S3I-201 (BioDeep_00001877993)
Volatile Flavor Compounds
代谢物信息卡片
化学式: C16H15NO7S (365.05692)
中文名称: NSC 74859, 苯甲酸，2-羟基-4-[[2-[[（4-甲基苯基）磺酰基]氧基]乙酰基]氨基]
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O
InChI: InChI=1S/C16H15NO7S/c1-10-2-5-12(6-3-10)25(22,23)24-9-15(19)17-11-4-7-13(16(20)21)14(18)8-11/h2-8,18H,9H2,1H3,(H,17,19)(H,20,21)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jing Pan, Min Shi, Fan Guo, Liang Ma, Ping Fu. Pharmacologic inhibiting STAT3 delays the progression of kidney fibrosis in hyperuricemia-induced chronic kidney disease.
Life sciences.
2021 Nov; 285(?):119946. doi:
10.1016/j.lfs.2021.119946. [PMID: 34516993] - Chao Zheng, Lan Huang, Wu Luo, Weihui Yu, Xueting Hu, Xinfu Guan, Yan Cai, Chunpeng Zou, Haimin Yin, Zheng Xu, Guang Liang, Yi Wang. Inhibition of STAT3 in tubular epithelial cells prevents kidney fibrosis and nephropathy in STZ-induced diabetic mice.
Cell death & disease.
2019 11; 10(11):848. doi:
10.1038/s41419-019-2085-0. [PMID: 31699972] - Zheng Xu, Chunpeng Zou, Weihui Yu, Sujing Xu, Lan Huang, Zia Khan, Jingying Wang, Guang Liang, Yi Wang. Inhibition of STAT3 activation mediated by toll-like receptor 4 attenuates angiotensin II-induced renal fibrosis and dysfunction.
British journal of pharmacology.
2019 07; 176(14):2627-2641. doi:
10.1111/bph.14686. [PMID: 30958891] - Yunxia Du, Wei Zhang, Shuxia Liu, Xiaojuan Feng, Fan Gao, Qingjuan Liu. S3I-201 ameliorates tubulointerstitial lesion of the kidneys in MRL/lpr mice.
Biochemical and biophysical research communications.
2018 09; 503(1):177-180. doi:
10.1016/j.bbrc.2018.05.207. [PMID: 29885836] - Jingsong Liu, Ying Zhong, Guoyong Liu, Xiaobai Zhang, Bofei Xiao, Shang Huang, Hong Liu, Liyu He. Role of Stat3 Signaling in Control of EMT of Tubular Epithelial Cells During Renal Fibrosis.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2017; 42(6):2552-2558. doi:
10.1159/000480216. [PMID: 28848189] - Futoshi Matsui, Stephen K Babitz, Audrey Rhee, Karen L Hile, Hongji Zhang, Kirstan K Meldrum. Mesenchymal stem cells protect against obstruction-induced renal fibrosis by decreasing STAT3 activation and STAT3-dependent MMP-9 production.
American journal of physiology. Renal physiology.
2017 01; 312(1):F25-F32. doi:
10.1152/ajprenal.00311.2016. [PMID: 27760767] - Gustaf Lindgren, Elisabeth Kjellén, Johan Wennerberg, Lars Ekblad. Wound-healing factors can prime head and neck cancer cells to increase their tumor-forming capacity.
The Laryngoscope.
2016 06; 126(6):E213-7. doi:
10.1002/lary.25907. [PMID: 26865530] - Francisco J Rios, Karla B Neves, Aurelie Nguyen Dinh Cat, Sarah Even, Roberto Palacios, Augusto C Montezano, Rhian M Touyz. Cholesteryl ester-transfer protein inhibitors stimulate aldosterone biosynthesis in adipocytes through Nox-dependent processes.
The Journal of pharmacology and experimental therapeutics.
2015 Apr; 353(1):27-34. doi:
10.1124/jpet.114.221002. [PMID: 25617244] - Wea-Lung Lin, Deng-Yu Lai, Yean-Jang Lee, Nai-Fang Chen, Tsui-Hwa Tseng. Antitumor progression potential of morusin suppressing STAT3 and NFκB in human hepatoma SK-Hep1 cells.
Toxicology letters.
2015 Jan; 232(2):490-8. doi:
10.1016/j.toxlet.2014.11.031. [PMID: 25476160] - Ayumi Takakura, Erik A Nelson, Nadeem Haque, Benjamin D Humphreys, Kambiz Zandi-Nejad, David A Frank, Jing Zhou. Pyrimethamine inhibits adult polycystic kidney disease by modulating STAT signaling pathways.
Human molecular genetics.
2011 Nov; 20(21):4143-54. doi:
10.1093/hmg/ddr338. [PMID: 21821671] - Maoyin Pang, Li Ma, Rujun Gong, Evelyn Tolbert, Haiping Mao, Murugavel Ponnusamy, Y Eugene Chin, Haidong Yan, Lance D Dworkin, Shougang Zhuang. A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy.
Kidney international.
2010 Aug; 78(3):257-68. doi:
10.1038/ki.2010.154. [PMID: 20520592]