5-carboxyfluorescein (BioDeep_00001877981)

   


代谢物信息卡片


5-carboxyfluorescein

化学式: C21H12O7 (376.0583002)
中文名称: 5-羧基荧光素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC2=C(C=C1C(=O)O)C(=O)OC23C4=C(C=C(C=C4)O)OC5=C3C=CC(=C5)O
InChI: InChI=1S/C21H12O7/c22-11-2-5-15-17(8-11)27-18-9-12(23)3-6-16(18)21(15)14-4-1-10(19(24)25)7-13(14)20(26)28-21/h1-9,22-23H,(H,24,25)

描述信息

D004396 - Coloring Agents > D005456 - Fluorescent Dyes > D005452 - Fluoresceins

同义名列表

1 个代谢物同义名

5-carboxyfluorescein



数据库引用编号

3 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Ryuto Tomabechi, Miki Miyasato, Taeka Sato, Tappei Takada, Kei Higuchi, Hisanao Kishimoto, Yoshiyuki Shirasaka, Katsuhisa Inoue. Identification of 5-Carboxyfluorescein as a Probe Substrate of SLC46A3 and Its Application in a Fluorescence-Based In Vitro Assay Evaluating the Interaction with SLC46A3. Molecular pharmaceutics. 2023 01; 20(1):491-499. doi: 10.1021/acs.molpharmaceut.2c00741. [PMID: 36458938]
  • Scott Legare, Fabian Heide, Ben A Bailey-Elkin, Jörg Stetefeld. Improved SARS-CoV-2 main protease high-throughput screening assay using a 5-carboxyfluorescein substrate. The Journal of biological chemistry. 2022 04; 298(4):101739. doi: 10.1016/j.jbc.2022.101739. [PMID: 35182525]
  • Dinh-Vu Le. Fluorescence Determination of Peptidase Activity Based on the Quenching of a Fluorophore-Labelled Peptide by Graphene Oxide. The protein journal. 2021 10; 40(5):682-688. doi: 10.1007/s10930-021-09985-6. [PMID: 33856620]
  • Youwen Zhang, Xiaohan Chen, Golbarg M Roozbahani, Xiyun Guan. Rapid and sensitive detection of the activity of ADAM17 using a graphene oxide-based fluorescence sensor. The Analyst. 2019 Feb; 144(5):1825-1830. doi: 10.1039/c8an02344a. [PMID: 30675599]
  • Hai Shi, Tao Gao, Liu Shi, Tianshu Chen, Yang Xiang, Yuanyang Li, Genxi Li. Molecular imaging of telomerase and the enzyme activity-triggered drug release by using a conformation-switchable nanoprobe in cancerous cells. Scientific reports. 2018 11; 8(1):16341. doi: 10.1038/s41598-018-34670-7. [PMID: 30397241]
  • Lanfang Yang, Nan Li, Ke Wang, Xiaoman Hai, Junxia Liu, Fuquan Dang. A novel peptide/Fe3O4@SiO2-Au nanocomposite-based fluorescence biosensor for the highly selective and sensitive detection of prostate-specific antigen. Talanta. 2018 Mar; 179(?):531-537. doi: 10.1016/j.talanta.2017.11.033. [PMID: 29310271]
  • Zhen Wang, Yan-Jiang Han, Shun Huang, Meng Wang, Wen-Lan Zhou, Hong-Sheng Li, Quan-Shi Wang, Hu-Bing Wu. Imaging the expression of glypican-3 in hepatocellular carcinoma by PET. Amino acids. 2018 02; 50(2):309-320. doi: 10.1007/s00726-017-2517-z. [PMID: 29204748]
  • Takahiro Fujimoto, Jian Wang, Kazuki Baba, Yuka Oki, Yuki Hiruta, Masayuki Ito, Shinobu Ito, Hideko Kanazawa. Transcutaneous drug delivery by liposomes using fractional laser technology. Lasers in surgery and medicine. 2017 07; 49(5):525-532. doi: 10.1002/lsm.22616. [PMID: 27990655]
  • Silvia Pescina, Marina Sala, Cristina Padula, Maria Carmina Scala, Antonia Spensiero, Silvana Belletti, Rita Gatti, Ettore Novellino, Pietro Campiglia, Patrizia Santi, Sara Nicoli, Carmine Ostacolo. Design and Synthesis of New Cell Penetrating Peptides: Diffusion and Distribution Inside the Cornea. Molecular pharmaceutics. 2016 11; 13(11):3876-3883. doi: 10.1021/acs.molpharmaceut.6b00658. [PMID: 27676095]
  • Milan Obradovic, J Alex Pasternak, Siew Hon Ng, Heather L Wilson. Use of flow cytometry and PCR analysis to detect 5-carboxyfluoroscein-stained obligate intracellular bacteria Lawsonia intracellularis invasion of McCoy cells. Journal of microbiological methods. 2016 07; 126(?):60-6. doi: 10.1016/j.mimet.2016.04.015. [PMID: 27154728]
  • Feng Li, Yanmei Zhang, DanYe Qiu, Jingwu Kang. Screening of epidermal growth factor receptor inhibitors in natural products by capillary electrophoresis combined with high performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2015 Jun; 1400(?):117-23. doi: 10.1016/j.chroma.2015.04.055. [PMID: 25981288]
  • Yanmei Zhang, Feng Li, Mingxia Li, Jingwu Kang. Screening of mammalian target of rapamycin inhibitors in natural product extracts by capillary electrophoresis in combination with high performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2015 Apr; 1388(?):267-73. doi: 10.1016/j.chroma.2015.02.033. [PMID: 25725958]
  • Wen-Jian Zhang, Dong-Xiao Yang, Ling-Lin Feng, Fei Wang, Gang Wei, Wei-Yue Lu. [Modification by wheat germ agglutinin delays the ocular elimination of liposome]. Yao xue xue bao = Acta pharmaceutica Sinica. 2014 Apr; 49(4):543-9. doi: ". [PMID: 24974475]
  • Sabina Gerber, Christian Lizak, Gaëlle Michaud, Monika Bucher, Tamis Darbre, Markus Aebi, Jean-Louis Reymond, Kaspar P Locher. Mechanism of bacterial oligosaccharyltransferase: in vitro quantification of sequon binding and catalysis. The Journal of biological chemistry. 2013 Mar; 288(13):8849-61. doi: 10.1074/jbc.m112.445940. [PMID: 23382388]
  • Xiaohui Wang, Xianghua Wen, Yu Xia, Ma Hu, Fang Zhao, Kun Ding. Ammonia oxidizing bacteria community dynamics in a pilot-scale wastewater treatment plant. PloS one. 2012; 7(4):e36272. doi: 10.1371/journal.pone.0036272. [PMID: 22558415]
  • Chi C Wong, Denis Barron, Caroline Orfila, Fabiola Dionisi, Peter Krajcsi, Gary Williamson. Interaction of hydroxycinnamic acids and their conjugates with organic anion transporters and ATP-binding cassette transporters. Molecular nutrition & food research. 2011 Jul; 55(7):979-88. doi: 10.1002/mnfr.201000652. [PMID: 21538853]
  • Monique da Rocha Queiroz Lima, Rita Maria Ribeiro Nogueira, Hermann Gonçalves Schatzmayr, Ana Maria Bispo de Filippis, Daniel Limonta, Flavia Barreto dos Santos. A new approach to dengue fatal cases diagnosis: NS1 antigen capture in tissues. PLoS neglected tropical diseases. 2011 May; 5(5):e1147. doi: 10.1371/journal.pntd.0001147. [PMID: 21572520]
  • Chi Chun Wong, Nigel P Botting, Caroline Orfila, Nawaf Al-Maharik, Gary Williamson. Flavonoid conjugates interact with organic anion transporters (OATs) and attenuate cytotoxicity of adefovir mediated by organic anion transporter 1 (OAT1/SLC22A6). Biochemical pharmacology. 2011 Apr; 81(7):942-9. doi: 10.1016/j.bcp.2011.01.004. [PMID: 21244849]
  • Chun Yang, Mingjun Zhang, Weiping Niu, Runjun Yang, Yonghong Zhang, Zhengyan Qiu, Boxing Sun, Zhihui Zhao. Analysis of DNA methylation in various swine tissues. PloS one. 2011 Jan; 6(1):e16229. doi: 10.1371/journal.pone.0016229. [PMID: 21283691]
  • Megha A Nagle, David M Truong, Ankur V Dnyanmote, Sun-Young Ahn, Satish A Eraly, Wei Wu, Sanjay K Nigam. Analysis of three-dimensional systems for developing and mature kidneys clarifies the role of OAT1 and OAT3 in antiviral handling. The Journal of biological chemistry. 2011 Jan; 286(1):243-51. doi: 10.1074/jbc.m110.139949. [PMID: 20921221]
  • Stefania Gimelli, Gianluca Caridi, Silvana Beri, Kyle McCracken, Renata Bocciardi, Paola Zordan, Monica Dagnino, Patrizia Fiorio, Luisa Murer, Elisa Benetti, Orsetta Zuffardi, Roberto Giorda, James M Wells, Giorgio Gimelli, Gian Marco Ghiggeri. Mutations in SOX17 are associated with congenital anomalies of the kidney and the urinary tract. Human mutation. 2010 Dec; 31(12):1352-9. doi: 10.1002/humu.21378. [PMID: 20960469]
  • Dongtao Ge, Dewang Wu, Zuyong Wang, Wei Shi, Ting Wu, Aifeng Zhang, Shimin Hong, Jun Wang, Ye Zhang, Lei Ren. Cellular uptake mechanism of molecular umbrella. Bioconjugate chemistry. 2009 Dec; 20(12):2311-6. doi: 10.1021/bc9003074. [PMID: 19919058]
  • Stefania Gimelli, Silvana Beri, Harry A Drabkin, Claudio Gambini, Andrea Gregorio, Patrizia Fiorio, Orsetta Zuffardi, Robert M Gemmill, Roberto Giorda, Giorgio Gimelli. The tumor suppressor gene TRC8/RNF139 is disrupted by a constitutional balanced translocation t(8;22)(q24.13;q11.21) in a young girl with dysgerminoma. Molecular cancer. 2009 Jul; 8(?):52. doi: 10.1186/1476-4598-8-52. [PMID: 19642973]
  • K B Mogensen, L Gangloff, P Boggild, K B K Teo, W I Milne, J P Kutter. Carbon nanotubes integrated in electrically insulated channels for lab-on-a-chip applications. Nanotechnology. 2009 Mar; 20(9):095503. doi: 10.1088/0957-4484/20/9/095503. [PMID: 19417490]
  • Wei Wang, Ruiqiong Li, George W Gokel. 'Aplosspan:' a bilayer-length, ion-selective ionophore that functions in phospholipid bilayers. Chemical communications (Cambridge, England). 2009 Feb; ?(8):911-3. doi: 10.1039/b816819a. [PMID: 19214313]
  • Casper J Breuker, Kathleen Victoir, Peter W De Jong, Eddy van der Meijden, Paul M Brakefield, Klaas Vrieling. AFLP markers for the R-gene in the flea beetle, Phyllotreta nemorum, conferring resistance to defenses in Barbarea vulgaris. Journal of insect science (Online). 2005 Dec; 5(?):38. doi: 10.1093/jis/5.1.38. [PMID: 17119620]
  • Chang-Moon Lee, Hyun-Chul Lee, Ki-Young Lee. O-palmitoylcurdlan sulfate (OPCurS)-coated liposomes for oral drug delivery. Journal of bioscience and bioengineering. 2005 Sep; 100(3):255-9. doi: 10.1263/jbb.100.255. [PMID: 16243273]
  • Alexandre Coulon, Emir Berkane, Anne Marie Sautereau, Konrad Urech, Pierre Rouge, Andre Lopez. Modes of membrane interaction of a natural cysteine-rich peptide: viscotoxin A3. Biochimica et biophysica acta. 2002 Feb; 1559(2):145-59. doi: 10.1016/s0005-2736(01)00446-1. [PMID: 11853681]
  • Q P Chen, Q T Li. Effect of cardiolipin on proton permeability of phospholipid liposomes: the role of hydration at the lipid-water interface. Archives of biochemistry and biophysics. 2001 May; 389(2):201-6. doi: 10.1006/abbi.2001.2319. [PMID: 11339809]
  • J W Kok, R J Veldman, K Klappe, H Koning, C M Filipeanu, M Müller. Differential expression of sphingolipids in MRP1 overexpressing HT29 cells. International journal of cancer. 2000 Jul; 87(2):172-8. doi: 10.1002/1097-0215(20000715)87:2<172::aid-ijc3>3.0.co;2-k. [PMID: 10861470]
  • T Cihlar, E S Ho. Fluorescence-based assay for the interaction of small molecules with the human renal organic anion transporter 1. Analytical biochemistry. 2000 Jul; 283(1):49-55. doi: 10.1006/abio.2000.4633. [PMID: 10929807]
  • Y S Quan, T Fujita, F Kamiyama, A Yamamoto. Electrophysiological studies on the evaluation of absorption enhancers in Caco-2 cells using a microelectrode technique. Biological & pharmaceutical bulletin. 2000 Jun; 23(6):738-42. doi: 10.1248/bpb.23.738. [PMID: 10864027]
  • A de la Maza, O Lopez, L Coderch, J L Parra. Solubilization of phosphatidylcholine liposomes by the amphoteric surfactant dodecyl betaine. Chemistry and physics of lipids. 1998 Jul; 94(1):71-9. doi: 10.1016/s0009-3084(98)00045-0. [PMID: 9721630]
  • G M Makrigiorgos, A I Kassis, A Mahmood, E A Bump, P Savvides. Novel fluorescein-based flow-cytometric method for detection of lipid peroxidation. Free radical biology & medicine. 1997; 22(1-2):93-100. doi: 10.1016/s0891-5849(96)00229-8. [PMID: 8958133]
  • G Saberwal, R Nagaraj. Interaction of hydrophobic peptides with model membranes: slow binding to membranes and not subtle variations in pore structure is responsible for the gradual release of entrapped solutes. Biochimica et biophysica acta. 1993 Sep; 1151(1):43-50. doi: 10.1016/0005-2736(93)90069-c. [PMID: 8357819]
  • R F Barber, P N Shek. Liposomes and tear fluid. I. Release of vesicle-entrapped carboxyfluorescein. Biochimica et biophysica acta. 1986 Nov; 879(2):157-63. doi: 10.1016/0005-2760(86)90098-6. [PMID: 3768395]
  • D Carrier, M Pézolet. Investigation of polylysine-dipalmitoylphosphatidylglycerol interactions in model membranes. Biochemistry. 1986 Jul; 25(14):4167-74. doi: 10.1021/bi00362a027. [PMID: 3741849]
  • K Hong, V D Vacquier. Fusion of liposomes induced by a cationic protein from the acrosome granule of abalone spermatozoa. Biochemistry. 1986 Feb; 25(3):543-9. doi: 10.1021/bi00351a004. [PMID: 3955012]
  • M Halks-Miller, L S Guo, R L Hamilton. Tocopherol-phospholipid liposomes: maximum content and stability to serum proteins. Lipids. 1985 Mar; 20(3):195-200. doi: 10.1007/bf02534254. [PMID: 4039400]