2-Methyl-N-(5-methyl-2-thiazolyl)-1,1,4-trioxo-3H-1$l^{6},2-benzothiazine-3-carboxamide (BioDeep_00001880910)
代谢物信息卡片
2-Methyl-N-(5-methyl-2-thiazolyl)-1,1,4-trioxo-3H-1$l^{6},2-benzothiazine-3-carboxamide
化学式: C14H13N3O4S2 (351.0347458)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CN=C(S1)NC(=O)C2C(=O)C3=CC=CC=C3S(=O)(=O)N2C
InChI: InChI=1S/C14H13N3O4S2/c1-8-7-15-14(22-8)16-13(19)11-12(18)9-5-3-4-6-10(9)23(20,21)17(11)2/h3-7,11H,1-2H3,(H,15,16,19)
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代谢反应
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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
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The open cardiovascular medicine journal.
2010 Oct; 4(?):198-205. doi:
10.2174/1874192401004010198. [PMID: 21331307] - Laura A Goodman, Bryan T Torres, Lisa R Reynolds, Steven C Budsberg. Effects of firocoxib, meloxicam, and tepoxalin administration on eicosanoid production in target tissues of healthy cats.
American journal of veterinary research.
2010 Sep; 71(9):1067-73. doi:
10.2460/ajvr.71.9.1067. [PMID: 20807147] - Serhat Gurocak, Iyimser Ure, Ahmet Cumaoglu, Ipek Isik Gonul, Ilker Sen, Ozgur Tan, Aysel Aricioglu, Ibrahim Bozkirli. Renal tissue damage after experimental pyelonephritis: role of antioxidants and selective cyclooxygenase-2 inhibitors.
Urology.
2010 Aug; 76(2):508.e1-5. doi:
10.1016/j.urology.2010.03.040. [PMID: 20510442] - P Grudé, J Guittard, C Garcia, I Daoulas, F Thoulon, T Ebner. Excretion mass balance evaluation, metabolite profile analysis and metabolite identification in plasma and excreta after oral administration of [14C]-meloxicam to the male cat: preliminary study.
Journal of veterinary pharmacology and therapeutics.
2010 Aug; 33(4):396-407. doi:
10.1111/j.1365-2885.2010.01157.x. [PMID: 20646203] - Michal Hofer, Milan Pospísil, Ladislav Dusek, Jirina Holá, Zuzana Hoferová, Lenka Weiterová. Basal and induced granulopoiesis in outbred, F1 hybrid and inbred mice: can inbreeding depression influence the experimental practice?.
Experimental biology and medicine (Maywood, N.J.).
2010 Aug; 235(8):928-31. doi:
10.1258/ebm.2010.010032. [PMID: 20660092] - Leonor Miranda Jiménez, Mario Binelli, Kalyne Bertolin, R Marc Pelletier, Bruce D Murphy. Scavenger receptor-B1 and luteal function in mice.
Journal of lipid research.
2010 Aug; 51(8):2362-71. doi:
10.1194/jlr.m006973. [PMID: 20404351] - Alassane Keita, Eric Pagot, Armelle Prunier, Christian Guidarini. Pre-emptive meloxicam for postoperative analgesia in piglets undergoing surgical castration.
Veterinary anaesthesia and analgesia.
2010 Jul; 37(4):367-74. doi:
10.1111/j.1467-2995.2010.00546.x. [PMID: 20636569] - Geraldine Dowling, Edward Malone, Tom Harbison, Sheila Martin. Analytical strategy for the determination of non-steroidal anti-inflammatory drugs in plasma and improved analytical strategy for the determination of authorized and non-authorized non-steroidal anti-inflammatory drugs in milk by LC-MS/MS.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2010 Jul; 27(7):962-82. doi:
10.1080/19440041003706779. [PMID: 20544456] - Fahad I Al-Jenoobi. Effect of itraconazole on the pharmacokinetics of diclofenac in beagle dogs.
Scientia pharmaceutica.
2010 Jul; 78(3):465-71. doi:
10.3797/scipharm.1003-10. [PMID: 21179359] - Lilianna Trynda-Lemiesz, Katarzyna Wiglusz. Interactions of human serum albumin with meloxicam: characterization of binding site.
Journal of pharmaceutical and biomedical analysis.
2010 Jun; 52(2):300-4. doi:
10.1016/j.jpba.2009.12.025. [PMID: 20089378] - Elvira L Massó González, Paola Patrignani, Stefania Tacconelli, Luis A García Rodríguez. Variability among nonsteroidal antiinflammatory drugs in risk of upper gastrointestinal bleeding.
Arthritis and rheumatism.
2010 Jun; 62(6):1592-601. doi:
10.1002/art.27412. [PMID: 20178131] - J N King, C Rudaz, L Borer, M Jung, W Seewald, P Lees. In vitro and ex vivo inhibition of canine cyclooxygenase isoforms by robenacoxib: a comparative study.
Research in veterinary science.
2010 Jun; 88(3):497-506. doi:
10.1016/j.rvsc.2009.11.002. [PMID: 20004922] - T Lehr, R Narbe, O Jöns, C Kloft, A Staab. Population pharmacokinetic modelling and simulation of single and multiple dose administration of meloxicam in cats.
Journal of veterinary pharmacology and therapeutics.
2010 Jun; 33(3):277-86. doi:
10.1111/j.1365-2885.2009.01134.x. [PMID: 20557445] - Adam W Stern, Jerry W Ritchey, Brittany Hall, Cornelia J Ketz-Riley, Suzanne G Genova. Nonsteroidal anti-inflammatory drug-associated renal papillary necrosis in a white-tailed deer (Odocoileus virginianus).
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.
2010 May; 22(3):476-8. doi:
10.1177/104063871002200328. [PMID: 20453233] - Johannes W J Bijlsma. Patient benefit-risk in arthritis--a rheumatologist's perspective.
Rheumatology (Oxford, England).
2010 May; 49 Suppl 2(?):ii11-17. doi:
10.1093/rheumatology/keq057. [PMID: 20407136] - Erin Baggaley, Søren Nielsen, David Marples. Dehydration-induced increase in aquaporin-2 protein abundance is blocked by nonsteroidal anti-inflammatory drugs.
American journal of physiology. Renal physiology.
2010 Apr; 298(4):F1051-8. doi:
10.1152/ajprenal.90202.2008. [PMID: 20130117] - Katarzyna Czapla, Beata Korchowiec, Ewa Rogalska. Differentiating oxicam nonsteroidal anti-inflammatory drugs in phosphoglyceride monolayers.
Langmuir : the ACS journal of surfaces and colloids.
2010 Mar; 26(5):3485-92. doi:
10.1021/la903052t. [PMID: 20030324] - Kyung Hee Choi, Ah Jeong Kim, In Ja Son, Kyung-Hwan Kim, Ki-Bong Kim, Hyuk Ahn, Eun Bong Lee. Risk factors of drug interaction between warfarin and nonsteroidal anti-inflammatory drugs in practical setting.
Journal of Korean medical science.
2010 Mar; 25(3):337-41. doi:
10.3346/jkms.2010.25.3.337. [PMID: 20191029] - Shauna L Blois, Dana G Allen, R Darren Wood, Peter D Conlon. Effects of aspirin, carprofen, deracoxib, and meloxicam on platelet function and systemic prostaglandin concentrations in healthy dogs.
American journal of veterinary research.
2010 Mar; 71(3):349-58. doi:
10.2460/ajvr.71.3.349. [PMID: 20187838] - Cristián Jesam, Ana María Salvatierra, Jill L Schwartz, Horacio B Croxatto. Suppression of follicular rupture with meloxicam, a cyclooxygenase-2 inhibitor: potential for emergency contraception.
Human reproduction (Oxford, England).
2010 Feb; 25(2):368-73. doi:
10.1093/humrep/dep392. [PMID: 19933235] - Kim E Hester, Michael J K Harper, Diane M Duffy. Oral administration of the cyclooxygenase-2 (COX-2) inhibitor meloxicam blocks ovulation in non-human primates when administered to simulate emergency contraception.
Human reproduction (Oxford, England).
2010 Feb; 25(2):360-7. doi:
10.1093/humrep/dep424. [PMID: 19965877] - Anil Kumar, Beenta Kumari, Puneet Kumar. Protective effects of selective and non-selective cyclooxygenase inhibitors in an animal model of chronic stress.
Neuroscience bulletin.
2010 Feb; 26(1):17-27. doi:
10.1007/s12264-010-0713-x. [PMID: 20101269] - Young-Chang Ah, Jin-Kyu Choi, Yang-Kyu Choi, Han-Moi Ki, Joon-Ho Bae. A novel transdermal patch incorporating meloxicam: in vitro and in vivo characterization.
International journal of pharmaceutics.
2010 Jan; 385(1-2):12-9. doi:
10.1016/j.ijpharm.2009.10.013. [PMID: 19833177] - Xuejun Cui, Kien Trinh, Yong-Jun Wang. Chinese herbal medicine for chronic neck pain due to cervical degenerative disc disease.
The Cochrane database of systematic reviews.
2010 Jan; ?(1):CD006556. doi:
10.1002/14651858.cd006556.pub2. [PMID: 20091597] - G Mickisch, M Gore, B Escudier, G Procopio, S Walzer, M Nuijten. Costs of managing adverse events in the treatment of first-line metastatic renal cell carcinoma: bevacizumab in combination with interferon-alpha2a compared with sunitinib.
British journal of cancer.
2010 Jan; 102(1):80-6. doi:
10.1038/sj.bjc.6605417. [PMID: 19920817] - Martin Janovský, Tomás Dolezal, Michaela Procháizková, Jirí Slíva, Miloslav Krsiak. Influence on analgesic activity and serum levels after meloxicam complexation with beta-cyclodextrin in mice and rats.
Arzneimittel-Forschung.
2010; 60(6):320-3. doi:
10.1055/s-0031-1296294. [PMID: 20648921] - Mohd Roslan Sulaiman, Azyyati Mohd Padzil, Khozirah Shaari, Syamimi Khalid, Wan Mastura Shaik Mossadeq, Azam Shah Mohamad, Syahida Ahmad, Ahmad Akira, Daud Israf, Nordin Lajis. Antinociceptive activity of Melicope ptelefolia ethanolic extract in experimental animals.
Journal of biomedicine & biotechnology.
2010; 2010(?):937642. doi:
10.1155/2010/937642. [PMID: 21274262] - Sutapa Mondal, Munna Sarkar. Non-steroidal anti-inflammatory drug induced membrane fusion: concentration and temperature effects.
The journal of physical chemistry. B.
2009 Dec; 113(51):16323-31. doi:
10.1021/jp9069527. [PMID: 19954169] - James W Carpenter, Christal G Pollock, David E Koch, Robert P Hunter. Single and multiple-dose pharmacokinetics of meloxicam after oral administration to the rabbit (Oryctolagus cuniculus).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2009 Dec; 40(4):601-6. doi:
10.1638/2007-0115.1. [PMID: 20063804] - Gretchen A Cole, Joanne Paul-Murphy, Lisa Krugner-Higby, Julia M Klauer, Scott E Medlin, Nicholas S Keuler, Kurt K Sladky. Analgesic effects of intramuscular administration of meloxicam in Hispaniolan parrots (Amazona ventralis) with experimentally induced arthritis.
American journal of veterinary research.
2009 Dec; 70(12):1471-6. doi:
10.2460/ajvr.70.12.1471. [PMID: 19951118] - Nobuo Shinohara, Akira Kumagai, Kouichi Kanagawa, Satoru Maruyama, Takashige Abe, Ataru Sazawa, Katsuya Nonomura. Multicenter phase II trial of combination therapy with meloxicam, a cox-2 inhibitor, and natural interferon-alpha for metastatic renal cell carcinoma.
Japanese journal of clinical oncology.
2009 Nov; 39(11):720-6. doi:
10.1093/jjco/hyp089. [PMID: 19684042]