Isoflavan (BioDeep_00001878061)

   


代谢物信息卡片


Isoflavan

化学式: C15H14O (210.1044594)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(COC2=CC=CC=C21)C3=CC=CC=C3
InChI: InChI=1S/C15H14O/c1-2-6-12(7-3-1)14-10-13-8-4-5-9-15(13)16-11-14/h1-9,14H,10-11H2

描述信息

The simplest member of the class of isoflavans that is chromane substituted by a phenyl substituent at position 3.

同义名列表

1 个代谢物同义名

Isoflavan



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dana Atrahimovich, Jacob Vaya, Hagai Tavori, Soliman Khatib. Glabridin protects paraoxonase 1 from linoleic acid hydroperoxide inhibition via specific interaction: a fluorescence-quenching study. Journal of agricultural and food chemistry. 2012 Apr; 60(14):3679-85. doi: 10.1021/jf2046009. [PMID: 22380866]
  • Zhihong Lin, Jie Gu, Jin Xiu, Tingyan Mi, Jie Dong, Jyoti Kumar Tiwari. Traditional chinese medicine for senile dementia. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):692621. doi: 10.1155/2012/692621. [PMID: 21808655]
  • Ilga Porth, Björn Hamberger, Richard White, Kermit Ritland. Defense mechanisms against herbivory in Picea: sequence evolution and expression regulation of gene family members in the phenylpropanoid pathway. BMC genomics. 2011 Dec; 12(?):608. doi: 10.1186/1471-2164-12-608. [PMID: 22177423]
  • Parisa Hasanein. Glabridin as a major active isoflavan from Glycyrrhiza glabra (licorice) reverses learning and memory deficits in diabetic rats. Acta physiologica Hungarica. 2011 Jun; 98(2):221-30. doi: 10.1556/aphysiol.98.2011.2.14. [PMID: 21616781]
  • Ya-Ling Hsu, Ling-Yu Wu, Ming-Feng Hou, Eing-Mei Tsai, Jau-Nan Lee, Hsin-Lin Liang, Yuh-Jyh Jong, Chih-Hsing Hung, Po-Lin Kuo. Glabridin, an isoflavan from licorice root, inhibits migration, invasion and angiogenesis of MDA-MB-231 human breast adenocarcinoma cells by inhibiting focal adhesion kinase/Rho signaling pathway. Molecular nutrition & food research. 2011 Feb; 55(2):318-27. doi: 10.1002/mnfr.201000148. [PMID: 20626003]
  • Eva Miadoková. Isoflavonoids - an overview of their biological activities and potential health benefits. Interdisciplinary toxicology. 2009 Dec; 2(4):211-8. doi: 10.2478/v10102-009-0021-3. [PMID: 21217857]
  • Uraiwan Songsiang, Suchana Wanich, Siripit Pitchuanchom, Siwames Netsopa, Komphet Uanporn, Chavi Yenjai. Bioactive constituents from the stems of Dalbergia parviflora. Fitoterapia. 2009 Oct; 80(7):427-31. doi: 10.1016/j.fitote.2009.06.002. [PMID: 19524648]
  • Lucia Racková, Viera Jancinová, Margita Petríková, Katarína Drábiková, Radomír Nosál, Milan Stefek, Daniela Kostálová, Nada Prónayová, Mária Kovácová. Mechanism of anti-inflammatory action of liquorice extract and glycyrrhizin. Natural product research. 2007 Dec; 21(14):1234-41. doi: 10.1080/14786410701371280. [PMID: 18075885]
  • Gordon V Louie, Thomas J Baiga, Marianne E Bowman, Takao Koeduka, John H Taylor, Snejina M Spassova, Eran Pichersky, Joseph P Noel. Structure and reaction mechanism of basil eugenol synthase. PloS one. 2007 Oct; 2(10):e993. doi: 10.1371/journal.pone.0000993. [PMID: 17912370]
  • Xi-Yong Yu, Shu-Guang Lin, Zhi-Wei Zhou, Xiao Chen, Jun Liang, Xue-Qing Yu, Balram Chowbay, Jing-Yuan Wen, Wei Duan, Eli Chan, Xiao-Tian Li, Jie Cao, Chun-Guang Li, Charlie Changli Xue, Shu-Feng Zhou. Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra. Pharmaceutical research. 2007 Sep; 24(9):1668-90. doi: 10.1007/s11095-007-9297-1. [PMID: 17551811]
  • Norimoto Shimada, Shusei Sato, Tomoyoshi Akashi, Yasukazu Nakamura, Satoshi Tabata, Shin-Ichi Ayabe, Toshio Aoki. Genome-wide analyses of the structural gene families involved in the legume-specific 5-deoxyisoflavonoid biosynthesis of Lotus japonicus. DNA research : an international journal for rapid publication of reports on genes and genomes. 2007 Feb; 14(1):25-36. doi: 10.1093/dnares/dsm004. [PMID: 17452423]
  • Charles E Wood, Susan E Appt, Thomas B Clarkson, Adrian A Franke, Cynthia J Lees, Daniel R Doerge, J Mark Cline. Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys. Biology of reproduction. 2006 Sep; 75(3):477-86. doi: 10.1095/biolreprod.106.052142. [PMID: 16723506]
  • Gil Belofsky, Roberto Carreno, Shannon M Goswick, David T John. Activity of isoflavans of Dalea aurea (Fabaceae) against the opportunistic ameba naegleria fowleri. Planta medica. 2006 Mar; 72(4):383-6. doi: 10.1055/s-2005-916252. [PMID: 16557484]
  • Eun-Mi Choi. The licorice root derived isoflavan glabridin increases the function of osteoblastic MC3T3-E1 cells. Biochemical pharmacology. 2005 Aug; 70(3):363-8. doi: 10.1016/j.bcp.2005.04.019. [PMID: 15922308]
  • Jong Soon Kang, Yeo Dae Yoon, Ig Jun Cho, Mi Hwa Han, Chang Woo Lee, Song-Kyu Park, Hwan Mook Kim. Glabridin, an isoflavan from licorice root, inhibits inducible nitric-oxide synthase expression and improves survival of mice in experimental model of septic shock. The Journal of pharmacology and experimental therapeutics. 2005 Mar; 312(3):1187-94. doi: 10.1124/jpet.104.077107. [PMID: 15537821]
  • Dalia Somjen, Esther Knoll, Jacob Vaya, Naftali Stern, Snait Tamir. Estrogen-like activity of licorice root constituents: glabridin and glabrene, in vascular tissues in vitro and in vivo. The Journal of steroid biochemistry and molecular biology. 2004 Jul; 91(3):147-55. doi: 10.1016/j.jsbmb.2004.04.003. [PMID: 15276622]
  • Jeong Seon Yoon, Sang Hyun Sung, Jong Hee Park, Young Choong Kim. Flavonoids from Spatholobus suberectus. Archives of pharmacal research. 2004 Jun; 27(6):589-92. doi: 10.1007/bf02980154. [PMID: 15283457]
  • Xiaofeng Ma, Pengfei Tu, Yingjie Chen, Tianyou Zhang, Yun Wei, Yoichiro Ito. Preparative isolation and purification of isoflavan and pterocarpan glycosides from Astragalus membranaceus Bge. var. mongholicus (Bge.) Hsiao by high-speed counter-current chromatography. Journal of chromatography. A. 2004 Jan; 1023(2):311-5. doi: 10.1016/j.chroma.2003.10.014. [PMID: 14753698]
  • Shufeng Zhou, Hwee-Ling Koh, Yihuai Gao, Zhi-yuan Gong, Edmund Jon Deoon Lee. Herbal bioactivation: the good, the bad and the ugly. Life sciences. 2004 Jan; 74(8):935-68. doi: 10.1016/j.lfs.2003.09.035. [PMID: 14672753]
  • Minpei Kuroda, Yoshihiro Mimaki, Yutaka Sashida, Tatsumasa Mae, Hideyuki Kishida, Tozo Nishiyama, Misuzu Tsukagawa, Eisaku Konishi, Kazuma Takahashi, Teruo Kawada, Kaku Nakagawa, Mikio Kitahara. Phenolics with PPAR-gamma ligand-binding activity obtained from licorice (Glycyrrhiza uralensis roots) and ameliorative effects of glycyrin on genetically diabetic KK-A(y) mice. Bioorganic & medicinal chemistry letters. 2003 Dec; 13(24):4267-72. doi: 10.1016/j.bmcl.2003.09.052. [PMID: 14643306]
  • Rivka Ofir, Snait Tamir, Soliman Khatib, Jacob Vaya. Inhibition of serotonin re-uptake by licorice constituents. Journal of molecular neuroscience : MN. 2003 Apr; 20(2):135-40. doi: 10.1385/jmn:20:2:135. [PMID: 12794307]
  • Elke Brouwers, Rafaëlla L'homme, Nawaf Al-Maharik, Oldrich Lapcík, Richard Hampl, Kristiina Wähälä, Heikki Mikola, Herman Adlercreutz. Time-resolved fluoroimmunoassay for equol in plasma and urine. The Journal of steroid biochemistry and molecular biology. 2003 Apr; 84(5):577-88. doi: 10.1016/s0960-0760(03)00071-2. [PMID: 12767283]
  • Majid Sairafianpour, Oliver Kayser, Jette Christensen, Mohammad Asfa, Matthias Witt, Dan Staerk, Jerzy W Jaroszewski. Leishmanicidal and antiplasmodial activity of constituents of Smirnowia iranica. Journal of natural products. 2002 Dec; 65(12):1754-8. doi: 10.1021/np020244s. [PMID: 12502308]
  • Toshio Fukai, Ai Marumo, Kiyoshi Kaitou, Toshihisa Kanda, Sumio Terada, Taro Nomura. Anti-Helicobacter pylori flavonoids from licorice extract. Life sciences. 2002 Aug; 71(12):1449-63. doi: 10.1016/s0024-3205(02)01864-7. [PMID: 12127165]
  • Ute M Kent, Michael Aviram, Mira Rosenblat, Paul F Hollenberg. The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9. Drug metabolism and disposition: the biological fate of chemicals. 2002 Jun; 30(6):709-15. doi: 10.1124/dmd.30.6.709. [PMID: 12019199]
  • S Tamir, M Eizenberg, D Somjen, S Izrael, J Vaya. Estrogen-like activity of glabrene and other constituents isolated from licorice root. The Journal of steroid biochemistry and molecular biology. 2001 Sep; 78(3):291-8. doi: 10.1016/s0960-0760(01)00093-0. [PMID: 11595510]
  • G Bojase, C C Wanjala, R R Majinda. Flavonoids from the stem bark of Bolusanthus speciosus. Phytochemistry. 2001 Apr; 56(8):837-41. doi: 10.1016/s0031-9422(01)00009-7. [PMID: 11324914]