1,4-Benzodiazepine (BioDeep_00001878054)
代谢物信息卡片
1,4-Benzodiazepine
化学式: C9H8N2 (144.0687448)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C(=C1)C=NC=CN2
InChI: InChI=1S/C9H8N2/c1-2-4-9-8(3-1)7-10-5-6-11-9/h1-7,11H
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- M Ia Holovenko, V B Larionov. [Kinetics of hydrolysis of 1,4-benzodiazepine derivative by carboxylesterases in mice organism].
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Cell communication and signaling : CCS.
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Toxicology letters.
2011 Sep; 205(3):265-72. doi:
10.1016/j.toxlet.2011.06.015. [PMID: 21712084] - R Parrish Waters, Ronald E See. Chronic cocaine self-administration attenuates the anxiogenic-like and stress potentiating effects of the benzodiazepine inverse agonist, FG 7142.
Pharmacology, biochemistry, and behavior.
2011 Sep; 99(3):408-13. doi:
10.1016/j.pbb.2011.05.021. [PMID: 21635914] - Daniel B Hawcutt, Sunil Sampath, Alison Timmis, Veronica Newland, Paul Newland, Richard Appleton. Serum phenytoin concentrations in paediatric patients following intravenous loading.
Archives of disease in childhood.
2011 Sep; 96(9):883-4. doi:
10.1136/adc.2011.215269. [PMID: 21596726] - Einat Peles, Shaul Schreiber, Vera Rados, Miriam Adelson. Low risk for hepatitis C seroconversion in methadone maintenance treatment.
Journal of addiction medicine.
2011 Sep; 5(3):214-20. doi:
10.1097/adm.0b013e31820e13dd. [PMID: 21844836] - Celso A Rodrigues de Almeida Costa, Daniele Oliveira Kohn, Valéria Martins de Lima, André Costa Gargano, Jorge Camilo Flório, Mirtes Costa. The GABAergic system contributes to the anxiolytic-like effect of essential oil from Cymbopogon citratus (lemongrass).
Journal of ethnopharmacology.
2011 Sep; 137(1):828-36. doi:
10.1016/j.jep.2011.07.003. [PMID: 21767622] - Poonam Mahendra, Shradha Bisht. Anti-anxiety activity of Coriandrum sativum assessed using different experimental anxiety models.
Indian journal of pharmacology.
2011 Sep; 43(5):574-7. doi:
10.4103/0253-7613.84975. [PMID: 22022003] - A V Turina, G J Quinteros, B Caruso, E L Moyano, M A Perillo. Surface active benzodiazepine-bromo-alkyl conjugate for potential GABAA-receptor purification.
Organic & biomolecular chemistry.
2011 Aug; 9(16):5737-47. doi:
10.1039/c1ob05210a. [PMID: 21717023] - Ismene A Dontas, Katerina A Marinou, Dimitrios Iliopoulos, Nektaria Tsantila, George Agrogiannis, Apostolos Papalois, Theodore Karatzas. Changes of blood biochemistry in the rabbit animal model in atherosclerosis research; a time- or stress-effect.
Lipids in health and disease.
2011 Aug; 10(?):139. doi:
10.1186/1476-511x-10-139. [PMID: 21838924] - Nicholas J Doperalski, Christopher J Martyniuk, Melinda S Prucha, Kevin J Kroll, Nancy D Denslow, David S Barber. Cloning and expression of the translocator protein (18 kDa), voltage-dependent anion channel, and diazepam binding inhibitor in the gonad of largemouth bass (Micropterus salmoides) across the reproductive cycle.
General and comparative endocrinology.
2011 Aug; 173(1):86-95. doi:
10.1016/j.ygcen.2011.04.027. [PMID: 21600210] - Caroline Drake, Hervé Boutin, Matthew S Jones, Adam Denes, Barry W McColl, Johann R Selvarajah, Sharon Hulme, Rachel F Georgiou, Rainer Hinz, Alexander Gerhard, Andy Vail, Christian Prenant, Peter Julyan, Renaud Maroy, Gavin Brown, Alison Smigova, Karl Herholz, Michael Kassiou, David Crossman, Sheila Francis, Spencer D Proctor, James C Russell, Stephen J Hopkins, Pippa J Tyrrell, Nancy J Rothwell, Stuart M Allan. Brain inflammation is induced by co-morbidities and risk factors for stroke.
Brain, behavior, and immunity.
2011 Aug; 25(6):1113-22. doi:
10.1016/j.bbi.2011.02.008. [PMID: 21356305] - J Braudeau, B Delatour, A Duchon, P Lopes Pereira, L Dauphinot, F de Chaumont, J-C Olivo-Marin, R H Dodd, Y Hérault, M-C Potier. Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice.
Journal of psychopharmacology (Oxford, England).
2011 Aug; 25(8):1030-42. doi:
10.1177/0269881111405366. [PMID: 21693554] - Herman Henkes, Michael Franz, Orin Kendall, Jacqueline Monroe, Anna Legaspi, Joann LeDoux, Christopher Haese, Daniel Williams, Suzanne McCall, Arthur Don Johnson, Thomas E Ceremuga. Evaluation of the anxiolytic properties of tetrahydropalmatine, a Corydalis yanhusuo compound, in the male Sprague-Dawley rat.
AANA journal.
2011 Aug; 79(4 Suppl):S75-80. doi:
". [PMID: 22403971] - Fatemeh Emadi, Narguess Yassa, Abbas Hadjiakhoondi, Cordian Beyer, Mohammad Sharifzadeh. Sedative effects of Iranian Artemisia annua in mice: possible benzodiazepine receptors involvement.
Pharmaceutical biology.
2011 Aug; 49(8):784-8. doi:
10.3109/13880209.2010.548389. [PMID: 21554148] - M Rabbani, S E Sajjadi, S Khalili. A Lack of tolerance to the anxiolytic action of Echium amoenum.
Research in pharmaceutical sciences.
2011 Jul; 6(2):101-6. doi:
". [PMID: 22224093] - Shilan Mozaffari, Hadi Esmaily, Roja Rahimi, Maryam Baeeri, Yara Sanei, Azar Asadi-Shahmirzadi, Mohammad-Hossein Salehi-Surmaghi, Mohammad Abdollahi. Effects of Hypericum perforatum extract on rat irritable bowel syndrome.
Pharmacognosy magazine.
2011 Jul; 7(27):213-23. doi:
10.4103/0973-1296.84235. [PMID: 21969792] - Kumaresan P Thirupathy, Asish Tulshkar, C Vijaya. Neuropharmacological activity of Lippia nodiflora Linn.
Pharmacognosy research.
2011 Jul; 3(3):194-200. doi:
10.4103/0974-8490.85007. [PMID: 22022169] - Huishan Han, Jae Kyung Jung, Sang Bae Han, Sang Yoon Nam, Ki Wan Oh, Jin Tae Hong. Anxiolytic-like effects of 4-O-methylhonokiol isolated from Magnolia officinalis through enhancement of GABAergic transmission and chloride influx.
Journal of medicinal food.
2011 Jul; 14(7-8):724-31. doi:
10.1089/jmf.2010.1111. [PMID: 21501091] - Boby Varkey Maramattom, Anu Jacob. N-methyl D-aspartate receptor encephalitis: A new addition to the spectrum of autoimmune encephalitis.
Annals of Indian Academy of Neurology.
2011 Jul; 14(3):153-7. doi:
10.4103/0972-2327.85872. [PMID: 22028524] - Masahito Shimizu, Yoichi Yasuda, Hiroyasu Sakai, Masaya Kubota, Daishi Terakura, Atsushi Baba, Tomohiko Ohno, Takahiro Kochi, Hisashi Tsurumi, Takuji Tanaka, Hisataka Moriwaki. Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice.
BMC cancer.
2011 Jun; 11(?):281. doi:
10.1186/1471-2407-11-281. [PMID: 21711565] - Emilia Balsemão-Pires, Yvon Jaillais, Bradley J S C Olson, Leonardo R Andrade, James G Umen, Joanne Chory, Gilberto Sachetto-Martins. The Arabidopsis translocator protein (AtTSPO) is regulated at multiple levels in response to salt stress and perturbations in tetrapyrrole metabolism.
BMC plant biology.
2011 Jun; 11(?):108. doi:
10.1186/1471-2229-11-108. [PMID: 21689410] - René Robert, Daniel Aiham Ghazali, Frédéric Favreau, Gérard Mauco, Thierry Hauet, Jean-Michel Goujon. Gender difference and sex hormone production in rodent renal ischemia reperfusion injury and repair.
Journal of inflammation (London, England).
2011 Jun; 8(?):14. doi:
10.1186/1476-9255-8-14. [PMID: 21658244] - Sora Han, Ki Sook Oh, Yoosik Yoon, Jeong Su Park, Yun Sun Park, Jeong Hye Han, Ae Lee Jeong, Sunyi Lee, Miyoung Park, Yeon A Choi, Jong Seok Lim, Young Yang. Herbal extract THI improves metabolic abnormality in mice fed a high-fat diet.
Nutrition research and practice.
2011 Jun; 5(3):198-204. doi:
10.4162/nrp.2011.5.3.198. [PMID: 21779522] - Marc Verleye, Sylvie Dumas, Isabelle Heulard, Nicolas Krafft, Jean-Marie Gillardin. Differential effects of etifoxine on anxiety-like behaviour and convulsions in BALB/cByJ and C57BL/6J mice: any relation to overexpression of central GABAA receptor beta2 subunits?.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2011 Jun; 21(6):457-70. doi:
10.1016/j.euroneuro.2010.09.008. [PMID: 20943351] - Einat Peles, Shaul Schreiber, Rachel Bar Hamburger, Miriam Adelson. No change of sleep after 6 and 12 months of methadone maintenance treatment.
Journal of addiction medicine.
2011 Jun; 5(2):141-7. doi:
10.1097/adm.0b013e3181e8b6c4. [PMID: 21769060] - Vittorio Coiro, Riccardo Volpi, Amos Casti, Maria Ludovica Maffei, Adriano Stella, Elio Volta, Paolo Chiodera. Naloxone decreases the inhibitory effect of alprazolam on the release of adrenocorticotropin/cortisol induced by physical exercise in man.
British journal of clinical pharmacology.
2011 Jun; 71(6):951-5. doi:
10.1111/j.1365-2125.2010.03900.x. [PMID: 21564163] - Herbert Bosshart. Withdrawal-induced delirium associated with a benzodiazepine switch: a case report.
Journal of medical case reports.
2011 May; 5(?):207. doi:
10.1186/1752-1947-5-207. [PMID: 21615891] - Elisa Torres, Maria D Gutierrez-Lopez, Andrea Mayado, Ana Rubio, Esther O'Shea, Maria I Colado. Changes in interleukin-1 signal modulators induced by 3,4-methylenedioxymethamphetamine (MDMA): regulation by CB2 receptors and implications for neurotoxicity.
Journal of neuroinflammation.
2011 May; 8(?):53. doi:
10.1186/1742-2094-8-53. [PMID: 21595923] - Liansheng Liu, Qian Li, Robert Sapolsky, Min Liao, Kshama Mehta, Aditi Bhargava, Pankaj J Pasricha. Transient gastric irritation in the neonatal rats leads to changes in hypothalamic CRF expression, depression- and anxiety-like behavior as adults.
PloS one.
2011 May; 6(5):e19498. doi:
10.1371/journal.pone.0019498. [PMID: 21589865] - Toni-Lee Sterley, Fleur M Howells, Vivienne A Russell. Effects of early life trauma are dependent on genetic predisposition: a rat study.
Behavioral and brain functions : BBF.
2011 May; 7(?):11. doi:
10.1186/1744-9081-7-11. [PMID: 21548935] - Laxmaiah Manchikanti, Yogesh Malla, Bradley W Wargo, Bert Fellows. Comparative evaluation of the accuracy of benzodiazepine testing in chronic pain patients utilizing immunoassay with liquid chromatography tandem mass spectrometry (LC/MS/MS) of urine drug testing.
Pain physician.
2011 May; 14(3):259-70. doi:
NULL. [PMID: 21587329] - Kyoko Makise, Gaku Inagawa, Koui Ka. [Anesthetic management in a patient with trifunctional protein deficiency].
Masui. The Japanese journal of anesthesiology.
2011 May; 60(5):628-30. doi:
". [PMID: 21626870] - Pablo R Moya, Meredith A Fox, Catherine L Jensen, Justin L Laporte, Helen T French, Jens R Wendland, Dennis L Murphy. Altered 5-HT2C receptor agonist-induced responses and 5-HT2C receptor RNA editing in the amygdala of serotonin transporter knockout mice.
BMC pharmacology.
2011 Apr; 11(?):3. doi:
10.1186/1471-2210-11-3. [PMID: 21473759] - Andrzej Banyś, Jakub Kaźmierski, Ryszard Jaszewski. Psychiatric manifestations in a patient after surgical management of aortic stenosis of systemic lupus erythematosus.
Archives of medical science : AMS.
2011 Apr; 7(2):342-4. doi:
10.5114/aoms.2011.22089. [PMID: 22291778] - Cristina Wasowski, Mariel Marder. Central nervous system activities of two diterpenes isolated from Aloysia virgata.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Mar; 18(5):393-401. doi:
10.1016/j.phymed.2010.08.017. [PMID: 21036579] - José Del Carmen Rejón-Orantes, Alma Rosa González-Esquinca, Miguel Pérez de la Mora, Gabriel Roldan Roldan, Diego Cortes. Annomontine, an alkaloid isolated from Annona purpurea, has anxiolytic-like effects in the elevated plus-maze.
Planta medica.
2011 Mar; 77(4):322-7. doi:
10.1055/s-0030-1250406. [PMID: 20890807] - J R Atack, K A Wafford, L J Street, G R Dawson, S Tye, K Van Laere, G Bormans, S M Sanabria-Bohórquez, I De Lepeleire, J N de Hoon, A Van Hecken, H D Burns, R M McKernan, M G Murphy, R J Hargreaves. MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans.
Journal of psychopharmacology (Oxford, England).
2011 Mar; 25(3):314-28. doi:
10.1177/0269881109354927. [PMID: 20147571]