3-[5-(Dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid (BioDeep_00001879257)

   


代谢物信息卡片


3-[5-(Dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid

化学式: C17H25N3O5S (383.1515)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C2C(C(=O)N2C(=C1SC3CC(NC3)C(=O)N(C)C)C(=O)O)C(C)O
InChI: InChI=1S/C17H25N3O5S/c1-7-12-11(8(2)21)16(23)20(12)13(17(24)25)14(7)26-9-5-10(18-6-9)15(22)19(3)4/h7-12,18,21H,5-6H2,1-4H3,(H,24,25)



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Guoxiu Xiang, Zhiwei Zhao, Shebin Zhang, Yimei Cai, Yuting He, Jianming Zeng, Cha Chen, Bin Huang. Porin deficiency or plasmid copy number increase mediated carbapenem-resistant Escherichia coli resistance evolution. Emerging microbes & infections. 2024 Dec; 13(1):2352432. doi: 10.1080/22221751.2024.2352432. [PMID: 38712634]
  • Elin Helset, Vesa Cheng, Hilde Sporsem, Christian Thorstensen, Ingvild Nordøy, Karianne Wiger Gammelsrud, Gorm Hanssen, Erica Ponzi, Jeffrey Lipman, Elisabeth von der Lippe. Meropenem pharmacokinetic/pharmacodynamic target attainment and clinical response in ICU patients: A prospective observational study. Acta anaesthesiologica Scandinavica. 2024 Apr; 68(4):502-511. doi: 10.1111/aas.14376. [PMID: 38286568]
  • Xi Qin, Yali Wu, Ya Zhao, Shangshang Qin, Qiuru Ji, Jinhao Jia, Mengqi Huo, Xiaoyu Zhao, Qing Ma, Xiaoyan Wang, Xiaofei Chen, Hui Zhang, Mingliang Zhang, Liuqing Yang, Weixia Li, Jinfa Tang. Revealing active constituents within traditional Chinese Medicine used for treating bacterial pneumonia, with emphasis on the mechanism of baicalein against multi-drug resistant Klebsiella pneumoniae. Journal of ethnopharmacology. 2024 Mar; 321(?):117488. doi: 10.1016/j.jep.2023.117488. [PMID: 38008277]
  • M Cem Şirin, Yasemin Cezaroğlu, E Sesli Çetin, Buket Arıdoğan, Diğdem Trak, Yasin Arslan. Antibacterial and antibiofilm efficacy of colistin & meropenem conjugated silver nanoparticles against Escherichia coli and Klebsiella pneumoniae. Journal of basic microbiology. 2023 Dec; 63(12):1397-1411. doi: 10.1002/jobm.202300440. [PMID: 37821405]
  • Yu-Hang Yan, Ting-Ting Zhang, Rong Li, Si-Yao Wang, Liu-Liu Wei, Xin-Yue Wang, Kai-Rong Zhu, Shan-Rui Li, Guo-Qing Liang, Zeng-Bao Yang, Ling-Ling Yang, Shangshang Qin, Guo-Bo Li. Discovery of 2-Aminothiazole-4-carboxylic Acids as Broad-Spectrum Metallo-β-lactamase Inhibitors by Mimicking Carbapenem Hydrolysate Binding. Journal of medicinal chemistry. 2023 Oct; 66(19):13746-13767. doi: 10.1021/acs.jmedchem.3c01189. [PMID: 37791640]
  • Saumya Singh, Taru Verma, Balaram Khamari, Eswarappa Pradeep Bulagonda, Dipankar Nandi, Siva Umapathy. Antimicrobial Resistance Studies Using Raman Spectroscopy on Clinically Relevant Bacterial Strains. Analytical chemistry. 2023 08; 95(30):11342-11351. doi: 10.1021/acs.analchem.3c01453. [PMID: 37463121]
  • Doris Yoong Wen Di, Guangxiang Cao, Chuanqing Zhong, Tao Yan. Diversity of blaPOM in carbapenem-resistant opportunistic pathogenic Pseudomonas otitidis in municipal wastewater. Journal of water and health. 2023 May; 21(5):560-570. doi: 10.2166/wh.2023.255. [PMID: 37254905]
  • Miroslava Kačániová, Nenad L Vukovic, Natália Čmiková, Lucia Galovičová, Marianna Schwarzová, Veronika Šimora, Przemysław Łukasz Kowalczewski, Maciej Ireneusz Kluz, Czeslaw Puchalski, Ladislav Bakay, Milena D Vukic. Salvia sclarea Essential Oil Chemical Composition and Biological Activities. International journal of molecular sciences. 2023 Mar; 24(6):. doi: 10.3390/ijms24065179. [PMID: 36982252]
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  • Wei Zhang, Chun-Yu Yan, Shu-Rui Li, Ting-Ting Fan, Shan-Shan Cao, Bin Cui, Meng-Ying Li, Bo-Yuan Fan, Bo Ji, Li Wang, Fei Cui, Jia Cui, Lei Wang, Yue Guan, Jing-Wen Wang. Efficacy and safety of piperacillin-tazobactam compared with meropenem in treating complicated urinary tract infections including acute pyelonephritis due to extended-spectrum β-lactamase-producing Enterobacteriaceae. Frontiers in cellular and infection microbiology. 2023; 13(?):1093842. doi: 10.3389/fcimb.2023.1093842. [PMID: 37207190]
  • C Campo-Beleño, R A Villamizar-Gallardo, L E López-Jácome, E E González, S Muñoz-Carranza, B Franco, R Morales-Espinosa, R Coria-Jimenez, R Franco-Cendejas, M Hernández-Durán, R Lara-Martínez, L F Jiménez-García, A M Fernández-Presas, R García-Contreras. Biologically synthesized silver nanoparticles as potent antibacterial effective against multidrug-resistant Pseudomonas aeruginosa. Letters in applied microbiology. 2022 Sep; 75(3):680-688. doi: 10.1111/lam.13759. [PMID: 35687297]
  • Kshipra Rajpoot, Shiv Kumar Prajapati, Akanksha Malaiya, Richa Jain, Aakanchha Jain. Meropenem-Loaded Nanostructured Lipid Carriers For Skin and Soft Tissue Infection Caused by Staphylococcus aureus: Formulation, Design, and Evaluation. AAPS PharmSciTech. 2022 Aug; 23(7):241. doi: 10.1208/s12249-022-02381-y. [PMID: 36008695]
  • S Hasan Radhi, S A Kamal, N Mohammed Sahi, H J Hussein. Assessment of Antibacterial Efficacy of Callistemon viminalis (Sol. ex Gaertn.) G. Don against Some Isolates Obtained from Urinary Tract Infections. Archives of Razi Institute. 2022 Apr; 77(2):891-897. doi: 10.22092/ari.2022.357125.1981. [PMID: 36284981]
  • Kiyoko Fujita, Iichiro Takata, Ippei Yoshida, Hajime Takashima, Hiroyuki Sugiyama. TP0586532, a non-hydroxamate LpxC inhibitor, reduces LPS release and IL-6 production both in vitro and in vivo. The Journal of antibiotics. 2022 03; 75(3):136-145. doi: 10.1038/s41429-021-00498-z. [PMID: 34987187]
  • Chongmei Tian, Mengyu Xing, Liping Fu, Yaping Zhao, Xueyu Fan, Siwei Wang. Emergence of uncommon KL38-OCL6-ST220 carbapenem-resistant Acinetobacter pittii strain, co-producing chromosomal NDM-1 and OXA-820 carbapenemases. Frontiers in cellular and infection microbiology. 2022; 12(?):943735. doi: 10.3389/fcimb.2022.943735. [PMID: 36034705]
  • Chongmei Tian, Mengyu Xing, Yaping Zhao, Xueyu Fan, Yongfeng Bai, Liping Fu, Siwei Wang. Whole genome sequencing of OXA-232-producing wzi93-KL112-O1 carbapenem-resistant Klebsiella pneumoniae in human bloodstream infection co-harboring chromosomal ISEcp1-based bla CTX-M-15 and one rmpA2-associated virulence plasmid. Frontiers in cellular and infection microbiology. 2022; 12(?):984479. doi: 10.3389/fcimb.2022.984479. [PMID: 36250056]
  • Anna Olsson, Marcus Hong, Hissa Al-Farsi, Christian G Giske, Pernilla Lagerbäck, Thomas Tängdén. Interactions of Polymyxin B in Combination with Aztreonam, Minocycline, Meropenem, and Rifampin against Escherichia coli Producing NDM and OXA-48-Group Carbapenemases. Antimicrobial agents and chemotherapy. 2021 11; 65(12):e0106521. doi: 10.1128/aac.01065-21. [PMID: 34516251]
  • Qiong-Dan Hu, Nan Mao, Xin-Chun Huang, Ding-Guo Chen, Qiong Zhang. Identification of Complex Pneumonia during the Outbreak of COVID-19: Bacterial Pneumonia Combined with Acute Eosinophilic Pneumonia in Patients with Maintenance Hemodialysis. Blood purification. 2021 ; 50(1):132-136. doi: 10.1159/000509789. [PMID: 32721968]
  • Feng Xie, Shengwang Dai, Yu Zhao, Pei Huang, Shen Yu, Biao Ren, Qiushui Wang, Zengchun Ji, Gil Alterovitz, Qi Zhang, Jingyu Zhang, Xiangyin Chen, Lan Jiang, Fuhang Song, Hongwei Liu, Frederick M Ausubel, Xueting Liu, Huanqin Dai, Lixin Zhang. Generation of Fluorinated Amychelin Siderophores against Pseudomonas aeruginosa Infections by a Combination of Genome Mining and Mutasynthesis. Cell chemical biology. 2020 12; 27(12):1532-1543.e6. doi: 10.1016/j.chembiol.2020.10.009. [PMID: 33186541]
  • Rachelle E Beattie, Troy Skwor, Krassimira R Hristova. Survivor microbial populations in post-chlorinated wastewater are strongly associated with untreated hospital sewage and include ceftazidime and meropenem resistant populations. The Science of the total environment. 2020 Oct; 740(?):140186. doi: 10.1016/j.scitotenv.2020.140186. [PMID: 32569917]
  • Chiara Rezzoagli, Martina Archetti, Ingrid Mignot, Michael Baumgartner, Rolf Kümmerli. Combining antibiotics with antivirulence compounds can have synergistic effects and reverse selection for antibiotic resistance in Pseudomonas aeruginosa. PLoS biology. 2020 08; 18(8):e3000805. doi: 10.1371/journal.pbio.3000805. [PMID: 32810152]
  • Wenxia Zhang, Yan Guo, Yang Yang, Dong Dong, Yonggui Zheng, Demei Zhu, Fupin Hu. Study of In Vitro Synergistic Bactericidal Activity of Dual β-Lactam Antibiotics Against KPC-2-Producing Klebsiella pneumoniae. Microbial drug resistance (Larchmont, N.Y.). 2020 Mar; 26(3):204-210. doi: 10.1089/mdr.2019.0126. [PMID: 31553260]
  • Shun-Kai Yang, Khatijah Yusoff, Warren Thomas, Riaz Akseer, Maryam Sultan Alhosani, Aisha Abushelaibi, Swee-Hua-Erin Lim, Kok-Song Lai. Lavender essential oil induces oxidative stress which modifies the bacterial membrane permeability of carbapenemase producing Klebsiella pneumoniae. Scientific reports. 2020 01; 10(1):819. doi: 10.1038/s41598-019-55601-0. [PMID: 31964900]
  • Alejandro Cabrera-Reina, Ana B Martínez-Piernas, Yannis Bertakis, Nikolaos P Xekoukoulotakis, Ana Agüera, José Antonio Sánchez Pérez. TiO2 photocatalysis under natural solar radiation for the degradation of the carbapenem antibiotics imipenem and meropenem in aqueous solutions at pilot plant scale. Water research. 2019 Dec; 166(?):115037. doi: 10.1016/j.watres.2019.115037. [PMID: 31494490]
  • Xingang Li, Xiaoping Wang, Yuanxing Wu, Shusen Sun, Kai Chen, Yanxia Lu, Qiang Wang, Zhigang Zhao. Plasma and cerebrospinal fluid population pharmacokinetic modeling and simulation of meropenem after intravenous and intrathecal administration in postoperative neurosurgical patients. Diagnostic microbiology and infectious disease. 2019 Apr; 93(4):386-392. doi: 10.1016/j.diagmicrobio.2018.08.003. [PMID: 30638947]
  • Nobuhiro Asai, Yusuke Koizumi, Atsuko Yamada, Daisuke Sakanashi, Hiroki Watanabe, Hideo Kato, Arufumi Shiota, Mao Hagihara, Hiroyuki Suematsu, Yuka Yamagishi, Hiroshige Mikamo. Pantoea dispersa bacteremia in an immunocompetent patient: a case report and review of the literature. Journal of medical case reports. 2019 Feb; 13(1):33. doi: 10.1186/s13256-019-1969-z. [PMID: 30755259]
  • Xiao-Ling Jia, Janak L Pathak, Jin-Fa Tong, Ji-Mei Su. A case report of hemolytic streptococcal gangrene in the danger triangle of the face with thrombocytopenia and hepatitis. BMC pediatrics. 2018 06; 18(1):198. doi: 10.1186/s12887-018-1177-9. [PMID: 29933752]
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  • Gowrishankar Soundararajan, Satya Prathyusha Bhamidimarri, Mathias Winterhalter. Understanding Carbapenem Translocation through OccD3 (OpdP) of Pseudomonas aeruginosa. ACS chemical biology. 2017 06; 12(6):1656-1664. doi: 10.1021/acschembio.6b01150. [PMID: 28440622]
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