Cimetidine sulfoxide (BioDeep_00001880086)

   


代谢物信息卡片


Cimetidine sulfoxide

化学式: C10H16N6OS (268.1106246)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C(N=CN1)CS(=O)CCNC(=NC)NC#N
InChI: InChI=1S/C10H16N6OS/c1-8-9(16-7-15-8)5-18(17)4-3-13-10(12-2)14-6-11/h7H,3-5H2,1-2H3,(H,15,16)(H2,12,13,14)

描述信息

Cimetidine sulfoxide (Cimetidine sulphoxide) is a sulfoxide metabolite of Cimetidine. Cimetidine is a histamine H2-receptor antagonist. Cimetidine has the potential for peptic ulcer disease and upper gastrointestinal haemorrhage treatment[1].

同义名列表

2 个代谢物同义名

Cimetidine sulfoxide; Cimetidine sulphoxide



数据库引用编号

5 个数据库交叉引用编号

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代谢反应

0 个相关的代谢反应过程信息。

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • R A Sams, D F Gerken, T M Dyke, S M Reed, S M Ashcraft. Pharmacokinetics of intravenous and intragastric cimetidine in horses. I. Effects of intravenous cimetidine on pharmacokinetics of intravenous phenylbutazone. Journal of veterinary pharmacology and therapeutics. 1997 Oct; 20(5):355-61. doi: 10.1046/j.1365-2885.1997.00083.x. [PMID: 9350255]
  • F León-Urrea, M E Girard-Cuesy, C Cervantes-Campos, M P Delgadillo-Valencia, M A Montoya-Cabrera. An improved high performance liquid chromatographic method for determination of cimetidine and its major metabolite in plasma. Archivos de investigacion medica. 1989 Oct; 20(4):309-13. doi: NULL. [PMID: 2488770]
  • S C Mitchell, R H Waring. The fate of cimetidine sulphoxide in the guinea pig. Xenobiotica; the fate of foreign compounds in biological systems. 1989 Feb; 19(2):179-88. doi: 10.3109/00498258909034690. [PMID: 2728492]
  • H A Strong, M Spino. Highly sensitive determination of cimetidine and its metabolites in serum and urine by high-performance liquid chromatography. Journal of chromatography. 1987 Nov; 422(?):301-8. doi: 10.1016/0378-4347(87)80467-x. [PMID: 3437018]
  • A Adedoyin, L Aarons, J B Houston. Dose-dependent pharmacokinetics of cimetidine in the rat. Xenobiotica; the fate of foreign compounds in biological systems. 1987 May; 17(5):595-604. doi: 10.3109/00498258709043966. [PMID: 3604263]
  • Q Lin, G L Lensmeyer, F C Larson. Quantitation of cimetidine and cimetidine sulfoxide in serum by solid-phase extraction and solvent-recycled liquid chromatography. Journal of analytical toxicology. 1985 Jul; 9(4):161-6. doi: 10.1093/jat/9.4.161. [PMID: 4033072]
  • C W Lloyd, W J Martin, J Nagle, A R Hauser. Determination of cimetidine and metabolites in plasma by reversed-phase high-performance liquid chromatographic radial compression technique. Journal of chromatography. 1985 Apr; 339(1):139-47. doi: 10.1016/s0378-4347(00)84635-6. [PMID: 4019663]
  • L A Bauer, C Wareing-Tran, W A Edwards, V Raisys, L Ferreri, R Jack, E P Dellinger, D Simonowitz. Cimetidine clearance in the obese. Clinical pharmacology and therapeutics. 1985 Apr; 37(4):425-30. doi: 10.1038/clpt.1985.66. [PMID: 3979004]
  • J A Ziemniak, H Bernhard, J J Schentag. Hepatic encephalopathy and altered cimetidine kinetics. Clinical pharmacology and therapeutics. 1983 Sep; 34(3):375-82. doi: 10.1038/clpt.1983.182. [PMID: 6883913]
  • S C Mitchell, J R Idle, R L Smith. Reductive metabolism of cimetidine sulfoxide in man. Drug metabolism and disposition: the biological fate of chemicals. 1982 May; 10(3):289-90. doi: NULL. [PMID: 6125368]