L-670,596 (BioDeep_00001878074)
代谢物信息卡片
化学式: C22H21F2NO4S (433.11592900000005)
中文名称: (-)-6-8-二氟-2,3,4,9-四氢-9-[[4-(甲基磺酰基)苯基]甲基]-1H-咔唑-1-乙酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CS(=O)(=O)C1=CC=C(C=C1)CN2C3=C(CCCC3CC(=O)O)C4=C2C(=CC(=C4)F)F
InChI: InChI=1S/C22H21F2NO4S/c1-30(28,29)16-7-5-13(6-8-16)12-25-21-14(9-20(26)27)3-2-4-17(21)18-10-15(23)11-19(24)22(18)25/h5-8,10-11,14H,2-4,9,12H2,1H3,(H,26,27)
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Christiane Quiniou, Florian Sennlaub, Martin H Beauchamp, Daniella Checchin, Isabelle Lahaie, Sonia Brault, Fernand Gobeil, Mirna Sirinyan, Amna Kooli, Pierre Hardy, Alexey Pshezhetsky, Sylvain Chemtob. Dominant role for calpain in thromboxane-induced neuromicrovascular endothelial cytotoxicity.
The Journal of pharmacology and experimental therapeutics.
2006 Feb; 316(2):618-27. doi:
10.1124/jpet.105.093898
. [PMID: 16214879] - Robert P Jankov, Rosetta Belcastro, Emira Ovcina, Julia Lee, Hamid Massaeli, Stephen J Lye, A Keith Tanswell. Thromboxane A(2) receptors mediate pulmonary hypertension in 60\% oxygen-exposed newborn rats by a cyclooxygenase-independent mechanism.
American journal of respiratory and critical care medicine.
2002 Jul; 166(2):208-14. doi:
10.1164/rccm.200112-124oc
. [PMID: 12119234] - B A Kiberd. The functional and structural changes of the glomerulus throughout the course of murine lupus nephritis.
Journal of the American Society of Nephrology : JASN.
1992 Oct; 3(4):930-9. doi:
10.1681/asn.v34930
. [PMID: 1450369] - B A Bresnahan, R J Roman, W M Bagchus, E A Lianos. Mesangial cell immune injury: effects of thromboxane receptor antagonism.
Journal of the American Society of Nephrology : JASN.
1991 Feb; 1(8):1041-7. doi:
10.1681/asn.v181041
. [PMID: 1832980] - G A Nuttall, M J Murray, E J Bowie. Protamine-heparin-induced pulmonary hypertension in pigs: effects of treatment with a thromboxane receptor antagonist on hemodynamics and coagulation.
Anesthesiology.
1991 Jan; 74(1):138-45. doi:
NULL
. [PMID: 1824742] - A W Ford-Hutchinson, Y Girard, A Lord, T R Jones, M Cirino, J F Evans, J Gillard, P Hamel, C Leveillé, P Masson. The pharmacology of L-670,596, a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist.
Canadian journal of physiology and pharmacology.
1989 Sep; 67(9):989-93. doi:
10.1139/y89-155
. [PMID: 2598135] - P Morsing, A Stenberg, A E Persson. Effect of thromboxane inhibition on tubuloglomerular feedback in hydronephrotic kidneys.
Kidney international.
1989 Sep; 36(3):447-52. doi:
10.1038/ki.1989.215
. [PMID: 2593488]