Methyl 3-[(4-anilino-2-methoxyphenyl)sulfamoyl]thiophene-2-carboxylate (BioDeep_00001877995)
代谢物信息卡片
Methyl 3-[(4-anilino-2-methoxyphenyl)sulfamoyl]thiophene-2-carboxylate
化学式: C19H18N2O5S2 (418.06570980000004)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=C(C=CC(=C1)NC2=CC=CC=C2)NS(=O)(=O)C3=C(SC=C3)C(=O)OC
InChI: InChI=1S/C19H18N2O5S2/c1-25-16-12-14(20-13-6-4-3-5-7-13)8-9-15(16)21-28(23,24)17-10-11-27-18(17)19(22)26-2/h3-12,20-21H,1-2H3
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jun Qian, Qian Li, Yangjie Song, Xuyan Gong, Kaili Hu, Guangbo Ge, Yao Sun. Pectolinarigenin ameliorates osteoporosis via enhancing Wnt signaling cascade in PPARβ-dependent manner.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jul; 129(?):155587. doi:
10.1016/j.phymed.2024.155587. [PMID: 38608598] - Seungchan An, Gyudong Kim, Hyun Jin Kim, Sungjin Ahn, Hyun Young Kim, Hyejin Ko, Young Eum Hyun, Mai Nguyen, Juri Jeong, Zijing Liu, Jinhe Han, Hongseok Choi, Jinha Yu, Ji Won Kim, Hyuk Woo Lee, Kenneth A Jacobson, Won Jea Cho, Young-Mi Kim, Keon Wook Kang, Minsoo Noh, Lak Shin Jeong. Discovery and Structure-Activity Relationships of Novel Template, Truncated 1'-Homologated Adenosine Derivatives as Pure Dual PPARγ/δ Modulators.
Journal of medicinal chemistry.
2020 12; 63(24):16012-16027. doi:
10.1021/acs.jmedchem.0c01874. [PMID: 33325691] - Masayo Hirao-Suzuki, Shuso Takeda, Takayuki Koga, Masufumi Takiguchi, Akihisa Toda. Cannabidiolic acid dampens the expression of cyclooxygenase-2 in MDA-MB-231 breast cancer cells: Possible implication of the peroxisome proliferator-activated receptor β/δ abrogation.
The Journal of toxicological sciences.
2020; 45(4):227-236. doi:
10.2131/jts.45.227. [PMID: 32238697] - Megan E Capozzi, Sara R Savage, Gary W McCollum, Sandra S Hammer, Carla J Ramos, Rong Yang, Colin A Bretz, John S Penn. The peroxisome proliferator-activated receptor-β/δ antagonist GSK0660 mitigates retinal cell inflammation and leukostasis.
Experimental eye research.
2020 01; 190(?):107885. doi:
10.1016/j.exer.2019.107885. [PMID: 31758977] - Ali Khorasani, Mehdi Abbasnejad, Saeed Esmaeili-Mahani. Phytohormone abscisic acid ameliorates cognitive impairments in streptozotocin-induced rat model of Alzheimer's disease through PPARβ/δ and PKA signaling.
The International journal of neuroscience.
2019 Nov; 129(11):1053-1065. doi:
10.1080/00207454.2019.1634067. [PMID: 31215291] - Shumei Ding, Jiajun Huang, Hongmei Qiu, Rongchun Chen, Jie Zhang, Bo Huang, Oumei Cheng, Qingsong Jiang. Effects of PPARs/20-HETE on the renal impairment under diabetic conditions.
Experimental cell research.
2019 09; 382(1):111455. doi:
10.1016/j.yexcr.2019.05.036. [PMID: 31163124] - Wenxia Zhong, Bin Fan, Huiying Cong, Tianyu Wang, Jianqiu Gu. Oleic acid-induced perilipin 5 expression and lipid droplets formation are regulated by the PI3K/PPARα pathway in HepG2 cells.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
2019 Aug; 44(8):840-848. doi:
10.1139/apnm-2018-0729. [PMID: 31274012] - Masayo Hirao-Suzuki, Shuso Takeda, Kazuhito Watanabe, Masufumi Takiguchi, Hironori Aramaki. Δ9-Tetrahydrocannabinol upregulates fatty acid 2-hydroxylase (FA2H) via PPARα induction: A possible evidence for the cancellation of PPARβ/δ-mediated inhibition of PPARα in MDA-MB-231 cells.
Archives of biochemistry and biophysics.
2019 02; 662(?):219-225. doi:
10.1016/j.abb.2018.12.011. [PMID: 30553767] - Cristina Mora, Cristina Pintado, Blanca Rubio, Lorena Mazuecos, Virginia López, Alejandro Fernández, Aurora Salamanca, Brenda Bárcena, Teresa Fernández-Agulló, Carmen Arribas, Nilda Gallardo, Antonio Andrés. Central leptin regulates heart lipid content by selectively increasing PPAR β/δ expression.
The Journal of endocrinology.
2018 Jan; 236(1):43-56. doi:
10.1530/joe-17-0554. [PMID: 29109080] - Jinha Yu, Seyeon Ahn, Hee Jin Kim, Moonyoung Lee, Sungjin Ahn, Jungmin Kim, Sun Hee Jin, Eunyoung Lee, Gyudong Kim, Jae Hoon Cheong, Kenneth A Jacobson, Lak Shin Jeong, Minsoo Noh. Polypharmacology of N6-(3-Iodobenzyl)adenosine-5'-N-methyluronamide (IB-MECA) and Related A3 Adenosine Receptor Ligands: Peroxisome Proliferator Activated Receptor (PPAR) γ Partial Agonist and PPARδ Antagonist Activity Suggests Their Antidiabetic Potential.
Journal of medicinal chemistry.
2017 09; 60(17):7459-7475. doi:
10.1021/acs.jmedchem.7b00805. [PMID: 28799755] - Christian Klingler, Xinjie Zhao, Till Adhikary, Jia Li, Guowang Xu, Hans-Ulrich Häring, Erwin Schleicher, Rainer Lehmann, Cora Weigert. Lysophosphatidylcholines activate PPARδ and protect human skeletal muscle cells from lipotoxicity.
Biochimica et biophysica acta.
2016 12; 1861(12 Pt A):1980-1992. doi:
10.1016/j.bbalip.2016.09.020. [PMID: 27697477] - Mayur Choudhary, Jin-Dong Ding, Xiaoping Qi, Michael E Boulton, Pei-Li Yao, Jeffrey M Peters, Goldis Malek. PPARβ/δ selectively regulates phenotypic features of age-related macular degeneration.
Aging.
2016 09; 8(9):1952-1978. doi:
10.18632/aging.101031. [PMID: 27622388] - Miguel Romero, Rosario Jiménez, Marta Toral, Elvira León-Gómez, Manuel Gómez-Gúzman, Manuel Sánchez, María José Zarzuelo, Isabel Rodríguez-Gómez, Geraldine Rath, Juan Tamargo, Francisco Pérez-Vizcaíno, Chantal Dessy, Juan Duarte. Vascular and Central Activation of Peroxisome Proliferator-Activated Receptor-β Attenuates Angiotensin II-Induced Hypertension: Role of RGS-5.
The Journal of pharmacology and experimental therapeutics.
2016 07; 358(1):151-63. doi:
10.1124/jpet.116.233106. [PMID: 27189971] - Shireesha Sankella, Abhimanyu Garg, Anil K Agarwal. Characterization of the Mouse and Human Monoacylglycerol O-Acyltransferase 1 (Mogat1) Promoter in Human Kidney Proximal Tubule and Rat Liver Cells.
PloS one.
2016; 11(9):e0162504. doi:
10.1371/journal.pone.0162504. [PMID: 27611931] - Marta Toral, Miguel Romero, Rosario Jiménez, Ayman Moawad Mahmoud, Emma Barroso, Manuel Gómez-Guzmán, Manuel Sánchez, Ángel Cogolludo, Ana B García-Redondo, Ana M Briones, Manuel Vázquez-Carrera, Francisco Pérez-Vizcaíno, Juan Duarte. Carnitine palmitoyltransferase-1 up-regulation by PPAR-β/δ prevents lipid-induced endothelial dysfunction.
Clinical science (London, England : 1979).
2015 Nov; 129(9):823-37. doi:
10.1042/cs20150111. [PMID: 26253087] - Jana Tumova, Lucia Malisova, Michal Andel, Jan Trnka. Protective Effect of Unsaturated Fatty Acids on Palmitic Acid-Induced Toxicity in Skeletal Muscle Cells is not Mediated by PPARδ Activation.
Lipids.
2015 Oct; 50(10):955-64. doi:
10.1007/s11745-015-4058-0. [PMID: 26255030] - Marta Toral, Manuel Gómez-Guzmán, Rosario Jiménez, Miguel Romero, María José Zarzuelo, María Pilar Utrilla, Carlos Hermenegildo, Ángel Cogolludo, Francisco Pérez-Vizcaíno, Julio Gálvez, Juan Duarte. Chronic peroxisome proliferator-activated receptorβ/δ agonist GW0742 prevents hypertension, vascular inflammatory and oxidative status, and endothelial dysfunction in diet-induced obesity.
Journal of hypertension.
2015 Sep; 33(9):1831-44. doi:
10.1097/hjh.0000000000000634. [PMID: 26147382] - Megan E Capozzi, Gary W McCollum, Sara R Savage, John S Penn. Peroxisome proliferator-activated receptor-β/δ regulates angiogenic cell behaviors and oxygen-induced retinopathy.
Investigative ophthalmology & visual science.
2013 Jun; 54(6):4197-207. doi:
10.1167/iovs.13-11608. [PMID: 23716627] - Sonja Lieber, Frithjof Scheer, Wolfgang Meissner, Simone Naruhn, Till Adhikary, Sabine Müller-Brüsselbach, Wibke E Diederich, Rolf Müller. (Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties.
Journal of medicinal chemistry.
2012 Mar; 55(6):2858-68. doi:
10.1021/jm2017122. [PMID: 22369181] - Alvaro A Sanchez-Siles, Norihisa Ishimura, Mohammad A K Rumi, Yuji Tamagawa, Satoko Ito, Shunji Ishihara, Toru Nabika, Yoshikazu Kinoshita. Administration of PPARβ/δ agonist reduces copper-induced liver damage in mice: possible implications in clinical practice.
Journal of clinical biochemistry and nutrition.
2011 Jul; 49(1):42-9. doi:
10.3164/jcbn.10-139. [PMID: 21765606] - S C Fan, B C Yu, Z C Chen, L J Chen, H H Chung, J T Cheng. The decreased expression of peroxisome proliferator-activated receptors delta (PPARdelta) is reversed by digoxin in the heart of diabetic rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2010 Aug; 42(9):637-42. doi:
10.1055/s-0030-1253373. [PMID: 20446238] - Teresa Coll, David Alvarez-Guardia, Emma Barroso, Anna Maria Gómez-Foix, Xavier Palomer, Juan C Laguna, Manuel Vázquez-Carrera. Activation of peroxisome proliferator-activated receptor-{delta} by GW501516 prevents fatty acid-induced nuclear factor-{kappa}B activation and insulin resistance in skeletal muscle cells.
Endocrinology.
2010 Apr; 151(4):1560-9. doi:
10.1210/en.2009-1211. [PMID: 20185762]