revaprazan (BioDeep_00001877992)
代谢物信息卡片
化学式: C22H23FN4 (362.1907)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1C2=CC=CC=C2CCN1C3=NC(=NC(=C3C)C)NC4=CC=C(C=C4)F
InChI: InChI=1S/C22H23FN4/c1-14-15(2)24-22(25-19-10-8-18(23)9-11-19)26-21(14)27-13-12-17-6-4-5-7-20(17)16(27)3/h4-11,16H,12-13H2,1-3H3,(H,24,25,26)
描述信息
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent
同义名列表
1 个代谢物同义名
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Hadiqa Nazish Raja, Fakhar Ud Din, Kanwal Shabbir, Salman Khan, Ali H Alamri, Ahmed Abdullah Al Awadh, Ahmed A Lahiq, Ali Alasiri. Sodium alginate-based smart gastro-retentive drug delivery system of revaprazan loaded SLNs; Formulation and characterization.
International journal of biological macromolecules.
2023 Dec; 253(Pt 6):127402. doi:
10.1016/j.ijbiomac.2023.127402. [PMID: 37832620] - Jung Sunwoo, Sang Chun Ji, Jaeseong Oh, Mu Seong Ban, Ji Yeon Nam, Bongtae Kim, Geun Seog Song, Kyung-Sang Yu, In-Jin Jang, SeungHwan Lee. Pharmacodynamics of tegoprazan and revaprazan after single and multiple oral doses in healthy subjects.
Alimentary pharmacology & therapeutics.
2020 12; 52(11-12):1640-1647. doi:
10.1111/apt.16121. [PMID: 33131095] - Jung Suk Kim, Jong Hyuck Park, Sung Chan Jeong, Dong Shik Kim, Abid Mehmood Yousaf, Fakhar Ud Din, Jong Oh Kim, Chul Soon Yong, Yu Seok Youn, Kyung Taek Oh, Sung Giu Jin, Han-Gon Choi. Novel revaprazan-loaded gelatin microsphere with enhanced drug solubility and oral bioavailability.
Journal of microencapsulation.
2018 Aug; 35(5):421-427. doi:
10.1080/02652048.2018.1515997. [PMID: 30136606] - Jong Hyuck Park, Dong Shik Kim, Omer Mustapha, Abid Mehmood Yousaf, Jung Suk Kim, Dong Wuk Kim, Chul Soon Yong, Yu Seok Youn, Kyung Taek Oh, Soo-Jeong Lim, Jong Oh Kim, Han-Gon Choi. Comparison of a revaprazan-loaded solid dispersion, solid SNEDDS and inclusion compound: Physicochemical characterisation and pharmacokinetics.
Colloids and surfaces. B, Biointerfaces.
2018 Feb; 162(?):420-426. doi:
10.1016/j.colsurfb.2017.12.017. [PMID: 29248606] - Yunju Jo, Eunkyoung Park, Sang Bong Ahn, Young Kwan Jo, Byungkwan Son, Seong Hwan Kim, Young Sook Park, Hyo Jeong Kim. A Proton Pump Inhibitor's Effect on Bone Metabolism Mediated by Osteoclast Action in Old Age: A Prospective Randomized Study.
Gut and liver.
2015 Sep; 9(5):607-14. doi:
10.5009/gnl14135. [PMID: 25473078] - Hyung-Keun Kim, Soo-Heon Park, Dae-Young Cheung, Young-Seok Cho, Jin-Il Kim, Sung-Soo Kim, Hiun-Suk Chae, Jae-Kwang Kim, In-Sik Chung. Clinical trial: inhibitory effect of revaprazan on gastric acid secretion in healthy male subjects.
Journal of gastroenterology and hepatology.
2010 Oct; 25(10):1618-25. doi:
10.1111/j.1440-1746.2010.06408.x. [PMID: 20880169] - Hiroki Mori, Hiroko Tonai-Kachi, Yasuo Ochi, Yasuhito Taniguchi, Hiroyuki Ohshiro, Nobuyuki Takahashi, Takeshi Aihara, Akiko Hirao, Teruhisa Kato, Minoru Sakakibara, Yoichi Kurebayashi. N-(2-hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (PF-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease.
The Journal of pharmacology and experimental therapeutics.
2009 Feb; 328(2):671-9. doi:
10.1124/jpet.108.146415. [PMID: 18981288] - Kyung-Sang Yu, Kyun-Seop Bae, Ji-Hong Shon, Joo-Youn Cho, So-Young Yi, Jae-Yong Chung, Hyeong-Seok Lim, In-Jin Jang, Sang-Goo Shin, Keun-Seog Song, Byoung-Seok Moon. Pharmacokinetic and pharmacodynamic evaluation of a novel proton pump inhibitor, YH1885, in healthy volunteers.
Journal of clinical pharmacology.
2004 Jan; 44(1):73-82. doi:
10.1177/0091270003261321. [PMID: 14681344] - K S Han, Y G Kim, J K Yoo, J W Lee, M G Lee. Pharmacokinetics of a new reversible proton pump inhibitor, YH1885, after intravenous and oral administrations to rats and dogs: hepatic first-pass effect in rats.
Biopharmaceutics & drug disposition.
1998 Nov; 19(8):493-500. doi:
10.1002/(sici)1099-081x(1998110)19:8<493::aid-bdd129>3.0.co;2-z. [PMID: 9840211] - K S Han, Y G Kim, J W Lee, M G Lee. Blood partition and protein binding of a new reversible proton pump inhibitor, YH1885.
Biopharmaceutics & drug disposition.
1998 Sep; 19(6):413-5. doi:
10.1002/(sici)1099-081x(199809)19:6<413::aid-bdd128>3.0.co;2-g. [PMID: 9737823] - K S Han, H C Choi, J K Yoo, J W Lee, M G Lee. Determination of a new proton pump inhibitor, YH1885, in human plasma and urine by high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Aug; 696(2):312-6. doi:
10.1016/s0378-4347(97)00238-7. [PMID: 9323554]
