, Cristine Skogastierna, Anders Rane, Lena Ekström. Single dose testosterone increases total cholesterol levels and induces the expression of HMG CoA reductase.
Substance abuse treatment, prevention, and policy.
2012 Mar; 7(?):12. doi:
10.1186/1747-597x-7-12. [PMID: 22433938] - Haiyan Liu, Yanhui Duan, Yanhua Jia, Yanzhao Gu, Jia Li, Cuihong Yan, Gengliang Yang. On-line simultaneous deproteinization of biological samples and trace enrichment of three dipine series using a poly(N-isopropylacrylamide-co-ethyleneglycol dimethacrylate) monolith.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Mar; 889-890(?):55-60. doi:
10.1016/j.jchromb.2012.01.030. [PMID: 22349122] - Przemysław Sosnowski, Hanna Krauss, Pawel Bogdanski, Joanna Suliburska, Anna Jablecka, Artur Cieslewicz, Danuta Pupek-Musialik, Rafał Jastak. The influence of short-term L-arginine supplementation on rats' muscular and hepatic cells in ischemia-reperfusion syndrome.
Journal of physiology and biochemistry.
2012 Mar; 68(1):1-9. doi:
10.1007/s13105-011-0111-5. [PMID: 21948185] - Wouter Bult, Hendrik de Leeuw, Olav M Steinebach, Martijn J van der Bom, Hubert Th Wolterbeek, Ron M A Heeren, Chris J G Bakker, Alfred D van Het Schip, Wim E Hennink, J Frank W Nijsen. Radioactive holmium acetylacetonate microspheres for interstitial microbrachytherapy: an in vitro and in vivo stability study.
Pharmaceutical research.
2012 Mar; 29(3):827-36. doi:
10.1007/s11095-011-0610-7. [PMID: 22068276] - Vijaya Chockalingam, Sdv Suryakiran Kadali, Pratheesh Gnanasambantham. Antiproliferative and antioxidant activity of Aegle marmelos (Linn.) leaves in Dalton's Lymphoma Ascites transplanted mice.
Indian journal of pharmacology.
2012 Mar; 44(2):225-9. doi:
10.4103/0253-7613.93854. [PMID: 22529480] - S S Butakova, A D Nozdrachev. Calcium channel blockers inhibit the hyperglycemic effect of calcitonin.
Bulletin of experimental biology and medicine.
2012 Mar; 152(5):553-9. doi:
10.1007/s10517-012-1573-3. [PMID: 22803131] - Shriganesh R Barnela, Sachin S Soni, Sonali S Saboo, Ashish S Bhansali. Medical management of renal stone.
Indian journal of endocrinology and metabolism.
2012 Mar; 16(2):236-9. doi:
10.4103/2230-8210.93741. [PMID: 22470860] - P Vejakama, A Thakkinstian, D Lertrattananon, A Ingsathit, C Ngarmukos, J Attia. Reno-protective effects of renin-angiotensin system blockade in type 2 diabetic patients: a systematic review and network meta-analysis.
Diabetologia.
2012 Mar; 55(3):566-78. doi:
10.1007/s00125-011-2398-8. [PMID: 22189484] - R Krysiak, M Samborek, R Stojko. Primary aldosteronism in pregnancy.
Acta clinica Belgica.
2012 Mar; 67(2):130-4. doi:
10.2143/acb.67.2.2062644. [PMID: 22712170] - Mehmet Hursitoglu, Tufan Tukek, Mehmet Ali Cikrikcioglu, Osman Kara, Rumeyza Kazancioglu, Oktay Ozkan, Mustafa Cakirca, Fatih Akdogan, Erdal Gundogan, Sengul Aydin, Ismet Beycan, Meltem Gursu, Serkan Dogan, Aybala Erek. Urotensin II levels in patients with chronic kidney disease and kidney transplants.
Upsala journal of medical sciences.
2012 Mar; 117(1):22-7. doi:
10.3109/03009734.2011.626541. [PMID: 22098077] - Patrik Rorsman, Matthias Braun, Quan Zhang. Regulation of calcium in pancreatic α- and β-cells in health and disease.
Cell calcium.
2012 Mar; 51(3-4):300-8. doi:
10.1016/j.ceca.2011.11.006. [PMID: 22177710] - Stefan Jacobson. Early postoperative complications in patients with Crohn's disease given and not given preoperative total parenteral nutrition.
Scandinavian journal of gastroenterology.
2012 Feb; 47(2):170-7. doi:
10.3109/00365521.2011.648954. [PMID: 22242614] - Amit Kumar, Bechan Sharma, Ravi S Pandey. Alterations in nitrogen metabolism in freshwater fishes, Channa punctatus and Clarias batrachus, exposed to a commercial-grade λ-cyhalothrin, REEVA-5.
International journal of experimental pathology.
2012 Feb; 93(1):34-45. doi:
10.1111/j.1365-2613.2011.00796.x. [PMID: 22264284] - Yewei Xing, William E Rainey, John W Apolzan, Omar L Francone, Ruth B S Harris, Wendy B Bollag. Adrenal cell aldosterone production is stimulated by very-low-density lipoprotein (VLDL).
Endocrinology.
2012 Feb; 153(2):721-31. doi:
10.1210/en.2011-1752. [PMID: 22186415] - Chao Sun, Li Wang, Jun Yan, Shumin Liu. Calcium ameliorates obesity induced by high-fat diet and its potential correlation with p38 MAPK pathway.
Molecular biology reports.
2012 Feb; 39(2):1755-63. doi:
10.1007/s11033-011-0916-x. [PMID: 21633889] - Hossein Zhaleh, Mehri Azadbakht, Ali Bidmeshki Pour. Possible involvement of calcium channels and plasma membrane receptors on Staurosporine-induced neurite outgrowth.
Bosnian journal of basic medical sciences.
2012 Feb; 12(1):20-5. doi:
10.17305/bjbms.2012.2526. [PMID: 22364299] - Subramanian Vaidyanathan, Bakul Soni, Tun Oo, Peter Hughes, Gurpreet Singh, Kamesh Pulya. Autonomic dysreflexia in a tetraplegic patient due to a blocked urethral catheter: spinal cord injury patients with lesions above T-6 require prompt treatment of an obstructed urinary catheter to prevent life-threatening complications of autonomic dysreflexia.
International journal of emergency medicine.
2012 Feb; 5(?):6. doi:
10.1186/1865-1380-5-6. [PMID: 22296914] - Ya-ting Tina Yang, Matthew Whiteman, Steven P Gieseg. HOCl causes necrotic cell death in human monocyte derived macrophages through calcium dependent calpain activation.
Biochimica et biophysica acta.
2012 Feb; 1823(2):420-9. doi:
10.1016/j.bbamcr.2011.09.019. [PMID: 22008466] - Gui-Lai Liu, Feng Yu, De-Zai Dai, Guo-Lin Zhang, Can Zhang, Yin Dai. Endoplasmic reticulum stress mediating downregulated StAR and 3-beta-HSD and low plasma testosterone caused by hypoxia is attenuated by CPU86017-RS and nifedipine.
Journal of biomedical science.
2012 Jan; 19(?):4. doi:
10.1186/1423-0127-19-4. [PMID: 22226148] - Marion Depla, Louis d'Alteroche, Amélie Le Gouge, Alain Moreau, Christophe Hourioux, Jean-Christophe Meunier, Julien Gaillard, Anne de Muret, Yannick Bacq, Farhad Kazemi, Aurélie Avargues, Emmanuelle Roch, Eric Piver, Catherine Gaudy-Graffin, Bruno Giraudeau, Philippe Roingeard. Viral sequence variation in chronic carriers of hepatitis C virus has a low impact on liver steatosis.
PloS one.
2012; 7(3):e33749. doi:
10.1371/journal.pone.0033749. [PMID: 22479436] - Jun-ichi Kusaba, Noriko Kajikawa, Hiromu Kawasaki, Yuji Kurosaki, Tetsuya Aiba. Comparative study on altered hepatic metabolism of CYP3A substrates in rats with glycerol-induced acute renal failure.
Biopharmaceutics & drug disposition.
2012 Jan; 33(1):22-9. doi:
10.1002/bdd.1774. [PMID: 22351566] - Jin Young Sung, Hyoung Chul Choi. Nifedipine inhibits vascular smooth muscle cell proliferation and reactive oxygen species production through AMP-activated protein kinase signaling pathway.
Vascular pharmacology.
2012 Jan; 56(1-2):1-8. doi:
10.1016/j.vph.2011.06.001. [PMID: 21708289] - Michael A Kalwat, Dean A Wiseman, Wei Luo, Zhanxiang Wang, Debbie C Thurmond. Gelsolin associates with the N terminus of syntaxin 4 to regulate insulin granule exocytosis.
Molecular endocrinology (Baltimore, Md.).
2012 Jan; 26(1):128-41. doi:
10.1210/me.2011-1112. [PMID: 22108804] - Katsuyoshi Sunaga, Kenichi Ohkawa, Kenichi Nakamura, Atsuko Ohkubo, Sonoko Harada, Tadashi Tsuda. Mechanism-based inhibition of recombinant human cytochrome P450 3A4 by tomato juice extract.
Biological & pharmaceutical bulletin.
2012; 35(3):329-34. doi:
10.1248/bpb.35.329. [PMID: 22382318] - Catherine Leclerc, Isabelle Néant, Marc Moreau. The calcium: an early signal that initiates the formation of the nervous system during embryogenesis.
Frontiers in molecular neuroscience.
2012; 5(?):3. doi:
10.3389/fnmol.2012.00064. [PMID: 22593733] - Blas Gil-Extremera, Pedro Cía-Gómez. Hypertension in the elderly.
International journal of hypertension.
2012; 2012(?):859176. doi:
10.1155/2012/859176. [PMID: 21876789] - Pius S Fasinu, Patrick J Bouic, Bernd Rosenkranz. An overview of the evidence and mechanisms of herb-drug interactions.
Frontiers in pharmacology.
2012; 3(?):69. doi:
10.3389/fphar.2012.00069. [PMID: 22557968] - Qiquan Sun, Song Jiang, Xue Li, Xianghua Huang, Kenan Xie, Dongrui Cheng, Jinsong Chen, Shuming Ji, Jiqiu Wen, Mingchao Zhang, Caihong Zeng, Zhihong Liu. The prevalence of immunologic injury in renal allograft recipients with de novo proteinuria.
PloS one.
2012; 7(5):e36654. doi:
10.1371/journal.pone.0036654. [PMID: 22586485] - Kristiaan Wouters, Céline Cudejko, Marion J J Gijbels, Lucia Fuentes, Kadiombo Bantubungi, Jonathan Vanhoutte, Rebecca Dièvart, Charlotte Paquet, Emmanuel Bouchaert, Sarah Anissa Hannou, Florence Gizard, Anne Tailleux, Menno P J de Winther, Bart Staels, Réjane Paumelle. Bone marrow p16INK4a-deficiency does not modulate obesity, glucose homeostasis or atherosclerosis development.
PloS one.
2012; 7(3):e32440. doi:
10.1371/journal.pone.0032440. [PMID: 22403661] - Sergei V Jargin. Testing of serum atherogenicity in cell cultures: questionable data published.
German medical science : GMS e-journal.
2012; 10(?):Doc02. doi:
10.3205/000153. [PMID: 22355278] - Kovanya Moodley, Viness Pillay, Yahya E Choonara, Lisa C du Toit, Valence M K Ndesendo, Pradeep Kumar, Shivaan Cooppan, Priya Bawa. Oral drug delivery systems comprising altered geometric configurations for controlled drug delivery.
International journal of molecular sciences.
2012; 13(1):18-43. doi:
10.3390/ijms13010018. [PMID: 22312236] - Zhi-Qiang Chen, Ying Liu, Ji-Hui Zhao, Lan Wang, Nian-Ping Feng. Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system.
International journal of nanomedicine.
2012; 7(?):1115-25. doi:
10.2147/ijn.s28761. [PMID: 22403491] - Thorsten Brenner, Thomas H Fleming, Claudia Rosenhagen, Ute Krauser, Markus Mieth, Thomas Bruckner, Eike Martin, Peter P Nawroth, Markus A Weigand, Angelika Bierhaus, Stefan Hofer. L-arginine and asymmetric dimethylarginine are early predictors for survival in septic patients with acute liver failure.
Mediators of inflammation.
2012; 2012(?):210454. doi:
10.1155/2012/210454. [PMID: 22619480] - A K Cybulska-Heinrich, M Mozaffarieh, J Flammer. Ginkgo biloba: an adjuvant therapy for progressive normal and high tension glaucoma.
Molecular vision.
2012; 18(?):390-402. doi:
". [PMID: 22355250] - Satoshi Numazawa, Makiko Takase, Tomomi Ahiko, Masakazu Ishii, Shun-ichi Shimizu, Takemi Yoshida. Possible involvement of transient receptor potential channels in electrophile-induced insulin secretion from RINm5F cells.
Biological & pharmaceutical bulletin.
2012; 35(3):346-54. doi:
10.1248/bpb.35.346. [PMID: 22382320] - Fang Yan, Ying Hu, Bin Di, Ping Lei He, Guibin Sun. Effects of some antihypertensive drugs on the metabolism and pharmacokinetics of indapamide in rats.
Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.
2012; 15(2):208-20. doi:
10.18433/j3sk5v. [PMID: 22579001] - Qinghua Shang, Zhaolan Liu, Keji Chen, Hao Xu, Jianping Liu. A systematic review of xuezhikang, an extract from red yeast rice, for coronary heart disease complicated by dyslipidemia.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):636547. doi:
10.1155/2012/636547. [PMID: 22567033] - Xiuli Cui, Guang Yang, Minglin Pan, Xiao-Nan Zhang, Shao-Nian Yang. Akt signals upstream of L-type calcium channels to optimize insulin secretion.
Pancreas.
2012 Jan; 41(1):15-21. doi:
10.1097/mpa.0b013e31822363a9. [PMID: 21792084] - Colomba Falcone, Maria Paola Buzzi, Sara Bozzini, Chiara Boiocchi, Angela D'Angelo, Sandra Schirinzi, Ciro Esposito, Massimo Torreggiani, Jasmine Choi, Michael Ochan Kilama, Giuseppe Mancia. Microalbuminuria and sRAGE in high-risk hypertensive patients treated with nifedipine/telmisartan combination treatment: a substudy of TALENT.
Mediators of inflammation.
2012; 2012(?):874149. doi:
10.1155/2012/874149. [PMID: 22474401] - Luiz Augusto Wentz, Sara Cioccari Oliveira, Carlos Heitor Cunha Moreira, Cassiano Kuchenbecker Rösing. Low prevalence of gingival overgrowth associated to new imunossupressive protocols with cyclosporin.
Brazilian oral research.
2012 Jan; 26(1):64-70. doi:
10.1590/s1806-83242011005000016. [PMID: 22344340] - Antoaneta Gateva, Zdravko Kamenov. Cardiovascular Risk Factors in Bulgarian Patients with Polycystic Ovary Syndrome and/or Obesity.
Obstetrics and gynecology international.
2012; 2012(?):306347. doi:
10.1155/2012/306347. [PMID: 22262974] - Rui-Xing Yin, Dong-Feng Wu, Jin-Zhen Wu, Xiao-Li Cao, Lynn Htet Htet Aung, Lin Miao, Xing-Jiang Long, Wan-Ying Liu, Lin Zhang, Meng Li. Interactions of several lipid-related gene polymorphisms and cigarette smoking on blood pressure levels.
International journal of biological sciences.
2012; 8(5):685-96. doi:
10.7150/ijbs.4401. [PMID: 22606049] - Nicolas Anton, Astrid de Crevoisier, Sabrina Schmitt, Thierry Vandamme. A new application of lipid nanoemulsions as coating agent, providing zero-order hydrophilic drug release from tablets.
Journal of drug delivery.
2012; 2012(?):271319. doi:
10.1155/2012/271319. [PMID: 22272376] - L E M Bouillet, A S Cardoso, E Perovano, R R Pereira, E M C Ribeiro, M J M Trópia, L G Fietto, R Tisi, E Martegani, I M Castro, R L Brandão. The involvement of calcium carriers and of the vacuole in the glucose-induced calcium signaling and activation of the plasma membrane H(+)-ATPase in Saccharomyces cerevisiae cells.
Cell calcium.
2012 Jan; 51(1):72-81. doi:
10.1016/j.ceca.2011.10.008. [PMID: 22153127] - M N Mamedov. [Broadened indications for the use of selective β-adrenoblockers].
Kardiologiia.
2012; 52(5):74-6. doi:
". [PMID: 22839590] - Myla E Moretti, Daniela Caprara, Irina Drehuta, Emily Yeung, Stefanie Cheung, Lisa Federico, Gideon Koren. The Fetal Safety of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers.
Obstetrics and gynecology international.
2012; 2012(?):658310. doi:
10.1155/2012/658310. [PMID: 22203847] - Sandra Valeria Santos de Cerqueira, Antonio Nei Santana Gondim, Danilo Roman-Campos, Jader Santos Cruz, Amilton Gustavo da Silva Passos, Sandra Lauton-Santos, Aline Lara, Silvia Guatimosim, Eduardo Antonio Conde-Garcia, Evaleide Diniz de Oliveira, Carla Maria Lins de Vasconcelos. R(+)-pulegone impairs Ca²+ homeostasis and causes negative inotropism in mammalian myocardium.
European journal of pharmacology.
2011 Dec; 672(1-3):135-42. doi:
10.1016/j.ejphar.2011.09.186. [PMID: 22004607] - Mark Kwaaitaal, Rik Huisman, Jens Maintz, Anja Reinstädler, Ralph Panstruga. Ionotropic glutamate receptor (iGluR)-like channels mediate MAMP-induced calcium influx in Arabidopsis thaliana.
The Biochemical journal.
2011 Dec; 440(3):355-65. doi:
10.1042/bj20111112. [PMID: 21848515] - Imran Imran, Liaqat Hussain, M Zia-Ul-Haq, Khalid Hussain Janbaz, Anwar H Gilani, Vincenzo De Feo. Gastrointestial and respiratory activities of Acacia leucophloea.
Journal of ethnopharmacology.
2011 Dec; 138(3):676-82. doi:
10.1016/j.jep.2011.09.019. [PMID: 21959184] - Masakazu Ishii, Ryouta Iizuka, Yuji Kiuchi, Yasuo Mori, Shunichi Shimizu. Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity.
Molecular and cellular biochemistry.
2011 Dec; 358(1-2):1-11. doi:
10.1007/s11010-011-0913-3. [PMID: 21656126] - Youichirou Higashi, Shohei Segawa, Takaaki Matsuo, Shogo Nakamura, Yukiko Kikkawa, Kentaro Nishida, Kazuki Nagasawa. Microglial zinc uptake via zinc transporters induces ATP release and the activation of microglia.
Glia.
2011 Dec; 59(12):1933-45. doi:
10.1002/glia.21235. [PMID: 22253048] - Héla Ghorbel, Ines Feki, Ines Friha, Abdel Majid Khabir, Tahya Boudawara, Mohamed Boudawara, Sami Sayadi. Biochemical and histological liver changes occurred after iron supplementation and possible remediation by garlic consumption.
Endocrine.
2011 Dec; 40(3):462-71. doi:
10.1007/s12020-011-9483-0. [PMID: 21553301] - Seong-Bae Hwang, Hye-Yoon Lee, Hoon-Yub Kim, Eun-Sook Lee, Jeoung-Won Bae. Life-threatening acute hyponatremia with generalized seizure induced by low-dose cyclophosphamide in a patient with breast cancer.
Journal of breast cancer.
2011 Dec; 14(4):345-8. doi:
10.4048/jbc.2011.14.4.345. [PMID: 22323925] - Isaac Zepeda-Jazo, Ana María Velarde-Buendía, René Enríquez-Figueroa, Jayakumar Bose, Sergey Shabala, Jesús Muñiz-Murguía, Igor I Pottosin. Polyamines interact with hydroxyl radicals in activating Ca(2+) and K(+) transport across the root epidermal plasma membranes.
Plant physiology.
2011 Dec; 157(4):2167-80. doi:
10.1104/pp.111.179671. [PMID: 21980172] - Giuseppe Derosa, Pamela Maffioli. Nifedipine and telmisartan for the treatment of hypertension: the TALENT study.
Expert review of cardiovascular therapy.
2011 Dec; 9(12):1499-503. doi:
10.1586/erc.11.155. [PMID: 22103868] - Maurice C van Staveren, Barbara Theeuwes-Oonk, Henk Jan Guchelaar, André B P van Kuilenburg, Jan Gerard Maring. Pharmacokinetics of orally administered uracil in healthy volunteers and in DPD-deficient patients, a possible tool for screening of DPD deficiency.
Cancer chemotherapy and pharmacology.
2011 Dec; 68(6):1611-7. doi:
10.1007/s00280-011-1661-5. [PMID: 21590448] - Saskia N de Wildt, Ron H N van Schaik, Offie P Soldin, Steve J Soldin, Parvaneh Yazdani Brojeni, Ilse P van der Heiden, Chris Parshuram, Irena Nulman, Gideon Koren. The interactions of age, genetics, and disease severity on tacrolimus dosing requirements after pediatric kidney and liver transplantation.
European journal of clinical pharmacology.
2011 Dec; 67(12):1231-41. doi:
10.1007/s00228-011-1083-7. [PMID: 21698374] - E O Adewoye, A O Ige, C T Latona. Effect of methanolic extract of Musa sapientum leaves on gastrointestinal transit time in normal and alloxan induced diabetic rats: possible mechanism of action.
Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria.
2011 Nov; 26(1):83-8. doi:
. [PMID: 22314993] - Fabio C Vicentini, Eduardo Mazzucchi, Artur H Brito, Elias A Chedid Neto, Alexandre Danilovic, Miguel Srougi. Adjuvant tamsulosin or nifedipine after extracorporeal shock wave lithotripsy for renal stones: a double blind, randomized, placebo-controlled trial.
Urology.
2011 Nov; 78(5):1016-21. doi:
10.1016/j.urology.2011.04.062. [PMID: 21802124] - Dinesh C Joshi, Mahendra Singh, Karthik Krishnamurthy, Preeti G Joshi, Nanda B Joshi. AMPA induced Ca2+ influx in motor neurons occurs through voltage gated Ca2+ channel and Ca2+ permeable AMPA receptor.
Neurochemistry international.
2011 Nov; 59(6):913-21. doi:
10.1016/j.neuint.2011.06.023. [PMID: 21777635] - Zhe Tian, Keishi Miyata, Mitsuhisa Tabata, Masato Yano, Hirokazu Tazume, Jun Aoi, Otowa Takahashi, Kimi Araki, Michio Kawasuji, Yuichi Oike. Nifedipine increases energy expenditure by increasing PGC-1α expression in skeletal muscle.
Hypertension research : official journal of the Japanese Society of Hypertension.
2011 Nov; 34(11):1221-7. doi:
10.1038/hr.2011.129. [PMID: 21814214] - Benjamin K Canales. Editorial comment.
Urology.
2011 Nov; 78(5):1021-2; author reply 1022. doi:
10.1016/j.urology.2011.05.038. [PMID: 22054367] - Dong Hee Na, Hye Young Ji, Eun Ji Park, Myung Sun Kim, Kwang-Hyeon Liu, Hye Suk Lee. Evaluation of metabolism-mediated herb-drug interactions.
Archives of pharmacal research.
2011 Nov; 34(11):1829-42. doi:
10.1007/s12272-011-1105-0. [PMID: 22139684] - Rosa Ventura-Martínez, Oscar Rivero-Osorno, Claudia Gómez, María Eva González-Trujano. Spasmolytic activity of Rosmarinus officinalis L. involves calcium channels in the guinea pig ileum.
Journal of ethnopharmacology.
2011 Oct; 137(3):1528-32. doi:
10.1016/j.jep.2011.08.047. [PMID: 21896322] - Chun-Chi Kuo, Jong-Khing Huang, Chiang-Ting Chou, Jin-Shiung Cheng, Jeng-Yu Tsai, Yi-Chien Fang, Shu-Shong Hsu, Wei-Chuan Liao, Hong-Tai Chang, Chin-Man Ho, Chung-Ren Jan. Effect of bisphenol A on Ca(2+) fluxes and viability in Madin-Darby canine renal tubular cells.
Drug and chemical toxicology.
2011 Oct; 34(4):454-61. doi:
10.3109/01480545.2011.556645. [PMID: 21770746] - Chaitali Banerjee, Ramansu Goswami, Soma Datta, R Rajagopal, Shibnath Mazumder. Arsenic-induced alteration in intracellular calcium homeostasis induces head kidney macrophage apoptosis involving the activation of calpain-2 and ERK in Clarias batrachus.
Toxicology and applied pharmacology.
2011 Oct; 256(1):44-51. doi:
10.1016/j.taap.2011.07.007. [PMID: 21798276] - Markus Hoenicka, Andreas Keyser, Leopold Rupprecht, Thomas Puehler, Stephan Hirt, Christof Schmid. Endothelium-dependent vasoconstriction in isolated vessel grafts: a novel mechanism of vasospasm?.
The Annals of thoracic surgery.
2011 Oct; 92(4):1299-306. doi:
10.1016/j.athoracsur.2011.05.114. [PMID: 21958775] - Khadiga Mohammed Gaafa, Mohammed M Badawy, Alaaeldin A Hamza. The protective effects of ascorbic acid, cimetidine, and nifedipine on diethyldithiocarbamate-induced hepatic toxicity in albino rats.
Drug and chemical toxicology.
2011 Oct; 34(4):405-19. doi:
10.3109/01480545.2011.586035. [PMID: 21770724] - D Kozielewicz, D Dybowska, W Halota, W Dróżdż. Natural leukocyte interferon alpha (Alfaferone) combined with ribavirin in the treatment of patients with HCV-related cirrhosis: our experience.
Infection.
2011 Oct; 39(5):433-7. doi:
10.1007/s15010-011-0135-3. [PMID: 21739360]