3-[4-[2-[[6-Amino-9-[5-(ethylcarbamoyl)-3,4-dihydroxy-2-oxolanyl]-2-purinyl]amino]ethyl]phenyl]propanoic acid (BioDeep_00001881684)

   


代谢物信息卡片


3-[4-[2-[[6-Amino-9-[5-(ethylcarbamoyl)-3,4-dihydroxy-2-oxolanyl]-2-purinyl]amino]ethyl]phenyl]propanoic acid

化学式: C23H29N7O6 (499.2179214)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCNC(=O)C1C(C(C(O1)N2C=NC3=C(N=C(N=C32)NCCC4=CC=C(C=C4)CCC(=O)O)N)O)O
InChI: InChI=1S/C23H29N7O6/c1-2-25-21(35)18-16(33)17(34)22(36-18)30-11-27-15-19(24)28-23(29-20(15)30)26-10-9-13-5-3-12(4-6-13)7-8-14(31)32/h3-6,11,16-18,22,33-34H,2,7-10H2,1H3,(H,25,35)(H,31,32)(H3,24,26,28,29)

描述信息

D018377 - Neurotransmitter Agents > D058905 - Purinergic Agents > D058913 - Purinergic Agonists
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents

同义名列表

1 个代谢物同义名

3-[4-[2-[[6-Amino-9-[5-(ethylcarbamoyl)-3,4-dihydroxy-2-oxolanyl]-2-purinyl]amino]ethyl]phenyl]propanoic acid



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Samantha L Cooper, Edward S Wragg, Patrizia Pannucci, Mark Soave, Stephen J Hill, Jeanette Woolard. Regionally selective cardiovascular responses to adenosine A2A and A2B receptor activation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2022 04; 36(4):e22214. doi: 10.1096/fj.202101945r. [PMID: 35230706]
  • Zoltan Czigany, Eve Christiana Craigie, Georg Lurje, Shaowei Song, Kei Yonezawa, Yuzo Yamamoto, Thomas Minor, René Hany Tolba. Adenosine A2a Receptor Stimulation Attenuates Ischemia-Reperfusion Injury and Improves Survival in A Porcine Model of DCD Liver Transplantation. International journal of molecular sciences. 2020 Sep; 21(18):. doi: 10.3390/ijms21186747. [PMID: 32938013]
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  • Vladimir Pedro Peralva Borges-Martins, Danielle Dias Pinto Ferreira, Arthur Cardoso Souto, Jessika Geisebel Oliveira Neto, Danniel Pereira-Figueiredo, Karin da Costa Calaza, Karen de Jesus Oliveira, Alex Christian Manhães, Ricardo Augusto de Melo Reis, Regina Célia Cussa Kubrusly. Caffeine regulates GABA transport via A1R blockade and cAMP signaling. Neurochemistry international. 2019 12; 131(?):104550. doi: 10.1016/j.neuint.2019.104550. [PMID: 31563462]
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  • N J Geraghty, S R Adhikary, D Watson, R Sluyter. The A2A receptor agonist CGS 21680 has beneficial and adverse effects on disease development in a humanised mouse model of graft-versus-host disease. International immunopharmacology. 2019 Jul; 72(?):479-486. doi: 10.1016/j.intimp.2019.04.037. [PMID: 31051404]
  • Xiang Kong, Yi Zuo, Yu'ang Huang, Jianjun Ge. Adenosine A2a receptor agonist CGS21680 treatment attenuates cardiopulmonary bypass‑associated inflammatory lung injury in juvenile rats. Molecular medicine reports. 2019 Jul; 20(1):117-124. doi: 10.3892/mmr.2019.10235. [PMID: 31115565]
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  • Christoph Eisner, SooMi Kim, Alexandra Grill, Yan Qin, Marion Hoerl, Josephine Briggs, Hayo Castrop, Manfred Thiel, Jurgen Schnermann. Profound hypothermia after adenosine kinase inhibition in A1AR-deficient mice suggests a receptor-independent effect of intracellular adenosine. Pflugers Archiv : European journal of physiology. 2017 02; 469(2):339-347. doi: 10.1007/s00424-016-1925-3. [PMID: 27975140]
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  • Shuang-Shuang Dai, Hao Wang, Nan Yang, Jian-Hong An, Wei Li, Ya-Lei Ning, Pei-Fang Zhu, Jiang-Fan Chen, Yuan-Guo Zhou. Plasma glutamate-modulated interaction of A2AR and mGluR5 on BMDCs aggravates traumatic brain injury-induced acute lung injury. The Journal of experimental medicine. 2013 Apr; 210(4):839-51. doi: 10.1084/jem.20122196. [PMID: 23478188]
  • Fabrizio Vincenzi, Melissa Padovan, Martina Targa, Carmen Corciulo, Sarah Giacuzzo, Stefania Merighi, Stefania Gessi, Marcello Govoni, Pier Andrea Borea, Katia Varani. A(2A) adenosine receptors are differentially modulated by pharmacological treatments in rheumatoid arthritis patients and their stimulation ameliorates adjuvant-induced arthritis in rats. PloS one. 2013; 8(1):e54195. doi: 10.1371/journal.pone.0054195. [PMID: 23326596]
  • Hang Xiao, Hai-Ying Shen, Wei Liu, Ren-Ping Xiong, Ping Li, Gang Meng, Nan Yang, Xing Chen, Liang-Yi Si, Yuan-Guo Zhou. Adenosine A2A receptor: a target for regulating renal interstitial fibrosis in obstructive nephropathy. PloS one. 2013; 8(4):e60173. doi: 10.1371/journal.pone.0060173. [PMID: 23585831]
  • Chiara Imarisio, Elisa Alchera, Salvatore Sutti, Guido Valente, Francesca Boccafoschi, Emanuele Albano, Rita Carini. Adenosine A(2a) receptor stimulation prevents hepatocyte lipotoxicity and non-alcoholic steatohepatitis (NASH) in rats. Clinical science (London, England : 1979). 2012 Sep; 123(5):323-32. doi: 10.1042/cs20110504. [PMID: 22439844]
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  • Emanuela Mazzon, Emanuela Esposito, Daniela Impellizzeri, Rosanna DI Paola, Alessia Melani, Placido Bramanti, Felicita Pedata, Salvatore Cuzzocrea. CGS 21680, an agonist of the adenosine (A2A) receptor, reduces progression of murine type II collagen-induced arthritis. The Journal of rheumatology. 2011 Oct; 38(10):2119-29. doi: 10.3899/jrheum.110111. [PMID: 21765105]
  • Daniela Impellizzeri, Rosanna Di Paola, Emanuela Esposito, Emanuela Mazzon, Irene Paterniti, Alessia Melani, Placido Bramanti, Felicita Pedata, Salvatore Cuzzocrea. CGS 21680, an agonist of the adenosine (A2A) receptor, decreases acute lung inflammation. European journal of pharmacology. 2011 Oct; 668(1-2):305-16. doi: 10.1016/j.ejphar.2011.06.049. [PMID: 21756897]
  • Gabriela E Garcia, Luan D Truong, Jiang-Fan Chen, Richard J Johnson, Lili Feng. Adenosine A(2A) receptor activation prevents progressive kidney fibrosis in a model of immune-associated chronic inflammation. Kidney international. 2011 Aug; 80(4):378-88. doi: 10.1038/ki.2011.101. [PMID: 21508927]
  • David A Ferenbach, Jeremy Hughes. Adenosine A(2A) agonists as therapy for glomerulonephritis. Kidney international. 2011 Aug; 80(4):329-31. doi: 10.1038/ki.2011.167. [PMID: 21799503]
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  • Mattias Carlström, Christopher S Wilcox, William J Welch. Adenosine A2A receptor activation attenuates tubuloglomerular feedback responses by stimulation of endothelial nitric oxide synthase. American journal of physiology. Renal physiology. 2011 Feb; 300(2):F457-64. doi: 10.1152/ajprenal.00567.2010. [PMID: 21106859]
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  • Ming-Chang Chiang, Hui-Mei Chen, Hsing-Lin Lai, Hsiao-Wen Chen, Szu-Yi Chou, Chiung-Mei Chen, Fuu-Jen Tsai, Yijuang Chern. The A2A adenosine receptor rescues the urea cycle deficiency of Huntington's disease by enhancing the activity of the ubiquitin-proteasome system. Human molecular genetics. 2009 Aug; 18(16):2929-42. doi: 10.1093/hmg/ddp230. [PMID: 19443488]
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  • Mohammed A Nayeem, Dovenia S Ponnoth, Matthew A Boegehold, Darryl C Zeldin, John R Falck, S Jamal Mustafa. High-salt diet enhances mouse aortic relaxation through adenosine A2A receptor via CYP epoxygenases. American journal of physiology. Regulatory, integrative and comparative physiology. 2009 Mar; 296(3):R567-74. doi: 10.1152/ajpregu.90798.2008. [PMID: 19109366]
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  • Elisa Alchera, Lorenza Tacchini, Chiara Imarisio, Caterina Dal Ponte, Cristina De Ponti, Elena Gammella, Gaetano Cairo, Emanuele Albano, Rita Carini. Adenosine-dependent activation of hypoxia-inducible factor-1 induces late preconditioning in liver cells. Hepatology (Baltimore, Md.). 2008 Jul; 48(1):230-9. doi: 10.1002/hep.22249. [PMID: 18506850]
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  • Guy A Higgins, Michael E Grzelak, Annamarie J Pond, Mary E Cohen-Williams, Robert A Hodgson, Geoffrey B Varty. The effect of caffeine to increase reaction time in the rat during a test of attention is mediated through antagonism of adenosine A2A receptors. Behavioural brain research. 2007 Dec; 185(1):32-42. doi: 10.1016/j.bbr.2007.07.013. [PMID: 17707919]
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