LDN-193189 (BioDeep_00001877998)
代谢物信息卡片
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline
化学式: C25H22N6 (406.1905852)
中文名称: LDN193189
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CN(CCN1)C2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC6=CC=CC=C56)N=C3
InChI: InChI=1S/C25H22N6/c1-2-4-24-22(3-1)21(9-10-27-24)23-16-29-31-17-19(15-28-25(23)31)18-5-7-20(8-6-18)30-13-11-26-12-14-30/h1-10,15-17,26H,11-14H2
描述信息
同义名列表
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
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代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
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PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Timothy E Thayer, Christian L Lino Cardenas, Trejeeve Martyn, Christopher J Nicholson, Lisa Traeger, Florian Wunderer, Charles Slocum, Haakon Sigurslid, Hannah R Shakartzi, Caitlin O'Rourke, Georgia Shelton, Mary D Buswell, Hanna Barnes, Leif R Neitzel, Clara D Ledsky, Jason Pingcheng Li, Megan F Burke, Eric Farber-Eger, Daniel S Perrien, Ravindra Kumar, Kathleen E Corey, Quinn S Wells, Kenneth D Bloch, Charles C Hong, Donald B Bloch, Rajeev Malhotra. The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease.
Scientific reports.
2020 06; 10(1):9831. doi:
10.1038/s41598-020-66770-8. [PMID: 32561790] - Tadayoshi Hayata, Masahiko Chiga, Yoichi Ezura, Makoto Asashima, Hidetaka Katabuchi, Ryuichi Nishinakamura, Masaki Noda. Dullard deficiency causes hemorrhage in the adult ovarian follicles.
Genes to cells : devoted to molecular & cellular mechanisms.
2018 May; 23(5):345-356. doi:
10.1111/gtc.12575. [PMID: 29521016] - Jiangfeng Liu, Weiling Wang, Ming Liu, Limin Su, Hong Zhou, Yin Xia, Jianhua Ran, Herbert Y Lin, Baoxue Yang. Repulsive guidance molecule b inhibits renal cyst development through the bone morphogenetic protein signaling pathway.
Cellular signalling.
2016 12; 28(12):1842-1851. doi:
10.1016/j.cellsig.2016.08.015. [PMID: 27575743] - Jeffrey Lehrberg, David M Gardiner. Regulation of Axolotl (Ambystoma mexicanum) Limb Blastema Cell Proliferation by Nerves and BMP2 in Organotypic Slice Culture.
PloS one.
2015; 10(4):e0123186. doi:
10.1371/journal.pone.0123186. [PMID: 25923915] - Yohei Kanamori, Masaru Murakami, Tohru Matsui, Masayuki Funaba. The regulation of hepcidin expression by serum treatment: requirements of the BMP response element and STAT- and AP-1-binding sites.
Gene.
2014 Nov; 551(2):119-26. doi:
10.1016/j.gene.2014.08.037. [PMID: 25151311] - Milan Theurl, Manfred Nairz, Andrea Schroll, Thomas Sonnweber, Malte Asshoff, David Haschka, Markus Seifert, Wolfgang Willenbacher, Doris Wilflingseder, Wilfried Posch, Anthony T Murphy, Derrick R Witcher, Igor Theurl, Günter Weiss. Hepcidin as a predictive factor and therapeutic target in erythropoiesis-stimulating agent treatment for anemia of chronic disease in rats.
Haematologica.
2014 Sep; 99(9):1516-24. doi:
10.3324/haematol.2013.099481. [PMID: 24895335] - Masashi Suenaga, Norio Kurosawa, Hiroki Asano, Yohei Kanamori, Takenao Umemoto, Hirofumi Yoshida, Masaru Murakami, Hiroyuki Kawachi, Tohru Matsui, Masayuki Funaba. Bmp4 expressed in preadipocytes is required for the onset of adipocyte differentiation.
Cytokine.
2013 Oct; 64(1):138-45. doi:
10.1016/j.cyto.2013.07.011. [PMID: 23911203] - Chia Chi Sun, Valentina Vaja, Shanzhuo Chen, Igor Theurl, Aaron Stepanek, Diane E Brown, Maria D Cappellini, Guenter Weiss, Charles C Hong, Herbert Y Lin, Jodie L Babitt. A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2013 Jul; 28(7):1733-43. doi:
10.1093/ndt/gfs584. [PMID: 23345622] - Blanca Herrera, María García-Álvaro, Silvia Cruz, Peter Walsh, Margarita Fernández, Cesáreo Roncero, Isabel Fabregat, Aránzazu Sánchez, Gareth J Inman. BMP9 is a proliferative and survival factor for human hepatocellular carcinoma cells.
PloS one.
2013; 8(7):e69535. doi:
10.1371/journal.pone.0069535. [PMID: 23936038] - Evelien Gebruers, María Lorena Cordero-Maldonado, Alexander I Gray, Carol Clements, Alan L Harvey, Ruangelie Edrada-Ebel, Peter A M de Witte, Alexander D Crawford, Camila V Esguerra. A phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling.
PloS one.
2013; 8(12):e83293. doi:
10.1371/journal.pone.0083293. [PMID: 24349481] - Chia Chi Sun, Valentina Vaja, Jodie L Babitt, Herbert Y Lin. Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation.
American journal of hematology.
2012 Apr; 87(4):392-400. doi:
10.1002/ajh.23110. [PMID: 22290531] - Matthias Derwall, Rajeev Malhotra, Carol S Lai, Yuko Beppu, Elena Aikawa, Jasbir S Seehra, Warren M Zapol, Kenneth D Bloch, Paul B Yu. Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology.
2012 Mar; 32(3):613-22. doi:
10.1161/atvbaha.111.242594. [PMID: 22223731] - Omar Saeed, Fumiyuki Otsuka, Rohini Polavarapu, Vinit Karmali, Daiana Weiss, Talina Davis, Brad Rostad, Kimberly Pachura, Lila Adams, John Elliott, W Robert Taylor, Jagat Narula, Frank Kolodgie, Renu Virmani, Charles C Hong, Aloke V Finn. Pharmacological suppression of hepcidin increases macrophage cholesterol efflux and reduces foam cell formation and atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology.
2012 Feb; 32(2):299-307. doi:
10.1161/atvbaha.111.240101. [PMID: 22095982] - Lijian Wang, Estela Trebicka, Ying Fu, Shiri Ellenbogen, Charles C Hong, Jodie L Babitt, Herbert Y Lin, Bobby J Cherayil. The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease.
Inflammatory bowel diseases.
2012 Jan; 18(1):112-9. doi:
10.1002/ibd.21675. [PMID: 21351217] - Andrea U Steinbicker, Chetana Sachidanandan, Ashley J Vonner, Rushdia Z Yusuf, Donna Y Deng, Carol S Lai, Kristen M Rauwerdink, Julia C Winn, Borja Saez, Colleen M Cook, Brian A Szekely, Cindy N Roy, Jasbir S Seehra, Gregory D Cuny, David T Scadden, Randall T Peterson, Kenneth D Bloch, Paul B Yu. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation.
Blood.
2011 May; 117(18):4915-23. doi:
10.1182/blood-2010-10-313064. [PMID: 21393479] - Gregory D Cuny, Paul B Yu, Joydev K Laha, Xuechao Xing, Ji-Feng Liu, Carol S Lai, Donna Y Deng, Chetana Sachidanandan, Kenneth D Bloch, Randall T Peterson. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors.
Bioorganic & medicinal chemistry letters.
2008 Aug; 18(15):4388-92. doi:
10.1016/j.bmcl.2008.06.052. [PMID: 18621530]